OR7G1

Functionⁱ

Odorant receptor.Curated

GO - Molecular functionⁱ

G-protein coupled receptor activity Source: UniProtKB-KW
olfactory receptor activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

detection of chemical stimulus involved in sensory perception of smell Source: GO_Central
G-protein coupled receptor signaling pathway Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Olfaction, Sensory transduction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Olfactory receptor 7G1 Alternative name(s): Olfactory receptor 19-15 Short name: OR19-15 Olfactory receptor OR19-8
Gene namesⁱ	Name:OR7G1 Synonyms:OR7G1P
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000161807.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8465 OR7G1
neXtProtⁱ	NX_Q8NGA0

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 29	ExtracellularSequence analysisAdd BLAST	29
Transmembraneⁱ	30 – 50	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	51 – 57	CytoplasmicSequence analysis	7
Transmembraneⁱ	58 – 78	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	79 – 97	ExtracellularSequence analysisAdd BLAST	19
Transmembraneⁱ	98 – 118	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	119 – 133	CytoplasmicSequence analysisAdd BLAST	15
Transmembraneⁱ	134 – 154	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	155 – 196	ExtracellularSequence analysisAdd BLAST	42
Transmembraneⁱ	197 – 217	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	218 – 244	CytoplasmicSequence analysisAdd BLAST	27
Transmembraneⁱ	245 – 265	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	266 – 269	ExtracellularSequence analysis	4
Transmembraneⁱ	270 – 290	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	291 – 311	CytoplasmicSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA32737

PharmGKBⁱ

PA32737

Polymorphism and mutation databases

BioMutaⁱ	OR7G1
DMDMⁱ	218511731

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000150650	1 – 311	Olfactory receptor 7G1Add BLAST		311

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	5	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	89	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	97 ↔ 179	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q8NGA0
PRIDEⁱ	Q8NGA0
ProteomicsDBⁱ	73458

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000161807 Expressed in 1 organ(s), highest expression level in blood
CleanExⁱ	HS_OR7G1
ExpressionAtlasⁱ	Q8NGA0 differential

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000444134

STRINGⁱ

9606.ENSP00000444134

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NGA0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IVB1 Eukaryota ENOG410YBQN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00840000129792
HOGENOMⁱ	HOG000041364
HOVERGENⁱ	HBG017625
InParanoidⁱ	Q8NGA0
KEGG Orthology (KO) More...KOⁱ	K04257
OMAⁱ	ESCFLAV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B53
PhylomeDBⁱ	Q8NGA0
TreeFamⁱ	TF337210

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8NGA0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGPRNQTAVS EFLLMKVTED PELKLIPFSL FLSMYLVTIL GNLLILLAVI 
        60         70         80         90        100
SDSHLHTPMY FLLFNLSFTD ICLTTTTVPK ILVNIQAQNQ SITYTGCLTQ 
       110        120        130        140        150
ICLVLVFAGL ESCFLAVMAY DRYVAICHPL RYTVLMNVHF WGLLILLSMF 
       160        170        180        190        200
MSTMDALVQS LMVLQLSFCK NVEIPLFFCE VVQVIKLACS DTLINNILIY 
       210        220        230        240        250
FASSVFGAIP LSGIIFSYSQ IVTSVLRMPS ARGKYKAFST CGCHLSVFSL 
       260        270        280        290        300
FYGTAFGVYI SSAVAESSRI TAVASVMYTV VPQMMNPFIY SLRNKEMKKA 
       310 
LRKLIGRLFP F

Length:311

Mass (Da):34,803

Last modified:December 16, 2008 - v2

Checksum:ⁱC408FFF590A95340

GO

Sequence cautionⁱ

The sequence BAC06141 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_048074	83	V → A. Corresponds to variant dbSNP:rs6511874Ensembl.	1
Natural variantⁱVAR_034255	141	W → C. Corresponds to variant dbSNP:rs2217657Ensembl.	1
Natural variantⁱVAR_048075	156	A → V. Corresponds to variant dbSNP:rs7246980Ensembl.	1
Natural variantⁱVAR_048076	167	S → F. Corresponds to variant dbSNP:rs7246969Ensembl.	1
Natural variantⁱVAR_034256	252	Y → C. Corresponds to variant dbSNP:rs2195951Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065926 Genomic DNA Translation: BAC06141.1 Sequence problems. AC011464 Genomic DNA No translation available. AF399538 Genomic DNA Translation: AAK95023.1 BK004267 Genomic DNA Translation: DAA04665.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32898.2
NCBI Reference Sequences More...RefSeqⁱ	NP_001005192.2, NM_001005192.2
UniGeneⁱ	Hs.553576

Genome annotation databases

Ensemblⁱ	ENST00000541538; ENSP00000444134; ENSG00000161807
GeneIDⁱ	125962
KEGGⁱ	hsa:125962
UCSC genome browser More...UCSCⁱ	uc021uoi.1 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8NGA0	Olfactory receptor		HUMAN		311	UniRef90_Q8NGA0
Olfactory receptor		PANTR		311
Olfactory receptor		PANPA		311
Olfactory receptor		GORGO		310
UPI000CEF62CC		PONAB		314
+2

Protein	Similar proteins		Species	Score	Length	Source
Q8NGA0	Olfactory receptor 8		MOUSE		310	UniRef50_Q8NGA0
Olfactory receptor 1082		RAT		317
Olfactory receptor		HUMAN		311
Olfactory receptor		PANPA		311
Olfactory receptor		PANTR		311
+193

Cross-referencesⁱ

Web resourcesⁱ

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065926 Genomic DNA Translation: BAC06141.1 Sequence problems. AC011464 Genomic DNA No translation available. AF399538 Genomic DNA Translation: AAK95023.1 BK004267 Genomic DNA Translation: DAA04665.1
CCDSⁱ	CCDS32898.2
RefSeqⁱ	NP_001005192.2, NM_001005192.2
UniGeneⁱ	Hs.553576

3D structure databases

ProteinModelPortalⁱ	Q8NGA0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000444134

STRINGⁱ

9606.ENSP00000444134

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

Polymorphism and mutation databases

BioMutaⁱ	OR7G1
DMDMⁱ	218511731

Proteomic databases

PaxDbⁱ	Q8NGA0
PRIDEⁱ	Q8NGA0
ProteomicsDBⁱ	73458

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000541538; ENSP00000444134; ENSG00000161807
GeneIDⁱ	125962
KEGGⁱ	hsa:125962
UCSCⁱ	uc021uoi.1 human

Organism-specific databases

CTDⁱ	125962
EuPathDBⁱ	HostDB:ENSG00000161807.3
GeneCardsⁱ	OR7G1
HGNCⁱ	HGNC:8465 OR7G1
neXtProtⁱ	NX_Q8NGA0
PharmGKBⁱ	PA32737
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IVB1 Eukaryota ENOG410YBQN LUCA
GeneTreeⁱ	ENSGT00840000129792
HOGENOMⁱ	HOG000041364
HOVERGENⁱ	HBG017625
InParanoidⁱ	Q8NGA0
KOⁱ	K04257
OMAⁱ	ESCFLAV
OrthoDBⁱ	EOG091G0B53
PhylomeDBⁱ	Q8NGA0
TreeFamⁱ	TF337210

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiⁱ	OR7G1
GenomeRNAiⁱ	125962
Protein Ontology More...PROⁱ	PR:Q8NGA0

Gene expression databases

Bgeeⁱ	ENSG00000161807 Expressed in 1 organ(s), highest expression level in blood
CleanExⁱ	HS_OR7G1
ExpressionAtlasⁱ	Q8NGA0 differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OR7G1_HUMAN
Accessionⁱ	Q8NGA0Primary (citable) accession number: Q8NGA0 Secondary accession number(s): Q6IFJ5, Q96RA1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
	Last sequence update:	December 16, 2008
	Last modified:	September 12, 2018
	This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8NGA0 (OR7G1_HUMAN)

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Olfactory receptor 7G1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ