Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 7G1

Gene

OR7G1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 7G1
Alternative name(s):
Olfactory receptor 19-15
Short name:
OR19-15
Olfactory receptor OR19-8
Gene namesi
Name:OR7G1
Synonyms:OR7G1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000161807.3
HGNCiHGNC:8465 OR7G1
neXtProtiNX_Q8NGA0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 57CytoplasmicSequence analysis7
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 97ExtracellularSequence analysisAdd BLAST19
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 133CytoplasmicSequence analysisAdd BLAST15
Transmembranei134 – 154Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini155 – 196ExtracellularSequence analysisAdd BLAST42
Transmembranei197 – 217Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini218 – 244CytoplasmicSequence analysisAdd BLAST27
Transmembranei245 – 265Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini266 – 269ExtracellularSequence analysis4
Transmembranei270 – 290Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini291 – 311CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32737

Polymorphism and mutation databases

BioMutaiOR7G1
DMDMi218511731

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506501 – 311Olfactory receptor 7G1Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGA0
PRIDEiQ8NGA0
ProteomicsDBi73458

Expressioni

Gene expression databases

BgeeiENSG00000161807 Expressed in 1 organ(s), highest expression level in blood
CleanExiHS_OR7G1
ExpressionAtlasiQ8NGA0 differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000444134

Structurei

3D structure databases

ProteinModelPortaliQ8NGA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVB1 Eukaryota
ENOG410YBQN LUCA
GeneTreeiENSGT00840000129792
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGA0
KOiK04257
OMAiESCFLAV
OrthoDBiEOG091G0B53
PhylomeDBiQ8NGA0
TreeFamiTF337210

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPRNQTAVS EFLLMKVTED PELKLIPFSL FLSMYLVTIL GNLLILLAVI
60 70 80 90 100
SDSHLHTPMY FLLFNLSFTD ICLTTTTVPK ILVNIQAQNQ SITYTGCLTQ
110 120 130 140 150
ICLVLVFAGL ESCFLAVMAY DRYVAICHPL RYTVLMNVHF WGLLILLSMF
160 170 180 190 200
MSTMDALVQS LMVLQLSFCK NVEIPLFFCE VVQVIKLACS DTLINNILIY
210 220 230 240 250
FASSVFGAIP LSGIIFSYSQ IVTSVLRMPS ARGKYKAFST CGCHLSVFSL
260 270 280 290 300
FYGTAFGVYI SSAVAESSRI TAVASVMYTV VPQMMNPFIY SLRNKEMKKA
310
LRKLIGRLFP F
Length:311
Mass (Da):34,803
Last modified:December 16, 2008 - v2
Checksum:iC408FFF590A95340
GO

Sequence cautioni

The sequence BAC06141 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04807483V → A. Corresponds to variant dbSNP:rs6511874Ensembl.1
Natural variantiVAR_034255141W → C. Corresponds to variant dbSNP:rs2217657Ensembl.1
Natural variantiVAR_048075156A → V. Corresponds to variant dbSNP:rs7246980Ensembl.1
Natural variantiVAR_048076167S → F. Corresponds to variant dbSNP:rs7246969Ensembl.1
Natural variantiVAR_034256252Y → C. Corresponds to variant dbSNP:rs2195951Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065926 Genomic DNA Translation: BAC06141.1 Sequence problems.
AC011464 Genomic DNA No translation available.
AF399538 Genomic DNA Translation: AAK95023.1
BK004267 Genomic DNA Translation: DAA04665.1
CCDSiCCDS32898.2
RefSeqiNP_001005192.2, NM_001005192.2
UniGeneiHs.553576

Genome annotation databases

EnsembliENST00000541538; ENSP00000444134; ENSG00000161807
GeneIDi125962
KEGGihsa:125962
UCSCiuc021uoi.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065926 Genomic DNA Translation: BAC06141.1 Sequence problems.
AC011464 Genomic DNA No translation available.
AF399538 Genomic DNA Translation: AAK95023.1
BK004267 Genomic DNA Translation: DAA04665.1
CCDSiCCDS32898.2
RefSeqiNP_001005192.2, NM_001005192.2
UniGeneiHs.553576

3D structure databases

ProteinModelPortaliQ8NGA0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000444134

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR7G1
DMDMi218511731

Proteomic databases

PaxDbiQ8NGA0
PRIDEiQ8NGA0
ProteomicsDBi73458

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000541538; ENSP00000444134; ENSG00000161807
GeneIDi125962
KEGGihsa:125962
UCSCiuc021uoi.1 human

Organism-specific databases

CTDi125962
EuPathDBiHostDB:ENSG00000161807.3
GeneCardsiOR7G1
HGNCiHGNC:8465 OR7G1
neXtProtiNX_Q8NGA0
PharmGKBiPA32737
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVB1 Eukaryota
ENOG410YBQN LUCA
GeneTreeiENSGT00840000129792
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGA0
KOiK04257
OMAiESCFLAV
OrthoDBiEOG091G0B53
PhylomeDBiQ8NGA0
TreeFamiTF337210

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR7G1
GenomeRNAii125962
PROiPR:Q8NGA0

Gene expression databases

BgeeiENSG00000161807 Expressed in 1 organ(s), highest expression level in blood
CleanExiHS_OR7G1
ExpressionAtlasiQ8NGA0 differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR7G1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGA0
Secondary accession number(s): Q6IFJ5, Q96RA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: September 12, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again