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Protein

Olfactory receptor 2AK2

Gene

OR2AK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2AK2
Alternative name(s):
Olfactory receptor 2AK1
Olfactory receptor OR1-47
Gene namesi
Name:OR2AK2
Synonyms:OR2AK1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000187080.7
HGNCiHGNC:19569 OR2AK2
neXtProtiNX_Q8NG84

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40ExtracellularSequence analysisAdd BLAST40
Transmembranei41 – 64Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini65 – 72CytoplasmicSequence analysis8
Transmembranei73 – 94Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini95 – 115ExtracellularSequence analysisAdd BLAST21
Transmembranei116 – 135Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini136 – 154CytoplasmicSequence analysisAdd BLAST19
Transmembranei155 – 173Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini174 – 210ExtracellularSequence analysisAdd BLAST37
Transmembranei211 – 234Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini235 – 251CytoplasmicSequence analysisAdd BLAST17
Transmembranei252 – 274Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini275 – 287ExtracellularSequence analysisAdd BLAST13
Transmembranei288 – 307Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini308 – 335CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187080
PharmGKBiPA134921949

Polymorphism and mutation databases

BioMutaiOR2AK2
DMDMi229462914

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504741 – 335Olfactory receptor 2AK2Add BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi20N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi112 ↔ 204PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NG84
PeptideAtlasiQ8NG84
PRIDEiQ8NG84
ProteomicsDBi73450

PTM databases

iPTMnetiQ8NG84
PhosphoSitePlusiQ8NG84

Expressioni

Gene expression databases

BgeeiENSG00000187080 Expressed in 5 organ(s), highest expression level in testis
CleanExiHS_OR2AK2

Organism-specific databases

HPAiHPA052544

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355436

Structurei

3D structure databases

ProteinModelPortaliQ8NG84
SMRiQ8NG84
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9IV Eukaryota
ENOG411152X LUCA
GeneTreeiENSGT00910000144053
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NG84
KOiK04257
OMAiKICCLMV
OrthoDBiEOG091G0ELL
PhylomeDBiQ8NG84
TreeFamiTF337295

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q8NG84-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNISDVISFD ILVSAMKTGN QSFGTDFLLV GLFQYGWINS LLFVVIATLF
60 70 80 90 100
TVALTGNIML IHLIRLNTRL HTPMYFLLSQ LSIVDLMYIS TTVPKMAVSF
110 120 130 140 150
LSQSKTIRFL GCEIQTYVFL ALGGTEALLL GFMSYDRYVA ICHPLHYPML
160 170 180 190 200
MSKKICCLMV ACAWASGSIN AFIHTLYVFQ LPFCRSRLIN HFFCEVPALL
210 220 230 240 250
SLVCQDTSQY EYTVLLSGLI ILLLPFLAIL ASYARVLIVV FQMSSGKGQA
260 270 280 290 300
KAVSTCSSHL IVASLFYATT LFTYTRPHSL RSPSRDKAVA VFYTIVTPLL
310 320 330
NPFIYSLRNK EVTGAVRRLL GYWICCRKYD FRSLY
Length:335
Mass (Da):37,763
Last modified:May 5, 2009 - v2
Checksum:i663745628F070E7F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2C9F2M8A0A2C9F2M8_HUMAN
Olfactory receptor
OR2AK2
320Annotation score:

Sequence cautioni

The sequence BAC06164 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05505199S → N. Corresponds to variant dbSNP:rs6664332Ensembl.1
Natural variantiVAR_055052203V → M1 PublicationCorresponds to variant dbSNP:rs4478844Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065951 Genomic DNA Translation: BAC06164.1 Different initiation.
AC099570 Genomic DNA No translation available.
BC136816 mRNA Translation: AAI36817.1
BK004457 Genomic DNA Translation: DAA04855.1
CCDSiCCDS31102.1
RefSeqiNP_001004491.1, NM_001004491.1
UniGeneiHs.690413

Genome annotation databases

EnsembliENST00000641852; ENSP00000493202; ENSG00000187080
GeneIDi391191
KEGGihsa:391191
UCSCiuc010pzd.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065951 Genomic DNA Translation: BAC06164.1 Different initiation.
AC099570 Genomic DNA No translation available.
BC136816 mRNA Translation: AAI36817.1
BK004457 Genomic DNA Translation: DAA04855.1
CCDSiCCDS31102.1
RefSeqiNP_001004491.1, NM_001004491.1
UniGeneiHs.690413

3D structure databases

ProteinModelPortaliQ8NG84
SMRiQ8NG84
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355436

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NG84
PhosphoSitePlusiQ8NG84

Polymorphism and mutation databases

BioMutaiOR2AK2
DMDMi229462914

Proteomic databases

PaxDbiQ8NG84
PeptideAtlasiQ8NG84
PRIDEiQ8NG84
ProteomicsDBi73450

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000641852; ENSP00000493202; ENSG00000187080
GeneIDi391191
KEGGihsa:391191
UCSCiuc010pzd.3 human

Organism-specific databases

CTDi391191
EuPathDBiHostDB:ENSG00000187080.7
GeneCardsiOR2AK2
HGNCiHGNC:19569 OR2AK2
HPAiHPA052544
neXtProtiNX_Q8NG84
OpenTargetsiENSG00000187080
PharmGKBiPA134921949
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9IV Eukaryota
ENOG411152X LUCA
GeneTreeiENSGT00910000144053
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NG84
KOiK04257
OMAiKICCLMV
OrthoDBiEOG091G0ELL
PhylomeDBiQ8NG84
TreeFamiTF337295

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR2AK2
GenomeRNAii391191
PROiPR:Q8NG84

Gene expression databases

BgeeiENSG00000187080 Expressed in 5 organ(s), highest expression level in testis
CleanExiHS_OR2AK2

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO2AK2_HUMAN
AccessioniPrimary (citable) accession number: Q8NG84
Secondary accession number(s): B2RND1, Q6IF05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: May 5, 2009
Last modified: September 12, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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