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UniProtKB - Q8NG81 (OR2M7_HUMAN)
Protein
Olfactory receptor 2M7
Gene
OR2M7
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.
CuratedGO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
PathwayCommonsi | Q8NG81 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 2M7Alternative name(s): Olfactory receptor OR1-58 |
Gene namesi | Name:OR2M7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19594, OR2M7 |
MIMi | 618509, gene |
neXtProti | NX_Q8NG81 |
VEuPathDBi | HostDB:ENSG00000177186 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 25 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 26 – 49 | Helical; Name=1Sequence analysisAdd BLAST | 24 | |
Topological domaini | 50 – 57 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 58 – 79 | Helical; Name=2Sequence analysisAdd BLAST | 22 | |
Topological domaini | 80 – 100 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 101 – 120 | Helical; Name=3Sequence analysisAdd BLAST | 20 | |
Topological domaini | 121 – 139 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 140 – 158 | Helical; Name=4Sequence analysisAdd BLAST | 19 | |
Topological domaini | 159 – 195 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 196 – 219 | Helical; Name=5Sequence analysisAdd BLAST | 24 | |
Topological domaini | 220 – 236 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 237 – 259 | Helical; Name=6Sequence analysisAdd BLAST | 23 | |
Topological domaini | 260 – 272 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 273 – 292 | Helical; Name=7Sequence analysisAdd BLAST | 20 | |
Topological domaini | 293 – 311 | CytoplasmicSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000177186 |
PharmGKBi | PA134874354 |
Miscellaneous databases
Pharosi | Q8NG81, Tdark |
Genetic variation databases
BioMutai | OR2M7 |
DMDMi | 38372497 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150494 | 1 – 312 | Olfactory receptor 2M7Add BLAST | 312 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 97 ↔ 189 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8NG81 |
PRIDEi | Q8NG81 |
PTM databases
GlyGeni | Q8NG81, 1 site |
iPTMneti | Q8NG81 |
PhosphoSitePlusi | Q8NG81 |
Expressioni
Gene expression databases
Bgeei | ENSG00000177186, Expressed in monocyte and 1 other tissue |
ExpressionAtlasi | Q8NG81, baseline and differential |
Organism-specific databases
HPAi | ENSG00000177186, Not detected |
Interactioni
Protein-protein interaction databases
BioGRIDi | 133853, 41 interactors |
STRINGi | 9606.ENSP00000324557 |
Miscellaneous databases
RNActi | Q8NG81, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SHXQ, Eukaryota |
GeneTreei | ENSGT01040000240488 |
HOGENOMi | CLU_012526_1_2_1 |
InParanoidi | Q8NG81 |
OMAi | YIQPTSH |
OrthoDBi | 1004475at2759 |
PhylomeDBi | Q8NG81 |
TreeFami | TF337295 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00245, OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NG81-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAWENQTFNS DFLLLGIFNH SPTHTFLFFL VLAIFSVAFM GNSIMVLLIY
60 70 80 90 100
LDTQLHTPMY FLLSQLSLMD LMLICTTVPK MAFNYLSGSK SISMAGCATQ
110 120 130 140 150
IFFYISLLGS ECFLLAVMSY DRYTAICHPL RYTNLMRPKI CGLMTAFSWI
160 170 180 190 200
LGSTDGIIDA VATFSFSYCG SREIAHFCCD FPSLLILSCN DTSIFEEVIF
210 220 230 240 250
ICCIVMLVFP VAIIITSYAR VILAVIHMGS GEGRRKAFTT CSSHLMVVGM
260 270 280 290 300
YYGAGLFMCI QPTSHHSPMQ DKMVSVFYTI VTPMLNPLIY SLRNKEVTRA
310
LMKILGKGKS GD
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059992 | 35 | F → L. Corresponds to variant dbSNP:rs7555424Ensembl. | 1 | |
Natural variantiVAR_053149 | 78 | V → A. Corresponds to variant dbSNP:rs7555310Ensembl. | 1 | |
Natural variantiVAR_053150 | 178 | C → F. Corresponds to variant dbSNP:rs4916130Ensembl. | 1 | |
Natural variantiVAR_059993 | 191 | D → N. Corresponds to variant dbSNP:rs4916129Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065954 Genomic DNA Translation: BAC06167.1 AL450303 Genomic DNA No translation available. BC136944 mRNA Translation: AAI36945.1 BC136946 mRNA Translation: AAI36947.1 BK004486 Genomic DNA Translation: DAA04884.1 |
CCDSi | CCDS31111.1 |
RefSeqi | NP_001004691.1, NM_001004691.1 |
Genome annotation databases
Ensembli | ENST00000317965.3; ENSP00000324557.2; ENSG00000177186.3 |
GeneIDi | 391196 |
KEGGi | hsa:391196 |
MANE-Selecti | ENST00000317965.3; ENSP00000324557.2; NM_001004691.1; NP_001004691.1 |
UCSCi | uc010pzk.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065954 Genomic DNA Translation: BAC06167.1 AL450303 Genomic DNA No translation available. BC136944 mRNA Translation: AAI36945.1 BC136946 mRNA Translation: AAI36947.1 BK004486 Genomic DNA Translation: DAA04884.1 |
CCDSi | CCDS31111.1 |
RefSeqi | NP_001004691.1, NM_001004691.1 |
3D structure databases
AlphaFoldDBi | Q8NG81 |
SMRi | Q8NG81 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 133853, 41 interactors |
STRINGi | 9606.ENSP00000324557 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q8NG81, 1 site |
iPTMneti | Q8NG81 |
PhosphoSitePlusi | Q8NG81 |
Genetic variation databases
BioMutai | OR2M7 |
DMDMi | 38372497 |
Proteomic databases
PaxDbi | Q8NG81 |
PRIDEi | Q8NG81 |
Protocols and materials databases
Antibodypediai | 57435, 88 antibodies from 20 providers |
DNASUi | 391196 |
Genome annotation databases
Ensembli | ENST00000317965.3; ENSP00000324557.2; ENSG00000177186.3 |
GeneIDi | 391196 |
KEGGi | hsa:391196 |
MANE-Selecti | ENST00000317965.3; ENSP00000324557.2; NM_001004691.1; NP_001004691.1 |
UCSCi | uc010pzk.2, human |
Organism-specific databases
CTDi | 391196 |
GeneCardsi | OR2M7 |
HGNCi | HGNC:19594, OR2M7 |
HPAi | ENSG00000177186, Not detected |
MIMi | 618509, gene |
neXtProti | NX_Q8NG81 |
OpenTargetsi | ENSG00000177186 |
PharmGKBi | PA134874354 |
VEuPathDBi | HostDB:ENSG00000177186 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SHXQ, Eukaryota |
GeneTreei | ENSGT01040000240488 |
HOGENOMi | CLU_012526_1_2_1 |
InParanoidi | Q8NG81 |
OMAi | YIQPTSH |
OrthoDBi | 1004475at2759 |
PhylomeDBi | Q8NG81 |
TreeFami | TF337295 |
Enzyme and pathway databases
PathwayCommonsi | Q8NG81 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Miscellaneous databases
BioGRID-ORCSi | 391196, 6 hits in 609 CRISPR screens |
GeneWikii | OR2M7 |
GenomeRNAii | 391196 |
Pharosi | Q8NG81, Tdark |
PROi | PR:Q8NG81 |
RNActi | Q8NG81, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000177186, Expressed in monocyte and 1 other tissue |
ExpressionAtlasi | Q8NG81, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00245, OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OR2M7_HUMAN | |
Accessioni | Q8NG81Primary (citable) accession number: Q8NG81 Secondary accession number(s): B2RNL0, Q6IEX6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 14, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families