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Entry version 133 (13 Feb 2019)
Sequence version 2 (01 Mar 2004)
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Protein

Tubulin--tyrosine ligase

Gene

TTL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
LigandATP-binding, Magnesium, Nucleotide-binding, Potassium

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
6.3.2.25 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8NG68

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tubulin--tyrosine ligase (EC:6.3.2.25By similarity)
Short name:
TTL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000114999.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21586 TTL

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608291 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NG68

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
150465

Open Targets

More...
OpenTargetsi
ENSG00000114999

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134934330

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5549

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TTL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47117358

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002124341 – 377Tubulin--tyrosine ligaseAdd BLAST377

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NG68

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NG68

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NG68

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NG68

PeptideAtlas

More...
PeptideAtlasi
Q8NG68

PRoteomics IDEntifications database

More...
PRIDEi
Q8NG68

ProteomicsDB human proteome resource

More...
ProteomicsDBi
73442

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NG68

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NG68

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000114999 Expressed in 203 organ(s), highest expression level in dorsal root ganglion

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NG68 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA066819

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127297, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NG68, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000233336

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q8NG68

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8NG68

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NG68

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 370TTLPROSITE-ProRule annotationAdd BLAST368

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tubulin--tyrosine ligase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2157 Eukaryota
ENOG410XQDM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161907

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231734

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG016579

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NG68

KEGG Orthology (KO)

More...
KOi
K06047

Identification of Orthologs from Complete Genome Data

More...
OMAi
SEPYNSA

Database of Orthologous Groups

More...
OrthoDBi
626048at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NG68

TreeFam database of animal gene trees

More...
TreeFami
TF350555

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004344 TTL/TTLL_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03133 TTL, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51221 TTL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8NG68-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYTFVVRDEN SSVYAEVSRL LLATGHWKRL RRDNPRFNLM LGERNRLPFG
60 70 80 90 100
RLGHEPGLVQ LVNYYRGADK LCRKASLVKL IKTSPELAES CTWFPESYVI
110 120 130 140 150
YPTNLKTPVA PAQNGIQPPI SNSRTDEREF FLASYNRKKE DGEGNVWIAK
160 170 180 190 200
SSAGAKGEGI LISSEASELL DFIDNQGQVH VIQKYLEHPL LLEPGHRKFD
210 220 230 240 250
IRSWVLVDHQ YNIYLYREGV LRTASEPYHV DNFQDKTCHL TNHCIQKEYS
260 270 280 290 300
KNYGKYEEGN EMFFKEFNQY LTSALNITLE SSILLQIKHI IRNCLLSVEP
310 320 330 340 350
AISTKHLPYQ SFQLFGFDFM VDEELKVWLI EVNGAPACAQ KLYAELCQGI
360 370
VDIAISSVFP PPDVEQPQTQ PAAFIKL
Length:377
Mass (Da):43,212
Last modified:March 1, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7A13E2C28E1AD6EA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti245I → V in CAD98091 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB071393 mRNA Translation: BAC06832.2
AC012442 Genomic DNA Translation: AAX81998.1
CH471217 Genomic DNA Translation: EAW73589.1
BC036819 mRNA Translation: AAH36819.1
BX538316 mRNA Translation: CAD98091.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2096.1

NCBI Reference Sequences

More...
RefSeqi
NP_714923.1, NM_153712.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.358997

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000233336; ENSP00000233336; ENSG00000114999

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
150465

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:150465

UCSC genome browser

More...
UCSCi
uc002thu.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071393 mRNA Translation: BAC06832.2
AC012442 Genomic DNA Translation: AAX81998.1
CH471217 Genomic DNA Translation: EAW73589.1
BC036819 mRNA Translation: AAH36819.1
BX538316 mRNA Translation: CAD98091.1
CCDSiCCDS2096.1
RefSeqiNP_714923.1, NM_153712.4
UniGeneiHs.358997

3D structure databases

ProteinModelPortaliQ8NG68
SMRiQ8NG68
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127297, 7 interactors
IntActiQ8NG68, 1 interactor
STRINGi9606.ENSP00000233336

Chemistry databases

BindingDBiQ8NG68
ChEMBLiCHEMBL5549

PTM databases

iPTMnetiQ8NG68
PhosphoSitePlusiQ8NG68

Polymorphism and mutation databases

BioMutaiTTL
DMDMi47117358

Proteomic databases

EPDiQ8NG68
jPOSTiQ8NG68
MaxQBiQ8NG68
PaxDbiQ8NG68
PeptideAtlasiQ8NG68
PRIDEiQ8NG68
ProteomicsDBi73442

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
150465
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233336; ENSP00000233336; ENSG00000114999
GeneIDi150465
KEGGihsa:150465
UCSCiuc002thu.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
150465
DisGeNETi150465
EuPathDBiHostDB:ENSG00000114999.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TTL
HGNCiHGNC:21586 TTL
HPAiHPA066819
MIMi608291 gene
neXtProtiNX_Q8NG68
OpenTargetsiENSG00000114999
PharmGKBiPA134934330

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2157 Eukaryota
ENOG410XQDM LUCA
GeneTreeiENSGT00940000161907
HOGENOMiHOG000231734
HOVERGENiHBG016579
InParanoidiQ8NG68
KOiK06047
OMAiSEPYNSA
OrthoDBi626048at2759
PhylomeDBiQ8NG68
TreeFamiTF350555

Enzyme and pathway databases

BRENDAi6.3.2.25 2681
ReactomeiR-HSA-8955332 Carboxyterminal post-translational modifications of tubulin
SIGNORiQ8NG68

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TTL human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
150465

Protein Ontology

More...
PROi
PR:Q8NG68

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000114999 Expressed in 203 organ(s), highest expression level in dorsal root ganglion
GenevisibleiQ8NG68 HS

Family and domain databases

InterProiView protein in InterPro
IPR004344 TTL/TTLL_fam
PfamiView protein in Pfam
PF03133 TTL, 1 hit
PROSITEiView protein in PROSITE
PS51221 TTL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NG68
Secondary accession number(s): Q585T3, Q7Z302, Q8N426
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2004
Last modified: February 13, 2019
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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