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Protein

Neuroligin-2

Gene

NLGN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Protein family/group databases

ESTHERihuman-NLGN2 Neuroligin
MEROPSiS09.995

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroligin-2
Gene namesi
Name:NLGN2
Synonyms:KIAA1366
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000169992.9
HGNCiHGNC:14290 NLGN2
MIMi606479 gene
neXtProtiNX_Q8NFZ4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini15 – 677ExtracellularSequence analysisAdd BLAST663
Transmembranei678 – 698HelicalSequence analysisAdd BLAST21
Topological domaini699 – 835CytoplasmicSequence analysisAdd BLAST137

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi57555
OpenTargetsiENSG00000169992
PharmGKBiPA31648

Polymorphism and mutation databases

DMDMi31076824

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 14Sequence analysisAdd BLAST14
ChainiPRO_000000864315 – 835Neuroligin-2Add BLAST821

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi106 ↔ 141By similarity
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi317 ↔ 328By similarity
Disulfide bondi487 ↔ 521By similarity
Glycosylationi522N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei713PhosphoserineBy similarity1
Modified residuei718PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8NFZ4
PaxDbiQ8NFZ4
PeptideAtlasiQ8NFZ4
PRIDEiQ8NFZ4
ProteomicsDBi73397

PTM databases

iPTMnetiQ8NFZ4
PhosphoSitePlusiQ8NFZ4

Expressioni

Tissue specificityi

Expressed in the blood vessel walls. Detected in colon, brain and pancreas islets of Langerhans (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells.2 Publications

Gene expression databases

BgeeiENSG00000169992 Expressed in 201 organ(s), highest expression level in ectocervix
CleanExiHS_NLGN2
ExpressionAtlasiQ8NFZ4 baseline and differential
GenevisibleiQ8NFZ4 HS

Organism-specific databases

HPAiHPA055321
HPA069278

Interactioni

Subunit structurei

Interacts with NRXN1, NRXN2 and NRXN3 (By similarity). Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3) (PubMed:9278515). Interacts with PATJ (By similarity). Interacts with GPHN (By similarity). Interacts with MDGA1 and MDGA2 (By similarity). Found in a complex with MAGI2 and IGSF9B, where it interacts with MAGI2 (via WW 1, WW 2 and PDZ 2 domains) (PubMed:23751499). Identified in a complex of 720 kDa composed of LHFPL4, NLGN2, GABRA1, GABRB2, GABRG2 and GABRB3 (By similarity). Interacts with LHFPL4; leading to mutual regulation of the protein level and synaptic clustering (By similarity). Interacts with NLGN2 (By similarity).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121611, 27 interactors
STRINGi9606.ENSP00000305288

Structurei

Secondary structure

1835
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8NFZ4
SMRiQ8NFZ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni678 – 698Required for interaction with LHFPL4By similarityAdd BLAST21

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
GeneTreeiENSGT00760000118946
HOGENOMiHOG000231424
HOVERGENiHBG008839
InParanoidiQ8NFZ4
KOiK07378
OMAiGCNQEEN
OrthoDBiEOG091G0CHW
PhylomeDBiQ8NFZ4
TreeFamiTF326187

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019819 Carboxylesterase_B_CS
IPR000460 Nlgn
IPR030023 NLGN2
PANTHERiPTHR43903:SF3 PTHR43903:SF3, 1 hit
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
PRINTSiPR01090 NEUROLIGIN
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00941 CARBOXYLESTERASE_B_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8NFZ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWLLALCLVG LAGAQRGGGG PGGGAPGGPG LGLGSLGEER FPVVNTAYGR
60 70 80 90 100
VRGVRRELNN EILGPVVQFL GVPYATPPLG ARRFQPPEAP ASWPGVRNAT
110 120 130 140 150
TLPPACPQNL HGALPAIMLP VWFTDNLEAA ATYVQNQSED CLYLNLYVPT
160 170 180 190 200
EDGPLTKKRD EATLNPPDTD IRDPGKKPVM LFLHGGSYME GTGNMFDGSV
210 220 230 240 250
LAAYGNVIVA TLNYRLGVLG FLSTGDQAAK GNYGLLDQIQ ALRWLSENIA
260 270 280 290 300
HFGGDPERIT IFGSGAGASC VNLLILSHHS EGLFQKAIAQ SGTAISSWSV
310 320 330 340 350
NYQPLKYTRL LAAKVGCDRE DSAEAVECLR RKPSRELVDQ DVQPARYHIA
360 370 380 390 400
FGPVVDGDVV PDDPEILMQQ GEFLNYDMLI GVNQGEGLKF VEDSAESEDG
410 420 430 440 450
VSASAFDFTV SNFVDNLYGY PEGKDVLRET IKFMYTDWAD RDNGEMRRKT
460 470 480 490 500
LLALFTDHQW VAPAVATAKL HADYQSPVYF YTFYHHCQAE GRPEWADAAH
510 520 530 540 550
GDELPYVFGV PMVGATDLFP CNFSKNDVML SAVVMTYWTN FAKTGDPNQP
560 570 580 590 600
VPQDTKFIHT KPNRFEEVVW SKFNSKEKQY LHIGLKPRVR DNYRANKVAF
610 620 630 640 650
WLELVPHLHN LHTELFTTTT RLPPYATRWP PRPPAGAPGT RRPPPPATLP
660 670 680 690 700
PEPEPEPGPR AYDRFPGDSR DYSTELSVTV AVGASLLFLN ILAFAALYYK
710 720 730 740 750
RDRRQELRCR RLSPPGGSGS GVPGGGPLLP AAGRELPPEE ELVSLQLKRG
760 770 780 790 800
GGVGADPAEA LRPACPPDYT LALRRAPDDV PLLAPGALTL LPSGLGPPPP
810 820 830
PPPPSLHPFG PFPPPPPTAT SHNNTLPHPH STTRV
Length:835
Mass (Da):90,820
Last modified:October 1, 2002 - v1
Checksum:i359938630193EF87
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L498I3L498_HUMAN
Neuroligin-2
NLGN2
194Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF376802 mRNA Translation: AAM46111.1
AB037787 mRNA Translation: BAA92604.1
CCDSiCCDS11103.1
RefSeqiNP_065846.1, NM_020795.3
UniGeneiHs.26229

Genome annotation databases

EnsembliENST00000302926; ENSP00000305288; ENSG00000169992
ENST00000575301; ENSP00000461168; ENSG00000169992
ENST00000639647; ENSP00000492323; ENSG00000283859
ENST00000640620; ENSP00000492198; ENSG00000283859
GeneIDi57555
KEGGihsa:57555
UCSCiuc002ggt.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF376802 mRNA Translation: AAM46111.1
AB037787 mRNA Translation: BAA92604.1
CCDSiCCDS11103.1
RefSeqiNP_065846.1, NM_020795.3
UniGeneiHs.26229

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XEQX-ray3.14A42-611[»]
ProteinModelPortaliQ8NFZ4
SMRiQ8NFZ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121611, 27 interactors
STRINGi9606.ENSP00000305288

Protein family/group databases

ESTHERihuman-NLGN2 Neuroligin
MEROPSiS09.995

PTM databases

iPTMnetiQ8NFZ4
PhosphoSitePlusiQ8NFZ4

Polymorphism and mutation databases

DMDMi31076824

Proteomic databases

EPDiQ8NFZ4
PaxDbiQ8NFZ4
PeptideAtlasiQ8NFZ4
PRIDEiQ8NFZ4
ProteomicsDBi73397

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302926; ENSP00000305288; ENSG00000169992
ENST00000575301; ENSP00000461168; ENSG00000169992
ENST00000639647; ENSP00000492323; ENSG00000283859
ENST00000640620; ENSP00000492198; ENSG00000283859
GeneIDi57555
KEGGihsa:57555
UCSCiuc002ggt.3 human

Organism-specific databases

CTDi57555
DisGeNETi57555
EuPathDBiHostDB:ENSG00000169992.9
GeneCardsiNLGN2
HGNCiHGNC:14290 NLGN2
HPAiHPA055321
HPA069278
MIMi606479 gene
neXtProtiNX_Q8NFZ4
OpenTargetsiENSG00000169992
PharmGKBiPA31648
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
GeneTreeiENSGT00760000118946
HOGENOMiHOG000231424
HOVERGENiHBG008839
InParanoidiQ8NFZ4
KOiK07378
OMAiGCNQEEN
OrthoDBiEOG091G0CHW
PhylomeDBiQ8NFZ4
TreeFamiTF326187

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Miscellaneous databases

ChiTaRSiNLGN2 human
GeneWikiiNLGN2
GenomeRNAii57555
PROiPR:Q8NFZ4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169992 Expressed in 201 organ(s), highest expression level in ectocervix
CleanExiHS_NLGN2
ExpressionAtlasiQ8NFZ4 baseline and differential
GenevisibleiQ8NFZ4 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019819 Carboxylesterase_B_CS
IPR000460 Nlgn
IPR030023 NLGN2
PANTHERiPTHR43903:SF3 PTHR43903:SF3, 1 hit
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
PRINTSiPR01090 NEUROLIGIN
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00941 CARBOXYLESTERASE_B_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNLGN2_HUMAN
AccessioniPrimary (citable) accession number: Q8NFZ4
Secondary accession number(s): Q9P2I1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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