UniProtKB - Q8NFZ3 (NLGNY_HUMAN)
Protein
Neuroligin-4, Y-linked
Gene
NLGN4Y
Organism
Homo sapiens (Human)
Status
Functioni
Putative neuronal cell surface protein involved in cell-cell-interactions.
GO - Molecular functioni
- cell adhesion molecule binding Source: BHF-UCL
- neurexin family protein binding Source: GO_Central
- scaffold protein binding Source: BHF-UCL
- signaling receptor activity Source: GO_Central
GO - Biological processi
- chemical synaptic transmission Source: GO_Central
- learning Source: BHF-UCL
- modulation of chemical synaptic transmission Source: GO_Central
- neuron cell-cell adhesion Source: GO_Central
- postsynaptic membrane assembly Source: GO_Central
- presynapse assembly Source: ARUK-UCL
- presynaptic membrane assembly Source: GO_Central
- social behavior Source: BHF-UCL
- synaptic vesicle endocytosis Source: GO_Central
- vocalization behavior Source: BHF-UCL
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | Q8NFZ3 |
Reactomei | R-HSA-6794361, Neurexins and neuroligins |
Protein family/group databases
ESTHERi | human-NLGN4Y, Neuroligin |
MEROPSi | S09.989 |
Names & Taxonomyi
Protein namesi | Recommended name: Neuroligin-4, Y-linkedShort name: Neuroligin Y |
Gene namesi | Name:NLGN4Y Synonyms:KIAA0951 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000165246.12 |
HGNCi | HGNC:15529, NLGN4Y |
MIMi | 400028, gene |
neXtProti | NX_Q8NFZ3 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
- postsynaptic density membrane Source: UniProtKB-SubCell
Other locations
- asymmetric, glutamatergic, excitatory synapse Source: ARUK-UCL
- cell surface Source: GO_Central
- presynapse Source: GOC
- spanning component of membrane Source: ARUK-UCL
- symmetric, GABA-ergic, inhibitory synapse Source: ARUK-UCL
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 44 – 676 | ExtracellularSequence analysisAdd BLAST | 633 | |
Transmembranei | 677 – 697 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 698 – 816 | CytoplasmicSequence analysisAdd BLAST | 119 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 22829 |
OpenTargetsi | ENSG00000165246 |
PharmGKBi | PA38386 |
Miscellaneous databases
Pharosi | Q8NFZ3, Tbio |
Polymorphism and mutation databases
BioMutai | NLGN4Y |
DMDMi | 31076823 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 43 | Sequence analysisAdd BLAST | 43 | |
ChainiPRO_0000008649 | 44 – 816 | Neuroligin-4, Y-linkedAdd BLAST | 773 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 102 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 110 ↔ 146 | By similarity | ||
Disulfide bondi | 306 ↔ 317 | By similarity | ||
Disulfide bondi | 476 ↔ 510 | By similarity | ||
Glycosylationi | 511 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 712 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q8NFZ3 |
jPOSTi | Q8NFZ3 |
MassIVEi | Q8NFZ3 |
PaxDbi | Q8NFZ3 |
PeptideAtlasi | Q8NFZ3 |
PRIDEi | Q8NFZ3 |
ProteomicsDBi | 27307 73395 [Q8NFZ3-1] 73396 [Q8NFZ3-2] |
PTM databases
GlyGeni | Q8NFZ3, 2 sites |
iPTMneti | Q8NFZ3 |
PhosphoSitePlusi | Q8NFZ3 |
Expressioni
Tissue specificityi
Expressed in fetal and adult brain, prostate and testis.1 Publication
Gene expression databases
Bgeei | ENSG00000165246, Expressed in corpus callosum and 144 other tissues |
ExpressionAtlasi | Q8NFZ3, baseline and differential |
Genevisiblei | Q8NFZ3, HS |
Organism-specific databases
HPAi | ENSG00000165246, Tissue enhanced (brain, seminal vesicle) |
Interactioni
Subunit structurei
Homodimer.
Interacts with NRXN1 in a calcium-dependent manner.
Interacts through its C-terminus with DLG4/PSD-95 third PDZ domain (By similarity).
By similarityGO - Molecular functioni
- cell adhesion molecule binding Source: BHF-UCL
- neurexin family protein binding Source: GO_Central
- scaffold protein binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 116504, 5 interactors |
Miscellaneous databases
RNActi | Q8NFZ3, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 359 – 364 | Interaction with NRXN1By similarity | 6 |
Sequence similaritiesi
Belongs to the type-B carboxylesterase/lipase family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
GeneTreei | ENSGT00940000156607 |
HOGENOMi | CLU_006586_5_1_1 |
InParanoidi | Q8NFZ3 |
PhylomeDBi | Q8NFZ3 |
TreeFami | TF326187 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR002018, CarbesteraseB IPR019819, Carboxylesterase_B_CS IPR000460, Nlgn IPR030025, NLGN4 |
PANTHERi | PTHR43903:SF5, PTHR43903:SF5, 2 hits |
Pfami | View protein in Pfam PF00135, COesterase, 1 hit |
PRINTSi | PR01090, NEUROLIGIN |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00941, CARBOXYLESTERASE_B_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8NFZ3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLRPQGLLWL PLLFTSVCVM LNSNVLLWIT ALAIKFTLID SQAQYPVVNT
60 70 80 90 100
NYGKIQGLRT PLPSEILGPV EQYLGVPYAS PPTGERRFQP PESPSSWTGI
110 120 130 140 150
RNATQFSAVC PQHLDERFLL HDMLPIWFTT SLDTLMTYVQ DQNEDCLYLN
160 170 180 190 200
IYVPMEDDIH EQNSKKPVMV YIHGGSYMEG TGNMIDGSIL ASYGNVIVIT
210 220 230 240 250
INYRLGILGF LSTGDQAAKG NYGLLDQIQA LRWIEENVGA FGGDPKRVTI
260 270 280 290 300
FGSGAGASCV SLLTLSHYSE GLFQKAIIQS GTALSSWAVN YQPAKYTRIL
310 320 330 340 350
ADKVGCNMLD TTDMVECLKN KNYKELIQQT ITPATYHIAF GPVIDGDVIP
360 370 380 390 400
DDPQILMEQG EFLNYDIMLG VNQGEGLKFV DGIVDNEDGV TPNDFDFSVS
410 420 430 440 450
NFVDNLYGYP EGKDTLRETI KFMYTDWADK ENPETRRKTL VALFTDHQWV
460 470 480 490 500
APAVATADLH AQYGSPTYFY AFYHHCQSEM KPSWADSAHG DEVPYVFGIP
510 520 530 540 550
MIGPTELFSC NFSKNDVMLS AVVMTYWTNF AKTGDPNQPV PQDTKFIHTK
560 570 580 590 600
PNRFEEVAWS KYNPKDQLYL HIGLKPRVRD HYRATKVAFW LELVPHLHNL
610 620 630 640 650
NEIFQYVSTT TKVPPPDMTS FPYGTRRSPA KIWPTTKRPA ITPANNPKHS
660 670 680 690 700
KDPHKTGPED TTVLIETKRD YSTELSVTIA VGASLLFLNI LAFAALYYKK
710 720 730 740 750
DKRRHETHRH PSPQRNTTND ITHIQNEEIM SLQMKQLEHD HECESLQAHD
760 770 780 790 800
TLRLTCPPDY TLTLRRSPDD IPFMTPNTIT MIPNTLMGMQ PLHTFKTFSG
810
GQNSTNLPHG HSTTRV
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB4DHI3 | B4DHI3_HUMAN | Neuroligin-4, Y-linked | NLGN4Y | 836 | Annotation score: | ||
A6NMU8 | A6NMU8_HUMAN | Neuroligin 4, Y-linked, isoform CRA... | NLGN4Y hCG_1988457 | 873 | Annotation score: | ||
H0Y7G6 | H0Y7G6_HUMAN | Neuroligin-4, Y-linked | NLGN4Y | 236 | Annotation score: | ||
A0A2R8YDT7 | A0A2R8YDT7_HUMAN | Neuroligin-4, Y-linked | NLGN4Y | 33 | Annotation score: |
Sequence cautioni
The sequence BAA76795 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 203 | Y → C in CAD97670 (PubMed:17974005).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007537 | 1 – 168 | Missing in isoform 2. 1 PublicationAdd BLAST | 168 | |
Alternative sequenceiVSP_044852 | 1 – 122 | Missing in isoform 3. 1 PublicationAdd BLAST | 122 | |
Alternative sequenceiVSP_044853 | 157 | D → DGTNIKRNADDITSNDHGED K in isoform 3 and isoform 4. 1 PublicationCurated | 1 | |
Alternative sequenceiVSP_044854 | 210 – 236 | FLSTG…RWIEE → MQEARLCGSSKMFNYFKSPF TNLINFF in isoform 3 and isoform 4. 1 PublicationCuratedAdd BLAST | 27 | |
Alternative sequenceiVSP_044855 | 237 – 816 | Missing in isoform 3 and isoform 4. 1 PublicationCuratedAdd BLAST | 580 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF376804 mRNA Translation: AAM46113.1 AB023168 mRNA Translation: BAA76795.2 Different initiation. BX537428 mRNA Translation: CAD97670.1 AC010726 Genomic DNA No translation available. AC010879 Genomic DNA No translation available. AC010979 Genomic DNA No translation available. AC011903 Genomic DNA No translation available. BC032567 mRNA Translation: AAH32567.1 BC113525 mRNA Translation: AAI13526.1 BC113551 mRNA Translation: AAI13552.1 |
CCDSi | CCDS14788.1 [Q8NFZ3-1] CCDS56619.1 [Q8NFZ3-2] |
RefSeqi | NP_001157710.1, NM_001164238.1 [Q8NFZ3-4] NP_001193779.1, NM_001206850.1 [Q8NFZ3-2] NP_055708.3, NM_014893.4 [Q8NFZ3-1] XP_016885523.1, XM_017030034.1 XP_016885524.1, XM_017030035.1 XP_016885525.1, XM_017030036.1 [Q8NFZ3-1] XP_016885526.1, XM_017030037.1 XP_016885527.1, XM_017030038.1 XP_016885529.1, XM_017030040.1 [Q8NFZ3-2] XP_016885530.1, XM_017030041.1 [Q8NFZ3-4] |
Genome annotation databases
Ensembli | ENST00000339174; ENSP00000342535; ENSG00000165246 [Q8NFZ3-1] ENST00000355905; ENSP00000348169; ENSG00000165246 [Q8NFZ3-1] ENST00000382872; ENSP00000372325; ENSG00000165246 [Q8NFZ3-2] |
GeneIDi | 22829 |
KEGGi | hsa:22829 |
UCSCi | uc004fte.3, human [Q8NFZ3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF376804 mRNA Translation: AAM46113.1 AB023168 mRNA Translation: BAA76795.2 Different initiation. BX537428 mRNA Translation: CAD97670.1 AC010726 Genomic DNA No translation available. AC010879 Genomic DNA No translation available. AC010979 Genomic DNA No translation available. AC011903 Genomic DNA No translation available. BC032567 mRNA Translation: AAH32567.1 BC113525 mRNA Translation: AAI13526.1 BC113551 mRNA Translation: AAI13552.1 |
CCDSi | CCDS14788.1 [Q8NFZ3-1] CCDS56619.1 [Q8NFZ3-2] |
RefSeqi | NP_001157710.1, NM_001164238.1 [Q8NFZ3-4] NP_001193779.1, NM_001206850.1 [Q8NFZ3-2] NP_055708.3, NM_014893.4 [Q8NFZ3-1] XP_016885523.1, XM_017030034.1 XP_016885524.1, XM_017030035.1 XP_016885525.1, XM_017030036.1 [Q8NFZ3-1] XP_016885526.1, XM_017030037.1 XP_016885527.1, XM_017030038.1 XP_016885529.1, XM_017030040.1 [Q8NFZ3-2] XP_016885530.1, XM_017030041.1 [Q8NFZ3-4] |
3D structure databases
SMRi | Q8NFZ3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116504, 5 interactors |
Protein family/group databases
ESTHERi | human-NLGN4Y, Neuroligin |
MEROPSi | S09.989 |
PTM databases
GlyGeni | Q8NFZ3, 2 sites |
iPTMneti | Q8NFZ3 |
PhosphoSitePlusi | Q8NFZ3 |
Polymorphism and mutation databases
BioMutai | NLGN4Y |
DMDMi | 31076823 |
Proteomic databases
EPDi | Q8NFZ3 |
jPOSTi | Q8NFZ3 |
MassIVEi | Q8NFZ3 |
PaxDbi | Q8NFZ3 |
PeptideAtlasi | Q8NFZ3 |
PRIDEi | Q8NFZ3 |
ProteomicsDBi | 27307 73395 [Q8NFZ3-1] 73396 [Q8NFZ3-2] |
Protocols and materials databases
Antibodypediai | 21872, 136 antibodies |
Genome annotation databases
Ensembli | ENST00000339174; ENSP00000342535; ENSG00000165246 [Q8NFZ3-1] ENST00000355905; ENSP00000348169; ENSG00000165246 [Q8NFZ3-1] ENST00000382872; ENSP00000372325; ENSG00000165246 [Q8NFZ3-2] |
GeneIDi | 22829 |
KEGGi | hsa:22829 |
UCSCi | uc004fte.3, human [Q8NFZ3-1] |
Organism-specific databases
CTDi | 22829 |
DisGeNETi | 22829 |
EuPathDBi | HostDB:ENSG00000165246.12 |
GeneCardsi | NLGN4Y |
HGNCi | HGNC:15529, NLGN4Y |
HPAi | ENSG00000165246, Tissue enhanced (brain, seminal vesicle) |
MIMi | 400028, gene |
neXtProti | NX_Q8NFZ3 |
OpenTargetsi | ENSG00000165246 |
PharmGKBi | PA38386 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156607 |
HOGENOMi | CLU_006586_5_1_1 |
InParanoidi | Q8NFZ3 |
PhylomeDBi | Q8NFZ3 |
TreeFami | TF326187 |
Enzyme and pathway databases
PathwayCommonsi | Q8NFZ3 |
Reactomei | R-HSA-6794361, Neurexins and neuroligins |
Miscellaneous databases
BioGRID-ORCSi | 22829, 1 hit in 448 CRISPR screens |
ChiTaRSi | NLGN4Y, human |
GenomeRNAii | 22829 |
Pharosi | Q8NFZ3, Tbio |
PROi | PR:Q8NFZ3 |
RNActi | Q8NFZ3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165246, Expressed in corpus callosum and 144 other tissues |
ExpressionAtlasi | Q8NFZ3, baseline and differential |
Genevisiblei | Q8NFZ3, HS |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR002018, CarbesteraseB IPR019819, Carboxylesterase_B_CS IPR000460, Nlgn IPR030025, NLGN4 |
PANTHERi | PTHR43903:SF5, PTHR43903:SF5, 2 hits |
Pfami | View protein in Pfam PF00135, COesterase, 1 hit |
PRINTSi | PR01090, NEUROLIGIN |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00941, CARBOXYLESTERASE_B_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NLGNY_HUMAN | |
Accessioni | Q8NFZ3Primary (citable) accession number: Q8NFZ3 Secondary accession number(s): F5H6W0 Q9Y2F8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 23, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome Y
Human chromosome Y: entries, gene names and cross-references to MIM