Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q8NFZ3 (NLGNY_HUMAN)

Entry version 168 (12 Aug 2020)
Sequence version 1 (01 Oct 2002)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Neuroligin-4, Y-linked

Gene

NLGN4Y

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative neuronal cell surface protein involved in cell-cell-interactions.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8NFZ3

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6794361, Neurexins and neuroligins

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...ESTHERi		human-NLGN4Y, Neuroligin

MEROPS protease database

More...MEROPSi		S09.989

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuroligin-4, Y-linked
Short name:
Neuroligin Y
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NLGN4Y
Synonyms:KIAA0951
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome Y

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000165246.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:15529, NLGN4Y

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		400028, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8NFZ3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini44 – 676ExtracellularSequence analysisAdd BLAST633
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei677 – 697HelicalSequence analysisAdd BLAST21
Topological domaini698 – 816CytoplasmicSequence analysisAdd BLAST119

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		22829

Open Targets

More...OpenTargetsi		ENSG00000165246

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38386

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8NFZ3, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NLGN4Y

Domain mapping of disease mutations (DMDM)

More...DMDMi		31076823

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 43Sequence analysisAdd BLAST43
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000864944 – 816Neuroligin-4, Y-linkedAdd BLAST773

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi110 ↔ 146By similarity
Disulfide bondi306 ↔ 317By similarity
Disulfide bondi476 ↔ 510By similarity
Glycosylationi511N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei712PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8NFZ3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8NFZ3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8NFZ3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8NFZ3

PeptideAtlas

More...PeptideAtlasi		Q8NFZ3

PRoteomics IDEntifications database

More...PRIDEi		Q8NFZ3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		27307
73395 [Q8NFZ3-1]
73396 [Q8NFZ3-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8NFZ3, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8NFZ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8NFZ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in fetal and adult brain, prostate and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000165246, Expressed in corpus callosum and 144 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8NFZ3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8NFZ3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000165246, Tissue enhanced (brain, seminal vesicle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with NRXN1 in a calcium-dependent manner.

Interacts through its C-terminus with DLG4/PSD-95 third PDZ domain (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116504, 5 interactors

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8NFZ3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8NFZ3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni359 – 364Interaction with NRXN1By similarity6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156607

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006586_5_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8NFZ3

KEGG Orthology (KO)

More...KOi		K07378

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8NFZ3

TreeFam database of animal gene trees

More...TreeFami		TF326187

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029058, AB_hydrolase
IPR002018, CarbesteraseB
IPR019819, Carboxylesterase_B_CS
IPR000460, Nlgn
IPR030025, NLGN4

The PANTHER Classification System

More...PANTHERi		PTHR43903:SF5, PTHR43903:SF5, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00135, COesterase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01090, NEUROLIGIN

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53474, SSF53474, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00941, CARBOXYLESTERASE_B_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NFZ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRPQGLLWL PLLFTSVCVM LNSNVLLWIT ALAIKFTLID SQAQYPVVNT 
        60         70         80         90        100
NYGKIQGLRT PLPSEILGPV EQYLGVPYAS PPTGERRFQP PESPSSWTGI 
       110        120        130        140        150
RNATQFSAVC PQHLDERFLL HDMLPIWFTT SLDTLMTYVQ DQNEDCLYLN 
       160        170        180        190        200
IYVPMEDDIH EQNSKKPVMV YIHGGSYMEG TGNMIDGSIL ASYGNVIVIT 
       210        220        230        240        250
INYRLGILGF LSTGDQAAKG NYGLLDQIQA LRWIEENVGA FGGDPKRVTI 
       260        270        280        290        300
FGSGAGASCV SLLTLSHYSE GLFQKAIIQS GTALSSWAVN YQPAKYTRIL 
       310        320        330        340        350
ADKVGCNMLD TTDMVECLKN KNYKELIQQT ITPATYHIAF GPVIDGDVIP 
       360        370        380        390        400
DDPQILMEQG EFLNYDIMLG VNQGEGLKFV DGIVDNEDGV TPNDFDFSVS 
       410        420        430        440        450
NFVDNLYGYP EGKDTLRETI KFMYTDWADK ENPETRRKTL VALFTDHQWV 
       460        470        480        490        500
APAVATADLH AQYGSPTYFY AFYHHCQSEM KPSWADSAHG DEVPYVFGIP 
       510        520        530        540        550
MIGPTELFSC NFSKNDVMLS AVVMTYWTNF AKTGDPNQPV PQDTKFIHTK 
       560        570        580        590        600
PNRFEEVAWS KYNPKDQLYL HIGLKPRVRD HYRATKVAFW LELVPHLHNL 
       610        620        630        640        650
NEIFQYVSTT TKVPPPDMTS FPYGTRRSPA KIWPTTKRPA ITPANNPKHS 
       660        670        680        690        700
KDPHKTGPED TTVLIETKRD YSTELSVTIA VGASLLFLNI LAFAALYYKK 
       710        720        730        740        750
DKRRHETHRH PSPQRNTTND ITHIQNEEIM SLQMKQLEHD HECESLQAHD 
       760        770        780        790        800
TLRLTCPPDY TLTLRRSPDD IPFMTPNTIT MIPNTLMGMQ PLHTFKTFSG 
       810 
GQNSTNLPHG HSTTRV
Length:816
Mass (Da):92,021
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB68910773B1BBF6
GO
Isoform 2 (identifier: Q8NFZ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-168: Missing.

Show »
Length:648
Mass (Da):72,885
Checksum:i1A2E6727A709BFBC
GO
Isoform 3 (identifier: Q8NFZ3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.
     157-157: D → DGTNIKRNADDITSNDHGEDK
     210-236: FLSTGDQAAKGNYGLLDQIQALRWIEE → MQEARLCGSSKMFNYFKSPFTNLINFF
     237-816: Missing.

Show »
Length:134
Mass (Da):15,225
Checksum:i91ADC5AA38A2EECD
GO
Isoform 4 (identifier: Q8NFZ3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-157: D → DGTNIKRNADDITSNDHGEDK
     210-236: FLSTGDQAAKGNYGLLDQIQALRWIEE → MQEARLCGSSKMFNYFKSPFTNLINFF
     237-816: Missing.

Show »
Length:256
Mass (Da):28,885
Checksum:i4D72B76AC6F59DDB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DHI3B4DHI3_HUMAN
Neuroligin-4, Y-linked
NLGN4Y
836Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6NMU8A6NMU8_HUMAN
Neuroligin 4, Y-linked, isoform CRA...
NLGN4Y hCG_1988457
873Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7G6H0Y7G6_HUMAN
Neuroligin-4, Y-linked
NLGN4Y
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YDT7A0A2R8YDT7_HUMAN
Neuroligin-4, Y-linked
NLGN4Y
33Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA76795 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti203Y → C in CAD97670 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0075371 – 168Missing in isoform 2. 1 PublicationAdd BLAST168
Alternative sequenceiVSP_0448521 – 122Missing in isoform 3. 1 PublicationAdd BLAST122
Alternative sequenceiVSP_044853157D → DGTNIKRNADDITSNDHGED K in isoform 3 and isoform 4. 1 PublicationCurated1
Alternative sequenceiVSP_044854210 – 236FLSTG…RWIEE → MQEARLCGSSKMFNYFKSPF TNLINFF in isoform 3 and isoform 4. 1 PublicationCuratedAdd BLAST27
Alternative sequenceiVSP_044855237 – 816Missing in isoform 3 and isoform 4. 1 PublicationCuratedAdd BLAST580

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF376804 mRNA Translation: AAM46113.1
AB023168 mRNA Translation: BAA76795.2 Different initiation.
BX537428 mRNA Translation: CAD97670.1
AC010726 Genomic DNA No translation available.
AC010879 Genomic DNA No translation available.
AC010979 Genomic DNA No translation available.
AC011903 Genomic DNA No translation available.
BC032567 mRNA Translation: AAH32567.1
BC113525 mRNA Translation: AAI13526.1
BC113551 mRNA Translation: AAI13552.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14788.1 [Q8NFZ3-1]
CCDS56619.1 [Q8NFZ3-2]

NCBI Reference Sequences

More...RefSeqi		NP_001157710.1, NM_001164238.1 [Q8NFZ3-4]
NP_001193779.1, NM_001206850.1 [Q8NFZ3-2]
NP_055708.3, NM_014893.4 [Q8NFZ3-1]
XP_016885523.1, XM_017030034.1
XP_016885524.1, XM_017030035.1
XP_016885525.1, XM_017030036.1 [Q8NFZ3-1]
XP_016885526.1, XM_017030037.1
XP_016885527.1, XM_017030038.1
XP_016885529.1, XM_017030040.1 [Q8NFZ3-2]
XP_016885530.1, XM_017030041.1 [Q8NFZ3-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000339174; ENSP00000342535; ENSG00000165246 [Q8NFZ3-1]
ENST00000355905; ENSP00000348169; ENSG00000165246 [Q8NFZ3-1]
ENST00000382872; ENSP00000372325; ENSG00000165246 [Q8NFZ3-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		22829

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:22829

UCSC genome browser

More...UCSCi		uc004fte.3, human [Q8NFZ3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF376804 mRNA Translation: AAM46113.1
AB023168 mRNA Translation: BAA76795.2 Different initiation.
BX537428 mRNA Translation: CAD97670.1
AC010726 Genomic DNA No translation available.
AC010879 Genomic DNA No translation available.
AC010979 Genomic DNA No translation available.
AC011903 Genomic DNA No translation available.
BC032567 mRNA Translation: AAH32567.1
BC113525 mRNA Translation: AAI13526.1
BC113551 mRNA Translation: AAI13552.1
CCDSiCCDS14788.1 [Q8NFZ3-1]
CCDS56619.1 [Q8NFZ3-2]
RefSeqiNP_001157710.1, NM_001164238.1 [Q8NFZ3-4]
NP_001193779.1, NM_001206850.1 [Q8NFZ3-2]
NP_055708.3, NM_014893.4 [Q8NFZ3-1]
XP_016885523.1, XM_017030034.1
XP_016885524.1, XM_017030035.1
XP_016885525.1, XM_017030036.1 [Q8NFZ3-1]
XP_016885526.1, XM_017030037.1
XP_016885527.1, XM_017030038.1
XP_016885529.1, XM_017030040.1 [Q8NFZ3-2]
XP_016885530.1, XM_017030041.1 [Q8NFZ3-4]

3D structure databases

SMRiQ8NFZ3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116504, 5 interactors

Protein family/group databases

ESTHERihuman-NLGN4Y, Neuroligin
MEROPSiS09.989

PTM databases

GlyGeniQ8NFZ3, 2 sites
iPTMnetiQ8NFZ3
PhosphoSitePlusiQ8NFZ3

Polymorphism and mutation databases

BioMutaiNLGN4Y
DMDMi31076823

Proteomic databases

EPDiQ8NFZ3
jPOSTiQ8NFZ3
MassIVEiQ8NFZ3
PaxDbiQ8NFZ3
PeptideAtlasiQ8NFZ3
PRIDEiQ8NFZ3
ProteomicsDBi27307
73395 [Q8NFZ3-1]
73396 [Q8NFZ3-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		21872, 136 antibodies

Genome annotation databases

EnsembliENST00000339174; ENSP00000342535; ENSG00000165246 [Q8NFZ3-1]
ENST00000355905; ENSP00000348169; ENSG00000165246 [Q8NFZ3-1]
ENST00000382872; ENSP00000372325; ENSG00000165246 [Q8NFZ3-2]
GeneIDi22829
KEGGihsa:22829
UCSCiuc004fte.3, human [Q8NFZ3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		22829
DisGeNETi22829
EuPathDBiHostDB:ENSG00000165246.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		NLGN4Y
HGNCiHGNC:15529, NLGN4Y
HPAiENSG00000165246, Tissue enhanced (brain, seminal vesicle)
MIMi400028, gene
neXtProtiNX_Q8NFZ3
OpenTargetsiENSG00000165246
PharmGKBiPA38386

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000156607
HOGENOMiCLU_006586_5_1_1
InParanoidiQ8NFZ3
KOiK07378
PhylomeDBiQ8NFZ3
TreeFamiTF326187

Enzyme and pathway databases

PathwayCommonsiQ8NFZ3
ReactomeiR-HSA-6794361, Neurexins and neuroligins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		22829, 1 hit in 475 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NLGN4Y, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		22829
PharosiQ8NFZ3, Tbio

Protein Ontology

More...PROi		PR:Q8NFZ3
RNActiQ8NFZ3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000165246, Expressed in corpus callosum and 144 other tissues
ExpressionAtlasiQ8NFZ3, baseline and differential
GenevisibleiQ8NFZ3, HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR002018, CarbesteraseB
IPR019819, Carboxylesterase_B_CS
IPR000460, Nlgn
IPR030025, NLGN4
PANTHERiPTHR43903:SF5, PTHR43903:SF5, 2 hits
PfamiView protein in Pfam
PF00135, COesterase, 1 hit
PRINTSiPR01090, NEUROLIGIN
SUPFAMiSSF53474, SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00941, CARBOXYLESTERASE_B_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNLGNY_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NFZ3
Secondary accession number(s): F5H6W0
, Q14D08, Q7Z3T5, Q8N5B6, Q9Y2F8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: October 1, 2002
Last modified: August 12, 2020
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again