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Entry version 140 (16 Jan 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Semaphorin-6D

Gene

SEMA6D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-416700 Other semaphorin interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Semaphorin-6D
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEMA6D
Synonyms:KIAA1479
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000137872.15

Human Gene Nomenclature Database

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HGNCi
HGNC:16770 SEMA6D

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609295 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NFY4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 662ExtracellularSequence analysisAdd BLAST642
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei663 – 683HelicalSequence analysisAdd BLAST21
Topological domaini684 – 1073CytoplasmicSequence analysisAdd BLAST390

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80031

Open Targets

More...
OpenTargetsi
ENSG00000137872

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134951035

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SEMA6D

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74715611

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004461521 – 1073Semaphorin-6DAdd BLAST1053

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi108 ↔ 118PROSITE-ProRule annotation
Disulfide bondi136 ↔ 145PROSITE-ProRule annotation
Disulfide bondi259 ↔ 370PROSITE-ProRule annotation
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi284 ↔ 329PROSITE-ProRule annotation
Glycosylationi435N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi461N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi477 ↔ 506PROSITE-ProRule annotation
Disulfide bondi515 ↔ 533PROSITE-ProRule annotation
Disulfide bondi521 ↔ 568PROSITE-ProRule annotation
Disulfide bondi525 ↔ 541PROSITE-ProRule annotation
Glycosylationi631N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei723PhosphoserineCombined sources1
Modified residuei734PhosphoserineBy similarity1
Modified residuei744PhosphoserineCombined sources1
Modified residuei773PhosphothreonineCombined sources1
Modified residuei931PhosphoserineCombined sources1
Modified residuei957PhosphoserineCombined sources1
Modified residuei983PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NFY4

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8NFY4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NFY4

PeptideAtlas

More...
PeptideAtlasi
Q8NFY4

PRoteomics IDEntifications database

More...
PRIDEi
Q8NFY4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
73385
73386 [Q8NFY4-2]
73387 [Q8NFY4-3]
73388 [Q8NFY4-4]
73389 [Q8NFY4-5]
73390 [Q8NFY4-6]
73391 [Q8NFY4-7]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q8NFY4

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NFY4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NFY4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137872 Expressed in 199 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NFY4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NFY4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043109

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123081, 2 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8NFY4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000324857

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8NFY4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NFY4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 512SemaPROSITE-ProRule annotationAdd BLAST486
Domaini514 – 569PSIAdd BLAST56

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3611 Eukaryota
ENOG410XQZC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159303

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232047

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG072910

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NFY4

KEGG Orthology (KO)

More...
KOi
K06842

Identification of Orthologs from Complete Genome Data

More...
OMAi
LLCAYML

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NFY4

TreeFam database of animal gene trees

More...
TreeFami
TF316102

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002165 Plexin_repeat
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11036 PTHR11036, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101912 SSF101912, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51004 SEMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: Q8NFY4-1) [UniParc]FASTAAdd to basket
Also known as: SEMA6D.4

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRVFLLCAYI LLLMVSQLRA VSFPEDDEPL NTVDYHYSRQ YPVFRGRPSG
60 70 80 90 100
NESQHRLDFQ LMLKIRDTLY IAGRDQVYTV NLNEMPKTEV IPNKKLTWRS
110 120 130 140 150
RQQDRENCAM KGKHKDECHN FIKVFVPRND EMVFVCGTNA FNPMCRYYRL
160 170 180 190 200
STLEYDGEEI SGLARCPFDA RQTNVALFAD GKLYSATVAD FLASDAVIYR
210 220 230 240 250
SMGDGSALRT IKYDSKWIKE PHFLHAIEYG NYVYFFFREI AVEHNNLGKA
260 270 280 290 300
VYSRVARICK NDMGGSQRVL EKHWTSFLKA RLNCSVPGDS FFYFDVLQSI
310 320 330 340 350
TDIIQINGIP TVVGVFTTQL NSIPGSAVCA FSMDDIEKVF KGRFKEQKTP
360 370 380 390 400
DSVWTAVPED KVPKPRPGCC AKHGLAEAYK TSIDFPDETL SFIKSHPLMD
410 420 430 440 450
SAVPPIADEP WFTKTRVRYR LTAISVDHSA GPYQNYTVIF VGSEAGMVLK
460 470 480 490 500
VLAKTSPFSL NDSVLLEEIE AYNHAKCSAE NEEDKKVISL QLDKDHHALY
510 520 530 540 550
VAFSSCIIRI PLSRCERYGS CKKSCIASRD PYCGWLSQGS CGRVTPGMLA
560 570 580 590 600
EGYEQDTEFG NTAHLGDCHE ILPTSTTPDY KIFGGPTSDM EVSSSSVTTM
610 620 630 640 650
ASIPEITPKV IDTWRPKLTS SRKFVVQDDP NTSDFTDPLS GIPKGVRWEV
660 670 680 690 700
QSGESNQMVH MNVLITCVFA AFVLGAFIAG VAVYCYRDMF VRKNRKIHKD
710 720 730 740 750
AESAQSCTDS SGSFAKLNGL FDSPVKEYQQ NIDSPKLYSN LLTSRKELPP
760 770 780 790 800
NGDTKSMVMD HRGQPPELAA LPTPESTPVL HQKTLQAMKS HSEKAHGHGA
810 820 830 840 850
SRKETPQFFP SSPPPHSPLS HGHIPSAIVL PNATHDYNTS FSNSNAHKAE
860 870 880 890 900
KKLQNIDHPL TKSSSKRDHR RSVDSRNTLN DLLKHLNDPN SNPKAIMGDI
910 920 930 940 950
QMAHQNLMLD PMGSMSEVPP KVPNREASLY SPPSTLPRNS PTKRVDVPTT
960 970 980 990 1000
PGVPMTSLER QRGYHKNSSQ RHSISAMPKN LNSPNGVLLS RQPSMNRGGY
1010 1020 1030 1040 1050
MPTPTGAKVD YIQGTPVSVH LQPSLSRQSS YTSNGTLPRT GLKRTPSLKP
1060 1070
DVPPKPSFVP QTPSVRPLNK YTY
Length:1,073
Mass (Da):119,872
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7DCE4DFC5BF70F9E
GO
Isoform 1 (identifier: Q8NFY4-2) [UniParc]FASTAAdd to basket
Also known as: SEMA6D.1

The sequence of this isoform differs from the canonical sequence as follows:
     549-549: L → LLLTEDFFAFHNHS
     570-644: Missing.

Show »
Length:1,011
Mass (Da):113,290
Checksum:i9D6B8B3633941B89
GO
Isoform 2 (identifier: Q8NFY4-3) [UniParc]FASTAAdd to basket
Also known as: SEMA6D.2

The sequence of this isoform differs from the canonical sequence as follows:
     570-644: Missing.

Show »
Length:998
Mass (Da):111,730
Checksum:i3F46D6872E8D5344
GO
Isoform 3 (identifier: Q8NFY4-4) [UniParc]FASTAAdd to basket
Also known as: SEMA6D.3

The sequence of this isoform differs from the canonical sequence as follows:
     589-644: Missing.

Show »
Length:1,017
Mass (Da):113,736
Checksum:i4D639CEBADD9F2A0
GO
Isoform 5 (identifier: Q8NFY4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     549-549: L → LLLTEDFFAFHNHS
     589-644: Missing.

Note: No experimental confirmation available.
Show »
Length:1,030
Mass (Da):115,296
Checksum:i659CF8EA114B048F
GO
Isoform 6 (identifier: Q8NFY4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     570-588: Missing.

Note: No experimental confirmation available.
Show »
Length:1,054
Mass (Da):117,866
Checksum:iA888C403FFACEE8F
GO
Isoform 7 (identifier: Q8NFY4-7) [UniParc]FASTAAdd to basket
Also known as: SEMA6Ds, Short

The sequence of this isoform differs from the canonical sequence as follows:
     477-1073: Missing.

Show »
Length:476
Mass (Da):54,217
Checksum:i3AAB6E77051D2D83
GO
Isoform 8 (identifier: Q8NFY4-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     570-588: Missing.
     601-1073: ASIPEITPKV...SVRPLNKYTY → VYDGKSSLESPTRWST

Note: No experimental confirmation available. Gene prediction based on mRNA data.
Show »
Length:597
Mass (Da):67,538
Checksum:i58D3EE7B6B68DB67
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YMP7H0YMP7_HUMAN
Semaphorin-6D
SEMA6D
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMV0H0YMV0_HUMAN
Semaphorin-6D
SEMA6D
219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMA6H0YMA6_HUMAN
Semaphorin-6D
SEMA6D
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YL82H0YL82_HUMAN
Semaphorin-6D
SEMA6D
22Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YM97H0YM97_HUMAN
Semaphorin-6D
SEMA6D
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA96003 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051931307N → S. Corresponds to variant dbSNP:rs3743279Ensembl.1
Natural variantiVAR_051932478S → N. Corresponds to variant dbSNP:rs532598Ensembl.1
Natural variantiVAR_051933969S → T. Corresponds to variant dbSNP:rs16960074Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016564477 – 1073Missing in isoform 7. 1 PublicationAdd BLAST597
Alternative sequenceiVSP_016565549L → LLLTEDFFAFHNHS in isoform 1 and isoform 5. 3 Publications1
Alternative sequenceiVSP_016566570 – 644Missing in isoform 1 and isoform 2. 3 PublicationsAdd BLAST75
Alternative sequenceiVSP_016572570 – 588Missing in isoform 6 and isoform 8. CuratedAdd BLAST19
Alternative sequenceiVSP_016567589 – 644Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_054084601 – 1073ASIPE…NKYTY → VYDGKSSLESPTRWST in isoform 8. CuratedAdd BLAST473

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF389426 mRNA Translation: AAM69449.1
AF389427 mRNA Translation: AAM69450.1
AF389428 mRNA Translation: AAM69451.1
AF389429 mRNA Translation: AAM69452.1
AF389430 mRNA Translation: AAM69453.1
AB040912 mRNA Translation: BAA96003.2 Different initiation.
AC018900 Genomic DNA No translation available.
AC044787 Genomic DNA No translation available.
AC009558 Genomic DNA No translation available.
AC012050 Genomic DNA No translation available.
AC023905 Genomic DNA No translation available.
AC066615 Genomic DNA No translation available.
AC084882 Genomic DNA No translation available.
BC150253 mRNA Translation: AAI50254.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32224.1 [Q8NFY4-2]
CCDS32225.1 [Q8NFY4-1]
CCDS32226.1 [Q8NFY4-4]
CCDS32227.1 [Q8NFY4-3]
CCDS32228.1 [Q8NFY4-8]
CCDS32229.1 [Q8NFY4-7]

NCBI Reference Sequences

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RefSeqi
NP_001185928.1, NM_001198999.1 [Q8NFY4-2]
NP_065909.1, NM_020858.1 [Q8NFY4-2]
NP_079242.2, NM_024966.2 [Q8NFY4-7]
NP_705869.1, NM_153616.1 [Q8NFY4-3]
NP_705870.1, NM_153617.1 [Q8NFY4-4]
NP_705871.1, NM_153618.1 [Q8NFY4-1]
NP_705872.1, NM_153619.1 [Q8NFY4-8]
XP_005254744.1, XM_005254687.2
XP_005254746.1, XM_005254689.3 [Q8NFY4-6]
XP_011520379.1, XM_011522077.2 [Q8NFY4-6]
XP_011520380.1, XM_011522078.2 [Q8NFY4-5]
XP_011520381.1, XM_011522079.2 [Q8NFY4-4]
XP_011520382.1, XM_011522080.2 [Q8NFY4-2]
XP_011520383.1, XM_011522081.2 [Q8NFY4-3]
XP_016878108.1, XM_017022619.1 [Q8NFY4-5]
XP_016878109.1, XM_017022620.1 [Q8NFY4-4]
XP_016878110.1, XM_017022621.1 [Q8NFY4-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.511265

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000316364; ENSP00000324857; ENSG00000137872 [Q8NFY4-1]
ENST00000354744; ENSP00000346786; ENSG00000137872 [Q8NFY4-4]
ENST00000355997; ENSP00000348276; ENSG00000137872 [Q8NFY4-8]
ENST00000358066; ENSP00000350770; ENSG00000137872 [Q8NFY4-2]
ENST00000389425; ENSP00000374076; ENSG00000137872 [Q8NFY4-7]
ENST00000389428; ENSP00000374079; ENSG00000137872 [Q8NFY4-3]
ENST00000536845; ENSP00000446152; ENSG00000137872 [Q8NFY4-1]
ENST00000558014; ENSP00000452815; ENSG00000137872 [Q8NFY4-2]
ENST00000558816; ENSP00000453661; ENSG00000137872 [Q8NFY4-8]

Database of genes from NCBI RefSeq genomes

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GeneIDi
80031

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:80031

UCSC genome browser

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UCSCi
uc001zvw.4 human [Q8NFY4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF389426 mRNA Translation: AAM69449.1
AF389427 mRNA Translation: AAM69450.1
AF389428 mRNA Translation: AAM69451.1
AF389429 mRNA Translation: AAM69452.1
AF389430 mRNA Translation: AAM69453.1
AB040912 mRNA Translation: BAA96003.2 Different initiation.
AC018900 Genomic DNA No translation available.
AC044787 Genomic DNA No translation available.
AC009558 Genomic DNA No translation available.
AC012050 Genomic DNA No translation available.
AC023905 Genomic DNA No translation available.
AC066615 Genomic DNA No translation available.
AC084882 Genomic DNA No translation available.
BC150253 mRNA Translation: AAI50254.1
CCDSiCCDS32224.1 [Q8NFY4-2]
CCDS32225.1 [Q8NFY4-1]
CCDS32226.1 [Q8NFY4-4]
CCDS32227.1 [Q8NFY4-3]
CCDS32228.1 [Q8NFY4-8]
CCDS32229.1 [Q8NFY4-7]
RefSeqiNP_001185928.1, NM_001198999.1 [Q8NFY4-2]
NP_065909.1, NM_020858.1 [Q8NFY4-2]
NP_079242.2, NM_024966.2 [Q8NFY4-7]
NP_705869.1, NM_153616.1 [Q8NFY4-3]
NP_705870.1, NM_153617.1 [Q8NFY4-4]
NP_705871.1, NM_153618.1 [Q8NFY4-1]
NP_705872.1, NM_153619.1 [Q8NFY4-8]
XP_005254744.1, XM_005254687.2
XP_005254746.1, XM_005254689.3 [Q8NFY4-6]
XP_011520379.1, XM_011522077.2 [Q8NFY4-6]
XP_011520380.1, XM_011522078.2 [Q8NFY4-5]
XP_011520381.1, XM_011522079.2 [Q8NFY4-4]
XP_011520382.1, XM_011522080.2 [Q8NFY4-2]
XP_011520383.1, XM_011522081.2 [Q8NFY4-3]
XP_016878108.1, XM_017022619.1 [Q8NFY4-5]
XP_016878109.1, XM_017022620.1 [Q8NFY4-4]
XP_016878110.1, XM_017022621.1 [Q8NFY4-3]
UniGeneiHs.511265

3D structure databases

ProteinModelPortaliQ8NFY4
SMRiQ8NFY4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123081, 2 interactors
CORUMiQ8NFY4
STRINGi9606.ENSP00000324857

PTM databases

CarbonylDBiQ8NFY4
iPTMnetiQ8NFY4
PhosphoSitePlusiQ8NFY4

Polymorphism and mutation databases

BioMutaiSEMA6D
DMDMi74715611

Proteomic databases

jPOSTiQ8NFY4
MaxQBiQ8NFY4
PaxDbiQ8NFY4
PeptideAtlasiQ8NFY4
PRIDEiQ8NFY4
ProteomicsDBi73385
73386 [Q8NFY4-2]
73387 [Q8NFY4-3]
73388 [Q8NFY4-4]
73389 [Q8NFY4-5]
73390 [Q8NFY4-6]
73391 [Q8NFY4-7]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316364; ENSP00000324857; ENSG00000137872 [Q8NFY4-1]
ENST00000354744; ENSP00000346786; ENSG00000137872 [Q8NFY4-4]
ENST00000355997; ENSP00000348276; ENSG00000137872 [Q8NFY4-8]
ENST00000358066; ENSP00000350770; ENSG00000137872 [Q8NFY4-2]
ENST00000389425; ENSP00000374076; ENSG00000137872 [Q8NFY4-7]
ENST00000389428; ENSP00000374079; ENSG00000137872 [Q8NFY4-3]
ENST00000536845; ENSP00000446152; ENSG00000137872 [Q8NFY4-1]
ENST00000558014; ENSP00000452815; ENSG00000137872 [Q8NFY4-2]
ENST00000558816; ENSP00000453661; ENSG00000137872 [Q8NFY4-8]
GeneIDi80031
KEGGihsa:80031
UCSCiuc001zvw.4 human [Q8NFY4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80031
DisGeNETi80031
EuPathDBiHostDB:ENSG00000137872.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SEMA6D
HGNCiHGNC:16770 SEMA6D
HPAiHPA043109
MIMi609295 gene
neXtProtiNX_Q8NFY4
OpenTargetsiENSG00000137872
PharmGKBiPA134951035

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00940000159303
HOGENOMiHOG000232047
HOVERGENiHBG072910
InParanoidiQ8NFY4
KOiK06842
OMAiLLCAYML
PhylomeDBiQ8NFY4
TreeFamiTF316102

Enzyme and pathway databases

ReactomeiR-HSA-416700 Other semaphorin interactions

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SEMA6D human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80031

Protein Ontology

More...
PROi
PR:Q8NFY4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137872 Expressed in 199 organ(s), highest expression level in forebrain
ExpressionAtlasiQ8NFY4 baseline and differential
GenevisibleiQ8NFY4 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR002165 Plexin_repeat
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEM6D_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NFY4
Secondary accession number(s): A6NF10
, A6NM95, A6NNK1, A7E2A0, Q8NFY3, Q8NFY5, Q8NFY6, Q8NFY7, Q9P249
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2002
Last modified: January 16, 2019
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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