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Entry version 147 (10 Apr 2019)
Sequence version 2 (17 Oct 2006)
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Protein

Rab effector MyRIP

Gene

MYRIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri63 – 105FYVE-typeAdd BLAST43

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-264876 Insulin processing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rab effector MyRIP
Alternative name(s):
Exophilin-8
Myosin-VIIa- and Rab-interacting protein
Synaptotagmin-like protein lacking C2 domains C
Short name:
SlaC2-c
Short name:
Slp homolog lacking C2 domains c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYRIP
Synonyms:SLAC2C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000170011.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19156 MYRIP

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611790 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NFW9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
25924

Open Targets

More...
OpenTargetsi
ENSG00000170011

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38800

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MYRIP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242669

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001902241 – 859Rab effector MyRIPAdd BLAST859

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei298PhosphoserineBy similarity1
Modified residuei350PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NFW9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NFW9

PeptideAtlas

More...
PeptideAtlasi
Q8NFW9

PRoteomics IDEntifications database

More...
PRIDEi
Q8NFW9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
73377
73378 [Q8NFW9-2]
73379 [Q8NFW9-3]
73380 [Q8NFW9-4]
73381 [Q8NFW9-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NFW9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NFW9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain, skin, heart, adrenal medulla, pancreas, intestine, liver, kidney, muscle and testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170011 Expressed in 206 organ(s), highest expression level in pigmented layer of retina

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8NFW9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8NFW9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA006433

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds MYO5A, MYO7A and F-actin (By similarity). Binds RAB27A that has been activated by GTP-binding via its N-terminus. Interacts with PRKAR2A. Interacts with components of the exocyst complex, including EXOC3 and EXOC4 (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
C1orf216Q8TAB55EBI-1759414,EBI-747505

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
117424, 3 interactors

Database of interacting proteins

More...
DIPi
DIP-48949N

Protein interaction database and analysis system

More...
IntActi
Q8NFW9, 9 interactors

Molecular INTeraction database

More...
MINTi
Q8NFW9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000301972

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8NFW9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NFW9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 124RabBDPROSITE-ProRule annotationAdd BLAST121

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni143 – 560Myosin-bindingAdd BLAST418
Regioni193 – 209PKA-bindingBy similarityAdd BLAST17
Regioni232 – 248Negative regulation of PKA-bindingBy similarityAdd BLAST17
Regioni495 – 856Actin-bindingAdd BLAST362

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri63 – 105FYVE-typeAdd BLAST43

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IHBX Eukaryota
ENOG41126RD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183138

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113712

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052562

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NFW9

KEGG Orthology (KO)

More...
KOi
K22237

Identification of Orthologs from Complete Genome Data

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OMAi
ESAGPWE

Database of Orthologous Groups

More...
OrthoDBi
492485at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NFW9

TreeFam database of animal gene trees

More...
TreeFami
TF331599

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006788 Myrip/Melanophilin
IPR010911 Rab_BD
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04698 Rab_eff_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50916 RABBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NFW9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRKLDLSGL TDDETEHVLQ VVQRDFNLRK KEEERLSELK QKLDEEGSKC
60 70 80 90 100
SILSKHQQFV EHCCMRCCSP FTFLVNTKRQ CGDCKFNVCK SCCSYQKHEK
110 120 130 140 150
AWVCCVCQQA RLLRAQSLEW FYNNVKSRFK RFGSAKVLKN LYRKHRLESG
160 170 180 190 200
ACFDILGGSL FESNLENEGS ISGSDSTFYR QSEGHSVMDT LAVALRVAEE
210 220 230 240 250
AIEEAISKAE AYGDSLDKQN EASYLRDHKE ELTEELATTI LQKIIRKQKS
260 270 280 290 300
KSEQQVEEEP GWPHPQSCST KVADEGTSAS PGGYRAPAAL WRSQSAFSIT
310 320 330 340 350
GEEALKTPPV EAPSRQPRDQ GQHPRAESAL PSWKSVDRLD ETNLAPVLQS
360 370 380 390 400
PDGNWVALKD GAPPPTRLLA KPKSGTFQAL EVASSVASAY DEMGSDSEED
410 420 430 440 450
FDWSEALSKL CPRSRALPRN PQPQPTQAQS SDQGPIAASP SSALSPNPEA
460 470 480 490 500
MCSDSETSSA GSSREVGHQA RLSWLQRKAP RNPAAEKMRL HGELDVNFNP
510 520 530 540 550
QLASRETSDS SEPEEAPHTT DRRARRWRRA RLGSEEPSKE PSSPSAQLRD
560 570 580 590 600
LDTHQVSDDL SETDISNEAR DPQTLTDTTE EKRRNRLYEL AMKMSEKETS
610 620 630 640 650
SGEDQESEPK TESENQKESL SSEDNSQSVQ EELKKKFSAV SLCNISTEVL
660 670 680 690 700
KVINATEELI AGSTGPWESP QVPPDRQKGM FPRGTDQVRL DEQLTSLEEN
710 720 730 740 750
VYLAAGTVYG LETQLTELED AARCIHSGTD ETHLADLEDQ VATAAAQVHH
760 770 780 790 800
AELQISDIES RISALTIAGL NIAPCVRFTR RRDQKQRTQV QTIDTSRQQR
810 820 830 840 850
RKLPAPPVKA EKIETSSVTT IKTFNHNFIL QGSSTNRTKE RKGTTKDLME

PALESAVMY
Length:859
Mass (Da):95,706
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC1087932C405DFDD
GO
Isoform 2 (identifier: Q8NFW9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     636-700: Missing.

Note: No experimental confirmation available.
Show »
Length:794
Mass (Da):88,565
Checksum:i2E76826EB1611C0A
GO
Isoform 3 (identifier: Q8NFW9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: MGRKLDLSGL...VCCVCQQARL → MQKSLRPIGL

Note: No experimental confirmation available.
Show »
Length:757
Mass (Da):83,766
Checksum:iFC56B17B4CEEB3B6
GO
Isoform 4 (identifier: Q8NFW9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-187: Missing.

Note: No experimental confirmation available.
Show »
Length:672
Mass (Da):74,108
Checksum:iB3B0FFAD3EAB9FE6
GO
Isoform 5 (identifier: Q8NFW9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     637-637: F → S
     638-859: Missing.

Note: No experimental confirmation available.
Show »
Length:637
Mass (Da):71,137
Checksum:i99D42DE8889A2D8D
GO
Isoform 6 (identifier: Q8NFW9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: MGRKLDLSGL...QFVEHCCMRC → MRKAASAASS...PGSAASASKR
     68-156: Missing.

Note: No experimental confirmation available.
Show »
Length:770
Mass (Da):83,948
Checksum:i3ADC2EC7D733AD03
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WFC5F8WFC5_HUMAN
Rab effector MyRIP
MYRIP
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti130K → E in BAG54185 (PubMed:14702039).Curated1
Sequence conflicti529R → G in BAG54276 (PubMed:14702039).Curated1
Sequence conflicti536E → G in BAG54276 (PubMed:14702039).Curated1
Sequence conflicti571D → E in AAM43954 (PubMed:11964381).Curated1
Sequence conflicti773A → T in BAH14439 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061755312A → T1 PublicationCorresponds to variant dbSNP:rs59923220Ensembl.1
Natural variantiVAR_061756365P → L. Corresponds to variant dbSNP:rs55785561Ensembl.1
Natural variantiVAR_051717673P → S. Corresponds to variant dbSNP:rs34800524Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0435391 – 187Missing in isoform 4. 1 PublicationAdd BLAST187
Alternative sequenceiVSP_0435401 – 112MGRKL…QQARL → MQKSLRPIGL in isoform 3. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_0548961 – 67MGRKL…CCMRC → MRKAASAASSRSTSSLWSTA ACAAARPSPSSSTPSASVEI ANSMSARAAAPTRSTKRPGS AASASKR in isoform 6. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_05489768 – 156Missing in isoform 6. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_043541636 – 700Missing in isoform 2. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_043542637F → S in isoform 5. 1 Publication1
Alternative sequenceiVSP_043543638 – 859Missing in isoform 5. 1 PublicationAdd BLAST222

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF396687 mRNA Translation: AAM43954.1
AB083783 mRNA Translation: BAC15555.1
AK125334 mRNA Translation: BAG54185.1
AK126013 mRNA Translation: BAG54276.1
AK294714 mRNA Translation: BAH11857.1
AK316068 mRNA Translation: BAH14439.1
AC099331 Genomic DNA No translation available.
AC099557 Genomic DNA No translation available.
AC104188 Genomic DNA No translation available.
AC110718 Genomic DNA No translation available.
AC130439 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64595.1
BC092512 mRNA Translation: AAH92512.1
BC109311 mRNA Translation: AAI09312.1
BC109312 mRNA Translation: AAI09313.1
AL050090 mRNA Translation: CAB43262.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2689.1 [Q8NFW9-1]
CCDS68390.1 [Q8NFW9-2]
CCDS68391.1 [Q8NFW9-6]
CCDS68392.1 [Q8NFW9-4]

Protein sequence database of the Protein Information Resource

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PIRi
T08739

NCBI Reference Sequences

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RefSeqi
NP_001271352.1, NM_001284423.1 [Q8NFW9-1]
NP_001271353.1, NM_001284424.1 [Q8NFW9-2]
NP_001271354.1, NM_001284425.1 [Q8NFW9-6]
NP_001271355.1, NM_001284426.1 [Q8NFW9-4]
NP_056275.2, NM_015460.3 [Q8NFW9-1]
XP_011531877.1, XM_011533575.1 [Q8NFW9-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.594535

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000302541; ENSP00000301972; ENSG00000170011 [Q8NFW9-1]
ENST00000396217; ENSP00000379519; ENSG00000170011 [Q8NFW9-6]
ENST00000425621; ENSP00000389323; ENSG00000170011 [Q8NFW9-2]
ENST00000444716; ENSP00000398665; ENSG00000170011 [Q8NFW9-1]
ENST00000458292; ENSP00000413392; ENSG00000170011 [Q8NFW9-5]
ENST00000539167; ENSP00000438297; ENSG00000170011 [Q8NFW9-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
25924

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:25924

UCSC genome browser

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UCSCi
uc003cka.5 human [Q8NFW9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF396687 mRNA Translation: AAM43954.1
AB083783 mRNA Translation: BAC15555.1
AK125334 mRNA Translation: BAG54185.1
AK126013 mRNA Translation: BAG54276.1
AK294714 mRNA Translation: BAH11857.1
AK316068 mRNA Translation: BAH14439.1
AC099331 Genomic DNA No translation available.
AC099557 Genomic DNA No translation available.
AC104188 Genomic DNA No translation available.
AC110718 Genomic DNA No translation available.
AC130439 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64595.1
BC092512 mRNA Translation: AAH92512.1
BC109311 mRNA Translation: AAI09312.1
BC109312 mRNA Translation: AAI09313.1
AL050090 mRNA Translation: CAB43262.1
CCDSiCCDS2689.1 [Q8NFW9-1]
CCDS68390.1 [Q8NFW9-2]
CCDS68391.1 [Q8NFW9-6]
CCDS68392.1 [Q8NFW9-4]
PIRiT08739
RefSeqiNP_001271352.1, NM_001284423.1 [Q8NFW9-1]
NP_001271353.1, NM_001284424.1 [Q8NFW9-2]
NP_001271354.1, NM_001284425.1 [Q8NFW9-6]
NP_001271355.1, NM_001284426.1 [Q8NFW9-4]
NP_056275.2, NM_015460.3 [Q8NFW9-1]
XP_011531877.1, XM_011533575.1 [Q8NFW9-1]
UniGeneiHs.594535

3D structure databases

ProteinModelPortaliQ8NFW9
SMRiQ8NFW9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117424, 3 interactors
DIPiDIP-48949N
IntActiQ8NFW9, 9 interactors
MINTiQ8NFW9
STRINGi9606.ENSP00000301972

PTM databases

iPTMnetiQ8NFW9
PhosphoSitePlusiQ8NFW9

Polymorphism and mutation databases

BioMutaiMYRIP
DMDMi116242669

Proteomic databases

jPOSTiQ8NFW9
PaxDbiQ8NFW9
PeptideAtlasiQ8NFW9
PRIDEiQ8NFW9
ProteomicsDBi73377
73378 [Q8NFW9-2]
73379 [Q8NFW9-3]
73380 [Q8NFW9-4]
73381 [Q8NFW9-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302541; ENSP00000301972; ENSG00000170011 [Q8NFW9-1]
ENST00000396217; ENSP00000379519; ENSG00000170011 [Q8NFW9-6]
ENST00000425621; ENSP00000389323; ENSG00000170011 [Q8NFW9-2]
ENST00000444716; ENSP00000398665; ENSG00000170011 [Q8NFW9-1]
ENST00000458292; ENSP00000413392; ENSG00000170011 [Q8NFW9-5]
ENST00000539167; ENSP00000438297; ENSG00000170011 [Q8NFW9-4]
GeneIDi25924
KEGGihsa:25924
UCSCiuc003cka.5 human [Q8NFW9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
25924
DisGeNETi25924
EuPathDBiHostDB:ENSG00000170011.13

GeneCards: human genes, protein and diseases

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GeneCardsi
MYRIP
HGNCiHGNC:19156 MYRIP
HPAiHPA006433
MIMi611790 gene
neXtProtiNX_Q8NFW9
OpenTargetsiENSG00000170011
PharmGKBiPA38800

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHBX Eukaryota
ENOG41126RD LUCA
GeneTreeiENSGT00950000183138
HOGENOMiHOG000113712
HOVERGENiHBG052562
InParanoidiQ8NFW9
KOiK22237
OMAiESAGPWE
OrthoDBi492485at2759
PhylomeDBiQ8NFW9
TreeFamiTF331599

Enzyme and pathway databases

ReactomeiR-HSA-264876 Insulin processing

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MYRIP human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
25924

Protein Ontology

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PROi
PR:Q8NFW9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170011 Expressed in 206 organ(s), highest expression level in pigmented layer of retina
ExpressionAtlasiQ8NFW9 baseline and differential
GenevisibleiQ8NFW9 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR006788 Myrip/Melanophilin
IPR010911 Rab_BD
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF04698 Rab_eff_C, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50916 RABBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYRIP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NFW9
Secondary accession number(s): B3KWM3
, B3KWW4, B7Z2H1, B7Z9V3, G3XAI8, Q32M41, Q32M42, Q569F7, Q8IUF5, Q9Y3V4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: October 17, 2006
Last modified: April 10, 2019
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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