Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Collagen alpha-1(XXII) chain

Gene

COL22A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts.

GO - Molecular functioni

  • extracellular matrix structural constituent Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-8948216 Collagen chain trimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XXII) chain
Gene namesi
Name:COL22A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000169436.16
HGNCiHGNC:22989 COL22A1
MIMi610026 gene
neXtProtiNX_Q8NFW1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi169044
OpenTargetsiENSG00000169436
PharmGKBiPA134914705

Polymorphism and mutation databases

BioMutaiCOL22A1
DMDMi296434458

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000031761528 – 1626Collagen alpha-1(XXII) chainAdd BLAST1599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi375N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NFW1
PeptideAtlasiQ8NFW1
PRIDEiQ8NFW1
ProteomicsDBi73370
73371 [Q8NFW1-2]
73372 [Q8NFW1-3]

PTM databases

iPTMnetiQ8NFW1
PhosphoSitePlusiQ8NFW1

Expressioni

Tissue specificityi

Restrictive expression is observed at tissue junctions such as the myotendinous junction in skeletal and heart muscle, the articular cartilage-synovial fluid junction, or the border between the anagen hair follicle and the dermis in the skin. It is deposited in the basement membrane zone of the myotendinous junction and the hair follicle and associated with the extrafibrillar matrix in cartilage.1 Publication

Gene expression databases

BgeeiENSG00000169436 Expressed in 98 organ(s), highest expression level in pituitary gland
CleanExiHS_COL22A1
ExpressionAtlasiQ8NFW1 baseline and differential
GenevisibleiQ8NFW1 HS

Organism-specific databases

HPAiHPA024830

Interactioni

Protein-protein interaction databases

ComplexPortaliCPX-1763 Collagen type XXII trimer
STRINGi9606.ENSP00000303153

Structurei

3D structure databases

ProteinModelPortaliQ8NFW1
SMRiQ8NFW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 213VWFAPROSITE-ProRule annotationAdd BLAST176
Domaini239 – 427Laminin G-likeAdd BLAST189
Domaini481 – 520Collagen-like 1Add BLAST40
Domaini526 – 565Collagen-like 2Add BLAST40
Domaini566 – 625Collagen-like 3Add BLAST60
Domaini657 – 708Collagen-like 4Add BLAST52
Domaini714 – 773Collagen-like 5Add BLAST60
Domaini774 – 833Collagen-like 6Add BLAST60
Domaini868 – 922Collagen-like 7Add BLAST55
Domaini925 – 984Collagen-like 8Add BLAST60
Domaini1047 – 1095Collagen-like 9Add BLAST49
Domaini1118 – 1155Collagen-like 10Add BLAST38
Domaini1156 – 1215Collagen-like 11Add BLAST60
Domaini1249 – 1308Collagen-like 12Add BLAST60
Domaini1315 – 1374Collagen-like 13Add BLAST60
Domaini1387 – 1446Collagen-like 14Add BLAST60
Domaini1495 – 1550Collagen-like 15Add BLAST56
Domaini1575 – 1604Collagen-like 16Add BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi161 – 165Poly-Ala5
Compositional biasi451 – 1607Pro-richAdd BLAST1157
Compositional biasi481 – 1603Gly-richAdd BLAST1123

Sequence similaritiesi

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
KOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00900000140804
HOGENOMiHOG000085653
HOVERGENiHBG106599
InParanoidiQ8NFW1
KOiK16630
OMAiNPGPHGQ
OrthoDBiEOG091G002N
PhylomeDBiQ8NFW1
TreeFamiTF332934

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR001791 Laminin_G
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01391 Collagen, 13 hits
PF00092 VWA, 1 hit
SMARTiView protein in SMART
SM00210 TSPN, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50234 VWFA, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NFW1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGLRGNAVA GLLWMLLLWS GGGGCQAQRA GCKSVHYDLV FLLDTSSSVG
60 70 80 90 100
KEDFEKVRQW VANLVDTFEV GPDRTRVGVV RYSDRPTTAF ELGLFGSQEE
110 120 130 140 150
VKAAARRLAY HGGNTNTGDA LRYITARSFS PHAGGRPRDR AYKQVAILLT
160 170 180 190 200
DGRSQDLVLD AAAAAHRAGI RIFAVGVGEA LKEELEEIAS EPKSAHVFHV
210 220 230 240 250
SDFNAIDKIR GKLRRRLCEN VLCPSVRVEG DRFKHTNGGT KEITGFDLMD
260 270 280 290 300
LFSVKEILGK RENGAQSSYV RMGSFPVVQS TEDVFPQGLP DEYAFVTTFR
310 320 330 340 350
FRKTSRKEDW YIWQVIDQYS IPQVSIRLDG ENKAVEYNAV GAMKDAVRVV
360 370 380 390 400
FRGSRVNDLF DRDWHKMALS IQAQNVSLHI DCALVQTLPI EERENIDIQG
410 420 430 440 450
KTVIGKRLYD SVPIDFDLQR IVIYCDSRHA ELETCCDIPS GPCQVTVVTE
460 470 480 490 500
PPPPPPPQRP PTPGSEQIGF LKTINCSCPA GEKGEMGVAG PMGLPGPKGD
510 520 530 540 550
IGAIGPVGAP GPKGEKGDVG IGPFGQGEKG EKGSLGLPGP PGRDGSKGMR
560 570 580 590 600
GEPGELGEPG LPGEVGMRGP QGPPGLPGPP GRVGAPGLQG ERGEKGTRGE
610 620 630 640 650
KGERGLDGFP GKPGDTGQQG RPGPSGVAGP QGEKGDVGPA GPPGVPGSVV
660 670 680 690 700
QQEGLKGEQG APGPRGHQGA PGPPGARGPI GPEGRDGPPG LQGLRGKKGD
710 720 730 740 750
MGPPGIPGLL GLQGPPGPPG VPGPPGPGGS PGLPGEIGFP GKPGPPGPTG
760 770 780 790 800
PPGKDGPNGP PGPPGTKGEP GERGEDGLPG KPGLRGEIGE QGLAGRPGEK
810 820 830 840 850
GEAGLPGAPG FPGVRGEKGD QGEKGELGLP GLKGDRGEKG EAGPAGPPGL
860 870 880 890 900
PGTTSLFTPH PRMPGEQGPK GEKGDPGLPG EPGLQGRPGE LGPQGPTGPP
910 920 930 940 950
GAKGQEGAHG APGAAGNPGA PGHVGAPGPS GPPGSVGAPG LRGTPGKDGE
960 970 980 990 1000
RGEKGAAGEE GSPGPVGPRG DPGAPGLPGP PGKGKDGEPG LRGSPGLPGP
1010 1020 1030 1040 1050
LGTKAACGKV RGSENCALGG QCVKGDRGAP GIPGSPGSRG DPGIGVAGPP
1060 1070 1080 1090 1100
GPSGPPGDKG SPGSRGLPGF PGPQGPAGRD GAPGNPGERG PPGKPGLSSL
1110 1120 1130 1140 1150
LSPGDINLLA KDVCNDCPPG PPGLPGLPGF KGDKGVPGKP GREGTEGKKG
1160 1170 1180 1190 1200
EAGPPGLPGP PGIAGPQGSQ GERGADGEVG QKGDQGHPGV PGFMGPPGNP
1210 1220 1230 1240 1250
GPPGADGIAG AAGPPGIQGS PGKEGPPGPQ GPSGLPGIPG EEGKEGRDGK
1260 1270 1280 1290 1300
PGPPGEPGKA GEPGLPGPEG ARGPPGFKGH TGDSGAPGPR GESGAMGLPG
1310 1320 1330 1340 1350
QEGLPGKDGD TGPTGPQGPQ GPRGPPGKNG SPGSPGEPGP SGTPGQKGSK
1360 1370 1380 1390 1400
GENGSPGLPG FLGPRGPPGE PGEKGVPGKE GVPGKPGEPG FKGERGDPGI
1410 1420 1430 1440 1450
KGDKGPPGGK GQPGDPGIPG HKGHTGLMGP QGLPGENGPV GPPGPPGQPG
1460 1470 1480 1490 1500
FPGLRGESPS METLRRLIQE ELGKQLETRL AYLLAQMPPA YMKSSQGRPG
1510 1520 1530 1540 1550
PPGPPGKDGL PGRAGPMGEP GRPGQGGLEG PSGPIGPKGE RGAKGDPGAP
1560 1570 1580 1590 1600
GVGLRGEMGP PGIPGQPGEP GYAKDGLPGI PGPQGETGPA GHPGLPGPPG
1610 1620
PPGQCDPSQC AYFASLAARP GNVKGP
Length:1,626
Mass (Da):161,145
Last modified:May 18, 2010 - v2
Checksum:i91018ABA2DD670EC
GO
Isoform 2 (identifier: Q8NFW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1005-1024: Missing.

Note: No experimental confirmation available.
Show »
Length:1,606
Mass (Da):159,212
Checksum:i29DC16D688B93F35
GO
Isoform 3 (identifier: Q8NFW1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     341-627: Missing.
     1005-1024: Missing.

Note: No experimental confirmation available.
Show »
Length:1,319
Mass (Da):129,678
Checksum:i249B873904A41A55
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YAX7H0YAX7_HUMAN
Collagen alpha-1(XXII) chain
COL22A1
65Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti753 – 767GKDGP…PPGTK → CILAAKTAPGLKQLN in AAH42075 (PubMed:16421571).CuratedAdd BLAST15

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038562320S → G2 PublicationsCorresponds to variant dbSNP:rs2292927Ensembl.1
Natural variantiVAR_038563703P → T. Corresponds to variant dbSNP:rs10111520Ensembl.1
Natural variantiVAR_038564938A → D1 PublicationCorresponds to variant dbSNP:rs4909444Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_038200341 – 627Missing in isoform 3. 1 PublicationAdd BLAST287
Alternative sequenceiVSP_0310871005 – 1024Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF406780 mRNA Translation: AAN03620.1
AC068476 Genomic DNA No translation available.
AC105130 Genomic DNA No translation available.
AC115720 Genomic DNA No translation available.
AP006262 Genomic DNA No translation available.
BC042075 mRNA Translation: AAH42075.1
BC144535 mRNA Translation: AAI44536.1
CCDSiCCDS6376.1 [Q8NFW1-1]
RefSeqiNP_690848.1, NM_152888.2 [Q8NFW1-1]
XP_011515185.1, XM_011516883.2 [Q8NFW1-2]
UniGeneiHs.117169

Genome annotation databases

EnsembliENST00000303045; ENSP00000303153; ENSG00000169436 [Q8NFW1-1]
ENST00000435777; ENSP00000387655; ENSG00000169436 [Q8NFW1-3]
GeneIDi169044
KEGGihsa:169044
UCSCiuc003yvd.3 human [Q8NFW1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF406780 mRNA Translation: AAN03620.1
AC068476 Genomic DNA No translation available.
AC105130 Genomic DNA No translation available.
AC115720 Genomic DNA No translation available.
AP006262 Genomic DNA No translation available.
BC042075 mRNA Translation: AAH42075.1
BC144535 mRNA Translation: AAI44536.1
CCDSiCCDS6376.1 [Q8NFW1-1]
RefSeqiNP_690848.1, NM_152888.2 [Q8NFW1-1]
XP_011515185.1, XM_011516883.2 [Q8NFW1-2]
UniGeneiHs.117169

3D structure databases

ProteinModelPortaliQ8NFW1
SMRiQ8NFW1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-1763 Collagen type XXII trimer
STRINGi9606.ENSP00000303153

PTM databases

iPTMnetiQ8NFW1
PhosphoSitePlusiQ8NFW1

Polymorphism and mutation databases

BioMutaiCOL22A1
DMDMi296434458

Proteomic databases

PaxDbiQ8NFW1
PeptideAtlasiQ8NFW1
PRIDEiQ8NFW1
ProteomicsDBi73370
73371 [Q8NFW1-2]
73372 [Q8NFW1-3]

Protocols and materials databases

DNASUi169044
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303045; ENSP00000303153; ENSG00000169436 [Q8NFW1-1]
ENST00000435777; ENSP00000387655; ENSG00000169436 [Q8NFW1-3]
GeneIDi169044
KEGGihsa:169044
UCSCiuc003yvd.3 human [Q8NFW1-1]

Organism-specific databases

CTDi169044
DisGeNETi169044
EuPathDBiHostDB:ENSG00000169436.16
GeneCardsiCOL22A1
H-InvDBiHIX0034283
HGNCiHGNC:22989 COL22A1
HPAiHPA024830
MIMi610026 gene
neXtProtiNX_Q8NFW1
OpenTargetsiENSG00000169436
PharmGKBiPA134914705
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
KOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00900000140804
HOGENOMiHOG000085653
HOVERGENiHBG106599
InParanoidiQ8NFW1
KOiK16630
OMAiNPGPHGQ
OrthoDBiEOG091G002N
PhylomeDBiQ8NFW1
TreeFamiTF332934

Enzyme and pathway databases

ReactomeiR-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-8948216 Collagen chain trimerization

Miscellaneous databases

ChiTaRSiCOL22A1 human
GenomeRNAii169044
PROiPR:Q8NFW1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169436 Expressed in 98 organ(s), highest expression level in pituitary gland
CleanExiHS_COL22A1
ExpressionAtlasiQ8NFW1 baseline and differential
GenevisibleiQ8NFW1 HS

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR001791 Laminin_G
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01391 Collagen, 13 hits
PF00092 VWA, 1 hit
SMARTiView protein in SMART
SM00210 TSPN, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50234 VWFA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOMA1_HUMAN
AccessioniPrimary (citable) accession number: Q8NFW1
Secondary accession number(s): B7ZMH0, C9K0G4, Q8IVT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again