SPDYE1

Functionⁱ

GO - Molecular functionⁱ

protein kinase binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of protein kinase activity Source: GO_Central

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Speedy protein E1 Alternative name(s): Williams-Beuren syndrome chromosomal region 19 protein
Gene namesⁱ	Name:SPDYE1 Synonyms:WBSCR19
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000136206.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16408 SPDYE1
MIMⁱ	617623 gene
neXtProtⁱ	NX_Q8NFV5

Pathology & Biotechⁱ

Involvement in diseaseⁱ

SPDYE1 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region (PubMed:12073013).1 Publication

Keywords - Diseaseⁱ

Williams-Beuren syndrome

Organism-specific databases

PharmGKBⁱ	PA38135

PharmGKBⁱ

PA38135

Polymorphism and mutation databases

BioMutaⁱ	SPDYE1
DMDMⁱ	296452952

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000322594	1 – 336	Speedy protein E1Add BLAST		336

Proteomic databases

PaxDbⁱ	Q8NFV5
PeptideAtlas More...PeptideAtlasⁱ	Q8NFV5
PRIDEⁱ	Q8NFV5
ProteomicsDBⁱ	73369

PTM databases

iPTMnetⁱ	Q8NFV5
PhosphoSitePlusⁱ	Q8NFV5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000136206
CleanExⁱ	HS_WBSCR19
Genevisibleⁱ	Q8NFV5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA051750

HPAⁱ

HPA051750

Interactionⁱ

GO - Molecular functionⁱ

protein kinase binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NFV5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	237 – 297	Arg-richAdd BLAST		61

Sequence similaritiesⁱ

Belongs to the Speedy/Ringo family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IX6P Eukaryota ENOG41119TB LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00420000029723
HOGENOMⁱ	HOG000132466
InParanoidⁱ	Q8NFV5
KEGG Orthology (KO) More...KOⁱ	K08694
OMAⁱ	WDKSEES
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MC6
PhylomeDBⁱ	Q8NFV5
TreeFamⁱ	TF329827

Family and domain databases

InterProⁱ	View protein in InterPro IPR020984 Speedy
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11357 Spy1, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8NFV5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQKHYTVAWF LYSAPGVDPS PPCRSLGWKR KREWSDESEE EPEKELAPEP 
        60         70         80         90        100
EETWVVETLC GLKMKLKQQR VSPILLEHHK DFNSQLAPGV DPSPPHRSFC 
       110        120        130        140        150
WKRKMEWWDK SEESEEEPRK VLAPEPEEIW VAEMLCGLKM KLKRRRVSLV 
       160        170        180        190        200
LPEHHEAFNR LLEDPVIKRF LAWDKDLRVS DKYLLAMVIA YFSRAGFPSW 
       210        220        230        240        250
QYQRLHFFLA LYLANDMEED DEDSKQNIFH FLYGKNRSRI PLLRKRRFQL 
       260        270        280        290        300
YRSMNPRARK NRSHIPLVRK RRFQLRRCMN PRARKNRSQI VLFQKRRFHF 
       310        320        330 
FCSMSCRAWV SPEELEEIQA YDPEHWVWAR DRARLS

Length:336

Mass (Da):40,668

Last modified:May 18, 2010 - v3

Checksum:ⁱ170B9D966BD4305C

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	58	T → M in AAM62309 (PubMed:12073013).Curated		1
Sequence conflictⁱ	76	L → P in AAM62309 (PubMed:12073013).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF412027 mRNA Translation: AAM62309.1 AC004951 Genomic DNA No translation available. AL137266 mRNA Translation: CAB70665.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5475.1
PIRⁱ	T46338
NCBI Reference Sequences More...RefSeqⁱ	NP_778234.2, NM_175064.2
UniGeneⁱ	Hs.645483

Genome annotation databases

Ensemblⁱ	ENST00000258704; ENSP00000258704; ENSG00000136206
GeneIDⁱ	285955
KEGGⁱ	hsa:285955
UCSC genome browser More...UCSCⁱ	uc003tjf.4 human

Protein	Similar proteins		Species	Score	Length
Q8NFV5	UPI000D0986C3		PANTR		407
Speedy protein E5		HUMAN		337
Uncharacterized protein		PANTR		337
Uncharacterized protein		PANTR		336
Uncharacterized protein		PANTR		336
+1

Protein	Similar proteins		Species	Score	Length
Q8NFV5	UPI000D0986C3		PANTR		407
Speedy protein E5		HUMAN		337
Uncharacterized protein		RHIBE		370
UPI0004F229B4		PAPAN		366
UPI000D500980		PANPA		372
+27

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF412027 mRNA Translation: AAM62309.1 AC004951 Genomic DNA No translation available. AL137266 mRNA Translation: CAB70665.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5475.1
PIRⁱ	T46338
NCBI Reference Sequences More...RefSeqⁱ	NP_778234.2, NM_175064.2
UniGeneⁱ	Hs.645483

3D structure databases

ProteinModelPortalⁱ	Q8NFV5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

PTM databases

iPTMnetⁱ	Q8NFV5
PhosphoSitePlusⁱ	Q8NFV5

Polymorphism and mutation databases

BioMutaⁱ	SPDYE1
DMDMⁱ	296452952

Proteomic databases

PaxDbⁱ	Q8NFV5
PeptideAtlas More...PeptideAtlasⁱ	Q8NFV5
PRIDEⁱ	Q8NFV5
ProteomicsDBⁱ	73369

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	285955
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000258704; ENSP00000258704; ENSG00000136206
GeneIDⁱ	285955
KEGGⁱ	hsa:285955
UCSC genome browser More...UCSCⁱ	uc003tjf.4 human

Organism-specific databases

CTDⁱ	285955
EuPathDBⁱ	HostDB:ENSG00000136206.3
GeneCardsⁱ	SPDYE1
H-InvDBⁱ	HIX0006637 HIX0033719 HIX0167618
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16408 SPDYE1
Human Protein Atlas More...HPAⁱ	HPA051750
MIMⁱ	617623 gene
neXtProtⁱ	NX_Q8NFV5
PharmGKBⁱ	PA38135
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IX6P Eukaryota ENOG41119TB LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00420000029723
HOGENOMⁱ	HOG000132466
InParanoidⁱ	Q8NFV5
KEGG Orthology (KO) More...KOⁱ	K08694
OMAⁱ	WDKSEES
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MC6
PhylomeDBⁱ	Q8NFV5
TreeFamⁱ	TF329827

Miscellaneous databases

GenomeRNAiⁱ	285955
Protein Ontology More...PROⁱ	PR:Q8NFV5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000136206
CleanExⁱ	HS_WBSCR19
Genevisibleⁱ	Q8NFV5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR020984 Speedy
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11357 Spy1, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SPDE1_HUMAN
Accessionⁱ	Q8NFV5Primary (citable) accession number: Q8NFV5 Secondary accession number(s): Q9NTH5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
	Last sequence update:	May 18, 2010
	Last modified:	June 20, 2018
	This is version 87 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8NFV5 (SPDE1_HUMAN)

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Speedy protein E1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ