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Entry version 151 (02 Dec 2020)
Sequence version 1 (01 Oct 2002)
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Protein

Protein ABHD11

Gene

ABHD11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

It is uncertain whether Met-1 or Met-10 is the initiator.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei141Charge relay systemBy similarity1
Active sitei237Charge relay systemBy similarity1
Active sitei296Charge relay systemBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8NFV4

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
human-ABHD11, ABHD11-Acetyl_transferase

MEROPS protease database

More...
MEROPSi
S33.976

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein ABHD11Curated (EC:3.-.-.-)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 11Curated
Short name:
Abhydrolase domain-containing protein 11Imported
Williams-Beuren syndrome chromosomal region 21 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABHD11Imported
Synonyms:WBSCR21
ORF Names:PP1226
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000106077.18

Human Gene Nomenclature Database

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HGNCi
HGNC:16407, ABHD11

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NFV4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

ABHD11 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

Keywords - Diseasei

Williams-Beuren syndrome

Organism-specific databases

DisGeNET

More...
DisGeNETi
83451

Open Targets

More...
OpenTargetsi
ENSG00000106077

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38134

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NFV4, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2189134

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ABHD11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751292

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002810031 – 315Protein ABHD11Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei87N6-succinyllysineBy similarity1

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8NFV4

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8NFV4

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8NFV4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NFV4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NFV4

PeptideAtlas

More...
PeptideAtlasi
Q8NFV4

PRoteomics IDEntifications database

More...
PRIDEi
Q8NFV4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
43672
73364 [Q8NFV4-1]
73365 [Q8NFV4-2]
73366 [Q8NFV4-3]
73367 [Q8NFV4-4]
73368 [Q8NFV4-5]

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q8NFV4-1 [Q8NFV4-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NFV4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NFV4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000106077, Expressed in left lobe of thyroid gland and 231 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NFV4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8NFV4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000106077, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
123653, 55 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NFV4, 45 interactors

Molecular INTeraction database

More...
MINTi
Q8NFV4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000222800

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NFV4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8NFV4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2382, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015880

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020336_53_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8NFV4

Identification of Orthologs from Complete Genome Data

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OMAi
LFGDMNN

Database of Orthologous Groups

More...
OrthoDBi
1268438at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NFV4

TreeFam database of animal gene trees

More...
TreeFami
TF314071

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058, AB_hydrolase
IPR000073, AB_hydrolase_1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12697, Abhydrolase_6, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00111, ABHYDROLASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474, SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NFV4-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRAGQQLASM LRWTRAWRLP REGLGPHGPS FARVPVAPSS SSGGRGGAEP
60 70 80 90 100
RPLPLSYRLL DGEAALPAVV FLHGLFGSKT NFNSIAKILA QQTGRRVLTV
110 120 130 140 150
DARNHGDSPH SPDMSYEIMS QDLQDLLPQL GLVPCVVVGH SMGGKTAMLL
160 170 180 190 200
ALQRPELVER LIAVDISPVE STGVSHFATY VAAMRAINIA DELPRSRARK
210 220 230 240 250
LADEQLSSVI QDMAVRQHLL TNLVEVDGRF VWRVNLDALT QHLDKILAFP
260 270 280 290 300
QRQESYLGPT LFLLGGNSQF VHPSHHPEIM RLFPRAQMQT VPNAGHWIHA
310
DRPQDFIAAI RGFLV
Length:315
Mass (Da):34,690
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i108A2A9ED4FCA866
GO
Isoform 2 (identifier: Q8NFV4-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     96-101: RVLTVD → ADGGCS
     102-315: Missing.

Show »
Length:101
Mass (Da):10,639
Checksum:i76C9F062C99779CB
GO
Isoform 3 (identifier: Q8NFV4-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     97-97: V → G
     98-315: Missing.

Show »
Length:97
Mass (Da):10,362
Checksum:i9B5EA9CB02195B7C
GO
Isoform 4 (identifier: Q8NFV4-4) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     51-57: Missing.

Show »
Length:308
Mass (Da):33,863
Checksum:i9F0658259A86D22B
GO
Isoform 5 (identifier: Q8NFV4-5) [UniParc]FASTAAdd to basket
Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     51-57: Missing.
     125-152: DLLPQLGLVPCVVVGHSMGGKTAMLLAL → PAPHLGTEGLRQALCGHEVLQGWSDLRL
     153-315: Missing.

Show »
Length:145
Mass (Da):15,640
Checksum:i0593926C8FA8D294
GO
Isoform 6 (identifier: Q8NFV4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-211: Missing.

Show »
Length:258
Mass (Da):28,473
Checksum:i4A86D8509A583128
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J7Q4C9J7Q4_HUMAN
Protein ABHD11
ABHD11
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZ58H7BZ58_HUMAN
Protein ABHD11
ABHD11
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC52H0YC52_HUMAN
Protein ABHD11
ABHD11
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C396H7C396_HUMAN
Protein ABHD11
ABHD11
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG17214 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence AAS07472 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02392451 – 57Missing in isoform 4 and isoform 5. 1 Publication7
Alternative sequenceiVSP_02392596 – 101RVLTVD → ADGGCS in isoform 2. 2 Publications6
Alternative sequenceiVSP_02392697V → G in isoform 3. 1 Publication1
Alternative sequenceiVSP_02392798 – 315Missing in isoform 3. 1 PublicationAdd BLAST218
Alternative sequenceiVSP_023928102 – 315Missing in isoform 2. 2 PublicationsAdd BLAST214
Alternative sequenceiVSP_023929125 – 152DLLPQ…MLLAL → PAPHLGTEGLRQALCGHEVL QGWSDLRL in isoform 5. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_023930153 – 315Missing in isoform 5. 1 PublicationAdd BLAST163
Alternative sequenceiVSP_046994155 – 211Missing in isoform 6. CuratedAdd BLAST57

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF412030 mRNA Translation: AAM62312.1
AF412031 mRNA Translation: AAM62313.1
AF412032 mRNA Translation: AAM62314.1
AY053499 mRNA Translation: AAL14848.1
AY053500 mRNA Translation: AAL14849.1
AC073846 Genomic DNA Translation: AAS07472.1 Sequence problems.
BC008251 mRNA Translation: AAH08251.2
BC011712 mRNA Translation: AAH11712.1
BC067750 mRNA Translation: AAH67750.1
AF217971 mRNA Translation: AAG17214.1 Sequence problems.

NCBI Reference Sequences

More...
RefSeqi
NP_001138836.1, NM_001145364.2 [Q8NFV4-6]
NP_001287987.1, NM_001301058.1
NP_001308311.1, NM_001321382.1
NP_683710.1, NM_148912.3 [Q8NFV4-1]
NP_683711.1, NM_148913.3 [Q8NFV4-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000222800; ENSP00000222800; ENSG00000106077 [Q8NFV4-1]
ENST00000357419; ENSP00000392945; ENSG00000106077 [Q8NFV4-2]
ENST00000395147; ENSP00000378579; ENSG00000106077 [Q8NFV4-6]
ENST00000437775; ENSP00000416970; ENSG00000106077 [Q8NFV4-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
83451

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:83451

UCSC genome browser

More...
UCSCi
uc003tzb.4, human [Q8NFV4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF412030 mRNA Translation: AAM62312.1
AF412031 mRNA Translation: AAM62313.1
AF412032 mRNA Translation: AAM62314.1
AY053499 mRNA Translation: AAL14848.1
AY053500 mRNA Translation: AAL14849.1
AC073846 Genomic DNA Translation: AAS07472.1 Sequence problems.
BC008251 mRNA Translation: AAH08251.2
BC011712 mRNA Translation: AAH11712.1
BC067750 mRNA Translation: AAH67750.1
AF217971 mRNA Translation: AAG17214.1 Sequence problems.
RefSeqiNP_001138836.1, NM_001145364.2 [Q8NFV4-6]
NP_001287987.1, NM_001301058.1
NP_001308311.1, NM_001321382.1
NP_683710.1, NM_148912.3 [Q8NFV4-1]
NP_683711.1, NM_148913.3 [Q8NFV4-4]

3D structure databases

SMRiQ8NFV4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123653, 55 interactors
IntActiQ8NFV4, 45 interactors
MINTiQ8NFV4
STRINGi9606.ENSP00000222800

Chemistry databases

ChEMBLiCHEMBL2189134

Protein family/group databases

ESTHERihuman-ABHD11, ABHD11-Acetyl_transferase
MEROPSiS33.976

PTM databases

iPTMnetiQ8NFV4
PhosphoSitePlusiQ8NFV4

Polymorphism and mutation databases

BioMutaiABHD11
DMDMi74751292

Proteomic databases

EPDiQ8NFV4
jPOSTiQ8NFV4
MassIVEiQ8NFV4
MaxQBiQ8NFV4
PaxDbiQ8NFV4
PeptideAtlasiQ8NFV4
PRIDEiQ8NFV4
ProteomicsDBi43672
73364 [Q8NFV4-1]
73365 [Q8NFV4-2]
73366 [Q8NFV4-3]
73367 [Q8NFV4-4]
73368 [Q8NFV4-5]
TopDownProteomicsiQ8NFV4-1 [Q8NFV4-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
14446, 120 antibodies

The DNASU plasmid repository

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DNASUi
83451

Genome annotation databases

EnsembliENST00000222800; ENSP00000222800; ENSG00000106077 [Q8NFV4-1]
ENST00000357419; ENSP00000392945; ENSG00000106077 [Q8NFV4-2]
ENST00000395147; ENSP00000378579; ENSG00000106077 [Q8NFV4-6]
ENST00000437775; ENSP00000416970; ENSG00000106077 [Q8NFV4-4]
GeneIDi83451
KEGGihsa:83451
UCSCiuc003tzb.4, human [Q8NFV4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
83451
DisGeNETi83451
EuPathDBiHostDB:ENSG00000106077.18

GeneCards: human genes, protein and diseases

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GeneCardsi
ABHD11
HGNCiHGNC:16407, ABHD11
HPAiENSG00000106077, Low tissue specificity
neXtProtiNX_Q8NFV4
OpenTargetsiENSG00000106077
PharmGKBiPA38134

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2382, Eukaryota
GeneTreeiENSGT00390000015880
HOGENOMiCLU_020336_53_0_1
InParanoidiQ8NFV4
OMAiLFGDMNN
OrthoDBi1268438at2759
PhylomeDBiQ8NFV4
TreeFamiTF314071

Enzyme and pathway databases

PathwayCommonsiQ8NFV4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
83451, 220 hits in 845 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ABHD11, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ABHD11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
83451
PharosiQ8NFV4, Tbio

Protein Ontology

More...
PROi
PR:Q8NFV4
RNActiQ8NFV4, protein

Gene expression databases

BgeeiENSG00000106077, Expressed in left lobe of thyroid gland and 231 other tissues
ExpressionAtlasiQ8NFV4, baseline and differential
GenevisibleiQ8NFV4, HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR000073, AB_hydrolase_1
PfamiView protein in Pfam
PF12697, Abhydrolase_6, 1 hit
PRINTSiPR00111, ABHYDROLASE
SUPFAMiSSF53474, SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABHDB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NFV4
Secondary accession number(s): H7BYM8
, Q6PJU0, Q8N722, Q8N723, Q8NFV2, Q8NFV3, Q9HBS8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2002
Last modified: December 2, 2020
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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