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UniProtKB - Q8NFU5 (IPMK_HUMAN)

Entry version 158 (25 May 2022)
Sequence version 1 (01 Oct 2002)
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Protein

Inositol polyphosphate multikinase

Gene

IPMK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931).

Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30624931).

Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12223481).

Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (PubMed:30420721, PubMed:28882892).

Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610).

Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity).

By similarity6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+2 PublicationsNote: Binds two Mg2+, but the interaction with the protein is mostly indirect.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by flavonoids that occupy the ATP-binding pocket. Inhibited by myricetin, quercetin, luteolin, kaempferol, isorhamnetin and diosmetin, and to a lesser degree by rhamnetin and apigenin.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=112 nM for myo-inositol-1,4,5-trisphosphate1 Publication
  2. KM=295 nM for myo-inositol-1,3,4,6-tetrakisphosphate1 Publication
  3. KM=129 nM for myo-inositol-1,3,4,5-tetrakisphosphate1 Publication
  4. KM=61 µM for ATP1 Publication
  5. KM=39 µM for phosphatidylinositol 4,5-bisphosphate1 Publication
  1. Vmax=27 nmol/min/mg enzyme with myo-inositol-1,4,5-trisphosphate as substrate1 Publication
  2. Vmax=114 nmol/min/mg enzyme with myo-inositol-1,3,4,6-tetrakisphosphate as substrate1 Publication
  3. Vmax=1.1 nmol/min/mg enzyme with myo-inositol-1,3,4,5-tetrakisphosphate as substrate1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phosphatidylinositol metabolism

This protein is involved in the pathway phosphatidylinositol metabolism, which is part of Phospholipid metabolism.4 Publications
View all proteins of this organism that are known to be involved in the pathway phosphatidylinositol metabolism and in Phospholipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei75ATPCombined sources1 Publication1
Binding sitei82SubstrateCombined sources1 Publication1
Binding sitei144ATPCombined sources1 Publication1
Binding sitei146SubstrateCombined sources1 Publication1
Binding sitei196SubstrateCombined sources1 Publication1
Binding sitei385ATPCombined sources1 Publication1
Binding sitei388SubstrateCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi131 – 133ATPCombined sources1 Publication3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processLipid metabolism, Phospholipid metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.1.151, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8NFU5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1855191, Synthesis of IPs in the nucleus

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q8NFU5

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8NFU5

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00949

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inositol polyphosphate multikinase (EC:2.7.1.1401 Publication, EC:2.7.1.1514 Publications, EC:2.7.1.153By similarity)
Alternative name(s):
Inositol 1,3,4,6-tetrakisphosphate 5-kinase1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IPMK
Synonyms:IMPK1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20739, IPMK

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609851, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8NFU5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000151151

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2 – 69Missing : No effect on affinity for phosphatidylinositol 4,5-bisphosphate and mildly increased enzyme activity; when associated with 279-S--V-365 DEL and 366-G--S-373. 1 PublicationAdd BLAST68
Mutagenesisi78Q → A: Strongly decreased enzyme activity. 1 Publication1
Mutagenesisi82R → A: Strongly decreased enzyme activity. 1 Publication1
Mutagenesisi144D → N: Loss of kinase activity and ability to execute necroptosis; when associated with A-146. 1 Publication1
Mutagenesisi146K → A: Loss of kinase activity and ability to execute necroptosis; when associated with N-144. 1 Publication1
Mutagenesisi160K → A: Strongly decreased enzyme activity. 1 Publication1
Mutagenesisi163Q → A: Moderately decreased enzyme activity. 1 Publication1
Mutagenesisi163Q → R: Decreased activity with inositol 1,4,5-trisphosphate. No effect on phosphorylation of inositol 1,3,4,5-tetrakisphosphate. 1 Publication1
Mutagenesisi164Q → A: Strongly decreased enzyme activity. 1 Publication1
Mutagenesisi164Q → R: Decreased activity with inositol 1,4,5-trisphosphate. Increased phosphorylation of inositol 1,3,4,5-tetrakisphosphate. 1 Publication1
Mutagenesisi167K → A: Decreased enzyme activity. 1 Publication1
Mutagenesisi196Q → A: Decreased enzyme activity. 1 Publication1
Mutagenesisi196Q → R: Decreased activity with inositol 1,4,5-trisphosphate. Increased phosphorylation of inositol 1,3,4,5-tetrakisphosphate. 1 Publication1
Mutagenesisi279 – 365Missing : No effect on affinity for phosphatidylinositol 4,5-bisphosphate and mildly increased enzyme activity; when associated with 2-A--P-69 DEL and 366-G--S-373 DEL. 1 PublicationAdd BLAST87
Mutagenesisi322 – 323RK → QQ: Interferes with nuclear localization. 1 Publication2
Mutagenesisi327 – 328KK → QQ: Interferes with nuclear localization. 1 Publication2
Mutagenesisi366 – 373FYHLPTGC → GGGGSGGGGS: No effect on affinity for phosphatidylinositol 4,5-bisphosphate and mildly increased enzyme activity; when associated with 2-A--P-69 DEL and 279-S--V-365 DEL. 1 Publication8
Mutagenesisi388H → A: Loss of enzyme activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		253430

MalaCards human disease database

More...MalaCardsi		IPMK

Open Targets

More...OpenTargetsi		ENSG00000151151

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		456333, Hereditary neuroendocrine tumor of small intestine

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134903369

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8NFU5, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4523401

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IPMK

Domain mapping of disease mutations (DMDM)

More...DMDMi		50401072

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000668702 – 416Inositol polyphosphate multikinaseAdd BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei7PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8NFU5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8NFU5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8NFU5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8NFU5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8NFU5

PeptideAtlas

More...PeptideAtlasi		Q8NFU5

PRoteomics IDEntifications database

More...PRIDEi		Q8NFU5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		73362

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8NFU5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8NFU5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000151151, Expressed in epithelium of mammary gland and 212 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8NFU5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000151151, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		128968, 7 interactors

Protein interaction database and analysis system

More...IntActi		Q8NFU5, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000363046

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q8NFU5

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8NFU5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1416
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8NFU5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8NFU5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 38DisorderedSequence analysisAdd BLAST38
Regioni160 – 167Substrate bindingCombined sources1 Publication8

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi320 – 330Nuclear localization signal1 PublicationAdd BLAST11

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the inositol phosphokinase (IPK) family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1620, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155309

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_042569_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8NFU5

Identification of Orthologs from Complete Genome Data

More...OMAi		YGFCITG

Database of Orthologous Groups

More...OrthoDBi		902814at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8NFU5

TreeFam database of animal gene trees

More...TreeFami		TF321442

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.470.160, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005522, IPK
IPR038286, IPK_sf

The PANTHER Classification System

More...PANTHERi		PTHR12400, PTHR12400, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03770, IPK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NFU5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATEPPSPLR VEAPGPPEMR TSPAIESTPE GTPQPAGGRL RFLNGCVPLS 
        60         70         80         90        100
HQVAGHMYGK DKVGILQHPD GTVLKQLQPP PRGPRELEFY NMVYAADCFD 
       110        120        130        140        150
GVLLELRKYL PKYYGIWSPP TAPNDLYLKL EDVTHKFNKP CIMDVKIGQK 
       160        170        180        190        200
SYDPFASSEK IQQQVSKYPL MEEIGFLVLG MRVYHVHSDS YETENQHYGR 
       210        220        230        240        250
SLTKETIKDG VSRFFHNGYC LRKDAVAASI QKIEKILQWF ENQKQLNFYA 
       260        270        280        290        300
SSLLFVYEGS SQPTTTKLND RTLAEKFLSK GQLSDTEVLE YNNNFHVLSS 
       310        320        330        340        350
TANGKIESSV GKSLSKMYAR HRKIYTKKHH SQTSLKVENL EQDNGWKSMS 
       360        370        380        390        400
QEHLNGNVLS QLEKVFYHLP TGCQEIAEVE VRMIDFAHVF PSNTIDEGYV 
       410 
YGLKHLISVL RSILDN
Length:416
Mass (Da):47,222
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i622D678696A892F9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022112349M → I. Corresponds to variant dbSNP:rs2275443Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF432853 mRNA Translation: AAM97838.1
BK000580 mRNA Translation: DAA01362.1
BC065709 mRNA Translation: AAH65709.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7250.1

NCBI Reference Sequences

More...RefSeqi		NP_689416.1, NM_152230.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373935.4; ENSP00000363046.3; ENSG00000151151.6

Database of genes from NCBI RefSeq genomes

More...GeneIDi		253430

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:253430

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000373935.4; ENSP00000363046.3; NM_152230.5; NP_689416.1

UCSC genome browser

More...UCSCi		uc001jkb.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF432853 mRNA Translation: AAM97838.1
BK000580 mRNA Translation: DAA01362.1
BC065709 mRNA Translation: AAH65709.1
CCDSiCCDS7250.1
RefSeqiNP_689416.1, NM_152230.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5W2GX-ray1.80A50-262[»]
A378-416[»]
5W2HX-ray1.90A50-262[»]
A378-416[»]
5W2IX-ray1.60A50-262[»]
A378-416[»]
6E7FX-ray2.50A/B70-279[»]
A/B374-416[»]
6M88X-ray1.90A50-262[»]
A378-416[»]
6M89X-ray1.85A50-262[»]
A378-416[»]
6M8AX-ray1.75A50-262[»]
A378-416[»]
6M8BX-ray1.80A50-262[»]
A378-416[»]
6M8CX-ray1.80A50-262[»]
A378-416[»]
6M8DX-ray2.00A50-262[»]
A378-416[»]
6M8EX-ray2.00A50-262[»]
A378-416[»]
AlphaFoldDBiQ8NFU5
SMRiQ8NFU5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi128968, 7 interactors
IntActiQ8NFU5, 4 interactors
STRINGi9606.ENSP00000363046

Chemistry databases

BindingDBiQ8NFU5
ChEMBLiCHEMBL4523401

PTM databases

iPTMnetiQ8NFU5
PhosphoSitePlusiQ8NFU5

Genetic variation databases

BioMutaiIPMK
DMDMi50401072

Proteomic databases

EPDiQ8NFU5
jPOSTiQ8NFU5
MassIVEiQ8NFU5
MaxQBiQ8NFU5
PaxDbiQ8NFU5
PeptideAtlasiQ8NFU5
PRIDEiQ8NFU5
ProteomicsDBi73362

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28039, 194 antibodies from 27 providers

The DNASU plasmid repository

More...DNASUi		253430

Genome annotation databases

EnsembliENST00000373935.4; ENSP00000363046.3; ENSG00000151151.6
GeneIDi253430
KEGGihsa:253430
MANE-SelectiENST00000373935.4; ENSP00000363046.3; NM_152230.5; NP_689416.1
UCSCiuc001jkb.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		253430
DisGeNETi253430

GeneCards: human genes, protein and diseases

More...GeneCardsi		IPMK
HGNCiHGNC:20739, IPMK
HPAiENSG00000151151, Low tissue specificity
MalaCardsiIPMK
MIMi609851, gene
neXtProtiNX_Q8NFU5
OpenTargetsiENSG00000151151
Orphaneti456333, Hereditary neuroendocrine tumor of small intestine
PharmGKBiPA134903369
VEuPathDBiHostDB:ENSG00000151151

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1620, Eukaryota
GeneTreeiENSGT00940000155309
HOGENOMiCLU_042569_0_0_1
InParanoidiQ8NFU5
OMAiYGFCITG
OrthoDBi902814at2759
PhylomeDBiQ8NFU5
TreeFamiTF321442

Enzyme and pathway databases

UniPathwayiUPA00949
BRENDAi2.7.1.151, 2681
PathwayCommonsiQ8NFU5
ReactomeiR-HSA-1855191, Synthesis of IPs in the nucleus
SABIO-RKiQ8NFU5
SignaLinkiQ8NFU5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		253430, 38 hits in 1069 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IPMK, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		253430
PharosiQ8NFU5, Tbio

Protein Ontology

More...PROi		PR:Q8NFU5
RNActiQ8NFU5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000151151, Expressed in epithelium of mammary gland and 212 other tissues
GenevisibleiQ8NFU5, HS

Family and domain databases

Gene3Di3.30.470.160, 1 hit
InterProiView protein in InterPro
IPR005522, IPK
IPR038286, IPK_sf
PANTHERiPTHR12400, PTHR12400, 1 hit
PfamiView protein in Pfam
PF03770, IPK, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIPMK_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NFU5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: May 25, 2022
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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