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UniProtKB - Q8NFU5 (IPMK_HUMAN)

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Protein

Inositol polyphosphate multikinase

Gene

IPMK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4).2 Publications

Catalytic activityi

2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS07712-MONOMER
BRENDAi2.7.1.151 2681
ReactomeiR-HSA-1855191 Synthesis of IPs in the nucleus
SABIO-RKiQ8NFU5

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol polyphosphate multikinase (EC:2.7.1.151)
Alternative name(s):
Inositol 1,3,4,6-tetrakisphosphate 5-kinase
Gene namesi
Name:IPMK
Synonyms:IMPK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000151151.5
HGNCiHGNC:20739 IPMK
MIMi609851 gene
neXtProtiNX_Q8NFU5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi322 – 323RK → QQ: Interferes with nuclear localization. 1 Publication2
Mutagenesisi327 – 328KK → QQ: Interferes with nuclear localization. 1 Publication2

Organism-specific databases

DisGeNETi253430
MalaCardsiIPMK
OpenTargetsiENSG00000151151
PharmGKBiPA134903369

Polymorphism and mutation databases

BioMutaiIPMK
DMDMi50401072

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000668702 – 416Inositol polyphosphate multikinaseAdd BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei7PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8NFU5
MaxQBiQ8NFU5
PaxDbiQ8NFU5
PeptideAtlasiQ8NFU5
PRIDEiQ8NFU5
ProteomicsDBi73362

PTM databases

iPTMnetiQ8NFU5
PhosphoSitePlusiQ8NFU5

Expressioni

Tissue specificityi

Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon.1 Publication

Gene expression databases

BgeeiENSG00000151151
CleanExiHS_IPMK
GenevisibleiQ8NFU5 HS

Organism-specific databases

HPAiHPA037837
HPA057542

Interactioni

Protein-protein interaction databases

BioGridi128968, 2 interactors
IntActiQ8NFU5, 2 interactors
STRINGi9606.ENSP00000363046

Structurei

Secondary structure

1416
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi66 – 68Combined sources3
Turni69 – 71Combined sources3
Beta strandi72 – 76Combined sources5
Turni79 – 81Combined sources3
Helixi82 – 93Combined sources12
Helixi101 – 106Combined sources6
Helixi107 – 109Combined sources3
Beta strandi113 – 117Combined sources5
Beta strandi127 – 131Combined sources5
Turni133 – 136Combined sources4
Beta strandi138 – 149Combined sources12
Helixi158 – 167Combined sources10
Helixi171 – 174Combined sources4
Beta strandi175 – 185Combined sources11
Turni186 – 189Combined sources4
Beta strandi190 – 194Combined sources5
Helixi196 – 200Combined sources5
Turni204 – 206Combined sources3
Helixi207 – 212Combined sources6
Helixi213 – 215Combined sources3
Beta strandi218 – 221Combined sources4
Helixi223 – 241Combined sources19
Beta strandi245 – 258Combined sources14
Beta strandi379 – 384Combined sources6
Beta strandi389 – 391Combined sources3
Helixi397 – 413Combined sources17

3D structure databases

ProteinModelPortaliQ8NFU5
SMRiQ8NFU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni140 – 148Substrate bindingBy similarity9

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi320 – 330Nuclear localization signalAdd BLAST11

Sequence similaritiesi

Belongs to the inositol phosphokinase (IPK) family.Curated

Phylogenomic databases

eggNOGiKOG1620 Eukaryota
ENOG410YHQ3 LUCA
GeneTreeiENSGT00390000014381
HOGENOMiHOG000116306
HOVERGENiHBG052124
InParanoidiQ8NFU5
KOiK00915
OMAiNTIDEGY
OrthoDBiEOG091G0KJW
PhylomeDBiQ8NFU5
TreeFamiTF321442

Family and domain databases

Gene3Di1.10.510.50, 2 hits
InterProiView protein in InterPro
IPR005522 IPK
IPR038286 IPK_sf
PANTHERiPTHR12400 PTHR12400, 1 hit
PfamiView protein in Pfam
PF03770 IPK, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NFU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATEPPSPLR VEAPGPPEMR TSPAIESTPE GTPQPAGGRL RFLNGCVPLS 
        60         70         80         90        100
HQVAGHMYGK DKVGILQHPD GTVLKQLQPP PRGPRELEFY NMVYAADCFD 
       110        120        130        140        150
GVLLELRKYL PKYYGIWSPP TAPNDLYLKL EDVTHKFNKP CIMDVKIGQK 
       160        170        180        190        200
SYDPFASSEK IQQQVSKYPL MEEIGFLVLG MRVYHVHSDS YETENQHYGR 
       210        220        230        240        250
SLTKETIKDG VSRFFHNGYC LRKDAVAASI QKIEKILQWF ENQKQLNFYA 
       260        270        280        290        300
SSLLFVYEGS SQPTTTKLND RTLAEKFLSK GQLSDTEVLE YNNNFHVLSS 
       310        320        330        340        350
TANGKIESSV GKSLSKMYAR HRKIYTKKHH SQTSLKVENL EQDNGWKSMS 
       360        370        380        390        400
QEHLNGNVLS QLEKVFYHLP TGCQEIAEVE VRMIDFAHVF PSNTIDEGYV 
       410 
YGLKHLISVL RSILDN
Length:416
Mass (Da):47,222
Last modified:October 1, 2002 - v1
Checksum:i622D678696A892F9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022112349M → I. Corresponds to variant dbSNP:rs2275443Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF432853 mRNA Translation: AAM97838.1
BK000580 mRNA Translation: DAA01362.1
BC065709 mRNA Translation: AAH65709.1
CCDSiCCDS7250.1
RefSeqiNP_689416.1, NM_152230.4
UniGeneiHs.30280

Genome annotation databases

EnsembliENST00000373935; ENSP00000363046; ENSG00000151151
GeneIDi253430
KEGGihsa:253430
UCSCiuc001jkb.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIPMK_HUMAN
AccessioniPrimary (citable) accession number: Q8NFU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: July 18, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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