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Entry version 134 (16 Oct 2019)
Sequence version 3 (23 Jan 2007)
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Protein

Thiosulfate:glutathione sulfurtransferase

Gene

TSTD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS-), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631). Provides the link between the first step in mammalian H2S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H2S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS- as substrate (PubMed:24981631). The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

GSS- is a potent inhibitor of TSTD1, since the presence of the sulfur dioxygenase (SDO) strongly increases the TSTD1 catalytic activity (PubMed:24981631).1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.0 mM for glutathione1 Publication
  2. KM=14.0 mM for thiosulfate1 Publication
  3. KM=0.04 mM for glutathione (in the presence of sulfur dioxygenase)1 Publication
  4. KM=10.7 mM for thiosulfate (in the presence of sulfur dioxygenase)1 Publication
  5. KM=11.0 mM for thiosulfate (when glutathione is the acceptor)1 Publication
  6. KM=10.4 mM for thiosulfate (when cystein is the acceptor)1 Publication
  7. KM=36.0 mM for thiosulfate (when coenzyme A is the acceptor)1 Publication
  8. KM=14.01 mM for thiosulfate (when DTT is the acceptor)1 Publication
  9. KM=12.0 mM for thiosulfate (when cyanide is the acceptor)1 Publication
  10. KM=1.7 mM for glutathione (when thiosulfate is the acceptor)1 Publication
  11. KM=2.5 mM for cystein (when thiosulfate is the acceptor)1 Publication
  12. KM=0.09 mM for coenzyme A (when thiosulfate is the acceptor)1 Publication
  13. KM=0.12 mM for DTT (when thiosulfate is the acceptor)1 Publication
  14. KM=0.22 mM for cyanide (when thiosulfate is the acceptor)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei79Cysteine persulfide intermediatePROSITE-ProRule annotation1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionTransferase

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:MONOMER-20304

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1614517 Sulfide oxidation to sulfate

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Thiosulfate:glutathione sulfurtransferase1 Publication (EC:2.8.1.-1 Publication)
    Short name:
    TST1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:TSTD1
    Synonyms:KAT
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:35410 TSTD1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    616041 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q8NFU3

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi79C → A or S: Leads to the loss of catalytic activity. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    100131187

    Open Targets

    More...
    OpenTargetsi
    ENSG00000215845

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA165752768

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q8NFU3

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    TSTD1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    68051988

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001394231 – 115Thiosulfate:glutathione sulfurtransferaseAdd BLAST115

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q8NFU3

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q8NFU3

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q8NFU3

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q8NFU3

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8NFU3

    PeptideAtlas

    More...
    PeptideAtlasi
    Q8NFU3

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8NFU3

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    73357 [Q8NFU3-1]
    73358 [Q8NFU3-2]
    73359 [Q8NFU3-3]
    73360 [Q8NFU3-4]

    Consortium for Top Down Proteomics

    More...
    TopDownProteomicsi
    Q8NFU3-1 [Q8NFU3-1]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q8NFU3

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8NFU3

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q8NFU3

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Highly expressed in kidney, liver and skeletal muscle. Lower levels of expression in heart, colon, thymus, spleen, placenta and lung. Weakly expressed in brain, small intestine and peripheral blood leukocytes. Expressed at high levels in the breast carcinoma cell lines MCF-7 and MDA-MB-468 and at a lower level in the breast carcinoma cell line MDA-MB-231, the colon carcinoma call line LoVo and the lung carcinoma cell line A-549. No expression in the cell lines EFO-27 and HeLa, or the normal breast tissue cell lines MCF-10A and H184A1. Detected in invasive ductal carcinoma, but not in the adjacent tissues.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000215845 Expressed in 192 organ(s), highest expression level in parotid gland

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q8NFU3 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q8NFU3 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA006518
    HPA006655

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000388293

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1115
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q8NFU3

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 115RhodanesePROSITE-ProRule annotationAdd BLAST99

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1530 Eukaryota
    COG0607 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000161394

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8NFU3

    KEGG Orthology (KO)

    More...
    KOi
    K01013

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    FFCQMGR

    Database of Orthologous Groups

    More...
    OrthoDBi
    1478958at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q8NFU3

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF323321

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.250.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001763 Rhodanese-like_dom
    IPR036873 Rhodanese-like_dom_sf
    IPR042457 TSTD1_mammal

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR45544 PTHR45544, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00581 Rhodanese, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00450 RHOD, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52821 SSF52821, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50206 RHODANESE_3, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 11 Publication (identifier: Q8NFU3-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAGAPTVSLP ELRSLLASGR ARLFDVRSRE EAAAGTIPGA LNIPVSELES
    60 70 80 90 100
    ALQMEPAAFQ ALYSAEKPKL EDEHLVFFCQ MGKRGLQATQ LARSLGYTGA
    110
    RNYAGAYREW LEKES
    Length:115
    Mass (Da):12,530
    Last modified:January 23, 2007 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i01963F5B8186B3A2
    GO
    Isoform 21 Publication (identifier: Q8NFU3-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         4-44: Missing.

    Show »
    Length:74
    Mass (Da):8,274
    Checksum:iE6BF433F3A12274B
    GO
    Isoform 31 Publication (identifier: Q8NFU3-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         100-115: ARNYAGAYREWLEKES → YGEVWLLAGR

    Show »
    Length:109
    Mass (Da):11,750
    Checksum:i8BB14CF3EA5223F4
    GO
    Isoform 4 (identifier: Q8NFU3-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         3-3: G → GGCRAPSS

    Note: No experimental confirmation available.Curated
    Show »
    Length:122
    Mass (Da):13,189
    Checksum:iE86B87A07C62B477
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    R4GNF9R4GNF9_HUMAN
    Thiosulfate:glutathione sulfurtrans...
    TSTD1
    62Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAH01699 differs from that shown. Reason: Erroneous initiation.Curated

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0141513G → GGCRAPSS in isoform 4. Curated1
    Alternative sequenceiVSP_0141524 – 44Missing in isoform 2. CuratedAdd BLAST41
    Alternative sequenceiVSP_014153100 – 115ARNYA…LEKES → YGEVWLLAGR in isoform 3. 1 PublicationAdd BLAST16

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF439442 Genomic DNA Translation: AAM69839.1
    AF439442 Genomic DNA Translation: AAM69840.1
    AL591806 Genomic DNA No translation available.
    BC001699 mRNA Translation: AAH01699.1 Different initiation.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS44257.1 [Q8NFU3-2]
    CCDS44258.1 [Q8NFU3-3]
    CCDS53400.1 [Q8NFU3-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001106676.1, NM_001113205.1 [Q8NFU3-3]
    NP_001106677.1, NM_001113206.1 [Q8NFU3-2]
    NP_001106678.1, NM_001113207.1 [Q8NFU3-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000318289; ENSP00000325518; ENSG00000215845 [Q8NFU3-3]
    ENST00000368023; ENSP00000357002; ENSG00000215845 [Q8NFU3-4]
    ENST00000368024; ENSP00000357003; ENSG00000215845 [Q8NFU3-2]
    ENST00000423014; ENSP00000388293; ENSG00000215845 [Q8NFU3-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    100131187

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:100131187

    UCSC genome browser

    More...
    UCSCi
    uc001fxh.5 human [Q8NFU3-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF439442 Genomic DNA Translation: AAM69839.1
    AF439442 Genomic DNA Translation: AAM69840.1
    AL591806 Genomic DNA No translation available.
    BC001699 mRNA Translation: AAH01699.1 Different initiation.
    CCDSiCCDS44257.1 [Q8NFU3-2]
    CCDS44258.1 [Q8NFU3-3]
    CCDS53400.1 [Q8NFU3-1]
    RefSeqiNP_001106676.1, NM_001113205.1 [Q8NFU3-3]
    NP_001106677.1, NM_001113206.1 [Q8NFU3-2]
    NP_001106678.1, NM_001113207.1 [Q8NFU3-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    6BEVX-ray1.04A/B1-115[»]
    SMRiQ8NFU3
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    STRINGi9606.ENSP00000388293

    PTM databases

    iPTMnetiQ8NFU3
    PhosphoSitePlusiQ8NFU3
    SwissPalmiQ8NFU3

    Polymorphism and mutation databases

    BioMutaiTSTD1
    DMDMi68051988

    Proteomic databases

    EPDiQ8NFU3
    jPOSTiQ8NFU3
    MassIVEiQ8NFU3
    MaxQBiQ8NFU3
    PaxDbiQ8NFU3
    PeptideAtlasiQ8NFU3
    PRIDEiQ8NFU3
    ProteomicsDBi73357 [Q8NFU3-1]
    73358 [Q8NFU3-2]
    73359 [Q8NFU3-3]
    73360 [Q8NFU3-4]
    TopDownProteomicsiQ8NFU3-1 [Q8NFU3-1]

    Genome annotation databases

    EnsembliENST00000318289; ENSP00000325518; ENSG00000215845 [Q8NFU3-3]
    ENST00000368023; ENSP00000357002; ENSG00000215845 [Q8NFU3-4]
    ENST00000368024; ENSP00000357003; ENSG00000215845 [Q8NFU3-2]
    ENST00000423014; ENSP00000388293; ENSG00000215845 [Q8NFU3-1]
    GeneIDi100131187
    KEGGihsa:100131187
    UCSCiuc001fxh.5 human [Q8NFU3-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    100131187
    DisGeNETi100131187

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    TSTD1
    HGNCiHGNC:35410 TSTD1
    HPAiHPA006518
    HPA006655
    MIMi616041 gene
    neXtProtiNX_Q8NFU3
    OpenTargetsiENSG00000215845
    PharmGKBiPA165752768

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1530 Eukaryota
    COG0607 LUCA
    GeneTreeiENSGT00940000161394
    InParanoidiQ8NFU3
    KOiK01013
    OMAiFFCQMGR
    OrthoDBi1478958at2759
    PhylomeDBiQ8NFU3
    TreeFamiTF323321

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-20304
    ReactomeiR-HSA-1614517 Sulfide oxidation to sulfate

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    TSTD1 human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    100131187
    PharosiQ8NFU3

    Protein Ontology

    More...
    PROi
    PR:Q8NFU3

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000215845 Expressed in 192 organ(s), highest expression level in parotid gland
    ExpressionAtlasiQ8NFU3 baseline and differential
    GenevisibleiQ8NFU3 HS

    Family and domain databases

    Gene3Di3.40.250.10, 1 hit
    InterProiView protein in InterPro
    IPR001763 Rhodanese-like_dom
    IPR036873 Rhodanese-like_dom_sf
    IPR042457 TSTD1_mammal
    PANTHERiPTHR45544 PTHR45544, 1 hit
    PfamiView protein in Pfam
    PF00581 Rhodanese, 1 hit
    SMARTiView protein in SMART
    SM00450 RHOD, 1 hit
    SUPFAMiSSF52821 SSF52821, 1 hit
    PROSITEiView protein in PROSITE
    PS50206 RHODANESE_3, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSTD1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NFU3
    Secondary accession number(s): Q5SY48
    , Q5SY49, Q5SY50, Q5SY51, Q8NFU2, Q9BV22
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: January 23, 2007
    Last modified: October 16, 2019
    This is version 134 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
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