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Protein

Delta and Notch-like epidermal growth factor-related receptor

Gene

DNER

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).By similarity

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • clathrin binding Source: UniProtKB
  • Notch binding Source: Ensembl
  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActivator, Receptor
Biological processNotch signaling pathway
LigandCalcium

Enzyme and pathway databases

ReactomeiR-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
SignaLinkiQ8NFT8
SIGNORiQ8NFT8

Names & Taxonomyi

Protein namesi
Recommended name:
Delta and Notch-like epidermal growth factor-related receptor
Gene namesi
Name:DNER
Synonyms:BET
ORF Names:UNQ262/PRO299
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000187957.7
HGNCiHGNC:24456 DNER
MIMi607299 gene
neXtProtiNX_Q8NFT8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini35 – 640ExtracellularSequence analysisAdd BLAST606
Transmembranei641 – 661HelicalSequence analysisAdd BLAST21
Topological domaini662 – 737CytoplasmicSequence analysisAdd BLAST76

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi92737
OpenTargetsiENSG00000187957
PharmGKBiPA162383959

Polymorphism and mutation databases

BioMutaiDNER
DMDMi74730301

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000025355735 – 737Delta and Notch-like epidermal growth factor-related receptorAdd BLAST703

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 59PROSITE-ProRule annotation
Disulfide bondi53 ↔ 80PROSITE-ProRule annotation
Disulfide bondi82 ↔ 91PROSITE-ProRule annotation
Disulfide bondi98 ↔ 108PROSITE-ProRule annotation
Disulfide bondi103 ↔ 121PROSITE-ProRule annotation
Disulfide bondi123 ↔ 132PROSITE-ProRule annotation
Glycosylationi223N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi319 ↔ 336PROSITE-ProRule annotation
Disulfide bondi338 ↔ 347PROSITE-ProRule annotation
Disulfide bondi353 ↔ 364PROSITE-ProRule annotation
Disulfide bondi358 ↔ 378PROSITE-ProRule annotation
Disulfide bondi380 ↔ 389PROSITE-ProRule annotation
Disulfide bondi396 ↔ 407PROSITE-ProRule annotation
Disulfide bondi401 ↔ 416PROSITE-ProRule annotation
Disulfide bondi418 ↔ 427PROSITE-ProRule annotation
Disulfide bondi434 ↔ 445PROSITE-ProRule annotation
Disulfide bondi439 ↔ 454PROSITE-ProRule annotation
Disulfide bondi456 ↔ 465PROSITE-ProRule annotation
Disulfide bondi472 ↔ 482PROSITE-ProRule annotation
Disulfide bondi477 ↔ 491PROSITE-ProRule annotation
Disulfide bondi493 ↔ 502PROSITE-ProRule annotation
Disulfide bondi509 ↔ 520PROSITE-ProRule annotation
Disulfide bondi514 ↔ 529PROSITE-ProRule annotation
Disulfide bondi531 ↔ 540PROSITE-ProRule annotation
Disulfide bondi547 ↔ 558PROSITE-ProRule annotation
Disulfide bondi552 ↔ 567PROSITE-ProRule annotation
Glycosylationi564N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi569 ↔ 578PROSITE-ProRule annotation
Disulfide bondi585 ↔ 596PROSITE-ProRule annotation
Disulfide bondi590 ↔ 605PROSITE-ProRule annotation
Disulfide bondi607 ↔ 616PROSITE-ProRule annotation
Modified residuei685PhosphoserineBy similarity1
Modified residuei711PhosphotyrosineBy similarity1
Modified residuei721PhosphotyrosineBy similarity1
Modified residuei722PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8NFT8
MaxQBiQ8NFT8
PaxDbiQ8NFT8
PeptideAtlasiQ8NFT8
PRIDEiQ8NFT8
ProteomicsDBi73354

PTM databases

iPTMnetiQ8NFT8
PhosphoSitePlusiQ8NFT8

Expressioni

Tissue specificityi

Expressed in brain, spinal cord and adrenal gland.1 Publication

Gene expression databases

BgeeiENSG00000187957 Expressed in 159 organ(s), highest expression level in substantia nigra
GenevisibleiQ8NFT8 HS

Organism-specific databases

HPAiHPA017320

Interactioni

Subunit structurei

Interacts with AP1G1. Interacts with NOTCH1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124973, 1 interactor
DIPiDIP-46249N
IntActiQ8NFT8, 4 interactors
STRINGi9606.ENSP00000345229

Structurei

3D structure databases

ProteinModelPortaliQ8NFT8
SMRiQ8NFT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 92EGF-like 1PROSITE-ProRule annotationAdd BLAST49
Domaini94 – 133EGF-like 2PROSITE-ProRule annotationAdd BLAST40
Domaini309 – 348EGF-like 3PROSITE-ProRule annotationAdd BLAST40
Domaini349 – 390EGF-like 4PROSITE-ProRule annotationAdd BLAST42
Domaini392 – 428EGF-like 5PROSITE-ProRule annotationAdd BLAST37
Domaini430 – 466EGF-like 6PROSITE-ProRule annotationAdd BLAST37
Domaini468 – 503EGF-like 7PROSITE-ProRule annotationAdd BLAST36
Domaini505 – 541EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini543 – 579EGF-like 9PROSITE-ProRule annotationAdd BLAST37
Domaini546 – 568Follistatin-likeAdd BLAST23
Domaini581 – 617EGF-like 10; calcium-bindingPROSITE-ProRule annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni44 – 133Interaction with NOTCH1By similarityAdd BLAST90
Regioni677 – 680Interaction with AP1G1 and somatodendritic targetingBy similarity4

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR71 Eukaryota
ENOG410ZUAK LUCA
GeneTreeiENSGT00930000150895
HOVERGENiHBG060866
InParanoidiQ8NFT8
OMAiCESYKDP
OrthoDBiEOG091G01VZ
PhylomeDBiQ8NFT8
TreeFamiTF351322

Family and domain databases

InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
PfamiView protein in Pfam
PF00008 EGF, 6 hits
PF12661 hEGF, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 10 hits
SM00179 EGF_CA, 7 hits
SUPFAMiSSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS00022 EGF_1, 10 hits
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 10 hits
PS01187 EGF_CA, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NFT8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPRRAQAPG AQLLPALALL LLLLGAGPRG SSLANPVPAA PLSAPGPCAA
60 70 80 90 100
QPCRNGGVCT SRPEPDPQHP APAGEPGYSC TCPAGISGAN CQLVADPCAS
110 120 130 140 150
NPCHHGNCSS SSSSSSDGYL CICNEGYEGP NCEQALPSLP ATGWTESMAP
160 170 180 190 200
RQLQPVPATQ EPDKILPRSQ ATVTLPTWQP KTGQKVVEMK WDQVEVIPDI
210 220 230 240 250
ACGNASSNSS AGGRLVSFEV PQNTSVKIRQ DATASLILLW KVTATGFQQC
260 270 280 290 300
SLIDGRSVTP LQASGGLVLL EEMLALGNNH FIGFVNDSVT KSIVALRLTL
310 320 330 340 350
VVKVSTCVPG ESHANDLECS GKGKCTTKPS EATFSCTCEE QYVGTFCEEY
360 370 380 390 400
DACQRKPCQN NASCIDANEK QDGSNFTCVC LPGYTGELCQ SKIDYCILDP
410 420 430 440 450
CRNGATCISS LSGFTCQCPE GYFGSACEEK VDPCASSPCQ NNGTCYVDGV
460 470 480 490 500
HFTCNCSPGF TGPTCAQLID FCALSPCAHG TCRSVGTSYK CLCDPGYHGL
510 520 530 540 550
YCEEEYNECL SAPCLNAATC RDLVNGYECV CLAEYKGTHC ELYKDPCANV
560 570 580 590 600
SCLNGATCDS DGLNGTCICA PGFTGEECDI DINECDSNPC HHGGSCLDQP
610 620 630 640 650
NGYNCHCPHG WVGANCEIHL QWKSGHMAES LTNMPRHSLY IIIGALCVAF
660 670 680 690 700
ILMLIILIVG ICRISRIEYQ GSSRPAYEEF YNCRSIDSEF SNAIASIRHA
710 720 730
RFGKKSRPAM YDVSPIAYED YSPDDKPLVT LIKTKDL
Length:737
Mass (Da):78,475
Last modified:October 1, 2002 - v1
Checksum:i25A8A8A3044308BE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028380433P → L1 PublicationCorresponds to variant dbSNP:rs17853365Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF442487 mRNA Translation: AAM21557.1
AY358891 mRNA Translation: AAQ89250.1
AC007559 Genomic DNA Translation: AAY14939.1
AC007748 Genomic DNA Translation: AAY24263.1
AC008273 Genomic DNA Translation: AAF19247.2
AC093384 Genomic DNA Translation: AAY14680.1
CH471063 Genomic DNA Translation: EAW70893.1
BC024766 mRNA Translation: AAH24766.2
BC035009 mRNA Translation: AAH35009.1
AL137311 mRNA Translation: CAB70690.1
CCDSiCCDS33390.1
PIRiT46247
RefSeqiNP_620711.3, NM_139072.3
UniGeneiHs.234074

Genome annotation databases

EnsembliENST00000341772; ENSP00000345229; ENSG00000187957
GeneIDi92737
KEGGihsa:92737
UCSCiuc002vpv.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF442487 mRNA Translation: AAM21557.1
AY358891 mRNA Translation: AAQ89250.1
AC007559 Genomic DNA Translation: AAY14939.1
AC007748 Genomic DNA Translation: AAY24263.1
AC008273 Genomic DNA Translation: AAF19247.2
AC093384 Genomic DNA Translation: AAY14680.1
CH471063 Genomic DNA Translation: EAW70893.1
BC024766 mRNA Translation: AAH24766.2
BC035009 mRNA Translation: AAH35009.1
AL137311 mRNA Translation: CAB70690.1
CCDSiCCDS33390.1
PIRiT46247
RefSeqiNP_620711.3, NM_139072.3
UniGeneiHs.234074

3D structure databases

ProteinModelPortaliQ8NFT8
SMRiQ8NFT8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124973, 1 interactor
DIPiDIP-46249N
IntActiQ8NFT8, 4 interactors
STRINGi9606.ENSP00000345229

PTM databases

iPTMnetiQ8NFT8
PhosphoSitePlusiQ8NFT8

Polymorphism and mutation databases

BioMutaiDNER
DMDMi74730301

Proteomic databases

EPDiQ8NFT8
MaxQBiQ8NFT8
PaxDbiQ8NFT8
PeptideAtlasiQ8NFT8
PRIDEiQ8NFT8
ProteomicsDBi73354

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341772; ENSP00000345229; ENSG00000187957
GeneIDi92737
KEGGihsa:92737
UCSCiuc002vpv.4 human

Organism-specific databases

CTDi92737
DisGeNETi92737
EuPathDBiHostDB:ENSG00000187957.7
GeneCardsiDNER
HGNCiHGNC:24456 DNER
HPAiHPA017320
MIMi607299 gene
neXtProtiNX_Q8NFT8
OpenTargetsiENSG00000187957
PharmGKBiPA162383959
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR71 Eukaryota
ENOG410ZUAK LUCA
GeneTreeiENSGT00930000150895
HOVERGENiHBG060866
InParanoidiQ8NFT8
OMAiCESYKDP
OrthoDBiEOG091G01VZ
PhylomeDBiQ8NFT8
TreeFamiTF351322

Enzyme and pathway databases

ReactomeiR-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
SignaLinkiQ8NFT8
SIGNORiQ8NFT8

Miscellaneous databases

ChiTaRSiDNER human
GeneWikiiDNER
GenomeRNAii92737
PROiPR:Q8NFT8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187957 Expressed in 159 organ(s), highest expression level in substantia nigra
GenevisibleiQ8NFT8 HS

Family and domain databases

InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
PfamiView protein in Pfam
PF00008 EGF, 6 hits
PF12661 hEGF, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 10 hits
SM00179 EGF_CA, 7 hits
SUPFAMiSSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS00022 EGF_1, 10 hits
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 10 hits
PS01187 EGF_CA, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDNER_HUMAN
AccessioniPrimary (citable) accession number: Q8NFT8
Secondary accession number(s): A6NP39
, Q53R88, Q53TP7, Q53TQ5, Q8IYT0, Q8TB42, Q9NTF1, Q9UDM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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