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Entry version 145 (05 Jun 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Delta and Notch-like epidermal growth factor-related receptor

Gene

DNER

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • clathrin binding Source: UniProtKB
  • Notch binding Source: GO_Central
  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Receptor
Biological processNotch signaling pathway
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8NFT8

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8NFT8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Delta and Notch-like epidermal growth factor-related receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNER
Synonyms:BET
ORF Names:UNQ262/PRO299
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24456 DNER

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607299 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NFT8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini35 – 640ExtracellularSequence analysisAdd BLAST606
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei641 – 661HelicalSequence analysisAdd BLAST21
Topological domaini662 – 737CytoplasmicSequence analysisAdd BLAST76

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
92737

Open Targets

More...
OpenTargetsi
ENSG00000187957

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162383959

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DNER

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74730301

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 34Sequence analysisAdd BLAST34
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025355735 – 737Delta and Notch-like epidermal growth factor-related receptorAdd BLAST703

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi48 ↔ 59PROSITE-ProRule annotation
Disulfide bondi53 ↔ 80PROSITE-ProRule annotation
Disulfide bondi82 ↔ 91PROSITE-ProRule annotation
Disulfide bondi98 ↔ 108PROSITE-ProRule annotation
Disulfide bondi103 ↔ 121PROSITE-ProRule annotation
Disulfide bondi123 ↔ 132PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi223N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi319 ↔ 336PROSITE-ProRule annotation
Disulfide bondi338 ↔ 347PROSITE-ProRule annotation
Disulfide bondi353 ↔ 364PROSITE-ProRule annotation
Disulfide bondi358 ↔ 378PROSITE-ProRule annotation
Disulfide bondi380 ↔ 389PROSITE-ProRule annotation
Disulfide bondi396 ↔ 407PROSITE-ProRule annotation
Disulfide bondi401 ↔ 416PROSITE-ProRule annotation
Disulfide bondi418 ↔ 427PROSITE-ProRule annotation
Disulfide bondi434 ↔ 445PROSITE-ProRule annotation
Disulfide bondi439 ↔ 454PROSITE-ProRule annotation
Disulfide bondi456 ↔ 465PROSITE-ProRule annotation
Disulfide bondi472 ↔ 482PROSITE-ProRule annotation
Disulfide bondi477 ↔ 491PROSITE-ProRule annotation
Disulfide bondi493 ↔ 502PROSITE-ProRule annotation
Disulfide bondi509 ↔ 520PROSITE-ProRule annotation
Disulfide bondi514 ↔ 529PROSITE-ProRule annotation
Disulfide bondi531 ↔ 540PROSITE-ProRule annotation
Disulfide bondi547 ↔ 558PROSITE-ProRule annotation
Disulfide bondi552 ↔ 567PROSITE-ProRule annotation
Glycosylationi564N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi569 ↔ 578PROSITE-ProRule annotation
Disulfide bondi585 ↔ 596PROSITE-ProRule annotation
Disulfide bondi590 ↔ 605PROSITE-ProRule annotation
Disulfide bondi607 ↔ 616PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei685PhosphoserineBy similarity1
Modified residuei711PhosphotyrosineBy similarity1
Modified residuei721PhosphotyrosineBy similarity1
Modified residuei722PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NFT8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NFT8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NFT8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NFT8

PeptideAtlas

More...
PeptideAtlasi
Q8NFT8

PRoteomics IDEntifications database

More...
PRIDEi
Q8NFT8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
73354

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NFT8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NFT8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, spinal cord and adrenal gland.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187957 Expressed in 159 organ(s), highest expression level in substantia nigra

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NFT8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA017320

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AP1G1. Interacts with NOTCH1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124973, 1 interactor

Database of interacting proteins

More...
DIPi
DIP-46249N

Protein interaction database and analysis system

More...
IntActi
Q8NFT8, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000345229

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NFT8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 92EGF-like 1PROSITE-ProRule annotationAdd BLAST49
Domaini94 – 133EGF-like 2PROSITE-ProRule annotationAdd BLAST40
Domaini309 – 348EGF-like 3PROSITE-ProRule annotationAdd BLAST40
Domaini349 – 390EGF-like 4PROSITE-ProRule annotationAdd BLAST42
Domaini392 – 428EGF-like 5PROSITE-ProRule annotationAdd BLAST37
Domaini430 – 466EGF-like 6PROSITE-ProRule annotationAdd BLAST37
Domaini468 – 503EGF-like 7PROSITE-ProRule annotationAdd BLAST36
Domaini505 – 541EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini543 – 579EGF-like 9PROSITE-ProRule annotationAdd BLAST37
Domaini546 – 568Follistatin-likeAdd BLAST23
Domaini581 – 617EGF-like 10; calcium-bindingPROSITE-ProRule annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni44 – 133Interaction with NOTCH1By similarityAdd BLAST90
Regioni677 – 680Interaction with AP1G1 and somatodendritic targetingBy similarity4

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR71 Eukaryota
ENOG410ZUAK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158872

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NFT8

Identification of Orthologs from Complete Genome Data

More...
OMAi
CESYKDP

Database of Orthologous Groups

More...
OrthoDBi
7525at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NFT8

TreeFam database of animal gene trees

More...
TreeFami
TF351322

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008 EGF, 6 hits
PF12661 hEGF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 10 hits
SM00179 EGF_CA, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS00022 EGF_1, 10 hits
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 10 hits
PS01187 EGF_CA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NFT8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPRRAQAPG AQLLPALALL LLLLGAGPRG SSLANPVPAA PLSAPGPCAA
60 70 80 90 100
QPCRNGGVCT SRPEPDPQHP APAGEPGYSC TCPAGISGAN CQLVADPCAS
110 120 130 140 150
NPCHHGNCSS SSSSSSDGYL CICNEGYEGP NCEQALPSLP ATGWTESMAP
160 170 180 190 200
RQLQPVPATQ EPDKILPRSQ ATVTLPTWQP KTGQKVVEMK WDQVEVIPDI
210 220 230 240 250
ACGNASSNSS AGGRLVSFEV PQNTSVKIRQ DATASLILLW KVTATGFQQC
260 270 280 290 300
SLIDGRSVTP LQASGGLVLL EEMLALGNNH FIGFVNDSVT KSIVALRLTL
310 320 330 340 350
VVKVSTCVPG ESHANDLECS GKGKCTTKPS EATFSCTCEE QYVGTFCEEY
360 370 380 390 400
DACQRKPCQN NASCIDANEK QDGSNFTCVC LPGYTGELCQ SKIDYCILDP
410 420 430 440 450
CRNGATCISS LSGFTCQCPE GYFGSACEEK VDPCASSPCQ NNGTCYVDGV
460 470 480 490 500
HFTCNCSPGF TGPTCAQLID FCALSPCAHG TCRSVGTSYK CLCDPGYHGL
510 520 530 540 550
YCEEEYNECL SAPCLNAATC RDLVNGYECV CLAEYKGTHC ELYKDPCANV
560 570 580 590 600
SCLNGATCDS DGLNGTCICA PGFTGEECDI DINECDSNPC HHGGSCLDQP
610 620 630 640 650
NGYNCHCPHG WVGANCEIHL QWKSGHMAES LTNMPRHSLY IIIGALCVAF
660 670 680 690 700
ILMLIILIVG ICRISRIEYQ GSSRPAYEEF YNCRSIDSEF SNAIASIRHA
710 720 730
RFGKKSRPAM YDVSPIAYED YSPDDKPLVT LIKTKDL
Length:737
Mass (Da):78,475
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i25A8A8A3044308BE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028380433P → L1 PublicationCorresponds to variant dbSNP:rs17853365Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF442487 mRNA Translation: AAM21557.1
AY358891 mRNA Translation: AAQ89250.1
AC007559 Genomic DNA Translation: AAY14939.1
AC007748 Genomic DNA Translation: AAY24263.1
AC008273 Genomic DNA Translation: AAF19247.2
AC093384 Genomic DNA Translation: AAY14680.1
CH471063 Genomic DNA Translation: EAW70893.1
BC024766 mRNA Translation: AAH24766.2
BC035009 mRNA Translation: AAH35009.1
AL137311 mRNA Translation: CAB70690.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33390.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T46247

NCBI Reference Sequences

More...
RefSeqi
NP_620711.3, NM_139072.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000341772; ENSP00000345229; ENSG00000187957

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
92737

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:92737

UCSC genome browser

More...
UCSCi
uc002vpv.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF442487 mRNA Translation: AAM21557.1
AY358891 mRNA Translation: AAQ89250.1
AC007559 Genomic DNA Translation: AAY14939.1
AC007748 Genomic DNA Translation: AAY24263.1
AC008273 Genomic DNA Translation: AAF19247.2
AC093384 Genomic DNA Translation: AAY14680.1
CH471063 Genomic DNA Translation: EAW70893.1
BC024766 mRNA Translation: AAH24766.2
BC035009 mRNA Translation: AAH35009.1
AL137311 mRNA Translation: CAB70690.1
CCDSiCCDS33390.1
PIRiT46247
RefSeqiNP_620711.3, NM_139072.3

3D structure databases

SMRiQ8NFT8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124973, 1 interactor
DIPiDIP-46249N
IntActiQ8NFT8, 4 interactors
STRINGi9606.ENSP00000345229

PTM databases

iPTMnetiQ8NFT8
PhosphoSitePlusiQ8NFT8

Polymorphism and mutation databases

BioMutaiDNER
DMDMi74730301

Proteomic databases

EPDiQ8NFT8
jPOSTiQ8NFT8
MaxQBiQ8NFT8
PaxDbiQ8NFT8
PeptideAtlasiQ8NFT8
PRIDEiQ8NFT8
ProteomicsDBi73354

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341772; ENSP00000345229; ENSG00000187957
GeneIDi92737
KEGGihsa:92737
UCSCiuc002vpv.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
92737
DisGeNETi92737

GeneCards: human genes, protein and diseases

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GeneCardsi
DNER
HGNCiHGNC:24456 DNER
HPAiHPA017320
MIMi607299 gene
neXtProtiNX_Q8NFT8
OpenTargetsiENSG00000187957
PharmGKBiPA162383959

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IR71 Eukaryota
ENOG410ZUAK LUCA
GeneTreeiENSGT00940000158872
InParanoidiQ8NFT8
OMAiCESYKDP
OrthoDBi7525at2759
PhylomeDBiQ8NFT8
TreeFamiTF351322

Enzyme and pathway databases

ReactomeiR-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
SignaLinkiQ8NFT8
SIGNORiQ8NFT8

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DNER human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DNER

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
92737

Protein Ontology

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PROi
PR:Q8NFT8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000187957 Expressed in 159 organ(s), highest expression level in substantia nigra
GenevisibleiQ8NFT8 HS

Family and domain databases

InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
PfamiView protein in Pfam
PF00008 EGF, 6 hits
PF12661 hEGF, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 10 hits
SM00179 EGF_CA, 7 hits
SUPFAMiSSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS00022 EGF_1, 10 hits
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 10 hits
PS01187 EGF_CA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDNER_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NFT8
Secondary accession number(s): A6NP39
, Q53R88, Q53TP7, Q53TQ5, Q8IYT0, Q8TB42, Q9NTF1, Q9UDM2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 1, 2002
Last modified: June 5, 2019
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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