UniProtKB - Q8NFT2 (STEA2_HUMAN)
Protein
Metalloreductase STEAP2
Gene
STEAP2
Organism
Homo sapiens (Human)
Status
Functioni
Metalloreductase that has the ability to reduce both Fe3+ to Fe2+ and Cu2+ to Cu1+. Uses NAD+ as acceptor (By similarity).By similarity
Cofactori
Protein has several cofactor binding sites:Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 118 | NADP; via amide nitrogenBy similarity | 1 | |
Binding sitei | 151 | NADP; via amide nitrogenBy similarity | 1 | |
Binding sitei | 152 | FADBy similarity | 1 | |
Binding sitei | 160 | FADBy similarity | 1 | |
Binding sitei | 281 | FADBy similarity | 1 | |
Binding sitei | 302 | FADBy similarity | 1 | |
Metal bindingi | 316 | Iron (heme axial ligand)By similarity | 1 | |
Binding sitei | 378 | FADBy similarity | 1 | |
Binding sitei | 395 | FADBy similarity | 1 | |
Metal bindingi | 409 | Iron (heme axial ligand)By similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 38 – 41 | NADPBy similarity | 4 | |
Nucleotide bindingi | 60 – 61 | NADPBy similarity | 2 | |
Nucleotide bindingi | 93 – 100 | NADPBy similarity | 8 |
GO - Molecular functioni
- cupric reductase activity Source: GO_Central
- ferric-chelate reductase (NADPH) activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- copper ion import Source: GO_Central
- endocytosis Source: UniProtKB
- Golgi to plasma membrane transport Source: UniProtKB
- iron ion homeostasis Source: UniProtKB-KW
- oxidation-reduction process Source: GO_Central
- regulated exocytosis Source: UniProtKB
- response to hormone Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Electron transport, Ion transport, Iron transport, Transport |
Ligand | Copper, FAD, Flavoprotein, Heme, Iron, Metal-binding, NAD, NADP |
Enzyme and pathway databases
PathwayCommonsi | Q8NFT2 |
Reactomei | R-HSA-917977, Transferrin endocytosis and recycling |
Protein family/group databases
TCDBi | 5.B.6.1.2, the transmembrane epithelial antigen protein-3 ferric reductase (steap) family |
Names & Taxonomyi
Protein namesi | Recommended name: Metalloreductase STEAP2 (EC:1.16.1.-)Alternative name(s): Prostate cancer-associated protein 1 Protein up-regulated in metastatic prostate cancer Short name: PUMPCn Six-transmembrane epithelial antigen of prostate 2 SixTransMembrane protein of prostate 1 |
Gene namesi | Name:STEAP2 Synonyms:PCANAP1, STAMP1 ORF Names:UNQ6507/PRO23203 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000157214.13 |
HGNCi | HGNC:17885, STEAP2 |
MIMi | 605094, gene |
neXtProti | NX_Q8NFT2 |
Subcellular locationi
Endosome
- Endosome membrane By similarity; Multi-pass membrane protein By similarity
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Cytosol
- cytosol Source: UniProtKB
Endosome
- early endosome Source: UniProtKB
- endosome Source: GO_Central
- endosome membrane Source: UniProtKB-SubCell
Golgi apparatus
- integral component of Golgi membrane Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- trans-Golgi network transport vesicle Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 208 – 228 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 259 – 279 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 305 – 325 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 359 – 379 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 393 – 413 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 432 – 452 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, Endosome, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 261729 |
OpenTargetsi | ENSG00000157214 |
PharmGKBi | PA38473 |
Miscellaneous databases
Pharosi | Q8NFT2, Tbio |
Polymorphism and mutation databases
BioMutai | STEAP2 |
DMDMi | 296452950 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191697 | 1 – 490 | Metalloreductase STEAP2Add BLAST | 490 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 483 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q8NFT2 |
MassIVEi | Q8NFT2 |
MaxQBi | Q8NFT2 |
PaxDbi | Q8NFT2 |
PeptideAtlasi | Q8NFT2 |
PRIDEi | Q8NFT2 |
ProteomicsDBi | 33900 73348 [Q8NFT2-1] 73349 [Q8NFT2-2] |
PTM databases
iPTMneti | Q8NFT2 |
PhosphoSitePlusi | Q8NFT2 |
SwissPalmi | Q8NFT2 |
Expressioni
Tissue specificityi
Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.3 Publications
Gene expression databases
Bgeei | ENSG00000157214, Expressed in prostate gland and 207 other tissues |
ExpressionAtlasi | Q8NFT2, baseline and differential |
Genevisiblei | Q8NFT2, HS |
Organism-specific databases
HPAi | ENSG00000157214, Tissue enriched (prostate) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 129285, 8 interactors |
CORUMi | Q8NFT2 |
IntActi | Q8NFT2, 7 interactors |
STRINGi | 9606.ENSP00000378119 |
Miscellaneous databases
RNActi | Q8NFT2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 259 – 407 | Ferric oxidoreductaseAdd BLAST | 149 |
Sequence similaritiesi
Belongs to the STEAP family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QVSJ, Eukaryota |
GeneTreei | ENSGT00390000008042 |
InParanoidi | Q8NFT2 |
OMAi | HVVYSLC |
PhylomeDBi | Q8NFT2 |
TreeFami | TF332031 |
Family and domain databases
InterProi | View protein in InterPro IPR013130, Fe3_Rdtase_TM_dom IPR036291, NAD(P)-bd_dom_sf IPR028939, P5C_Rdtase_cat_N |
Pfami | View protein in Pfam PF03807, F420_oxidored, 1 hit PF01794, Ferric_reduct, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8NFT2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MESISMMGSP KSLSETFLPN GINGIKDARK VTVGVIGSGD FAKSLTIRLI
60 70 80 90 100
RCGYHVVIGS RNPKFASEFF PHVVDVTHHE DALTKTNIIF VAIHREHYTS
110 120 130 140 150
LWDLRHLLVG KILIDVSNNM RINQYPESNA EYLASLFPDS LIVKGFNVVS
160 170 180 190 200
AWALQLGPKD ASRQVYICSN NIQARQQVIE LARQLNFIPI DLGSLSSARE
210 220 230 240 250
IENLPLRLFT LWRGPVVVAI SLATFFFLYS FVRDVIHPYA RNQQSDFYKI
260 270 280 290 300
PIEIVNKTLP IVAITLLSLV YLAGLLAAAY QLYYGTKYRR FPPWLETWLQ
310 320 330 340 350
CRKQLGLLSF FFAMVHVAYS LCLPMRRSER YLFLNMAYQQ VHANIENSWN
360 370 380 390 400
EEEVWRIEMY ISFGIMSLGL LSLLAVTSIP SVSNALNWRE FSFIQSTLGY
410 420 430 440 450
VALLISTFHV LIYGWKRAFE EEYYRFYTPP NFVLALVLPS IVILGKIILF
460 470 480 490
LPCISRKLKR IKKGWEKSQF LEEGMGGTIP HVSPERVTVM
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB5MC02 | B5MC02_HUMAN | Metalloreductase STEAP2 | STEAP2 | 403 | Annotation score: | ||
C9JLP2 | C9JLP2_HUMAN | Metalloreductase STEAP2 | STEAP2 | 181 | Annotation score: | ||
C9JHX5 | C9JHX5_HUMAN | Metalloreductase STEAP2 | STEAP2 | 88 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 17 | F → V in AAN04080 (PubMed:12429817).Curated | 1 | |
Sequence conflicti | 211 | L → F in AAG32148 (PubMed:12095985).Curated | 1 | |
Sequence conflicti | 211 | L → F in AAG32149 (PubMed:12095985).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060387 | 17 | F → CCombined sources4 PublicationsCorresponds to variant dbSNP:rs194520Ensembl. | 1 | |
Natural variantiVAR_060388 | 40 | D → Y. Corresponds to variant dbSNP:rs17863046Ensembl. | 1 | |
Natural variantiVAR_057727 | 214 | G → E. Corresponds to variant dbSNP:rs13228098Ensembl. | 1 | |
Natural variantiVAR_057728 | 456 | R → Q1 PublicationCorresponds to variant dbSNP:rs194524Ensembl. | 1 | |
Natural variantiVAR_060389 | 475 | M → I4 PublicationsCorresponds to variant dbSNP:rs194525Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045590 | 396 – 490 | STLGY…RVTVM → IFCSFADTQTELELEFVFLL TLLL in isoform 3. 1 PublicationAdd BLAST | 95 | |
Alternative sequenceiVSP_030999 | 445 – 490 | GKIIL…RVTVM → DLLQLCRYPD in isoform 2. 2 PublicationsAdd BLAST | 46 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY008444 mRNA Translation: AAG32148.1 AY008445 mRNA Translation: AAG32149.1 AF455138 mRNA Translation: AAN04080.1 AF526382 mRNA Translation: AAQ08976.1 AY358267 mRNA Translation: AAQ88634.1 AC002064 Genomic DNA No translation available. AC004969 Genomic DNA No translation available. CH236949 Genomic DNA Translation: EAL24165.1 CH471091 Genomic DNA Translation: EAW76890.1 CH471091 Genomic DNA Translation: EAW76894.1 |
CCDSi | CCDS43612.1 [Q8NFT2-2] CCDS5615.1 [Q8NFT2-1] CCDS59064.1 [Q8NFT2-3] |
RefSeqi | NP_001035755.1, NM_001040665.1 [Q8NFT2-1] NP_001035756.1, NM_001040666.1 [Q8NFT2-2] NP_001231873.1, NM_001244944.1 [Q8NFT2-1] NP_001231875.1, NM_001244946.1 [Q8NFT2-3] NP_694544.2, NM_152999.3 [Q8NFT2-1] XP_006715984.1, XM_006715921.3 [Q8NFT2-1] XP_016867442.1, XM_017011953.1 [Q8NFT2-1] XP_016867443.1, XM_017011954.1 [Q8NFT2-1] |
Genome annotation databases
Ensembli | ENST00000287908; ENSP00000287908; ENSG00000157214 [Q8NFT2-1] ENST00000394621; ENSP00000378119; ENSG00000157214 [Q8NFT2-1] ENST00000394622; ENSP00000378120; ENSG00000157214 [Q8NFT2-1] ENST00000394626; ENSP00000378123; ENSG00000157214 [Q8NFT2-2] ENST00000394629; ENSP00000378125; ENSG00000157214 [Q8NFT2-2] ENST00000394632; ENSP00000378128; ENSG00000157214 [Q8NFT2-3] |
GeneIDi | 261729 |
KEGGi | hsa:261729 |
UCSCi | uc003ujz.4, human [Q8NFT2-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY008444 mRNA Translation: AAG32148.1 AY008445 mRNA Translation: AAG32149.1 AF455138 mRNA Translation: AAN04080.1 AF526382 mRNA Translation: AAQ08976.1 AY358267 mRNA Translation: AAQ88634.1 AC002064 Genomic DNA No translation available. AC004969 Genomic DNA No translation available. CH236949 Genomic DNA Translation: EAL24165.1 CH471091 Genomic DNA Translation: EAW76890.1 CH471091 Genomic DNA Translation: EAW76894.1 |
CCDSi | CCDS43612.1 [Q8NFT2-2] CCDS5615.1 [Q8NFT2-1] CCDS59064.1 [Q8NFT2-3] |
RefSeqi | NP_001035755.1, NM_001040665.1 [Q8NFT2-1] NP_001035756.1, NM_001040666.1 [Q8NFT2-2] NP_001231873.1, NM_001244944.1 [Q8NFT2-1] NP_001231875.1, NM_001244946.1 [Q8NFT2-3] NP_694544.2, NM_152999.3 [Q8NFT2-1] XP_006715984.1, XM_006715921.3 [Q8NFT2-1] XP_016867442.1, XM_017011953.1 [Q8NFT2-1] XP_016867443.1, XM_017011954.1 [Q8NFT2-1] |
3D structure databases
SMRi | Q8NFT2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129285, 8 interactors |
CORUMi | Q8NFT2 |
IntActi | Q8NFT2, 7 interactors |
STRINGi | 9606.ENSP00000378119 |
Protein family/group databases
TCDBi | 5.B.6.1.2, the transmembrane epithelial antigen protein-3 ferric reductase (steap) family |
PTM databases
iPTMneti | Q8NFT2 |
PhosphoSitePlusi | Q8NFT2 |
SwissPalmi | Q8NFT2 |
Polymorphism and mutation databases
BioMutai | STEAP2 |
DMDMi | 296452950 |
Proteomic databases
jPOSTi | Q8NFT2 |
MassIVEi | Q8NFT2 |
MaxQBi | Q8NFT2 |
PaxDbi | Q8NFT2 |
PeptideAtlasi | Q8NFT2 |
PRIDEi | Q8NFT2 |
ProteomicsDBi | 33900 73348 [Q8NFT2-1] 73349 [Q8NFT2-2] |
Protocols and materials databases
Antibodypediai | 29828, 203 antibodies |
DNASUi | 261729 |
Genome annotation databases
Ensembli | ENST00000287908; ENSP00000287908; ENSG00000157214 [Q8NFT2-1] ENST00000394621; ENSP00000378119; ENSG00000157214 [Q8NFT2-1] ENST00000394622; ENSP00000378120; ENSG00000157214 [Q8NFT2-1] ENST00000394626; ENSP00000378123; ENSG00000157214 [Q8NFT2-2] ENST00000394629; ENSP00000378125; ENSG00000157214 [Q8NFT2-2] ENST00000394632; ENSP00000378128; ENSG00000157214 [Q8NFT2-3] |
GeneIDi | 261729 |
KEGGi | hsa:261729 |
UCSCi | uc003ujz.4, human [Q8NFT2-1] |
Organism-specific databases
CTDi | 261729 |
DisGeNETi | 261729 |
EuPathDBi | HostDB:ENSG00000157214.13 |
GeneCardsi | STEAP2 |
HGNCi | HGNC:17885, STEAP2 |
HPAi | ENSG00000157214, Tissue enriched (prostate) |
MIMi | 605094, gene |
neXtProti | NX_Q8NFT2 |
OpenTargetsi | ENSG00000157214 |
PharmGKBi | PA38473 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVSJ, Eukaryota |
GeneTreei | ENSGT00390000008042 |
InParanoidi | Q8NFT2 |
OMAi | HVVYSLC |
PhylomeDBi | Q8NFT2 |
TreeFami | TF332031 |
Enzyme and pathway databases
PathwayCommonsi | Q8NFT2 |
Reactomei | R-HSA-917977, Transferrin endocytosis and recycling |
Miscellaneous databases
BioGRID-ORCSi | 261729, 8 hits in 844 CRISPR screens |
ChiTaRSi | STEAP2, human |
GeneWikii | STEAP2 |
GenomeRNAii | 261729 |
Pharosi | Q8NFT2, Tbio |
PROi | PR:Q8NFT2 |
RNActi | Q8NFT2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000157214, Expressed in prostate gland and 207 other tissues |
ExpressionAtlasi | Q8NFT2, baseline and differential |
Genevisiblei | Q8NFT2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR013130, Fe3_Rdtase_TM_dom IPR036291, NAD(P)-bd_dom_sf IPR028939, P5C_Rdtase_cat_N |
Pfami | View protein in Pfam PF03807, F420_oxidored, 1 hit PF01794, Ferric_reduct, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STEA2_HUMAN | |
Accessioni | Q8NFT2Primary (citable) accession number: Q8NFT2 Secondary accession number(s): A4D1F1 Q8IUE7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 148 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations