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Entry version 118 (16 Oct 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Interleukin-17 receptor E

Gene

IL17RE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processInflammatory response

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-448424 Interleukin-17 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-17 receptor E
Short name:
IL-17 receptor E
Short name:
IL-17RE
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL17RE
ORF Names:UNQ3056/PRO9877
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18439 IL17RE

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614995 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NFR9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 454ExtracellularSequence analysisAdd BLAST431
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei455 – 475HelicalSequence analysisAdd BLAST21
Topological domaini476 – 667CytoplasmicSequence analysisAdd BLAST192

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
132014

Open Targets

More...
OpenTargetsi
ENSG00000163701

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134896136

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NFR9

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL17RE

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74730297

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030946724 – 667Interleukin-17 receptor EAdd BLAST644

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi318N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi364N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NFR9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NFR9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NFR9

PeptideAtlas

More...
PeptideAtlasi
Q8NFR9

PRoteomics IDEntifications database

More...
PRIDEi
Q8NFR9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
73342 [Q8NFR9-1]
73343 [Q8NFR9-2]
73344 [Q8NFR9-3]
73345 [Q8NFR9-4]
73346 [Q8NFR9-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NFR9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NFR9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in mucosal tissues with high levels in keratinocytes and colon epithelial cells. Very low expression in dermal fibroblasts. Expressed in various tumor cell lines.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163701 Expressed in 94 organ(s), highest expression level in skin of leg

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8NFR9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NFR9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019011

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms heterodimers with IL17RA; the heterodimer binds IL17C.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q96F462EBI-5591275,EBI-5591258

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126304, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NFR9, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000373325

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NFR9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini487 – 624SEFIRPROSITE-ProRule annotationAdd BLAST138

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFAR Eukaryota
ENOG410XTAY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161421

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NFR9

KEGG Orthology (KO)

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KOi
K05168

Database of Orthologous Groups

More...
OrthoDBi
238258at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NFR9

TreeFam database of animal gene trees

More...
TreeFami
TF335690

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039465 IL-17_rcpt-like
IPR027841 IL-17_rcpt_C/E_N
IPR013568 SEFIR_dom

The PANTHER Classification System

More...
PANTHERi
PTHR15583 PTHR15583, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15037 IL17_R_N, 2 hits
PF08357 SEFIR, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51534 SEFIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NFR9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSSRLAALL LPLLLIVIDL SDSAGIGFRH LPHWNTRCPL ASHTDDSFTG
60 70 80 90 100
SSAYIPCRTW WALFSTKPWC VRVWHCSRCL CQHLLSGGSG LQRGLFHLLV
110 120 130 140 150
QKSKKSSTFK FYRRHKMPAP AQRKLLPRRH LSEKSHHISI PSPDISHKGL
160 170 180 190 200
RSKRTQPSDP ETWESLPRLD SQRHGGPEFS FDLLPEARAI RVTISSGPEV
210 220 230 240 250
SVRLCHQWAL ECEELSSPYD VQKIVSGGHT VELPYEFLLP CLCIEASYLQ
260 270 280 290 300
EDTVRRKKCP FQSWPEAYGS DFWKSVHFTD YSQHTQMVMA LTLRCPLKLE
310 320 330 340 350
AALCQRHDWH TLCKDLPNAT ARESDGWYVL EKVDLHPQLC FKFSFGNSSH
360 370 380 390 400
VECPHQTGSL TSWNVSMDTQ AQQLILHFSS RMHATFSAAW SLPGLGQDTL
410 420 430 440 450
VPPVYTVSQA RGSSPVSLDL IIPFLRPGCC VLVWRSDVQF AWKHLLCPDV
460 470 480 490 500
SYRHLGLLIL ALLALLTLLG VVLALTCRRP QSGPGPARPV LLLHAADSEA
510 520 530 540 550
QRRLVGALAE LLRAALGGGR DVIVDLWEGR HVARVGPLPW LWAARTRVAR
560 570 580 590 600
EQGTVLLLWS GADLRPVSGP DPRAAPLLAL LHAAPRPLLL LAYFSRLCAK
610 620 630 640 650
GDIPPPLRAL PRYRLLRDLP RLLRALDARP FAEATSWGRL GARQRRQSRL
660
ELCSRLEREA ARLADLG
Length:667
Mass (Da):74,810
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1493744E7354067D
GO
Isoform 2 (identifier: Q8NFR9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.

Show »
Length:551
Mass (Da):61,658
Checksum:i2A2B20E30F565006
GO
Isoform 3 (identifier: Q8NFR9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     433-533: VWRSDVQFAW...VDLWEGRHVA → LHASLSSPGG...GAAAPGGSAG
     534-667: Missing.

Show »
Length:533
Mass (Da):58,121
Checksum:i50C7F4E844688570
GO
Isoform 4 (identifier: Q8NFR9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     433-506: VWRSDVQFAW...DSEAQRRLVG → ASSWSRHKPT...RMSLTDTWGS
     507-667: Missing.

Show »
Length:390
Mass (Da):43,699
Checksum:i31D49E817A1FC686
GO
Isoform 5 (identifier: Q8NFR9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-271: YGSD → CECC
     272-667: Missing.

Note: No experimental confirmation available.
Show »
Length:271
Mass (Da):30,781
Checksum:i160836A0A928DBC8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQN7J3KQN7_HUMAN
Interleukin 17 receptor E, isoform ...
IL17RE hCG_1759140
700Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6NL85A6NL85_HUMAN
Interleukin-17 receptor E
IL17RE
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J1R2C9J1R2_HUMAN
Interleukin-17 receptor E
IL17RE
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WB54F8WB54_HUMAN
Interleukin-17 receptor E
IL17RE
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCU7F8WCU7_HUMAN
Interleukin-17 receptor E
IL17RE
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Isoform 3 : The sequence BAB85028 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti270S → P in BAC04864 (PubMed:14702039).Curated1
Sequence conflicti445L → F in BAC04864 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036956219Y → C. Corresponds to variant dbSNP:rs7356031Ensembl.1
Natural variantiVAR_036957402P → S. Corresponds to variant dbSNP:rs9870003Ensembl.1
Natural variantiVAR_036958417S → T. Corresponds to variant dbSNP:rs7647642Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0291901 – 116Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST116
Alternative sequenceiVSP_029191268 – 271YGSD → CECC in isoform 5. 1 Publication4
Alternative sequenceiVSP_029192272 – 667Missing in isoform 5. 1 PublicationAdd BLAST396
Alternative sequenceiVSP_029193433 – 533VWRSD…GRHVA → LHASLSSPGGEDAWLIGVGG SVPSGVAVRCPVCLEAPLVS GCLLQTPGALDPGTAGPPHP TGCCSGPHLPAPTVRPGPSA ASAPPARGGLGGAAAPGGSA G in isoform 3. 1 PublicationAdd BLAST101
Alternative sequenceiVSP_029194433 – 506VWRSD…RRLVG → ASSWSRHKPTWEEFPSQWGL PSPPAPCFTQLPGRRRCLAH RGGGLCALRCGGQMSSLPGS TSCVRMSLTDTWGS in isoform 4. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_029195507 – 667Missing in isoform 4. 1 PublicationAdd BLAST161
Alternative sequenceiVSP_029196534 – 667Missing in isoform 3. 1 PublicationAdd BLAST134

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF458069 mRNA Translation: AAM77573.1
AY358451 mRNA Translation: AAQ88816.1
AK074238 mRNA Translation: BAB85028.1 Frameshift.
AK096793 mRNA Translation: BAC04863.1
AK096801 mRNA Translation: BAC04864.1
AK314476 mRNA Translation: BAG37081.1
CH471055 Genomic DNA Translation: EAW64019.1
CH471055 Genomic DNA Translation: EAW64020.1
CH471055 Genomic DNA Translation: EAW64016.1
BC063110 mRNA Translation: AAH63110.1
BC137077 mRNA Translation: AAI37078.1
BC137078 mRNA Translation: AAI37079.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2589.1 [Q8NFR9-1]
CCDS54552.1 [Q8NFR9-3]

NCBI Reference Sequences

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RefSeqi
NP_001180309.1, NM_001193380.1 [Q8NFR9-3]
NP_705613.1, NM_153480.1 [Q8NFR9-1]
NP_705614.1, NM_153481.1 [Q8NFR9-2]
NP_705616.2, NM_153483.2
XP_006713039.1, XM_006712976.1 [Q8NFR9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000383814; ENSP00000373325; ENSG00000163701 [Q8NFR9-1]
ENST00000454190; ENSP00000388086; ENSG00000163701 [Q8NFR9-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
132014

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:132014

UCSC genome browser

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UCSCi
uc003btw.4 human [Q8NFR9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF458069 mRNA Translation: AAM77573.1
AY358451 mRNA Translation: AAQ88816.1
AK074238 mRNA Translation: BAB85028.1 Frameshift.
AK096793 mRNA Translation: BAC04863.1
AK096801 mRNA Translation: BAC04864.1
AK314476 mRNA Translation: BAG37081.1
CH471055 Genomic DNA Translation: EAW64019.1
CH471055 Genomic DNA Translation: EAW64020.1
CH471055 Genomic DNA Translation: EAW64016.1
BC063110 mRNA Translation: AAH63110.1
BC137077 mRNA Translation: AAI37078.1
BC137078 mRNA Translation: AAI37079.1
CCDSiCCDS2589.1 [Q8NFR9-1]
CCDS54552.1 [Q8NFR9-3]
RefSeqiNP_001180309.1, NM_001193380.1 [Q8NFR9-3]
NP_705613.1, NM_153480.1 [Q8NFR9-1]
NP_705614.1, NM_153481.1 [Q8NFR9-2]
NP_705616.2, NM_153483.2
XP_006713039.1, XM_006712976.1 [Q8NFR9-2]

3D structure databases

SMRiQ8NFR9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi126304, 12 interactors
IntActiQ8NFR9, 10 interactors
STRINGi9606.ENSP00000373325

PTM databases

iPTMnetiQ8NFR9
PhosphoSitePlusiQ8NFR9

Polymorphism and mutation databases

BioMutaiIL17RE
DMDMi74730297

Proteomic databases

jPOSTiQ8NFR9
MassIVEiQ8NFR9
PaxDbiQ8NFR9
PeptideAtlasiQ8NFR9
PRIDEiQ8NFR9
ProteomicsDBi73342 [Q8NFR9-1]
73343 [Q8NFR9-2]
73344 [Q8NFR9-3]
73345 [Q8NFR9-4]
73346 [Q8NFR9-5]

Genome annotation databases

EnsembliENST00000383814; ENSP00000373325; ENSG00000163701 [Q8NFR9-1]
ENST00000454190; ENSP00000388086; ENSG00000163701 [Q8NFR9-3]
GeneIDi132014
KEGGihsa:132014
UCSCiuc003btw.4 human [Q8NFR9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
132014
DisGeNETi132014

GeneCards: human genes, protein and diseases

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GeneCardsi
IL17RE
HGNCiHGNC:18439 IL17RE
HPAiHPA019011
MIMi614995 gene
neXtProtiNX_Q8NFR9
OpenTargetsiENSG00000163701
PharmGKBiPA134896136

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFAR Eukaryota
ENOG410XTAY LUCA
GeneTreeiENSGT00940000161421
InParanoidiQ8NFR9
KOiK05168
OrthoDBi238258at2759
PhylomeDBiQ8NFR9
TreeFamiTF335690

Enzyme and pathway databases

ReactomeiR-HSA-448424 Interleukin-17 signaling

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
132014
PharosiQ8NFR9

Protein Ontology

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PROi
PR:Q8NFR9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163701 Expressed in 94 organ(s), highest expression level in skin of leg
ExpressionAtlasiQ8NFR9 baseline and differential
GenevisibleiQ8NFR9 HS

Family and domain databases

InterProiView protein in InterPro
IPR039465 IL-17_rcpt-like
IPR027841 IL-17_rcpt_C/E_N
IPR013568 SEFIR_dom
PANTHERiPTHR15583 PTHR15583, 1 hit
PfamiView protein in Pfam
PF15037 IL17_R_N, 2 hits
PF08357 SEFIR, 2 hits
PROSITEiView protein in PROSITE
PS51534 SEFIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI17RE_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NFR9
Secondary accession number(s): B2RB34
, B2RNR1, B9EH65, Q6P532, Q8N8H7, Q8N8H8, Q8TEC2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2002
Last modified: October 16, 2019
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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