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Entry version 108 (17 Jun 2020)
Sequence version 2 (11 Jan 2011)
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Protein

Coiled-coil domain-containing protein 148

Gene

CCDC148

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 148
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC148
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000153237.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25191 CCDC148

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NFR7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
130940

Open Targets

More...
OpenTargetsi
ENSG00000153237

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162381559

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NFR7 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC148

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373336

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003260631 – 591Coiled-coil domain-containing protein 148Add BLAST591

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NFR7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NFR7

PeptideAtlas

More...
PeptideAtlasi
Q8NFR7

PRoteomics IDEntifications database

More...
PRIDEi
Q8NFR7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
27674
73339 [Q8NFR7-1]
73340 [Q8NFR7-2]
73341 [Q8NFR7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NFR7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NFR7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000153237 Expressed in bronchial epithelial cell and 114 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NFR7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NFR7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000153237 Tissue enhanced (parathyroid gland, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
126264, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NFR7, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000283233

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NFR7 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili166 – 195Sequence analysisAdd BLAST30
Coiled coili352 – 417Sequence analysisAdd BLAST66
Coiled coili466 – 498Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi395 – 428Glu/Lys-richAdd BLAST34

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIXT Eukaryota
ENOG410YDEU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153988

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_032590_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NFR7

Database of Orthologous Groups

More...
OrthoDBi
989516at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NFR7

TreeFam database of animal gene trees

More...
TreeFami
TF332726

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039902 CCDC148/CCDC112

The PANTHER Classification System

More...
PANTHERi
PTHR21549 PTHR21549, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NFR7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCAASASPDN LVFHMKNEMR NIKYKPVDYQ QLRALTEAKK LASASAKLKI
60 70 80 90 100
RKAMLTSKLS KEQTLIKQHK QVWWQEYQRL NEVRCKMESE IKSLLNEENI
110 120 130 140 150
GNECLCDLTN FEQELSEQQC TYLKNVINPI QQLRADLKYR QHHTLQHSHP
160 170 180 190 200
HIEFNSMKVL EEVDFVKKQL KTVFERLRLE QQRIENDLSD WSIKILDHSL
210 220 230 240 250
EEKTNPLSEL PIELESLECP YPDLKSSILS EFYKFTQKYQ KKLQDFNLQL
260 270 280 290 300
EDIYRNCQLS EEDHWIYQAI LDQYPGDLFG RRTLYLDMLQ RYFPHKSRHD
310 320 330 340 350
LVEHEKYCDQ YRFAIEQQNI LISNWNKNKK DFIQKAVLTL TEACATHEME
360 370 380 390 400
SMLAKDKKKQ QELCADLKAK VRQWRAHQEE VARLEMEISA RRREKEEEKE
410 420 430 440 450
KLWKKKELLQ RAEKKKKIKK YWAKKKQKWQ EMEMRDLQRL EELKKLIAEQ
460 470 480 490 500
SLKDRERVKY RQELLERRLM EKKEVALQEA HEDKERARRL EALRKQVAVV
510 520 530 540 550
AQFDPVRMMS DTMASKARMG IEIEEEFILQ KPLFTLNTYN EQQIISDPRL
560 570 580 590
RFELALREAG LHRTLYAKEI LPKISPQKPP RKDMESTVFK I
Length:591
Mass (Da):71,076
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB83A5D4FBEFCFFCF
GO
Isoform 2 (identifier: Q8NFR7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: Missing.
     153-162: EFNSMKVLEE → MNVFVTLQIL
     417-426: KIKKYWAKKK → SFGIRMILAS
     427-591: Missing.

Show »
Length:274
Mass (Da):33,109
Checksum:i4814900F586D8C3B
GO
Isoform 3 (identifier: Q8NFR7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-591: Missing.

Show »
Length:255
Mass (Da):30,378
Checksum:i6F27BB36E5EB3F97
GO
Isoform 4 (identifier: Q8NFR7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: Missing.
     371-385: VRQWRAHQEEVARLE → SQVCLYQQHENGLIQ
     386-591: Missing.

Show »
Length:299
Mass (Da):35,794
Checksum:i92F5F5B9D8903ED0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZV3B8ZZV3_HUMAN
Coiled-coil domain-containing prote...
CCDC148
600Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBK8F8WBK8_HUMAN
Coiled-coil domain-containing prote...
CCDC148
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCV9F8WCV9_HUMAN
Coiled-coil domain-containing prote...
CCDC148
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCW7F8WCW7_HUMAN
Coiled-coil domain-containing prote...
CCDC148
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WC92F8WC92_HUMAN
Coiled-coil domain-containing prote...
CCDC148
15Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI07598 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti307Y → F in AAI07597 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03998275Q → R. Corresponds to variant dbSNP:rs4664950Ensembl.1
Natural variantiVAR_039983157M → V1 PublicationCorresponds to variant dbSNP:rs12620556Ensembl.1
Natural variantiVAR_039984329K → R4 PublicationsCorresponds to variant dbSNP:rs7559772Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0325321 – 152Missing in isoform 2. 1 PublicationAdd BLAST152
Alternative sequenceiVSP_0453951 – 86Missing in isoform 4. 1 PublicationAdd BLAST86
Alternative sequenceiVSP_032533153 – 162EFNSMKVLEE → MNVFVTLQIL in isoform 2. 1 Publication10
Alternative sequenceiVSP_032536256 – 591Missing in isoform 3. 2 PublicationsAdd BLAST336
Alternative sequenceiVSP_045396371 – 385VRQWR…VARLE → SQVCLYQQHENGLIQ in isoform 4. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_045397386 – 591Missing in isoform 4. 1 PublicationAdd BLAST206
Alternative sequenceiVSP_032534417 – 426KIKKYWAKKK → SFGIRMILAS in isoform 2. 1 Publication10
Alternative sequenceiVSP_032535427 – 591Missing in isoform 2. 1 PublicationAdd BLAST165

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF458588 mRNA Translation: AAM49716.1
AK058105 mRNA Translation: BAB71668.1
AK311042 mRNA No translation available.
AC019044 Genomic DNA Translation: AAX88983.1
AC069146 Genomic DNA Translation: AAX88933.1
AC008070 Genomic DNA Translation: AAY14928.1
CH471058 Genomic DNA Translation: EAX11435.1
BC015395 mRNA Translation: AAH15395.1
BC105928 mRNA Translation: AAI05929.1
BC107596 mRNA Translation: AAI07597.1
BC107597 mRNA Translation: AAI07598.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33304.1 [Q8NFR7-1]
CCDS77476.1 [Q8NFR7-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001288613.1, NM_001301684.1
NP_001288614.1, NM_001301685.1 [Q8NFR7-3]
NP_620158.3, NM_138803.3 [Q8NFR7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000283233; ENSP00000283233; ENSG00000153237 [Q8NFR7-1]
ENST00000409889; ENSP00000386583; ENSG00000153237 [Q8NFR7-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
130940

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:130940

UCSC genome browser

More...
UCSCi
uc002tzq.4 human [Q8NFR7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF458588 mRNA Translation: AAM49716.1
AK058105 mRNA Translation: BAB71668.1
AK311042 mRNA No translation available.
AC019044 Genomic DNA Translation: AAX88983.1
AC069146 Genomic DNA Translation: AAX88933.1
AC008070 Genomic DNA Translation: AAY14928.1
CH471058 Genomic DNA Translation: EAX11435.1
BC015395 mRNA Translation: AAH15395.1
BC105928 mRNA Translation: AAI05929.1
BC107596 mRNA Translation: AAI07597.1
BC107597 mRNA Translation: AAI07598.1 Frameshift.
CCDSiCCDS33304.1 [Q8NFR7-1]
CCDS77476.1 [Q8NFR7-3]
RefSeqiNP_001288613.1, NM_001301684.1
NP_001288614.1, NM_001301685.1 [Q8NFR7-3]
NP_620158.3, NM_138803.3 [Q8NFR7-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi126264, 9 interactors
IntActiQ8NFR7, 10 interactors
STRINGi9606.ENSP00000283233

PTM databases

iPTMnetiQ8NFR7
PhosphoSitePlusiQ8NFR7

Polymorphism and mutation databases

BioMutaiCCDC148
DMDMi317373336

Proteomic databases

jPOSTiQ8NFR7
PaxDbiQ8NFR7
PeptideAtlasiQ8NFR7
PRIDEiQ8NFR7
ProteomicsDBi27674
73339 [Q8NFR7-1]
73340 [Q8NFR7-2]
73341 [Q8NFR7-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
33710 81 antibodies

Genome annotation databases

EnsembliENST00000283233; ENSP00000283233; ENSG00000153237 [Q8NFR7-1]
ENST00000409889; ENSP00000386583; ENSG00000153237 [Q8NFR7-3]
GeneIDi130940
KEGGihsa:130940
UCSCiuc002tzq.4 human [Q8NFR7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
130940
DisGeNETi130940
EuPathDBiHostDB:ENSG00000153237.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC148
HGNCiHGNC:25191 CCDC148
HPAiENSG00000153237 Tissue enhanced (parathyroid gland, testis)
neXtProtiNX_Q8NFR7
OpenTargetsiENSG00000153237
PharmGKBiPA162381559

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIXT Eukaryota
ENOG410YDEU LUCA
GeneTreeiENSGT00940000153988
HOGENOMiCLU_032590_0_0_1
InParanoidiQ8NFR7
OrthoDBi989516at2759
PhylomeDBiQ8NFR7
TreeFamiTF332726

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
130940 6 hits in 785 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
130940
PharosiQ8NFR7 Tdark

Protein Ontology

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PROi
PR:Q8NFR7
RNActiQ8NFR7 protein

Gene expression databases

BgeeiENSG00000153237 Expressed in bronchial epithelial cell and 114 other tissues
ExpressionAtlasiQ8NFR7 baseline and differential
GenevisibleiQ8NFR7 HS

Family and domain databases

InterProiView protein in InterPro
IPR039902 CCDC148/CCDC112
PANTHERiPTHR21549 PTHR21549, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC148_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NFR7
Secondary accession number(s): F5H839
, Q3B7I3, Q3B7I4, Q3KR41, Q4ZG12, Q4ZG23, Q53TM6, Q96BN5, Q96LM2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 11, 2011
Last modified: June 17, 2020
This is version 108 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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