UniProtKB - Q8NFN8 (GP156_HUMAN)
Protein
Probable G-protein coupled receptor 156
Gene
GPR156
Organism
Homo sapiens (Human)
Status
Functioni
Orphan receptor.
GO - Molecular functioni
- G protein-coupled GABA receptor activity Source: GO_Central
- transmembrane signaling receptor activity Source: GO_Central
GO - Biological processi
- gamma-aminobutyric acid signaling pathway Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q8NFN8 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor 156Alternative name(s): G-protein coupled receptor PGR28 GABAB-related G-protein coupled receptor |
Gene namesi | Name:GPR156 Synonyms:GABABL, PGR28 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000175697.10 |
HGNCi | HGNC:20844, GPR156 |
MIMi | 610464, gene |
neXtProti | NX_Q8NFN8 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- G protein-coupled receptor heterodimeric complex Source: GO_Central
- plasma membrane Source: HPA
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 47 | ExtracellularSequence analysisAdd BLAST | 47 | |
Transmembranei | 48 – 68 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 69 – 86 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 87 – 107 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 108 – 118 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 119 – 139 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 140 – 164 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 165 – 185 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 186 – 222 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 223 – 243 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 244 – 257 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 258 – 278 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 279 – 288 | ExtracellularSequence analysis | 10 | |
Transmembranei | 289 – 309 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 310 – 814 | CytoplasmicSequence analysisAdd BLAST | 505 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000175697 |
PharmGKBi | PA134918005 |
Miscellaneous databases
Pharosi | Q8NFN8, Tbio |
Polymorphism and mutation databases
BioMutai | GPR156 |
DMDMi | 296434518 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000206899 | 1 – 814 | Probable G-protein coupled receptor 156Add BLAST | 814 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 6 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q8NFN8 |
PeptideAtlasi | Q8NFN8 |
PRIDEi | Q8NFN8 |
ProteomicsDBi | 20211 73328 [Q8NFN8-1] |
PTM databases
GlyGeni | Q8NFN8, 1 site |
iPTMneti | Q8NFN8 |
PhosphoSitePlusi | Q8NFN8 |
Expressioni
Tissue specificityi
Ubiquitous expression both in the CNS and in peripheral tissues. Very high expression in fetal brain and testis relative to expression in other tissues.1 Publication
Gene expression databases
Bgeei | ENSG00000175697, Expressed in ventricular zone and 117 other tissues |
ExpressionAtlasi | Q8NFN8, baseline and differential |
Genevisiblei | Q8NFN8, HS |
Organism-specific databases
HPAi | ENSG00000175697, Tissue enhanced (testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 127920, 70 interactors |
IntActi | Q8NFN8, 69 interactors |
STRINGi | 9606.ENSP00000417261 |
Miscellaneous databases
RNActi | Q8NFN8, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 354 – 390 | Sequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 600 – 603 | Poly-Arg | 4 | |
Compositional biasi | 748 – 751 | Poly-Ser | 4 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1055, Eukaryota |
GeneTreei | ENSGT00940000159755 |
HOGENOMi | CLU_350195_0_0_1 |
InParanoidi | Q8NFN8 |
OMAi | MSAECTY |
OrthoDBi | 336447at2759 |
PhylomeDBi | Q8NFN8 |
TreeFami | TF313965 |
Family and domain databases
CDDi | cd15292, 7tmC_GPR156, 1 hit |
InterProi | View protein in InterPro IPR002455, GPCR3_GABA-B IPR017978, GPCR_3_C IPR041946, GPR156_7TM |
PANTHERi | PTHR10519, PTHR10519, 1 hit |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit |
PROSITEi | View protein in PROSITE PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8NFN8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEPEINCSEL CDSFPGQELD RRPLHDLCKT TITSSHHSSK TISSLSPVLL
60 70 80 90 100
GIVWTFLSCG LLLILFFLAF TIHCRKNRIV KMSSPNLNIV TLLGSCLTYS
110 120 130 140 150
SAYLFGIQDV LVGSSMETLI QTRLSMLCIG TSLVFGPILG KSWRLYKVFT
160 170 180 190 200
QRVPDKRVII KDLQLLGLVA ALLMADVILL MTWVLTDPIQ CLQILSVSMT
210 220 230 240 250
VTGKDVSCTS TSTHFCASRY SDVWIALIWG CKGLLLLYGA YLAGLTGHVS
260 270 280 290 300
SPPVNQSLTI MVGVNLLVLA AGLLFVVTRY LHSWPNLVFG LTSGGIFVCT
310 320 330 340 350
TTINCFIFIP QLKQWKAFEE ENQTIRRMAK YFSTPNKSFH TQYGEEENCH
360 370 380 390 400
PRGEKSSMER LLTEKNAVIE SLQEQVNNAK EKIVRLMSAE CTYDLPEGAA
410 420 430 440 450
PPASSPNKDV QAVASVHTLA AAQGPSGHLS DFQNDPGMAA RDSQCTSGPS
460 470 480 490 500
SYAQSLEGPG KDSSFSPGKE EKISDSKDFS DHLDSGCSQK PWTEQSLGPE
510 520 530 540 550
RGDQVPMNPS QSLLPERGGS DPQRQRHLEN SEEPPERRSR VSSVIREKLQ
560 570 580 590 600
EVLQDLGLGP EASLSTAPSC HQQTWKNSAA FSPQKMPLSK ELGFSPYMVR
610 620 630 640 650
RRRAAQRARS HFPGSAPSSV GHRANRTVPG AHSRLHVQNG DSPSLAPQTT
660 670 680 690 700
DSRVRRPSSR KPSLPSDPQD RPGTLEGSKQ SQTEPEGARG SKAAFLRQPS
710 720 730 740 750
GSGRAPSPAA PCLSKASPDL PEQWQLWPPV PSGCASLSSQ HSYFDTESSS
760 770 780 790 800
SDEFFCRCHR PYCEICFQSS SDSSDSGTSD TDPEPTGGLA SWEKLWARSK
810
PIVNFKDDLK PTLV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8WAW3 | F8WAW3_HUMAN | Probable G-protein-coupled receptor... | GPR156 | 78 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049284 | 516 | E → D2 PublicationsCorresponds to variant dbSNP:rs902790Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044603 | 197 – 200 | Missing in isoform 2. 1 Publication | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF488739 mRNA Translation: AAN03795.1 AC063952 Genomic DNA No translation available. AC092897 Genomic DNA No translation available. BC113701 mRNA Translation: AAI13702.1 BC143606 mRNA Translation: AAI43607.1 AY255565 mRNA Translation: AAO85077.1 |
CCDSi | CCDS2997.1 [Q8NFN8-1] CCDS54629.1 [Q8NFN8-2] |
RefSeqi | NP_001161743.1, NM_001168271.1 [Q8NFN8-2] NP_694547.2, NM_153002.2 [Q8NFN8-1] XP_005247222.1, XM_005247165.2 XP_016861284.1, XM_017005795.1 [Q8NFN8-1] XP_016861285.1, XM_017005796.1 [Q8NFN8-1] XP_016861286.1, XM_017005797.1 |
Genome annotation databases
Ensembli | ENST00000315843; ENSP00000324553; ENSG00000175697 [Q8NFN8-1] ENST00000461057; ENSP00000418758; ENSG00000175697 [Q8NFN8-2] ENST00000464295; ENSP00000417261; ENSG00000175697 [Q8NFN8-1] |
GeneIDi | 165829 |
KEGGi | hsa:165829 |
UCSCi | uc011bjf.3, human [Q8NFN8-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF488739 mRNA Translation: AAN03795.1 AC063952 Genomic DNA No translation available. AC092897 Genomic DNA No translation available. BC113701 mRNA Translation: AAI13702.1 BC143606 mRNA Translation: AAI43607.1 AY255565 mRNA Translation: AAO85077.1 |
CCDSi | CCDS2997.1 [Q8NFN8-1] CCDS54629.1 [Q8NFN8-2] |
RefSeqi | NP_001161743.1, NM_001168271.1 [Q8NFN8-2] NP_694547.2, NM_153002.2 [Q8NFN8-1] XP_005247222.1, XM_005247165.2 XP_016861284.1, XM_017005795.1 [Q8NFN8-1] XP_016861285.1, XM_017005796.1 [Q8NFN8-1] XP_016861286.1, XM_017005797.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127920, 70 interactors |
IntActi | Q8NFN8, 69 interactors |
STRINGi | 9606.ENSP00000417261 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q8NFN8, 1 site |
iPTMneti | Q8NFN8 |
PhosphoSitePlusi | Q8NFN8 |
Polymorphism and mutation databases
BioMutai | GPR156 |
DMDMi | 296434518 |
Proteomic databases
PaxDbi | Q8NFN8 |
PeptideAtlasi | Q8NFN8 |
PRIDEi | Q8NFN8 |
ProteomicsDBi | 20211 73328 [Q8NFN8-1] |
Protocols and materials databases
Antibodypediai | 32788, 80 antibodies |
DNASUi | 165829 |
Genome annotation databases
Ensembli | ENST00000315843; ENSP00000324553; ENSG00000175697 [Q8NFN8-1] ENST00000461057; ENSP00000418758; ENSG00000175697 [Q8NFN8-2] ENST00000464295; ENSP00000417261; ENSG00000175697 [Q8NFN8-1] |
GeneIDi | 165829 |
KEGGi | hsa:165829 |
UCSCi | uc011bjf.3, human [Q8NFN8-1] |
Organism-specific databases
CTDi | 165829 |
EuPathDBi | HostDB:ENSG00000175697.10 |
GeneCardsi | GPR156 |
HGNCi | HGNC:20844, GPR156 |
HPAi | ENSG00000175697, Tissue enhanced (testis) |
MIMi | 610464, gene |
neXtProti | NX_Q8NFN8 |
OpenTargetsi | ENSG00000175697 |
PharmGKBi | PA134918005 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1055, Eukaryota |
GeneTreei | ENSGT00940000159755 |
HOGENOMi | CLU_350195_0_0_1 |
InParanoidi | Q8NFN8 |
OMAi | MSAECTY |
OrthoDBi | 336447at2759 |
PhylomeDBi | Q8NFN8 |
TreeFami | TF313965 |
Enzyme and pathway databases
PathwayCommonsi | Q8NFN8 |
Miscellaneous databases
BioGRID-ORCSi | 165829, 7 hits in 842 CRISPR screens |
ChiTaRSi | GPR156, human |
GeneWikii | GPR156 |
GenomeRNAii | 165829 |
Pharosi | Q8NFN8, Tbio |
PROi | PR:Q8NFN8 |
RNActi | Q8NFN8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175697, Expressed in ventricular zone and 117 other tissues |
ExpressionAtlasi | Q8NFN8, baseline and differential |
Genevisiblei | Q8NFN8, HS |
Family and domain databases
CDDi | cd15292, 7tmC_GPR156, 1 hit |
InterProi | View protein in InterPro IPR002455, GPCR3_GABA-B IPR017978, GPCR_3_C IPR041946, GPR156_7TM |
PANTHERi | PTHR10519, PTHR10519, 1 hit |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit |
PROSITEi | View protein in PROSITE PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GP156_HUMAN | |
Accessioni | Q8NFN8Primary (citable) accession number: Q8NFN8 Secondary accession number(s): B7ZL66 Q86SN6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2005 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 131 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries