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UniProtKB - Q8NFN8 (GP156_HUMAN)

Entry version 135 (29 Sep 2021)
Sequence version 2 (18 May 2010)
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Protein

Probable G-protein coupled receptor 156

Gene

GPR156

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan receptor.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8NFN8

Protein family/group databases

Transport Classification Database

More...TCDBi		9.A.14.15.4, the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable G-protein coupled receptor 156
Alternative name(s):
G-protein coupled receptor PGR28
GABAB-related G-protein coupled receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPR156
Synonyms:GABABL, PGR28
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20844, GPR156

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610464, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8NFN8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000175697

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 47ExtracellularSequence analysisAdd BLAST47
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Topological domaini69 – 86CytoplasmicSequence analysisAdd BLAST18
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 118ExtracellularSequence analysisAdd BLAST11
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 164CytoplasmicSequence analysisAdd BLAST25
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 222ExtracellularSequence analysisAdd BLAST37
Transmembranei223 – 243HelicalSequence analysisAdd BLAST21
Topological domaini244 – 257CytoplasmicSequence analysisAdd BLAST14
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Topological domaini279 – 288ExtracellularSequence analysis10
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310 – 814CytoplasmicSequence analysisAdd BLAST505

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000175697

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134918005

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8NFN8, Tdark

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4523897

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GPR156

Domain mapping of disease mutations (DMDM)

More...DMDMi		296434518

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002068991 – 814Probable G-protein coupled receptor 156Add BLAST814

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8NFN8

PeptideAtlas

More...PeptideAtlasi		Q8NFN8

PRoteomics IDEntifications database

More...PRIDEi		Q8NFN8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		20211
73328 [Q8NFN8-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8NFN8, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8NFN8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8NFN8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous expression both in the CNS and in peripheral tissues. Very high expression in fetal brain and testis relative to expression in other tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000175697, Expressed in ventricular zone and 118 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8NFN8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8NFN8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000175697, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127920, 70 interactors

Protein interaction database and analysis system

More...IntActi		Q8NFN8, 69 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000417261

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8NFN8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni422 – 545DisorderedSequence analysisAdd BLAST124
Regioni557 – 724DisorderedSequence analysisAdd BLAST168
Regioni769 – 792DisorderedSequence analysisAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili354 – 390Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi437 – 461Polar residuesSequence analysisAdd BLAST25
Compositional biasi464 – 484Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi520 – 545Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi565 – 584Polar residuesSequence analysisAdd BLAST20
Compositional biasi637 – 653Polar residuesSequence analysisAdd BLAST17
Compositional biasi673 – 687Polar residuesSequence analysisAdd BLAST15
Compositional biasi769 – 785Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1055, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159755

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_350195_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8NFN8

Identification of Orthologs from Complete Genome Data

More...OMAi		THFCASQ

Database of Orthologous Groups

More...OrthoDBi		336447at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8NFN8

TreeFam database of animal gene trees

More...TreeFami		TF313965

Family and domain databases

Conserved Domains Database

More...CDDi		cd15292, 7tmC_GPR156, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002455, GPCR3_GABA-B
IPR017978, GPCR_3_C
IPR041946, GPR156_7TM

The PANTHER Classification System

More...PANTHERi		PTHR10519, PTHR10519, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00003, 7tm_3, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50259, G_PROTEIN_RECEP_F3_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NFN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPEINCSEL CDSFPGQELD RRPLHDLCKT TITSSHHSSK TISSLSPVLL 
        60         70         80         90        100
GIVWTFLSCG LLLILFFLAF TIHCRKNRIV KMSSPNLNIV TLLGSCLTYS 
       110        120        130        140        150
SAYLFGIQDV LVGSSMETLI QTRLSMLCIG TSLVFGPILG KSWRLYKVFT 
       160        170        180        190        200
QRVPDKRVII KDLQLLGLVA ALLMADVILL MTWVLTDPIQ CLQILSVSMT 
       210        220        230        240        250
VTGKDVSCTS TSTHFCASRY SDVWIALIWG CKGLLLLYGA YLAGLTGHVS 
       260        270        280        290        300
SPPVNQSLTI MVGVNLLVLA AGLLFVVTRY LHSWPNLVFG LTSGGIFVCT 
       310        320        330        340        350
TTINCFIFIP QLKQWKAFEE ENQTIRRMAK YFSTPNKSFH TQYGEEENCH 
       360        370        380        390        400
PRGEKSSMER LLTEKNAVIE SLQEQVNNAK EKIVRLMSAE CTYDLPEGAA 
       410        420        430        440        450
PPASSPNKDV QAVASVHTLA AAQGPSGHLS DFQNDPGMAA RDSQCTSGPS 
       460        470        480        490        500
SYAQSLEGPG KDSSFSPGKE EKISDSKDFS DHLDSGCSQK PWTEQSLGPE 
       510        520        530        540        550
RGDQVPMNPS QSLLPERGGS DPQRQRHLEN SEEPPERRSR VSSVIREKLQ 
       560        570        580        590        600
EVLQDLGLGP EASLSTAPSC HQQTWKNSAA FSPQKMPLSK ELGFSPYMVR 
       610        620        630        640        650
RRRAAQRARS HFPGSAPSSV GHRANRTVPG AHSRLHVQNG DSPSLAPQTT 
       660        670        680        690        700
DSRVRRPSSR KPSLPSDPQD RPGTLEGSKQ SQTEPEGARG SKAAFLRQPS 
       710        720        730        740        750
GSGRAPSPAA PCLSKASPDL PEQWQLWPPV PSGCASLSSQ HSYFDTESSS 
       760        770        780        790        800
SDEFFCRCHR PYCEICFQSS SDSSDSGTSD TDPEPTGGLA SWEKLWARSK 
       810 
PIVNFKDDLK PTLV
Length:814
Mass (Da):89,097
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i496B0654A26B4ADB
GO
Isoform 2 (identifier: Q8NFN8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-200: Missing.

Show »
Length:810
Mass (Da):88,679
Checksum:iCB7A2A4E901E04D3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WAW3F8WAW3_HUMAN
Probable G-protein-coupled receptor...
GPR156
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049284516E → D2 PublicationsCorresponds to variant dbSNP:rs902790Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_044603197 – 200Missing in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF488739 mRNA Translation: AAN03795.1
AC063952 Genomic DNA No translation available.
AC092897 Genomic DNA No translation available.
BC113701 mRNA Translation: AAI13702.1
BC143606 mRNA Translation: AAI43607.1
AY255565 mRNA Translation: AAO85077.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2997.1 [Q8NFN8-1]
CCDS54629.1 [Q8NFN8-2]

NCBI Reference Sequences

More...RefSeqi		NP_001161743.1, NM_001168271.1 [Q8NFN8-2]
NP_694547.2, NM_153002.2 [Q8NFN8-1]
XP_005247222.1, XM_005247165.2
XP_016861284.1, XM_017005795.1 [Q8NFN8-1]
XP_016861285.1, XM_017005796.1 [Q8NFN8-1]
XP_016861286.1, XM_017005797.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000461057; ENSP00000418758; ENSG00000175697 [Q8NFN8-2]
ENST00000464295; ENSP00000417261; ENSG00000175697 [Q8NFN8-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		165829

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:165829

UCSC genome browser

More...UCSCi		uc011bjf.3, human [Q8NFN8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF488739 mRNA Translation: AAN03795.1
AC063952 Genomic DNA No translation available.
AC092897 Genomic DNA No translation available.
BC113701 mRNA Translation: AAI13702.1
BC143606 mRNA Translation: AAI43607.1
AY255565 mRNA Translation: AAO85077.1
CCDSiCCDS2997.1 [Q8NFN8-1]
CCDS54629.1 [Q8NFN8-2]
RefSeqiNP_001161743.1, NM_001168271.1 [Q8NFN8-2]
NP_694547.2, NM_153002.2 [Q8NFN8-1]
XP_005247222.1, XM_005247165.2
XP_016861284.1, XM_017005795.1 [Q8NFN8-1]
XP_016861285.1, XM_017005796.1 [Q8NFN8-1]
XP_016861286.1, XM_017005797.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi127920, 70 interactors
IntActiQ8NFN8, 69 interactors
STRINGi9606.ENSP00000417261

Chemistry databases

ChEMBLiCHEMBL4523897

Protein family/group databases

TCDBi9.A.14.15.4, the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniQ8NFN8, 1 site
iPTMnetiQ8NFN8
PhosphoSitePlusiQ8NFN8

Genetic variation databases

BioMutaiGPR156
DMDMi296434518

Proteomic databases

PaxDbiQ8NFN8
PeptideAtlasiQ8NFN8
PRIDEiQ8NFN8
ProteomicsDBi20211
73328 [Q8NFN8-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32788, 88 antibodies

The DNASU plasmid repository

More...DNASUi		165829

Genome annotation databases

EnsembliENST00000461057; ENSP00000418758; ENSG00000175697 [Q8NFN8-2]
ENST00000464295; ENSP00000417261; ENSG00000175697 [Q8NFN8-1]
GeneIDi165829
KEGGihsa:165829
UCSCiuc011bjf.3, human [Q8NFN8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		165829

GeneCards: human genes, protein and diseases

More...GeneCardsi		GPR156
HGNCiHGNC:20844, GPR156
HPAiENSG00000175697, Tissue enhanced (testis)
MIMi610464, gene
neXtProtiNX_Q8NFN8
OpenTargetsiENSG00000175697
PharmGKBiPA134918005
VEuPathDBiHostDB:ENSG00000175697

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1055, Eukaryota
GeneTreeiENSGT00940000159755
HOGENOMiCLU_350195_0_0_1
InParanoidiQ8NFN8
OMAiTHFCASQ
OrthoDBi336447at2759
PhylomeDBiQ8NFN8
TreeFamiTF313965

Enzyme and pathway databases

PathwayCommonsiQ8NFN8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		165829, 9 hits in 1007 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GPR156, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GPR156

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		165829
PharosiQ8NFN8, Tdark

Protein Ontology

More...PROi		PR:Q8NFN8
RNActiQ8NFN8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000175697, Expressed in ventricular zone and 118 other tissues
ExpressionAtlasiQ8NFN8, baseline and differential
GenevisibleiQ8NFN8, HS

Family and domain databases

CDDicd15292, 7tmC_GPR156, 1 hit
InterProiView protein in InterPro
IPR002455, GPCR3_GABA-B
IPR017978, GPCR_3_C
IPR041946, GPR156_7TM
PANTHERiPTHR10519, PTHR10519, 1 hit
PfamiView protein in Pfam
PF00003, 7tm_3, 1 hit
PROSITEiView protein in PROSITE
PS50259, G_PROTEIN_RECEP_F3_4, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGP156_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NFN8
Secondary accession number(s): B7ZL66
, E9PFZ4, Q14CM1, Q86SN6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: May 18, 2010
Last modified: September 29, 2021
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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