UniProtKB - Q8NFM4 (ADCY4_HUMAN)
Protein
Adenylate cyclase type 4
Gene
ADCY4
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.By similarity
Catalytic activityi
- EC:4.6.1.1By similarity
Cofactori
Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).By similarity
Activity regulationi
Activated by forskolin. Insensitive to calcium/calmodulin. Stimulated by GNAS and by the G-protein beta and gamma subunit complex.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 278 | Magnesium 1; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 278 | Magnesium 2; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 279 | Magnesium 2; via carbonyl oxygen; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 322 | Magnesium 1; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 322 | Magnesium 2; catalyticPROSITE-ProRule annotation | 1 | |
Binding sitei | 366 | ATPBy similarity | 1 | |
Binding sitei | 925 | ATPBy similarity | 1 | |
Binding sitei | 1052 | ATPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 278 – 283 | ATPBy similarity | 6 | |
Nucleotide bindingi | 320 – 322 | ATPBy similarity | 3 | |
Nucleotide bindingi | 1005 – 1007 | ATPBy similarity | 3 | |
Nucleotide bindingi | 1012 – 1016 | ATPBy similarity | 5 |
GO - Molecular functioni
- adenylate cyclase activity Source: BHF-UCL
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- protein kinase C binding Source: UniProtKB
GO - Biological processi
- activation of adenylate cyclase activity Source: Reactome
- activation of protein kinase A activity Source: Reactome
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: Reactome
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: UniProtKB
- cAMP biosynthetic process Source: BHF-UCL
- cellular response to glucagon stimulus Source: Reactome
- G protein-coupled receptor signaling pathway Source: Reactome
- renal water homeostasis Source: Reactome
Keywordsi
Molecular function | Lyase |
Biological process | cAMP biosynthesis |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8NFM4 |
Reactomei | R-HSA-163359, Glucagon signaling in metabolic regulation R-HSA-163615, PKA activation R-HSA-164378, PKA activation in glucagon signalling R-HSA-170660, Adenylate cyclase activating pathway R-HSA-170670, Adenylate cyclase inhibitory pathway R-HSA-418555, G alpha (s) signalling events R-HSA-418594, G alpha (i) signalling events R-HSA-418597, G alpha (z) signalling events R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-5610787, Hedgehog 'off' state R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production R-HSA-9664323, FCGR3A-mediated IL10 synthesis |
SIGNORi | Q8NFM4 |
Names & Taxonomyi
Protein namesi | Recommended name: Adenylate cyclase type 4 (EC:4.6.1.1By similarity)Alternative name(s): ATP pyrophosphate-lyase 4 Adenylate cyclase type IV Adenylyl cyclase 4 |
Gene namesi | Name:ADCY4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000129467.13 |
HGNCi | HGNC:235, ADCY4 |
MIMi | 600292, gene |
neXtProti | NX_Q8NFM4 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Curated
Other locations
- Cytoplasm 1 Publication
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 28 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 29 – 50 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 61 – 80 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 94 – 117 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 120 – 138 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 141 – 162 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 170 – 190 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 191 – 585 | CytoplasmicSequence analysisAdd BLAST | 395 | |
Transmembranei | 586 – 607 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 611 – 633 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 664 – 687 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 688 – 714 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 715 – 736 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 744 – 764 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 791 – 807 | HelicalSequence analysisAdd BLAST | 17 | |
Topological domaini | 808 – 1077 | CytoplasmicSequence analysisAdd BLAST | 270 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 196883 |
OpenTargetsi | ENSG00000129467 |
PharmGKBi | PA24562 |
Miscellaneous databases
Pharosi | Q8NFM4, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2097167 |
Polymorphism and mutation databases
BioMutai | ADCY4 |
DMDMi | 25008336 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000195690 | 1 – 1077 | Adenylate cyclase type 4Add BLAST | 1077 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 520 | PhosphoserineBy similarity | 1 | |
Modified residuei | 536 | PhosphothreonineBy similarity | 1 | |
Glycosylationi | 697 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 704 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q8NFM4 |
jPOSTi | Q8NFM4 |
MassIVEi | Q8NFM4 |
MaxQBi | Q8NFM4 |
PaxDbi | Q8NFM4 |
PeptideAtlasi | Q8NFM4 |
PRIDEi | Q8NFM4 |
ProteomicsDBi | 68278 73323 [Q8NFM4-1] |
PTM databases
GlyGeni | Q8NFM4, 2 sites |
iPTMneti | Q8NFM4 |
PhosphoSitePlusi | Q8NFM4 |
Expressioni
Tissue specificityi
Detected in the zona glomerulosa and the zona fasciculata in the adrenal gland (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000129467, Expressed in left lobe of thyroid gland and 180 other tissues |
ExpressionAtlasi | Q8NFM4, baseline and differential |
Genevisiblei | Q8NFM4, HS |
Organism-specific databases
HPAi | ENSG00000129467, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ8NFM4
GO - Molecular functioni
- protein kinase C binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 128229, 6 interactors |
IntActi | Q8NFM4, 9 interactors |
STRINGi | 9606.ENSP00000312126 |
Chemistry databases
BindingDBi | Q8NFM4 |
Miscellaneous databases
RNActi | Q8NFM4, protein |
Family & Domainsi
Domaini
The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal modules have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two modules.By similarity
Sequence similaritiesi
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3619, Eukaryota |
GeneTreei | ENSGT00940000159445 |
HOGENOMi | CLU_001072_2_5_1 |
InParanoidi | Q8NFM4 |
OMAi | CVQKGPK |
OrthoDBi | 363718at2759 |
PhylomeDBi | Q8NFM4 |
TreeFami | TF313845 |
Family and domain databases
Gene3Di | 3.30.70.1230, 2 hits |
InterProi | View protein in InterPro IPR001054, A/G_cyclase IPR018297, A/G_cyclase_CS IPR032628, AC_N IPR030672, Adcy IPR009398, Adcy_conserved_dom IPR029787, Nucleotide_cyclase |
Pfami | View protein in Pfam PF16214, AC_N, 1 hit PF06327, DUF1053, 1 hit PF00211, Guanylate_cyc, 2 hits |
PIRSFi | PIRSF039050, Ade_cyc, 1 hit |
SMARTi | View protein in SMART SM00044, CYCc, 2 hits |
SUPFAMi | SSF55073, SSF55073, 2 hits |
PROSITEi | View protein in PROSITE PS00452, GUANYLATE_CYCLASE_1, 2 hits PS50125, GUANYLATE_CYCLASE_2, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8NFM4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MARLFSPRPP PSEDLFYETY YSLSQQYPLL LLLLGIVLCA LAALLAVAWA
60 70 80 90 100
SGRELTSDPS FLTTVLCALG GFSLLLGLAS REQRLQRWTR PLSGLVWVAL
110 120 130 140 150
LALGHAFLFT GGVVSAWDQV SYFLFVIFTA YAMLPLGMRD AAVAGLASSL
160 170 180 190 200
SHLLVLGLYL GPQPDSRPAL LPQLAANAVL FLCGNVAGVY HKALMERALR
210 220 230 240 250
ATFREALSSL HSRRRLDTEK KHQEHLLLSI LPAYLAREMK AEIMARLQAG
260 270 280 290 300
QGSRPESTNN FHSLYVKRHQ GVSVLYADIV GFTRLASECS PKELVLMLNE
310 320 330 340 350
LFGKFDQIAK EHECMRIKIL GDCYYCVSGL PLSLPDHAIN CVRMGLDMCR
360 370 380 390 400
AIRKLRAATG VDINMRVGVH SGSVLCGVIG LQKWQYDVWS HDVTLANHME
410 420 430 440 450
AGGVPGRVHI TGATLALLAG AYAVEDAGME HRDPYLRELG EPTYLVIDPR
460 470 480 490 500
AEEEDEKGTA GGLLSSLEGL KMRPSLLMTR YLESWGAAKP FAHLSHGDSP
510 520 530 540 550
VSTSTPLPEK TLASFSTQWS LDRSRTPRGL DDELDTGDAK FFQVIEQLNS
560 570 580 590 600
QKQWKQSKDF NPLTLYFREK EMEKEYRLSA IPAFKYYEAC TFLVFLSNFI
610 620 630 640 650
IQMLVTNRPP ALAITYSITF LLFLLILFVC FSEDLMRCVL KGPKMLHWLP
660 670 680 690 700
ALSGLVATRP GLRIALGTAT ILLVFAMAIT SLFFFPTSSD CPFQAPNVSS
710 720 730 740 750
MISNLSWELP GSLPLISVPY SMHCCTLGFL SCSLFLHMSF ELKLLLLLLW
760 770 780 790 800
LAASCSLFLH SHAWLSECLI VRLYLGPLDS RPGVLKEPKL MGAISFFIFF
810 820 830 840 850
FTLLVLARQN EYYCRLDFLW KKKLRQEREE TETMENLTRL LLENVLPAHV
860 870 880 890 900
APQFIGQNRR NEDLYHQSYE CVCVLFASVP DFKEFYSESN INHEGLECLR
910 920 930 940 950
LLNEIIADFD ELLSKPKFSG VEKIKTIGST YMAATGLNAT SGQDAQQDAE
960 970 980 990 1000
RSCSHLGTMV EFAVALGSKL DVINKHSFNN FRLRVGLNHG PVVAGVIGAQ
1010 1020 1030 1040 1050
KPQYDIWGNT VNVASRMEST GVLGKIQVTE ETAWALQSLG YTCYSRGVIK
1060 1070
VKGKGQLCTY FLNTDLTRTG PPSATLG
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V258 | G3V258_HUMAN | Adenylate cyclase | ADCY4 | 449 | Annotation score: | ||
G3V262 | G3V262_HUMAN | Adenylate cyclase | ADCY4 | 216 | Annotation score: | ||
H0YJ57 | H0YJ57_HUMAN | Adenylate cyclase type 4 | ADCY4 | 137 | Annotation score: | ||
H0YN72 | H0YN72_HUMAN | Adenylate cyclase type 4 | ADCY4 | 115 | Annotation score: | ||
H0YLM0 | H0YLM0_HUMAN | Adenylate cyclase type 4 | ADCY4 | 36 | Annotation score: |
Sequence cautioni
The sequence BAB71270 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 571 | E → G in BAB71270 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055816 | 1 – 45 | MARLF…LAALL → MSRGTRESACCMLTSWASRG WPASVPLRSWCSCSMSSLAS STRLP in isoform 2. 1 PublicationAdd BLAST | 45 | |
Alternative sequenceiVSP_055817 | 46 – 352 | Missing in isoform 2. 1 PublicationAdd BLAST | 307 | |
Alternative sequenceiVSP_055818 | 720 – 726 | YSMHCCT → VSVPTCP in isoform 2. 1 Publication | 7 | |
Alternative sequenceiVSP_055819 | 727 – 1077 | Missing in isoform 2. 1 PublicationAdd BLAST | 351 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF497516 mRNA Translation: AAM94373.1 AK056745 mRNA Translation: BAB71270.1 Different initiation. AK122714 mRNA Translation: BAG53686.1 AK126468 mRNA Translation: BAC86560.1 AL096870 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW66023.1 CH471078 Genomic DNA Translation: EAW66026.1 CH471078 Genomic DNA Translation: EAW66027.1 CH471078 Genomic DNA Translation: EAW66028.1 BC117473 mRNA Translation: AAI17474.1 BC117475 mRNA Translation: AAI17476.1 |
CCDSi | CCDS9627.1 [Q8NFM4-1] |
RefSeqi | NP_001185497.1, NM_001198568.1 [Q8NFM4-1] NP_001185521.1, NM_001198592.1 [Q8NFM4-1] NP_640340.2, NM_139247.3 [Q8NFM4-1] |
Genome annotation databases
Ensembli | ENST00000310677; ENSP00000312126; ENSG00000129467 [Q8NFM4-1] ENST00000418030; ENSP00000393177; ENSG00000129467 [Q8NFM4-1] ENST00000554068; ENSP00000452250; ENSG00000129467 [Q8NFM4-1] ENST00000642645; ENSP00000495316; ENSG00000284814 [Q8NFM4-1] ENST00000644961; ENSP00000494454; ENSG00000284814 [Q8NFM4-1] ENST00000646612; ENSP00000494977; ENSG00000284814 [Q8NFM4-1] |
GeneIDi | 196883 |
KEGGi | hsa:196883 |
UCSCi | uc001wow.4, human [Q8NFM4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF497516 mRNA Translation: AAM94373.1 AK056745 mRNA Translation: BAB71270.1 Different initiation. AK122714 mRNA Translation: BAG53686.1 AK126468 mRNA Translation: BAC86560.1 AL096870 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW66023.1 CH471078 Genomic DNA Translation: EAW66026.1 CH471078 Genomic DNA Translation: EAW66027.1 CH471078 Genomic DNA Translation: EAW66028.1 BC117473 mRNA Translation: AAI17474.1 BC117475 mRNA Translation: AAI17476.1 |
CCDSi | CCDS9627.1 [Q8NFM4-1] |
RefSeqi | NP_001185497.1, NM_001198568.1 [Q8NFM4-1] NP_001185521.1, NM_001198592.1 [Q8NFM4-1] NP_640340.2, NM_139247.3 [Q8NFM4-1] |
3D structure databases
SMRi | Q8NFM4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 128229, 6 interactors |
IntActi | Q8NFM4, 9 interactors |
STRINGi | 9606.ENSP00000312126 |
Chemistry databases
BindingDBi | Q8NFM4 |
ChEMBLi | CHEMBL2097167 |
PTM databases
GlyGeni | Q8NFM4, 2 sites |
iPTMneti | Q8NFM4 |
PhosphoSitePlusi | Q8NFM4 |
Polymorphism and mutation databases
BioMutai | ADCY4 |
DMDMi | 25008336 |
Proteomic databases
EPDi | Q8NFM4 |
jPOSTi | Q8NFM4 |
MassIVEi | Q8NFM4 |
MaxQBi | Q8NFM4 |
PaxDbi | Q8NFM4 |
PeptideAtlasi | Q8NFM4 |
PRIDEi | Q8NFM4 |
ProteomicsDBi | 68278 73323 [Q8NFM4-1] |
Protocols and materials databases
Antibodypediai | 3908, 217 antibodies |
Genome annotation databases
Ensembli | ENST00000310677; ENSP00000312126; ENSG00000129467 [Q8NFM4-1] ENST00000418030; ENSP00000393177; ENSG00000129467 [Q8NFM4-1] ENST00000554068; ENSP00000452250; ENSG00000129467 [Q8NFM4-1] ENST00000642645; ENSP00000495316; ENSG00000284814 [Q8NFM4-1] ENST00000644961; ENSP00000494454; ENSG00000284814 [Q8NFM4-1] ENST00000646612; ENSP00000494977; ENSG00000284814 [Q8NFM4-1] |
GeneIDi | 196883 |
KEGGi | hsa:196883 |
UCSCi | uc001wow.4, human [Q8NFM4-1] |
Organism-specific databases
CTDi | 196883 |
DisGeNETi | 196883 |
EuPathDBi | HostDB:ENSG00000129467.13 |
GeneCardsi | ADCY4 |
HGNCi | HGNC:235, ADCY4 |
HPAi | ENSG00000129467, Low tissue specificity |
MIMi | 600292, gene |
neXtProti | NX_Q8NFM4 |
OpenTargetsi | ENSG00000129467 |
PharmGKBi | PA24562 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3619, Eukaryota |
GeneTreei | ENSGT00940000159445 |
HOGENOMi | CLU_001072_2_5_1 |
InParanoidi | Q8NFM4 |
OMAi | CVQKGPK |
OrthoDBi | 363718at2759 |
PhylomeDBi | Q8NFM4 |
TreeFami | TF313845 |
Enzyme and pathway databases
PathwayCommonsi | Q8NFM4 |
Reactomei | R-HSA-163359, Glucagon signaling in metabolic regulation R-HSA-163615, PKA activation R-HSA-164378, PKA activation in glucagon signalling R-HSA-170660, Adenylate cyclase activating pathway R-HSA-170670, Adenylate cyclase inhibitory pathway R-HSA-418555, G alpha (s) signalling events R-HSA-418594, G alpha (i) signalling events R-HSA-418597, G alpha (z) signalling events R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-5610787, Hedgehog 'off' state R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production R-HSA-9664323, FCGR3A-mediated IL10 synthesis |
SIGNORi | Q8NFM4 |
Miscellaneous databases
BioGRID-ORCSi | 196883, 7 hits in 840 CRISPR screens |
ChiTaRSi | ADCY4, human |
GeneWikii | ADCY4 |
GenomeRNAii | 196883 |
Pharosi | Q8NFM4, Tbio |
PROi | PR:Q8NFM4 |
RNActi | Q8NFM4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000129467, Expressed in left lobe of thyroid gland and 180 other tissues |
ExpressionAtlasi | Q8NFM4, baseline and differential |
Genevisiblei | Q8NFM4, HS |
Family and domain databases
Gene3Di | 3.30.70.1230, 2 hits |
InterProi | View protein in InterPro IPR001054, A/G_cyclase IPR018297, A/G_cyclase_CS IPR032628, AC_N IPR030672, Adcy IPR009398, Adcy_conserved_dom IPR029787, Nucleotide_cyclase |
Pfami | View protein in Pfam PF16214, AC_N, 1 hit PF06327, DUF1053, 1 hit PF00211, Guanylate_cyc, 2 hits |
PIRSFi | PIRSF039050, Ade_cyc, 1 hit |
SMARTi | View protein in SMART SM00044, CYCc, 2 hits |
SUPFAMi | SSF55073, SSF55073, 2 hits |
PROSITEi | View protein in PROSITE PS00452, GUANYLATE_CYCLASE_1, 2 hits PS50125, GUANYLATE_CYCLASE_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADCY4_HUMAN | |
Accessioni | Q8NFM4Primary (citable) accession number: Q8NFM4 Secondary accession number(s): B3KV74 Q96ML7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2002 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM