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Protein

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7

Gene

B3GNT7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratan sulfate-related glycans. May play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues.1 Publication

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.149 2681
ReactomeiR-HSA-2022854 Keratan sulfate biosynthesis
R-HSA-913709 O-linked glycosylation of mucins
UniPathwayi
UPA00378

Protein family/group databases

CAZyiGT31 Glycosyltransferase Family 31

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (EC:2.4.1.-)
Short name:
BGnT-7
Short name:
Beta-1,3-Gn-T7
Short name:
Beta-1,3-N-acetylglucosaminyltransferase 7
Short name:
Beta3Gn-T7
Gene namesi
Name:B3GNT7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000156966.6
HGNCiHGNC:18811 B3GNT7
MIMi615313 gene
neXtProtiNX_Q8NFL0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 26Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini27 – 401LumenalSequence analysisAdd BLAST375

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi93010
OpenTargetsiENSG00000156966
PharmGKBiPA38692

Polymorphism and mutation databases

BioMutaiB3GNT7
DMDMi74723834

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002646181 – 401UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7Add BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi214N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi391N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8NFL0
PaxDbiQ8NFL0
PeptideAtlasiQ8NFL0
PRIDEiQ8NFL0
ProteomicsDBi73322

PTM databases

iPTMnetiQ8NFL0
PhosphoSitePlusiQ8NFL0

Expressioni

Gene expression databases

BgeeiENSG00000156966 Expressed in 177 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_B3GNT7
GenevisibleiQ8NFL0 HS

Organism-specific databases

HPAiHPA035625
HPA035626

Interactioni

Protein-protein interaction databases

IntActiQ8NFL0, 2 interactors
STRINGi9606.ENSP00000287590

Structurei

3D structure databases

ProteinModelPortaliQ8NFL0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2287 Eukaryota
ENOG410ZZ1B LUCA
GeneTreeiENSGT00760000118879
HOGENOMiHOG000232195
HOVERGENiHBG050653
InParanoidiQ8NFL0
KOiK09664
OMAiLYSKASY
OrthoDBiEOG091G0AXM
PhylomeDBiQ8NFL0
TreeFamiTF318639

Family and domain databases

InterProiView protein in InterPro
IPR002659 Glyco_trans_31
PANTHERiPTHR11214 PTHR11214, 1 hit
PfamiView protein in Pfam
PF01762 Galactosyl_T, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NFL0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLWKKTVYR SLCLALALLV AVTVFQRSLT PGQFLQEPPP PTLEPQKAQK
60 70 80 90 100
PNGQLVNPNN FWKNPKDVAA PTPMASQGPQ AWDVTTTNCS ANINLTHQPW
110 120 130 140 150
FQVLEPQFRQ FLFYRHCRYF PMLLNHPEKC RGDVYLLVVV KSVITQHDRR
160 170 180 190 200
EAIRQTWGRE RQSAGGGRGA VRTLFLLGTA SKQEERTHYQ QLLAYEDRLY
210 220 230 240 250
GDILQWGFLD TFFNLTLKEI HFLKWLDIYC PHVPFIFKGD DDVFVNPTNL
260 270 280 290 300
LEFLADRQPQ ENLFVGDVLQ HARPIRRKDN KYYIPGALYG KASYPPYAGG
310 320 330 340 350
GGFLMAGSLA RRLHHACDTL ELYPIDDVFL GMCLEVLGVQ PTAHEGFKTF
360 370 380 390 400
GISRNRNSRM NKEPCFFRAM LVVHKLLPPE LLAMWGLVHS NLTCSRKLQV

L
Length:401
Mass (Da):45,987
Last modified:October 1, 2002 - v1
Checksum:iCAF27F0A48DFEE31
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029633233V → I. Corresponds to variant dbSNP:rs2290130Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF502430 mRNA Translation: AAM61770.1
AK126207 mRNA Translation: BAG54296.1
AC017104 Genomic DNA Translation: AAY24246.1
CCDSiCCDS46540.1
RefSeqiNP_660279.1, NM_145236.2
UniGeneiHs.299329

Genome annotation databases

EnsembliENST00000287590; ENSP00000287590; ENSG00000156966
GeneIDi93010
KEGGihsa:93010
UCSCiuc002vrs.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

Beta 1,3-N-acetylglucosaminyltransferase 7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF502430 mRNA Translation: AAM61770.1
AK126207 mRNA Translation: BAG54296.1
AC017104 Genomic DNA Translation: AAY24246.1
CCDSiCCDS46540.1
RefSeqiNP_660279.1, NM_145236.2
UniGeneiHs.299329

3D structure databases

ProteinModelPortaliQ8NFL0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8NFL0, 2 interactors
STRINGi9606.ENSP00000287590

Protein family/group databases

CAZyiGT31 Glycosyltransferase Family 31

PTM databases

iPTMnetiQ8NFL0
PhosphoSitePlusiQ8NFL0

Polymorphism and mutation databases

BioMutaiB3GNT7
DMDMi74723834

Proteomic databases

EPDiQ8NFL0
PaxDbiQ8NFL0
PeptideAtlasiQ8NFL0
PRIDEiQ8NFL0
ProteomicsDBi73322

Protocols and materials databases

DNASUi93010
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287590; ENSP00000287590; ENSG00000156966
GeneIDi93010
KEGGihsa:93010
UCSCiuc002vrs.4 human

Organism-specific databases

CTDi93010
DisGeNETi93010
EuPathDBiHostDB:ENSG00000156966.6
GeneCardsiB3GNT7
HGNCiHGNC:18811 B3GNT7
HPAiHPA035625
HPA035626
MIMi615313 gene
neXtProtiNX_Q8NFL0
OpenTargetsiENSG00000156966
PharmGKBiPA38692
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2287 Eukaryota
ENOG410ZZ1B LUCA
GeneTreeiENSGT00760000118879
HOGENOMiHOG000232195
HOVERGENiHBG050653
InParanoidiQ8NFL0
KOiK09664
OMAiLYSKASY
OrthoDBiEOG091G0AXM
PhylomeDBiQ8NFL0
TreeFamiTF318639

Enzyme and pathway databases

UniPathwayi
UPA00378

BRENDAi2.4.1.149 2681
ReactomeiR-HSA-2022854 Keratan sulfate biosynthesis
R-HSA-913709 O-linked glycosylation of mucins

Miscellaneous databases

GenomeRNAii93010
PROiPR:Q8NFL0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156966 Expressed in 177 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_B3GNT7
GenevisibleiQ8NFL0 HS

Family and domain databases

InterProiView protein in InterPro
IPR002659 Glyco_trans_31
PANTHERiPTHR11214 PTHR11214, 1 hit
PfamiView protein in Pfam
PF01762 Galactosyl_T, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB3GN7_HUMAN
AccessioniPrimary (citable) accession number: Q8NFL0
Secondary accession number(s): B3KWY4, B7WNP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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