UniProtKB - Q8NFK1 (CXG3_HUMAN)
Protein
Gap junction gamma-3 protein
Gene
GJC3
Organism
Homo sapiens (Human)
Status
Functioni
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity
GO - Molecular functioni
- gap junction channel activity Source: GO_Central
GO - Biological processi
- AV node cell to bundle of His cell communication by electrical coupling Source: GOC
- cell-cell signaling Source: GO_Central
- myelination Source: Ensembl
- sensory perception of sound Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q8NFK1 |
Protein family/group databases
TCDBi | 1.A.24.1.7, the gap junction-forming connexin (connexin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Gap junction gamma-3 proteinAlternative name(s): Connexin-30.2 Short name: Cx30.2 Connexin-31.3 Short name: Cx31.3 Gap junction epsilon-1 protein |
Gene namesi | Name:GJC3 Synonyms:GJE1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17495, GJC3 |
MIMi | 611925, gene |
neXtProti | NX_Q8NFK1 |
VEuPathDBi | HostDB:ENSG00000176402.5 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- gap junction By similarity
Plasma Membrane
- connexin complex Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- myelin sheath Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 22 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 23 – 43 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 44 – 75 | ExtracellularSequence analysisAdd BLAST | 32 | |
Transmembranei | 76 – 96 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 97 – 132 | CytoplasmicSequence analysisAdd BLAST | 36 | |
Transmembranei | 133 – 153 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 154 – 194 | ExtracellularSequence analysisAdd BLAST | 41 | |
Transmembranei | 195 – 215 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 216 – 279 | CytoplasmicSequence analysisAdd BLAST | 64 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Gap junction, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 349149 |
OpenTargetsi | ENSG00000176402 |
PharmGKBi | PA162389705 |
Miscellaneous databases
Pharosi | Q8NFK1, Tbio |
Genetic variation databases
BioMutai | GJC3 |
DMDMi | 32171365 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000057874 | 1 – 279 | Gap junction gamma-3 proteinAdd BLAST | 279 |
Proteomic databases
MassIVEi | Q8NFK1 |
PaxDbi | Q8NFK1 |
PeptideAtlasi | Q8NFK1 |
PRIDEi | Q8NFK1 |
ProteomicsDBi | 73321 |
PTM databases
iPTMneti | Q8NFK1 |
PhosphoSitePlusi | Q8NFK1 |
Expressioni
Tissue specificityi
CNS specific. Expression is restricted to brain, spinal cord, and sciatic nerve. According to PubMed:12881038, expression is abundant in skeletal muscle, liver, and heart, and to a minor degree in pancreas and kidney.2 Publications
Gene expression databases
Bgeei | ENSG00000176402, Expressed in tibial nerve and 92 other tissues |
Organism-specific databases
HPAi | ENSG00000176402, Tissue enhanced (breast, pancreas, salivary gland) |
Interactioni
Subunit structurei
A connexon is composed of a hexamer of connexins.
By similarityBinary interactionsi
Hide detailsQ8NFK1
With | #Exp. | IntAct |
---|---|---|
MS4A13 [Q5J8X5] | 3 | EBI-20110678,EBI-12070086 |
STX7 [O15400] | 3 | EBI-20110678,EBI-3221827 |
Protein-protein interaction databases
BioGRIDi | 131549, 2 interactors |
IntActi | Q8NFK1, 2 interactors |
STRINGi | 9606.ENSP00000325775 |
Miscellaneous databases
RNActi | Q8NFK1, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QVY2, Eukaryota |
GeneTreei | ENSGT00970000193389 |
HOGENOMi | CLU_037388_4_0_1 |
InParanoidi | Q8NFK1 |
OMAi | CYDAFHP |
OrthoDBi | 1092887at2759 |
PhylomeDBi | Q8NFK1 |
TreeFami | TF329606 |
Family and domain databases
Gene3Di | 1.20.1440.80, 1 hit |
InterProi | View protein in InterPro IPR000500, Connexin IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf |
PANTHERi | PTHR11984, PTHR11984, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit |
PRINTSi | PR00206, CONNEXIN |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NFK1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCGRFLRRLL AEESRRSTPV GRLLLPVLLG FRLVLLAASG PGVYGDEQSE
60 70 80 90 100
FVCHTQQPGC KAACFDAFHP LSPLRFWVFQ VILVAVPSAL YMGFTLYHVI
110 120 130 140 150
WHWELSGKGK EEETLIQGRE GNTDVPGAGS LRLLWAYVAQ LGARLVLEGA
160 170 180 190 200
ALGLQYHLYG FQMPSSFACR REPCLGSITC NLSRPSEKTI FLKTMFGVSG
210 220 230 240 250
FCLLFTFLEL VLLGLGRWWR TWKHKSSSSK YFLTSESTRR HKKATDSLPV
260 270
VETKEQFQEA VPGRSLAQEK QRPVGPRDA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF503615 mRNA Translation: AAM21145.1 AY297109 mRNA Translation: AAP51161.1 CH236956 Genomic DNA Translation: EAL23863.1 CH471091 Genomic DNA Translation: EAW76624.1 BC043381 mRNA Translation: AAH43381.1 |
CCDSi | CCDS34697.1 |
RefSeqi | NP_853516.1, NM_181538.2 |
Genome annotation databases
Ensembli | ENST00000312891; ENSP00000325775; ENSG00000176402 |
GeneIDi | 349149 |
KEGGi | hsa:349149 |
UCSCi | uc011kjd.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF503615 mRNA Translation: AAM21145.1 AY297109 mRNA Translation: AAP51161.1 CH236956 Genomic DNA Translation: EAL23863.1 CH471091 Genomic DNA Translation: EAW76624.1 BC043381 mRNA Translation: AAH43381.1 |
CCDSi | CCDS34697.1 |
RefSeqi | NP_853516.1, NM_181538.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6L3T | electron microscopy | 2.34 | A/B/C/D/E/F | 1-279 | [»] | |
6L3U | electron microscopy | 2.53 | A/B/C/D/E/F | 1-279 | [»] | |
6L3V | electron microscopy | 2.63 | A/B/C/D/E/F | 1-279 | [»] | |
SMRi | Q8NFK1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 131549, 2 interactors |
IntActi | Q8NFK1, 2 interactors |
STRINGi | 9606.ENSP00000325775 |
Protein family/group databases
TCDBi | 1.A.24.1.7, the gap junction-forming connexin (connexin) family |
PTM databases
iPTMneti | Q8NFK1 |
PhosphoSitePlusi | Q8NFK1 |
Genetic variation databases
BioMutai | GJC3 |
DMDMi | 32171365 |
Proteomic databases
MassIVEi | Q8NFK1 |
PaxDbi | Q8NFK1 |
PeptideAtlasi | Q8NFK1 |
PRIDEi | Q8NFK1 |
ProteomicsDBi | 73321 |
Protocols and materials databases
Antibodypediai | 3109, 173 antibodies |
DNASUi | 349149 |
Genome annotation databases
Ensembli | ENST00000312891; ENSP00000325775; ENSG00000176402 |
GeneIDi | 349149 |
KEGGi | hsa:349149 |
UCSCi | uc011kjd.2, human |
Organism-specific databases
CTDi | 349149 |
DisGeNETi | 349149 |
GeneCardsi | GJC3 |
HGNCi | HGNC:17495, GJC3 |
HPAi | ENSG00000176402, Tissue enhanced (breast, pancreas, salivary gland) |
MIMi | 611925, gene |
neXtProti | NX_Q8NFK1 |
OpenTargetsi | ENSG00000176402 |
PharmGKBi | PA162389705 |
VEuPathDBi | HostDB:ENSG00000176402.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVY2, Eukaryota |
GeneTreei | ENSGT00970000193389 |
HOGENOMi | CLU_037388_4_0_1 |
InParanoidi | Q8NFK1 |
OMAi | CYDAFHP |
OrthoDBi | 1092887at2759 |
PhylomeDBi | Q8NFK1 |
TreeFami | TF329606 |
Enzyme and pathway databases
PathwayCommonsi | Q8NFK1 |
Miscellaneous databases
BioGRID-ORCSi | 349149, 6 hits in 873 CRISPR screens |
GeneWikii | GJC3 |
GenomeRNAii | 349149 |
Pharosi | Q8NFK1, Tbio |
PROi | PR:Q8NFK1 |
RNActi | Q8NFK1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000176402, Expressed in tibial nerve and 92 other tissues |
Family and domain databases
Gene3Di | 1.20.1440.80, 1 hit |
InterProi | View protein in InterPro IPR000500, Connexin IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf |
PANTHERi | PTHR11984, PTHR11984, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit |
PRINTSi | PR00206, CONNEXIN |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXG3_HUMAN | |
Accessioni | Q8NFK1Primary (citable) accession number: Q8NFK1 Secondary accession number(s): A4D296, Q86XI9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families