GJC3

Functionⁱ

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

GO - Molecular functionⁱ

protein homodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

AV node cell to bundle of His cell communication by electrical coupling Source: GOC
myelination Source: Ensembl
sensory perception of sound Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein family/group databases

TCDBⁱ	1.A.24.1.7 the gap junction-forming connexin (connexin) family

TCDBⁱ

1.A.24.1.7 the gap junction-forming connexin (connexin) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Gap junction gamma-3 protein Alternative name(s): Connexin-30.2 Short name: Cx30.2 Connexin-31.3 Short name: Cx31.3 Gap junction epsilon-1 protein
Gene namesⁱ	Name:GJC3 Synonyms:GJE1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000176402.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17495 GJC3
MIMⁱ	611925 gene
neXtProtⁱ	NX_Q8NFK1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 22	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	23 – 43	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	44 – 75	ExtracellularSequence analysisAdd BLAST	32
Transmembraneⁱ	76 – 96	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	97 – 132	CytoplasmicSequence analysisAdd BLAST	36
Transmembraneⁱ	133 – 153	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	154 – 194	ExtracellularSequence analysisAdd BLAST	41
Transmembraneⁱ	195 – 215	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	216 – 279	CytoplasmicSequence analysisAdd BLAST	64

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Gap junction, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	349149
Open Targets More...OpenTargetsⁱ	ENSG00000176402
PharmGKBⁱ	PA162389705

Polymorphism and mutation databases

BioMutaⁱ	GJC3
DMDMⁱ	32171365

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000057874	1 – 279	Gap junction gamma-3 proteinAdd BLAST		279

Proteomic databases

PaxDbⁱ	Q8NFK1
PeptideAtlas More...PeptideAtlasⁱ	Q8NFK1
PRIDEⁱ	Q8NFK1
ProteomicsDBⁱ	73321

PTM databases

iPTMnetⁱ	Q8NFK1
PhosphoSitePlusⁱ	Q8NFK1

Expressionⁱ

Tissue specificityⁱ

CNS specific. Expression is restricted to brain, spinal cord, and sciatic nerve. According to PubMed:12881038, expression is abundant in skeletal muscle, liver, and heart, and to a minor degree in pancreas and kidney.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000176402 Expressed in 77 organ(s), highest expression level in tibial nerve
CleanExⁱ	HS_GJC3

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA015024

HPAⁱ

HPA015024

Interactionⁱ

Subunit structureⁱ

A connexon is composed of a hexamer of connexins.By similarity

GO - Molecular functionⁱ

protein homodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	Q8NFK1, 2 interactors
STRINGⁱ	9606.ENSP00000325775

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NFK1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the connexin family. Gamma-type subfamily.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410J8Q3 Eukaryota ENOG4111D69 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144026
HOGENOMⁱ	HOG000231127
HOVERGENⁱ	HBG107788
InParanoidⁱ	Q8NFK1
KEGG Orthology (KO) More...KOⁱ	K07628
OMAⁱ	GCKAACY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06LA
PhylomeDBⁱ	Q8NFK1
TreeFamⁱ	TF329606

Family and domain databases

Gene3Dⁱ	1.20.1440.80, 1 hit
InterProⁱ	View protein in InterPro IPR000500 Connexin IPR019570 Connexin_CCC IPR017990 Connexin_CS IPR013092 Connexin_N IPR038359 Connexin_N_sf
PANTHERⁱ	PTHR11984 PTHR11984, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00029 Connexin, 1 hit
PRINTSⁱ	PR00206 CONNEXIN
SMARTⁱ	View protein in SMART SM00037 CNX, 1 hit SM01089 Connexin_CCC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00407 CONNEXINS_1, 1 hit PS00408 CONNEXINS_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8NFK1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MCGRFLRRLL AEESRRSTPV GRLLLPVLLG FRLVLLAASG PGVYGDEQSE 
        60         70         80         90        100
FVCHTQQPGC KAACFDAFHP LSPLRFWVFQ VILVAVPSAL YMGFTLYHVI 
       110        120        130        140        150
WHWELSGKGK EEETLIQGRE GNTDVPGAGS LRLLWAYVAQ LGARLVLEGA 
       160        170        180        190        200
ALGLQYHLYG FQMPSSFACR REPCLGSITC NLSRPSEKTI FLKTMFGVSG 
       210        220        230        240        250
FCLLFTFLEL VLLGLGRWWR TWKHKSSSSK YFLTSESTRR HKKATDSLPV 
       260        270 
VETKEQFQEA VPGRSLAQEK QRPVGPRDA

Length:279

Mass (Da):31,299

Last modified:October 1, 2002 - v1

Checksum:ⁱ71810BB8E30533BC

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF503615 mRNA Translation: AAM21145.1 AY297109 mRNA Translation: AAP51161.1 CH236956 Genomic DNA Translation: EAL23863.1 CH471091 Genomic DNA Translation: EAW76624.1 BC043381 mRNA Translation: AAH43381.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34697.1
NCBI Reference Sequences More...RefSeqⁱ	NP_853516.1, NM_181538.2
UniGeneⁱ	Hs.647524

Genome annotation databases

Ensemblⁱ	ENST00000312891; ENSP00000325775; ENSG00000176402
GeneIDⁱ	349149
KEGGⁱ	hsa:349149
UCSC genome browser More...UCSCⁱ	uc011kjd.2 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8NFK1	Uncharacterized protein		MACNE		279	UniRef90_Q8NFK1
Uncharacterized protein		CERAT		279
Gap junction protein		PANTR		279
Gap junction protein		PONAB		279
Uncharacterized protein		MACMU		279
+19

Protein	Similar proteins		Species	Score	Length	Source
Q8NFK1	Gap junction protein		NOMLE		279	UniRef50_Q8NFK1
Gap junction protein		PONAB		279
Gap junction protein		COLAP		279
Uncharacterized protein		MACFA		279
Uncharacterized protein		MACMU		279
+83

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF503615 mRNA Translation: AAM21145.1 AY297109 mRNA Translation: AAP51161.1 CH236956 Genomic DNA Translation: EAL23863.1 CH471091 Genomic DNA Translation: EAW76624.1 BC043381 mRNA Translation: AAH43381.1
CCDSⁱ	CCDS34697.1
RefSeqⁱ	NP_853516.1, NM_181538.2
UniGeneⁱ	Hs.647524

3D structure databases

ProteinModelPortalⁱ	Q8NFK1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q8NFK1, 2 interactors
STRINGⁱ	9606.ENSP00000325775

Protein family/group databases

TCDBⁱ	1.A.24.1.7 the gap junction-forming connexin (connexin) family

TCDBⁱ

1.A.24.1.7 the gap junction-forming connexin (connexin) family

PTM databases

iPTMnetⁱ	Q8NFK1
PhosphoSitePlusⁱ	Q8NFK1

Polymorphism and mutation databases

BioMutaⁱ	GJC3
DMDMⁱ	32171365

Proteomic databases

PaxDbⁱ	Q8NFK1
PeptideAtlasⁱ	Q8NFK1
PRIDEⁱ	Q8NFK1
ProteomicsDBⁱ	73321

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	349149
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000312891; ENSP00000325775; ENSG00000176402
GeneIDⁱ	349149
KEGGⁱ	hsa:349149
UCSCⁱ	uc011kjd.2 human

Organism-specific databases

CTDⁱ	349149
DisGeNETⁱ	349149
EuPathDBⁱ	HostDB:ENSG00000176402.5
GeneCardsⁱ	GJC3
HGNCⁱ	HGNC:17495 GJC3
HPAⁱ	HPA015024
MIMⁱ	611925 gene
neXtProtⁱ	NX_Q8NFK1
OpenTargetsⁱ	ENSG00000176402
PharmGKBⁱ	PA162389705
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J8Q3 Eukaryota ENOG4111D69 LUCA
GeneTreeⁱ	ENSGT00910000144026
HOGENOMⁱ	HOG000231127
HOVERGENⁱ	HBG107788
InParanoidⁱ	Q8NFK1
KOⁱ	K07628
OMAⁱ	GCKAACY
OrthoDBⁱ	EOG091G06LA
PhylomeDBⁱ	Q8NFK1
TreeFamⁱ	TF329606

Miscellaneous databases

GeneWikiⁱ	GJC3
GenomeRNAiⁱ	349149
Protein Ontology More...PROⁱ	PR:Q8NFK1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000176402 Expressed in 77 organ(s), highest expression level in tibial nerve
CleanExⁱ	HS_GJC3

Family and domain databases

Gene3Dⁱ	1.20.1440.80, 1 hit
InterProⁱ	View protein in InterPro IPR000500 Connexin IPR019570 Connexin_CCC IPR017990 Connexin_CS IPR013092 Connexin_N IPR038359 Connexin_N_sf
PANTHERⁱ	PTHR11984 PTHR11984, 1 hit
Pfamⁱ	View protein in Pfam PF00029 Connexin, 1 hit
PRINTSⁱ	PR00206 CONNEXIN
SMARTⁱ	View protein in SMART SM00037 CNX, 1 hit SM01089 Connexin_CCC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00407 CONNEXINS_1, 1 hit PS00408 CONNEXINS_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CXG3_HUMAN
Accessionⁱ	Q8NFK1Primary (citable) accession number: Q8NFK1 Secondary accession number(s): A4D296, Q86XI9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 20, 2003
	Last sequence update:	October 1, 2002
	Last modified:	November 7, 2018
	This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8NFK1 (CXG3_HUMAN)

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Gap junction gamma-3 protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ