NUP43

Functionⁱ

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.1 Publication

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
cell division Source: UniProtKB-KW
chromosome segregation Source: UniProtKB-KW
mRNA export from nucleus Source: Reactome
viral process Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Cell division, Chromosome partition, Mitosis, mRNA transport, Protein transport, Translocation, Transport

Biological process

Cell cycle, Cell division, Chromosome partition, Mitosis, mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1169408 ISG15 antiviral mechanism R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-159227 Transport of the SLBP independent Mature mRNA R-HSA-159230 Transport of the SLBP Dependant Mature mRNA R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-165054 Rev-mediated nuclear export of HIV RNA R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168276 NS1 Mediated Effects on Host Pathways R-HSA-168325 Viral Messenger RNA Synthesis R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-180746 Nuclear import of Rev protein R-HSA-180910 Vpr-mediated nuclear import of PICs R-HSA-191859 snRNP Assembly R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-3108214 SUMOylation of DNA damage response and repair proteins R-HSA-3232142 SUMOylation of ubiquitinylation proteins R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly R-HSA-3371453 Regulation of HSF1-mediated heat shock response R-HSA-4085377 SUMOylation of SUMOylation proteins R-HSA-4551638 SUMOylation of chromatin organization proteins R-HSA-4570464 SUMOylation of RNA binding proteins R-HSA-4615885 SUMOylation of DNA replication proteins R-HSA-5578749 Transcriptional regulation by small RNAs R-HSA-5663220 RHO GTPases Activate Formins R-HSA-6784531 tRNA processing in the nucleus R-HSA-68877 Mitotic Prometaphase
SignaLinkⁱ	Q8NFH3

Reactomeⁱ

R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-68877 Mitotic Prometaphase

SignaLinkⁱ

Q8NFH3

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nucleoporin Nup43 Alternative name(s): Nup107-160 subcomplex subunit Nup43 p42
Gene namesⁱ	Name:NUP43
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000120253.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21182 NUP43
MIMⁱ	608141 gene
neXtProtⁱ	NX_Q8NFH3

Keywords - Cellular componentⁱ

Centromere, Chromosome, Kinetochore, Nuclear pore complex, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	348995
Open Targets More...OpenTargetsⁱ	ENSG00000120253
PharmGKBⁱ	PA134930788

Polymorphism and mutation databases

BioMutaⁱ	NUP43
DMDMⁱ	27923819

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051111	1 – 380	Nucleoporin Nup43Add BLAST		380

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q8NFH3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8NFH3
PaxDbⁱ	Q8NFH3
PeptideAtlas More...PeptideAtlasⁱ	Q8NFH3
PRIDEⁱ	Q8NFH3
ProteomicsDBⁱ	73305

PTM databases

iPTMnetⁱ	Q8NFH3
PhosphoSitePlusⁱ	Q8NFH3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000120253 Expressed in 238 organ(s), highest expression level in oocyte
CleanExⁱ	HS_NUP43
ExpressionAtlasⁱ	Q8NFH3 baseline and differential
Genevisibleⁱ	Q8NFH3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA027126 HPA027291 HPA028500

HPAⁱ

HPA027126
HPA027291
HPA028500

Interactionⁱ

Subunit structureⁱ

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13.2 Publications

Protein-protein interaction databases

BioGridⁱ	131544, 52 interactors
CORUMⁱ	Q8NFH3
IntActⁱ	Q8NFH3, 18 interactors
Molecular INTeraction database More...MINTⁱ	Q8NFH3
STRINGⁱ	9606.ENSP00000342262

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	5 – 8	Combined sources	4
Beta strandⁱ	10 – 18	Combined sources	9
Beta strandⁱ	31 – 48	Combined sources	18
Beta strandⁱ	66 – 75	Combined sources	10
Beta strandⁱ	77 – 92	Combined sources	16
Beta strandⁱ	97 – 102	Combined sources	6
Turnⁱ	104 – 106	Combined sources	3
Beta strandⁱ	109 – 115	Combined sources	7
Beta strandⁱ	118 – 120	Combined sources	3
Beta strandⁱ	134 – 140	Combined sources	7
Beta strandⁱ	143 – 148	Combined sources	6
Beta strandⁱ	151 – 157	Combined sources	7
Beta strandⁱ	164 – 168	Combined sources	5
Beta strandⁱ	175 – 182	Combined sources	8
Beta strandⁱ	185 – 190	Combined sources	6
Beta strandⁱ	193 – 199	Combined sources	7
Beta strandⁱ	203 – 205	Combined sources	3
Beta strandⁱ	208 – 212	Combined sources	5
Beta strandⁱ	214 – 217	Combined sources	4
Beta strandⁱ	220 – 225	Combined sources	6
Beta strandⁱ	232 – 237	Combined sources	6
Beta strandⁱ	242 – 246	Combined sources	5
Beta strandⁱ	254 – 257	Combined sources	4
Beta strandⁱ	264 – 269	Combined sources	6
Beta strandⁱ	276 – 281	Combined sources	6
Beta strandⁱ	286 – 290	Combined sources	5
Beta strandⁱ	341 – 344	Combined sources	4
Beta strandⁱ	353 – 359	Combined sources	7
Beta strandⁱ	362 – 367	Combined sources	6
Beta strandⁱ	370 – 376	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8NFH3
SMRⁱ	Q8NFH3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	8 – 57	WD 1Add BLAST	50
Repeatⁱ	72 – 110	WD 2Add BLAST	39
Repeatⁱ	127 – 166	WD 3Add BLAST	40
Repeatⁱ	170 – 208	WD 4Add BLAST	39
Repeatⁱ	215 – 255	WD 5Add BLAST	41
Repeatⁱ	259 – 299	WD 6Add BLAST	41

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG4714 Eukaryota ENOG410ZTD5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004803
HOGENOMⁱ	HOG000007964
HOVERGENⁱ	HBG052696
InParanoidⁱ	Q8NFH3
KEGG Orthology (KO) More...KOⁱ	K14305
OMAⁱ	QFFDQER
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DV7
PhylomeDBⁱ	Q8NFH3
TreeFamⁱ	TF321692

Family and domain databases

InterProⁱ	View protein in InterPro IPR037628 Nup43 IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
PANTHERⁱ	PTHR22652 PTHR22652, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00400 WD40, 1 hit
SMARTⁱ	View protein in SMART SM00320 WD40, 5 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 1 hit PS50082 WD_REPEATS_2, 2 hits PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8NFH3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEIYAKFVS QKISKTRWRP LPPGSLQTAE TFATGSWDNE ENYISLWSIG 
        60         70         80         90        100
DFGNLDSDGG FEGDHQLLCD IRHHGDVMDL QFFDQERIVA ASSTGCVTVF 
       110        120        130        140        150
LHHPNNQTLS VNQQWTTAHY HTGPGSPSYS SAPCTGVVCN NPEIVTVGED 
       160        170        180        190        200
GRINLFRADH KEAVRTIDNA DSSTLHAVTF LRTPEILTVN SIGQLKIWDF 
       210        220        230        240        250
RQQGNEPSQI LSLTGDRVPL HCVDRHPNQQ HVVATGGQDG MLSIWDVRQG 
       260        270        280        290        300
TMPVSLLKAH EAEMWEVHFH PSNPEHLFTC SEDGSLWHWD ASTDVPEKSS 
       310        320        330        340        350
LFHQGGRSST FLSHSISNQA NVHQSVISSW LSTDPAKDRI EITSLLPSRS 
       360        370        380
LSVNTLDVLG PCLVCGTDAE AIYVTRHLFS

Length:380

Mass (Da):42,151

Last modified:October 1, 2002 - v1

Checksum:ⁱEE44714B8E5BFB42

GO

Isoform 2 (identifier: Q8NFH3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
168-264: DNADSSTLHA...SLLKAHEAEM → V

« Hide

        10         20         30         40         50
MEEIYAKFVS QKISKTRWRP LPPGSLQTAE TFATGSWDNE ENYISLWSIG 
        60         70         80         90        100
DFGNLDSDGG FEGDHQLLCD IRHHGDVMDL QFFDQERIVA ASSTGCVTVF 
       110        120        130        140        150
LHHPNNQTLS VNQQWTTAHY HTGPGSPSYS SAPCTGVVCN NPEIVTVGED 
       160        170        180        190        200
GRINLFRADH KEAVRTIVWE VHFHPSNPEH LFTCSEDGSL WHWDASTDVP 
       210        220        230        240        250
EKSSLFHQGG RSSTFLSHSI SNQANVHQSV ISSWLSTDPA KDRIEITSLL 
       260        270        280 
PSRSLSVNTL DVLGPCLVCG TDAEAIYVTR HLFS

Note: No experimental confirmation available.

Show »

Length:284

Mass (Da):31,512

Checksum:ⁱFF600FBC0ABC96D3

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B4DVD1	B4DVD1_HUMAN	cDNA FLJ54281, highly similar to Nu... cDNA FLJ54281, highly similar to Nucleoporin Nup43	NUP43	187	Annotation score:
F5H0E3	F5H0E3_HUMAN	Nucleoporin Nup43 Nucleoporin Nup43	NUP43	178	Annotation score:
B4E301	B4E301_HUMAN	cDNA FLJ61080, highly similar to Nu... cDNA FLJ61080, highly similar to Nucleoporin Nup43	NUP43	117	Annotation score:

Sequence cautionⁱ

The sequence BAB14536 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	247	V → A in BAB14536 (PubMed:14702039).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056167	168 – 264	DNADS…HEAEM → V in isoform 2. 1 PublicationAdd BLAST		97

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF514997 mRNA Translation: AAM76708.1 AK023349 mRNA Translation: BAB14536.1 Different initiation. AK304244 mRNA Translation: BAG65112.1 AL355312 Genomic DNA No translation available. BC065028 mRNA Translation: AAH65028.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5218.1 [Q8NFH3-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_942590.1, NM_198887.2 [Q8NFH3-1]
UniGeneⁱ	Hs.510375

Genome annotation databases

Ensemblⁱ	ENST00000340413; ENSP00000342262; ENSG00000120253 [Q8NFH3-1] ENST00000367404; ENSP00000356374; ENSG00000120253 [Q8NFH3-2]
GeneIDⁱ	348995
KEGGⁱ	hsa:348995
UCSC genome browser More...UCSCⁱ	uc003qmz.5 human [Q8NFH3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8NFH3	NUP43 protein (Fragment)		HUMAN		287	UniRef100_Q8NFH3
UPI0002B7BE23		HUMAN		399

Protein	Similar proteins		Species	Score	Length	Source
Q8NFH3	Nucleoporin Nup43		MOUSE		380	UniRef90_Q8NFH3
NUP43 protein (Fragment)		HUMAN		287
Nucleoporin 43		PONAB		445
Uncharacterized protein		NEOLE		387
Nucleoporin 43		SARHA		381
+123
Q8NFH3-2	NUP43 isoform 6		PANTR		284	UniRef90_Q8NFH3-2
Uncharacterized protein		PANPA		284
Nucleoporin 43		CALJA		284
Uncharacterized protein		MACMU		284
Uncharacterized protein		Cebus capucinus imitator		284
+15

Protein	Similar proteins		Species	Score	Length	Source
Q8NFH3	Nucleoporin Nup43		MOUSE		380	UniRef50_Q8NFH3
NUP43 protein (Fragment)		HUMAN		287
Nucleoporin 43		PONAB		445
Uncharacterized protein		NEOLE		387
Nucleoporin 43		SARHA		381
+237
Q8NFH3-2	Uncharacterized protein		MACFA		284	UniRef50_Q8NFH3-2
NUP43 isoform 2		PONAB		284
Nucleoporin 43		GORGO		284
Nucleoporin 43		CALJA		284
Uncharacterized protein		NOMLE		284
+16

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF514997 mRNA Translation: AAM76708.1 AK023349 mRNA Translation: BAB14536.1 Different initiation. AK304244 mRNA Translation: BAG65112.1 AL355312 Genomic DNA No translation available. BC065028 mRNA Translation: AAH65028.1
CCDSⁱ	CCDS5218.1 [Q8NFH3-1]
RefSeqⁱ	NP_942590.1, NM_198887.2 [Q8NFH3-1]
UniGeneⁱ	Hs.510375

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4I79	X-ray	1.75	A/B	1-380	[»]
	5A9Q	electron microscopy	23.00	0/9/I/R	1-380	[»]
ProteinModelPortalⁱ	Q8NFH3
SMRⁱ	Q8NFH3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	131544, 52 interactors
CORUMⁱ	Q8NFH3
IntActⁱ	Q8NFH3, 18 interactors
MINTⁱ	Q8NFH3
STRINGⁱ	9606.ENSP00000342262

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetⁱ	Q8NFH3
PhosphoSitePlusⁱ	Q8NFH3

Polymorphism and mutation databases

BioMutaⁱ	NUP43
DMDMⁱ	27923819

Proteomic databases

EPDⁱ	Q8NFH3
MaxQBⁱ	Q8NFH3
PaxDbⁱ	Q8NFH3
PeptideAtlasⁱ	Q8NFH3
PRIDEⁱ	Q8NFH3
ProteomicsDBⁱ	73305

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	348995
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000340413; ENSP00000342262; ENSG00000120253 [Q8NFH3-1] ENST00000367404; ENSP00000356374; ENSG00000120253 [Q8NFH3-2]
GeneIDⁱ	348995
KEGGⁱ	hsa:348995
UCSCⁱ	uc003qmz.5 human [Q8NFH3-1]

Organism-specific databases

CTDⁱ	348995
DisGeNETⁱ	348995
EuPathDBⁱ	HostDB:ENSG00000120253.13
GeneCardsⁱ	NUP43
HGNCⁱ	HGNC:21182 NUP43
HPAⁱ	HPA027126 HPA027291 HPA028500
MIMⁱ	608141 gene
neXtProtⁱ	NX_Q8NFH3
OpenTargetsⁱ	ENSG00000120253
PharmGKBⁱ	PA134930788
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4714 Eukaryota ENOG410ZTD5 LUCA
GeneTreeⁱ	ENSGT00390000004803
HOGENOMⁱ	HOG000007964
HOVERGENⁱ	HBG052696
InParanoidⁱ	Q8NFH3
KOⁱ	K14305
OMAⁱ	QFFDQER
OrthoDBⁱ	EOG091G0DV7
PhylomeDBⁱ	Q8NFH3
TreeFamⁱ	TF321692

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1169408 ISG15 antiviral mechanism R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-159227 Transport of the SLBP independent Mature mRNA R-HSA-159230 Transport of the SLBP Dependant Mature mRNA R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-165054 Rev-mediated nuclear export of HIV RNA R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus R-HSA-168276 NS1 Mediated Effects on Host Pathways R-HSA-168325 Viral Messenger RNA Synthesis R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-180746 Nuclear import of Rev protein R-HSA-180910 Vpr-mediated nuclear import of PICs R-HSA-191859 snRNP Assembly R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-3108214 SUMOylation of DNA damage response and repair proteins R-HSA-3232142 SUMOylation of ubiquitinylation proteins R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly R-HSA-3371453 Regulation of HSF1-mediated heat shock response R-HSA-4085377 SUMOylation of SUMOylation proteins R-HSA-4551638 SUMOylation of chromatin organization proteins R-HSA-4570464 SUMOylation of RNA binding proteins R-HSA-4615885 SUMOylation of DNA replication proteins R-HSA-5578749 Transcriptional regulation by small RNAs R-HSA-5663220 RHO GTPases Activate Formins R-HSA-6784531 tRNA processing in the nucleus R-HSA-68877 Mitotic Prometaphase
SignaLinkⁱ	Q8NFH3

Reactomeⁱ

R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-68877 Mitotic Prometaphase

SignaLinkⁱ

Q8NFH3

Miscellaneous databases

GeneWikiⁱ	NUP43
GenomeRNAiⁱ	348995
Protein Ontology More...PROⁱ	PR:Q8NFH3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000120253 Expressed in 238 organ(s), highest expression level in oocyte
CleanExⁱ	HS_NUP43
ExpressionAtlasⁱ	Q8NFH3 baseline and differential
Genevisibleⁱ	Q8NFH3 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR037628 Nup43 IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
PANTHERⁱ	PTHR22652 PTHR22652, 1 hit
Pfamⁱ	View protein in Pfam PF00400 WD40, 1 hit
SMARTⁱ	View protein in SMART SM00320 WD40, 5 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 1 hit PS50082 WD_REPEATS_2, 2 hits PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NUP43_HUMAN
Accessionⁱ	Q8NFH3Primary (citable) accession number: Q8NFH3 Secondary accession number(s): B4E2F0, Q9H8S0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 27, 2003
	Last sequence update:	October 1, 2002
	Last modified:	September 12, 2018
	This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8NFH3 (NUP43_HUMAN)

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Nucleoporin Nup43

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ