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Protein

Ankyrin repeat and protein kinase domain-containing protein 1

Gene

ANKK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51ATPPROSITE-ProRule annotation1
Active sitei145Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 36ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and protein kinase domain-containing protein 1 (EC:2.7.11.1)
Alternative name(s):
Protein kinase PKK2
Sugen kinase 288
Short name:
SgK288
X-kinase
Gene namesi
Name:ANKK1
Synonyms:PKK2, SGK288
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000170209.4
HGNCiHGNC:21027 ANKK1
MIMi608774 gene
neXtProtiNX_Q8NFD2

Pathology & Biotechi

Organism-specific databases

DisGeNETi255239
OpenTargetsiENSG00000170209
PharmGKBiPA134872551

Chemistry databases

ChEMBLiCHEMBL5547

Polymorphism and mutation databases

BioMutaiANKK1
DMDMi74762569

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000856201 – 765Ankyrin repeat and protein kinase domain-containing protein 1Add BLAST765

Proteomic databases

MaxQBiQ8NFD2
PaxDbiQ8NFD2
PeptideAtlasiQ8NFD2
PRIDEiQ8NFD2
ProteomicsDBi73287

PTM databases

iPTMnetiQ8NFD2
PhosphoSitePlusiQ8NFD2

Expressioni

Tissue specificityi

Highly expressed in brain and weakly expressed in placenta and spinal cord.2 Publications

Gene expression databases

BgeeiENSG00000170209 Expressed in 74 organ(s), highest expression level in right uterine tube
CleanExiHS_ANKK1
ExpressionAtlasiQ8NFD2 baseline and differential

Organism-specific databases

HPAiHPA012813

Interactioni

Protein-protein interaction databases

IntActiQ8NFD2, 5 interactors
STRINGi9606.ENSP00000306678

Chemistry databases

BindingDBiQ8NFD2

Structurei

3D structure databases

ProteinModelPortaliQ8NFD2
SMRiQ8NFD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 289Protein kinasePROSITE-ProRule annotationAdd BLAST268
Repeati361 – 390ANK 1Add BLAST30
Repeati394 – 423ANK 2Add BLAST30
Repeati427 – 456ANK 3Add BLAST30
Repeati460 – 489ANK 4Add BLAST30
Repeati493 – 522ANK 5Add BLAST30
Repeati526 – 555ANK 6Add BLAST30
Repeati559 – 588ANK 7Add BLAST30
Repeati592 – 621ANK 8Add BLAST30
Repeati625 – 654ANK 9Add BLAST30
Repeati658 – 687ANK 10Add BLAST30
Repeati691 – 720ANK 11Add BLAST30
Repeati724 – 753ANK 12Add BLAST30

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IT5N Eukaryota
COG0666 LUCA
GeneTreeiENSGT00550000074536
HOGENOMiHOG000294086
HOVERGENiHBG061582
InParanoidiQ8NFD2
KOiK16289
OMAiPCFLDIT
OrthoDBiEOG091G00GN
PhylomeDBiQ8NFD2
TreeFamiTF106506

Family and domain databases

CDDicd00204 ANK, 4 hits
Gene3Di1.25.40.20, 5 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12796 Ank_2, 4 hits
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 11 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 11 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8NFD2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAADPTELRL GSLPVFTRDD FEGDWRLVAS GGFSQVFQAR HRRWRTEYAI
60 70 80 90 100
KCAPCLPPDA ASSDVNYLIE EAAKMKKIKF QHIVSIYGVC KQPLGIVMEF
110 120 130 140 150
MANGSLEKVL STHSLCWKLR FRIIHETSLA MNFLHSIKPP LLHLDLKPGN
160 170 180 190 200
ILLDSNMHVK ISDFGLSKWM EQSTRMQYIE RSALRGMLSY IPPEMFLESN
210 220 230 240 250
KAPGPKYDVY SFAIVIWELL TQKKPYSGFN MMMIIIRVAA GMRPSLQPVS
260 270 280 290 300
DQWPSEAQQM VDLMKRCWDQ DPKKRPCFLD ITIETDILLS LLQSRVAVPE
310 320 330 340 350
SKALARKVSC KLSLRQPGEV NEDISQELMD SDSGNYLKRA LQLSDRKNLV
360 370 380 390 400
PRDEELCIYE NKVTPLHFLV AQGSVEQVRL LLAHEVDVDC QTASGYTPLL
410 420 430 440 450
IAAQDQQPDL CALLLAHGAD ANRVDEDGWA PLHFAAQNGD DGTARLLLDH
460 470 480 490 500
GACVDAQERE GWTPLHLAAQ NNFENVARLL VSRQADPNLH EAEGKTPLHV
510 520 530 540 550
AAYFGHVSLV KLLTSQGAEL DAQQRNLRTP LHLAVERGKV RAIQHLLKSG
560 570 580 590 600
AVPDALDQSG YGPLHTAAAR GKYLICKMLL RYGASLELPT HQGWTPLHLA
610 620 630 640 650
AYKGHLEIIH LLAESHANMG ALGAVNWTPL HLAARHGEEA VVSALLQCGA
660 670 680 690 700
DPNAAEQSGW TPLHLAVQRS TFLSVINLLE HHANVHARNK VGWTPAHLAA
710 720 730 740 750
LKGNTAILKV LVEAGAQLDV QDGVSCTPLQ LALRSRKQGI MSFLEGKEPS
760
VATLGGSKPG AEMEI
Length:765
Mass (Da):84,632
Last modified:October 1, 2002 - v1
Checksum:i549F6161B2976BF5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YH32H0YH32_HUMAN
Ankyrin repeat and protein kinase d...
ANKK1
54Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0403594D → Y1 PublicationCorresponds to variant dbSNP:rs35657708Ensembl.1
Natural variantiVAR_040360122R → H1 PublicationCorresponds to variant dbSNP:rs35877321Ensembl.1
Natural variantiVAR_036784239A → T1 PublicationCorresponds to variant dbSNP:rs7118900Ensembl.1
Natural variantiVAR_040361276P → L1 PublicationCorresponds to variant dbSNP:rs35488601Ensembl.1
Natural variantiVAR_036785318G → R1 PublicationCorresponds to variant dbSNP:rs11604671Ensembl.1
Natural variantiVAR_040362347K → T in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040363366L → F1 PublicationCorresponds to variant dbSNP:rs56339158Ensembl.1
Natural variantiVAR_040364367H → Q1 PublicationCorresponds to variant dbSNP:rs34298987Ensembl.1
Natural variantiVAR_040365376E → K1 PublicationCorresponds to variant dbSNP:rs56299709Ensembl.1
Natural variantiVAR_040366426E → K1 PublicationCorresponds to variant dbSNP:rs55699907Ensembl.1
Natural variantiVAR_036786442G → R1 PublicationCorresponds to variant dbSNP:rs4938016Ensembl.1
Natural variantiVAR_040367451G → R1 PublicationCorresponds to variant dbSNP:rs34983219Ensembl.1
Natural variantiVAR_036787490H → R1 PublicationCorresponds to variant dbSNP:rs2734849Ensembl.1
Natural variantiVAR_040368595T → I1 PublicationCorresponds to variant dbSNP:rs55787008Ensembl.1
Natural variantiVAR_040369596P → L1 PublicationCorresponds to variant dbSNP:rs7104979Ensembl.1
Natural variantiVAR_040370653N → S1 PublicationCorresponds to variant dbSNP:rs55849504Ensembl.1
Natural variantiVAR_040371670S → G1 PublicationCorresponds to variant dbSNP:rs56006094Ensembl.1
Natural variantiVAR_025010713E → K2 PublicationsCorresponds to variant dbSNP:rs1800497EnsemblClinVar.1
Natural variantiVAR_040372717Q → L in a lung large cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040373736R → L in a lung squamous cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040374764E → K in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ541797 mRNA Translation: CAD62569.2
AF487542 mRNA Translation: AAQ09005.1
AF525298 Genomic DNA Translation: AAM91924.1
CCDSiCCDS44734.1
RefSeqiNP_848605.1, NM_178510.1
UniGeneiHs.448473

Genome annotation databases

EnsembliENST00000303941; ENSP00000306678; ENSG00000170209
GeneIDi255239
KEGGihsa:255239
UCSCiuc001pny.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ541797 mRNA Translation: CAD62569.2
AF487542 mRNA Translation: AAQ09005.1
AF525298 Genomic DNA Translation: AAM91924.1
CCDSiCCDS44734.1
RefSeqiNP_848605.1, NM_178510.1
UniGeneiHs.448473

3D structure databases

ProteinModelPortaliQ8NFD2
SMRiQ8NFD2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8NFD2, 5 interactors
STRINGi9606.ENSP00000306678

Chemistry databases

BindingDBiQ8NFD2
ChEMBLiCHEMBL5547

PTM databases

iPTMnetiQ8NFD2
PhosphoSitePlusiQ8NFD2

Polymorphism and mutation databases

BioMutaiANKK1
DMDMi74762569

Proteomic databases

MaxQBiQ8NFD2
PaxDbiQ8NFD2
PeptideAtlasiQ8NFD2
PRIDEiQ8NFD2
ProteomicsDBi73287

Protocols and materials databases

DNASUi255239
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303941; ENSP00000306678; ENSG00000170209
GeneIDi255239
KEGGihsa:255239
UCSCiuc001pny.3 human

Organism-specific databases

CTDi255239
DisGeNETi255239
EuPathDBiHostDB:ENSG00000170209.4
GeneCardsiANKK1
HGNCiHGNC:21027 ANKK1
HPAiHPA012813
MIMi608774 gene
neXtProtiNX_Q8NFD2
OpenTargetsiENSG00000170209
PharmGKBiPA134872551
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IT5N Eukaryota
COG0666 LUCA
GeneTreeiENSGT00550000074536
HOGENOMiHOG000294086
HOVERGENiHBG061582
InParanoidiQ8NFD2
KOiK16289
OMAiPCFLDIT
OrthoDBiEOG091G00GN
PhylomeDBiQ8NFD2
TreeFamiTF106506

Miscellaneous databases

GeneWikiiANKK1
GenomeRNAii255239
PROiPR:Q8NFD2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170209 Expressed in 74 organ(s), highest expression level in right uterine tube
CleanExiHS_ANKK1
ExpressionAtlasiQ8NFD2 baseline and differential

Family and domain databases

CDDicd00204 ANK, 4 hits
Gene3Di1.25.40.20, 5 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12796 Ank_2, 4 hits
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 11 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 11 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiANKK1_HUMAN
AccessioniPrimary (citable) accession number: Q8NFD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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