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UniProtKB - Q8NFC6 (BD1L1_HUMAN)

Entry version 135 (17 Jun 2020)
Sequence version 2 (02 Oct 2007)
Previous versions | rss
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Protein

Biorientation of chromosomes in cell division protein 1-like 1

Gene

BOD1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705). Does not regulate spindle orientation (PubMed:26166705).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi2872 – 2884A.T hookAdd BLAST13

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Biorientation of chromosomes in cell division protein 1-like 1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BOD1L1Imported
Synonyms:BOD1L, FAM44A, KIAA13271 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000038219.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:31792 BOD1L1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616746 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8NFC6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		259282

Open Targets

More...OpenTargetsi		ENSG00000038219

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164716652

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8NFC6 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BOD1L1

Domain mapping of disease mutations (DMDM)

More...DMDMi		158931124

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001870271 – 3051Biorientation of chromosomes in cell division protein 1-like 1Add BLAST3051

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei266PhosphoserineCombined sources1
Modified residuei473N6-acetyllysineCombined sources1
Modified residuei482PhosphoserineCombined sources1
Modified residuei484PhosphoserineCombined sources1
Modified residuei635PhosphoserineCombined sources1
Modified residuei659PhosphoserineCombined sources1
Modified residuei660PhosphothreonineCombined sources1
Modified residuei733PhosphothreonineCombined sources1
Modified residuei1077PhosphoserineCombined sources1
Modified residuei1145PhosphoserineCombined sources1
Modified residuei1318PhosphoserineCombined sources1
Modified residuei1354PhosphothreonineCombined sources1
Modified residuei1531PhosphoserineCombined sources1
Modified residuei1701PhosphoserineCombined sources1
Modified residuei1710PhosphoserineCombined sources1
Modified residuei2013PhosphoserineBy similarity1
Modified residuei2025PhosphoserineBy similarity1
Modified residuei2128PhosphoserineCombined sources1
Modified residuei2203PhosphoserineCombined sources1
Modified residuei2475PhosphoserineCombined sources1
Modified residuei2501PhosphoserineCombined sources1
Modified residuei2618PhosphoserineBy similarity1
Modified residuei2905PhosphoserineCombined sources1
Modified residuei2907PhosphoserineCombined sources1
Modified residuei2954PhosphoserineCombined sources1
Modified residuei2956PhosphothreonineCombined sources1
Modified residuei2958PhosphoserineCombined sources1
Modified residuei2964PhosphoserineCombined sources1
Modified residuei2973PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki2981Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki2982Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei2986PhosphoserineCombined sources1
Modified residuei3019PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8NFC6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8NFC6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8NFC6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8NFC6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8NFC6

PeptideAtlas

More...PeptideAtlasi		Q8NFC6

PRoteomics IDEntifications database

More...PRIDEi		Q8NFC6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		73286

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8NFC6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8NFC6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000038219 Expressed in tendon and 201 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8NFC6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8NFC6 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000038219 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		129238, 66 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q8NFC6

Protein interaction database and analysis system

More...IntActi		Q8NFC6, 35 interactors

Molecular INTeraction database

More...MINTi		Q8NFC6

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000040738

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8NFC6 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8NFC6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5 – 36Pro-richAdd BLAST32
Compositional biasi315 – 1046Lys-richAdd BLAST732
Compositional biasi2760 – 2765Poly-Glu6
Compositional biasi2988 – 2997Poly-Glu10

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BOD1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IKUQ Eukaryota
ENOG4111M2Q LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156198

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000519_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8NFC6

Identification of Orthologs from Complete Genome Data

More...OMAi		EKHADHR

Database of Orthologous Groups

More...OrthoDBi		1333373at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8NFC6

TreeFam database of animal gene trees

More...TreeFami		TF335808

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043244 BOD1L1

The PANTHER Classification System

More...PANTHERi		PTHR47391 PTHR47391, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8NFC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATNPQPQPP PPAPPPPPPQ PQPQPPPPPP GPGAGPGAGG AGGAGAGAGD 
        60         70         80         90        100
PQLVAMIVNH LKSQGLFDQF RRDCLADVDT KPAYQNLRQR VDNFVANHLA 
       110        120        130        140        150
THTWSPHLNK NQLRNNIRQQ VLKSGMLESG IDRIISQVVD PKINHTFRPQ 
       160        170        180        190        200
VEKAVHEFLA TLNHKEEGSG NTAPDDEKPD TSLITQGVPT PGPSANVAND 
       210        220        230        240        250
AMSILETITS LNQEASAARA STETSNAKTS ERASKKLPSQ PTTDTSTDKE 
       260        270        280        290        300
RTSEDMADKE KSTADSGGEG LETAPKSEEF SDLPCPVEEI KNYTKEHNNL 
       310        320        330        340        350
ILLNKDVQQE SSEQKNKSTD KGEKKPDSNE KGERKKEKKE KTEKKFDHSK 
       360        370        380        390        400
KSEDTQKVKD EKQAKEKEVE SLKLPSEKNS NKAKTVEGTK EDFSLIDSDV 
       410        420        430        440        450
DGLTDITVSS VHTSDLSSFE EDTEEEVVTS DSMEEGEITS DDEEKNKQNK 
       460        470        480        490        500
TKTQTSDSSE GKTKSVRHAY VHKPYLYSKY YSDSDDELTV EQRRQSIAKE 
       510        520        530        540        550
KEERLLRRQI NREKLEEKRK QKAEKTKSSK TKGQGRSSVD LEESSTKSLE 
       560        570        580        590        600
PKAARIKEVL KERKVLEKKV ALSKKRKKDS RNVEENSKKK QQYEEDSKET 
       610        620        630        640        650
LKTSEHCEKE KISSSKELKH VHAKSEPSKP ARRLSESLHV VDENKNESKL 
       660        670        680        690        700
EREHKRRTST PVIMEGVQEE TDTRDVKRQV ERSEICTEEP QKQKSTLKNE 
       710        720        730        740        750
KHLKKDDSET PHLKSLLKKE VKSSKEKPER EKTPSEDKLS VKHKYKGDCM 
       760        770        780        790        800
HKTGDETELH SSEKGLKVEE NIQKQSQQTK LSSDDKTERK SKHRNERKLS 
       810        820        830        840        850
VLGKDGKPVS EYIIKTDENV RKENNKKERR LSAEKTKAEH KSRRSSDSKI 
       860        870        880        890        900
QKDSLGSKQH GITLQRRSES YSEDKCDMDS TNMDSNLKPE EVVHKEKRRT 
       910        920        930        940        950
KSLLEEKLVL KSKSKTQGKQ VKVVETELQE GATKQATTPK PDKEKNTEEN 
       960        970        980        990       1000
DSEKQRKSKV EDKPFEETGV EPVLETASSS AHSTQKDSSH RAKLPLAKEK 
      1010       1020       1030       1040       1050
YKSDKDSTST RLERKLSDGH KSRSLKHSSK DIKKKDENKS DDKDGKEVDS 
      1060       1070       1080       1090       1100
SHEKARGNSS LMEKKLSRRL CENRRGSLSQ EMAKGEEKLA ANTLSTPSGS 
      1110       1120       1130       1140       1150
SLQRPKKSGD MTLIPEQEPM EIDSEPGVEN VFEVSKTQDN RNNNSQQDID 
      1160       1170       1180       1190       1200
SENMKQKTSA TVQKDELRTC TADSKATAPA YKPGRGTGVN SNSEKHADHR 
      1210       1220       1230       1240       1250
STLTKKMHIQ SAVSKMNPGE KEPIHRGTTE VNIDSETVHR MLLSAPSEND 
      1260       1270       1280       1290       1300
RVQKNLKNTA AEEHVAQGDA TLEHSTNLDS SPSLSSVTVV PLRESYDPDV 
      1310       1320       1330       1340       1350
IPLFDKRTVL EGSTASTSPA DHSALPNQSL TVRESEVLKT SDSKEGGEGF 
      1360       1370       1380       1390       1400
TVDTPAKASI TSKRHIPEAH QATLLDGKQG KVIMPLGSKL TGVIVENENI 
      1410       1420       1430       1440       1450
TKEGGLVDMA KKENDLNAEP NLKQTIKATV ENGKKDGIAV DHVVGLNTEK 
      1460       1470       1480       1490       1500
YAETVKLKHK RSPGKVKDIS IDVERRNENS EVDTSAGSGS APSVLHQRNG 
      1510       1520       1530       1540       1550
QTEDVATGPR RAEKTSVATS TEGKDKDVTL SPVKAGPATT TSSETRQSEV 
      1560       1570       1580       1590       1600
ALPCTSIEAD EGLIIGTHSR NNPLHVGAEA SECTVFAAAE EGGAVVTEGF 
      1610       1620       1630       1640       1650
AESETFLTST KEGESGECAV AESEDRAADL LAVHAVKIEA NVNSVVTEEK 
      1660       1670       1680       1690       1700
DDAVTSAGSE EKCDGSLSRD SEIVEGTITF ISEVESDGAV TSAGTEIRAG 
      1710       1720       1730       1740       1750
SISSEEVDGS QGNMMRMGPK KETEGTVTCT GAEGRSDNFV ICSVTGAGPR 
      1760       1770       1780       1790       1800
EERMVTGAGV VLGDNDAPPG TSASQEGDGS VNDGTEGESA VTSTGITEDG 
      1810       1820       1830       1840       1850
EGPASCTGSE DSSEGFAISS ESEENGESAM DSTVAKEGTN VPLVAAGPCD 
      1860       1870       1880       1890       1900
DEGIVTSTGA KEEDEEGEDV VTSTGRGNEI GHASTCTGLG EESEGVLICE 
      1910       1920       1930       1940       1950
SAEGDSQIGT VVEHVEAEAG AAIMNANENN VDSMSGTEKG SKDTDICSSA 
      1960       1970       1980       1990       2000
KGIVESSVTS AVSGKDEVTP VPGGCEGPMT SAASDQSDSQ LEKVEDTTIS 
      2010       2020       2030       2040       2050
TGLVGGSYDV LVSGEVPECE VAHTSPSEKE DEDIITSVEN EECDGLMATT 
      2060       2070       2080       2090       2100
ASGDITNQNS LAGGKNQGKV LIISTSTTND YTPQVSAITD VEGGLSDALR 
      2110       2120       2130       2140       2150
TEENMEGTRV TTEEFEAPMP SAVSGDDSQL TASRSEEKDE CAMISTSIGE 
      2160       2170       2180       2190       2200
EFELPISSAT TIKCAESLQP VAAAVEERAT GPVLISTADF EGPMPSAPPE 
      2210       2220       2230       2240       2250
AESPLASTSK EEKDECALIS TSIAEECEAS VSGVVVESEN ERAGTVMEEK 
      2260       2270       2280       2290       2300
DGSGIISTSS VEDCEGPVSS AVPQEEGDPS VTPAEEMGDT AMISTSTSEG 
      2310       2320       2330       2340       2350
CEAVMIGAVL QDEDRLTITR VEDLSDAAII STSTAECMPI SASIDRHEEN 
      2360       2370       2380       2390       2400
QLTADNPEGN GDLSATEVSK HKVPMPSLIA ENNCRCPGPV RGGKEPGPVL 
      2410       2420       2430       2440       2450
AVSTEEGHNG PSVHKPSAGQ GHPSAVCAEK EEKHGKECPE IGPFAGRGQK 
      2460       2470       2480       2490       2500
ESTLHLINAE EKNVLLNSLQ KEDKSPETGT AGGSSTASYS AGRGLEGNAN 
      2510       2520       2530       2540       2550
SPAHLRGPEQ TSGQTAKDPS VSIRYLAAVN TGAIKADDMP PVQGTVAEHS 
      2560       2570       2580       2590       2600
FLPAEQQGSE DNLKTSTTKC ITGQESKIAP SHTMIPPATY SVALLAPKCE 
      2610       2620       2630       2640       2650
QDLTIKNDYS GKWTDQASAE KTGDDNSTRK SFPEEGDIMV TVSSEENVCD 
      2660       2670       2680       2690       2700
IGNEESPLNV LGGLKLKANL KMEAYVPSEE EKNGEILAPP ESLCGGKPSG 
      2710       2720       2730       2740       2750
IAELQREPLL VNESLNVENS GFRTNEEIHS ESYNKGEISS GRKDNAEAIS 
      2760       2770       2780       2790       2800
GHSVEADPKE VEEEERHMPK RKRKQHYLSS EDEPDDNPDV LDSRIETAQR 
      2810       2820       2830       2840       2850
QCPETEPHDT KEENSRDLEE LPKTSSETNS TTSRVMEEKD EYSSSETTGE 
      2860       2870       2880       2890       2900
KPEQNDDDTI KSQEEDQPII IKRKRGRPRK YPVETTLKMK DDSKTDTGIV 
      2910       2920       2930       2940       2950
TVEQSPSSSK LKVMQTDESN KETANLQERS ISNDDGEEKI VTSVRRRGRK 
      2960       2970       2980       2990       3000
PKRSLTVSDD AESSEPERKR QKSVSDPVED KKEQESDEEE EEEEEDEPSG 
      3010       3020       3030       3040       3050
ATTRSTTRSE AQRSKTQLSP SIKRKREVSP PGARTRGQQR VEEAPVKKAK 

R
Length:3,051
Mass (Da):330,466
Last modified:October 2, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44AD19BDDFDCE560
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y9Y2H0Y9Y2_HUMAN
Biorientation of chromosomes in cel...
BOD1L1
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDD0F8WDD0_HUMAN
Biorientation of chromosomes in cel...
BOD1L1
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH16987 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15299 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence CAB70705 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti337E → K in AAH65546 (PubMed:15489334).Curated1
Sequence conflicti337E → K in AAH87835 (PubMed:15489334).Curated1
Sequence conflicti498 – 502AKEKE → GILWF in AAM94279 (Ref. 2) Curated5
Sequence conflicti1417N → S in BAB15299 (PubMed:14702039).Curated1
Sequence conflicti1438I → V in BAB15299 (PubMed:14702039).Curated1
Sequence conflicti1740V → M in BAB15299 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036124246S → I in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_035220429T → M. Corresponds to variant dbSNP:rs2035820Ensembl.1
Natural variantiVAR_035221650L → I. Corresponds to variant dbSNP:rs1971278Ensembl.1
Natural variantiVAR_0352221369A → G. Corresponds to variant dbSNP:rs17745712Ensembl.1
Natural variantiVAR_0352231448T → A. Corresponds to variant dbSNP:rs17745676Ensembl.1
Natural variantiVAR_0352241515T → A. Corresponds to variant dbSNP:rs16888885Ensembl.1
Natural variantiVAR_0352251645V → I. Corresponds to variant dbSNP:rs17807493Ensembl.1
Natural variantiVAR_0352262361G → S. Corresponds to variant dbSNP:rs3822227Ensembl.1
Natural variantiVAR_0352272396P → L1 PublicationCorresponds to variant dbSNP:rs3733557Ensembl.1
Natural variantiVAR_0611662944V → M. Corresponds to variant dbSNP:rs28538279Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC006445 Genomic DNA No translation available.
AF528529 mRNA Translation: AAM94279.1
BC016987 mRNA Translation: AAH16987.1 Different initiation.
BC065546 mRNA Translation: AAH65546.1
BC087835 mRNA Translation: AAH87835.1
AK025965 mRNA Translation: BAB15299.1 Different termination.
AB037748 mRNA Translation: BAA92565.2
AL137350 mRNA Translation: CAB70705.1 Different termination.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3411.2

Protein sequence database of the Protein Information Resource

More...PIRi		T46424

NCBI Reference Sequences

More...RefSeqi		NP_683692.2, NM_148894.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000040738; ENSP00000040738; ENSG00000038219

Database of genes from NCBI RefSeq genomes

More...GeneIDi		259282

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:259282

UCSC genome browser

More...UCSCi		uc003gmz.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006445 Genomic DNA No translation available.
AF528529 mRNA Translation: AAM94279.1
BC016987 mRNA Translation: AAH16987.1 Different initiation.
BC065546 mRNA Translation: AAH65546.1
BC087835 mRNA Translation: AAH87835.1
AK025965 mRNA Translation: BAB15299.1 Different termination.
AB037748 mRNA Translation: BAA92565.2
AL137350 mRNA Translation: CAB70705.1 Different termination.
CCDSiCCDS3411.2
PIRiT46424
RefSeqiNP_683692.2, NM_148894.2

3D structure databases

SMRiQ8NFC6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi129238, 66 interactors
CORUMiQ8NFC6
IntActiQ8NFC6, 35 interactors
MINTiQ8NFC6
STRINGi9606.ENSP00000040738

PTM databases

iPTMnetiQ8NFC6
PhosphoSitePlusiQ8NFC6

Polymorphism and mutation databases

BioMutaiBOD1L1
DMDMi158931124

Proteomic databases

EPDiQ8NFC6
jPOSTiQ8NFC6
MassIVEiQ8NFC6
MaxQBiQ8NFC6
PaxDbiQ8NFC6
PeptideAtlasiQ8NFC6
PRIDEiQ8NFC6
ProteomicsDBi73286

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		50158 38 antibodies

The DNASU plasmid repository

More...DNASUi		259282

Genome annotation databases

EnsembliENST00000040738; ENSP00000040738; ENSG00000038219
GeneIDi259282
KEGGihsa:259282
UCSCiuc003gmz.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		259282
DisGeNETi259282
EuPathDBiHostDB:ENSG00000038219.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		BOD1L1
HGNCiHGNC:31792 BOD1L1
HPAiENSG00000038219 Low tissue specificity
MIMi616746 gene
neXtProtiNX_Q8NFC6
OpenTargetsiENSG00000038219
PharmGKBiPA164716652

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IKUQ Eukaryota
ENOG4111M2Q LUCA
GeneTreeiENSGT00940000156198
HOGENOMiCLU_000519_0_0_1
InParanoidiQ8NFC6
OMAiEKHADHR
OrthoDBi1333373at2759
PhylomeDBiQ8NFC6
TreeFamiTF335808

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		259282 60 hits in 788 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		BOD1L1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		259282
PharosiQ8NFC6 Tdark

Protein Ontology

More...PROi		PR:Q8NFC6
RNActiQ8NFC6 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000038219 Expressed in tendon and 201 other tissues
ExpressionAtlasiQ8NFC6 baseline and differential
GenevisibleiQ8NFC6 HS

Family and domain databases

InterProiView protein in InterPro
IPR043244 BOD1L1
PANTHERiPTHR47391 PTHR47391, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBD1L1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NFC6
Secondary accession number(s): Q6P0M8
, Q96AL1, Q9H6G0, Q9NTD6, Q9P2L9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 2, 2007
Last modified: June 17, 2020
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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