UniProtKB - Q8NFB2 (T185A_HUMAN)
Protein
Transmembrane protein 185A
Gene
TMEM185A
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 185AAlternative name(s): Protein FAM11A |
Gene namesi | Name:TMEM185A Synonyms:CXorf13, FAM11A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17125, TMEM185A |
MIMi | 300031, gene |
neXtProti | NX_Q8NFB2 |
VEuPathDBi | HostDB:ENSG00000269556.7 |
Subcellular locationi
Other locations
- dendrite By similarity
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- dendrite Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 16 – 36 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 41 – 61 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 81 – 101 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 111 – 131 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 177 – 197 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 211 – 231 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 240 – 260 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell projection, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 84548 |
MalaCardsi | TMEM185A |
Orphaneti | 100974, FRAXF syndrome |
PharmGKBi | PA27062 |
Miscellaneous databases
Pharosi | Q8NFB2, Tdark |
Genetic variation databases
BioMutai | TMEM185A |
DMDMi | 550544296 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000188007 | 1 – 350 | Transmembrane protein 185AAdd BLAST | 350 |
Proteomic databases
jPOSTi | Q8NFB2 |
MassIVEi | Q8NFB2 |
MaxQBi | Q8NFB2 |
PaxDbi | Q8NFB2 |
PeptideAtlasi | Q8NFB2 |
PRIDEi | Q8NFB2 |
ProteomicsDBi | 73285 |
PTM databases
iPTMneti | Q8NFB2 |
PhosphoSitePlusi | Q8NFB2 |
SwissPalmi | Q8NFB2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000269556, Expressed in testis and 200 other tissues |
ExpressionAtlasi | Q8NFB2, baseline and differential |
Genevisiblei | Q8NFB2, HS |
Organism-specific databases
HPAi | ENSG00000269556, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with MAP1B.
1 PublicationBinary interactionsi
Hide detailsQ8NFB2
Protein-protein interaction databases
BioGRIDi | 124133, 61 interactors |
IntActi | Q8NFB2, 53 interactors |
STRINGi | 9606.ENSP00000471932 |
Miscellaneous databases
RNActi | Q8NFB2, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 298 – 350 | Mediates interaction with MAP1B1 PublicationAdd BLAST | 53 |
Sequence similaritiesi
Belongs to the TMEM185 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3879, Eukaryota |
HOGENOMi | CLU_053027_0_0_1 |
InParanoidi | Q8NFB2 |
OrthoDBi | 554512at2759 |
PhylomeDBi | Q8NFB2 |
TreeFami | TF313829 |
Family and domain databases
InterProi | View protein in InterPro IPR019396, TM_Fragile-X-F-assoc |
PANTHERi | PTHR13568, PTHR13568, 1 hit |
Pfami | View protein in Pfam PF10269, Tmemb_185A, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
Q8NFB2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNLRGLFQDF NPSKFLIYAC LLLFSVLLAL RLDGIIQWSY WAVFAPIWLW
60 70 80 90 100
KLMVIVGASV GTGVWARNPQ YRAEGETCVE FKAMLIAVGI HLLLLMFEVL
110 120 130 140 150
VCDRIERGSH FWLLVFMPLF FVSPVSVAAC VWGFRHDRSL ELEILCSVNI
160 170 180 190 200
LQFIFIALRL DKIIHWPWLV VCVPLWILMS FLCLVVLYYI VWSVLFLRSM
210 220 230 240 250
DVIAEQRRTH ITMALSWMTI VVPLLTFEIL LVHKLDGHNA FSSIPIFVPL
260 270 280 290 300
WLSLITLMAT TFGQKGGNHW WFGIRKDFCQ FLLEIFPFLR EYGNISYDLH
310 320 330 340 350
HEDNEETEET PVPEPPKIAP MFRKKARVVI TQSPGKYVLP PPKLNIEMPD
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB3KY49 | B3KY49_HUMAN | Family with sequence similarity 11,... | TMEM185A FAM11A, hCG_1999996 | 172 | Annotation score: | ||
E7EMM1 | E7EMM1_HUMAN | Transmembrane protein 185A | TMEM185A | 173 | Annotation score: | ||
B7Z4G6 | B7Z4G6_HUMAN | Transmembrane protein 185A | TMEM185A | 291 | Annotation score: | ||
E5RFI9 | E5RFI9_HUMAN | Transmembrane protein 185A | TMEM185A | 79 | Annotation score: | ||
H0YAP3 | H0YAP3_HUMAN | Transmembrane protein 185A | TMEM185A | 223 | Annotation score: | ||
E5RGV1 | E5RGV1_HUMAN | Transmembrane protein 185A | TMEM185A | 60 | Annotation score: | ||
H0YBJ6 | H0YBJ6_HUMAN | Transmembrane protein 185A | TMEM185A | 60 | Annotation score: | ||
A0A087X081 | A0A087X081_HUMAN | Transmembrane protein 185A | TMEM185A | 45 | Annotation score: |
Sequence cautioni
The sequence AAH13793 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033922 | 179 | M → V. Corresponds to variant dbSNP:rs396058Ensembl. | 1 | |
Natural variantiVAR_033923 | 243 | S → C5 PublicationsCorresponds to variant dbSNP:rs609828Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF530473 mRNA Translation: AAM94598.1 AK096308 mRNA Translation: BAG53255.1 AK097391 mRNA Translation: BAC05031.1 AC231844 Genomic DNA No translation available. AC233288 Genomic DNA No translation available. CH471169 Genomic DNA Translation: EAW99368.1 BC013793 mRNA Translation: AAH13793.1 Different initiation. BC103821 mRNA Translation: AAI03822.1 BC103822 mRNA Translation: AAI03823.1 AF353675 mRNA Translation: AAK39521.1 |
CCDSi | CCDS14689.1 |
RefSeqi | NP_001167563.1, NM_001174092.2 NP_001269231.1, NM_001282302.1 NP_115897.1, NM_032508.3 |
Genome annotation databases
Ensembli | ENST00000600449; ENSP00000471932; ENSG00000269556 |
GeneIDi | 84548 |
KEGGi | hsa:84548 |
UCSCi | uc033ezr.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF530473 mRNA Translation: AAM94598.1 AK096308 mRNA Translation: BAG53255.1 AK097391 mRNA Translation: BAC05031.1 AC231844 Genomic DNA No translation available. AC233288 Genomic DNA No translation available. CH471169 Genomic DNA Translation: EAW99368.1 BC013793 mRNA Translation: AAH13793.1 Different initiation. BC103821 mRNA Translation: AAI03822.1 BC103822 mRNA Translation: AAI03823.1 AF353675 mRNA Translation: AAK39521.1 |
CCDSi | CCDS14689.1 |
RefSeqi | NP_001167563.1, NM_001174092.2 NP_001269231.1, NM_001282302.1 NP_115897.1, NM_032508.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 124133, 61 interactors |
IntActi | Q8NFB2, 53 interactors |
STRINGi | 9606.ENSP00000471932 |
PTM databases
iPTMneti | Q8NFB2 |
PhosphoSitePlusi | Q8NFB2 |
SwissPalmi | Q8NFB2 |
Genetic variation databases
BioMutai | TMEM185A |
DMDMi | 550544296 |
Proteomic databases
jPOSTi | Q8NFB2 |
MassIVEi | Q8NFB2 |
MaxQBi | Q8NFB2 |
PaxDbi | Q8NFB2 |
PeptideAtlasi | Q8NFB2 |
PRIDEi | Q8NFB2 |
ProteomicsDBi | 73285 |
Protocols and materials databases
Antibodypediai | 74111, 52 antibodies |
Genome annotation databases
Ensembli | ENST00000600449; ENSP00000471932; ENSG00000269556 |
GeneIDi | 84548 |
KEGGi | hsa:84548 |
UCSCi | uc033ezr.1, human |
Organism-specific databases
CTDi | 84548 |
DisGeNETi | 84548 |
GeneCardsi | TMEM185A |
HGNCi | HGNC:17125, TMEM185A |
HPAi | ENSG00000269556, Low tissue specificity |
MalaCardsi | TMEM185A |
MIMi | 300031, gene |
neXtProti | NX_Q8NFB2 |
Orphaneti | 100974, FRAXF syndrome |
PharmGKBi | PA27062 |
VEuPathDBi | HostDB:ENSG00000269556.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3879, Eukaryota |
HOGENOMi | CLU_053027_0_0_1 |
InParanoidi | Q8NFB2 |
OrthoDBi | 554512at2759 |
PhylomeDBi | Q8NFB2 |
TreeFami | TF313829 |
Enzyme and pathway databases
PathwayCommonsi | Q8NFB2 |
Miscellaneous databases
BioGRID-ORCSi | 84548, 2 hits in 503 CRISPR screens |
ChiTaRSi | TMEM185A, human |
GenomeRNAii | 84548 |
Pharosi | Q8NFB2, Tdark |
PROi | PR:Q8NFB2 |
RNActi | Q8NFB2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000269556, Expressed in testis and 200 other tissues |
ExpressionAtlasi | Q8NFB2, baseline and differential |
Genevisiblei | Q8NFB2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019396, TM_Fragile-X-F-assoc |
PANTHERi | PTHR13568, PTHR13568, 1 hit |
Pfami | View protein in Pfam PF10269, Tmemb_185A, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | T185A_HUMAN | |
Accessioni | Q8NFB2Primary (citable) accession number: Q8NFB2 Secondary accession number(s): B3KTZ3 Q96KE8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | October 16, 2013 | |
Last modified: | February 10, 2021 | |
This is version 127 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families