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Protein

Transmembrane protein 185A

Gene

TMEM185A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 185A
Alternative name(s):
Protein FAM11A
Gene namesi
Name:TMEM185A
Synonyms:CXorf13, FAM11A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000269556.7
HGNCiHGNC:17125 TMEM185A
MIMi300031 gene
neXtProtiNX_Q8NFB2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84548
MalaCardsiTMEM185A
Orphaneti100974 FRAXF syndrome
PharmGKBiPA27062

Polymorphism and mutation databases

BioMutaiTMEM185A
DMDMi550544296

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001880071 – 350Transmembrane protein 185AAdd BLAST350

Proteomic databases

MaxQBiQ8NFB2
PaxDbiQ8NFB2
PeptideAtlasiQ8NFB2
PRIDEiQ8NFB2
ProteomicsDBi73285

PTM databases

iPTMnetiQ8NFB2
PhosphoSitePlusiQ8NFB2

Expressioni

Gene expression databases

BgeeiENSG00000269556 Expressed in 183 organ(s), highest expression level in testis
CleanExiHS_TMEM185A
ExpressionAtlasiQ8NFB2 baseline and differential
GenevisibleiQ8NFB2 HS

Organism-specific databases

HPAiHPA048295
HPA071744

Interactioni

Subunit structurei

Interacts with MAP1B.1 Publication

Protein-protein interaction databases

BioGridi124133, 61 interactors
STRINGi9606.ENSP00000359449

Structurei

3D structure databases

ProteinModelPortaliQ8NFB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni298 – 350Mediates interaction with MAP1B1 PublicationAdd BLAST53

Sequence similaritiesi

Belongs to the TMEM185 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3879 Eukaryota
ENOG410XURH LUCA
HOGENOMiHOG000231372
HOVERGENiHBG051528
InParanoidiQ8NFB2
OrthoDBiEOG091G0CR4
PhylomeDBiQ8NFB2
TreeFamiTF313829

Family and domain databases

InterProiView protein in InterPro
IPR019396 TM_Fragile-X-F-assoc
PANTHERiPTHR13568 PTHR13568, 1 hit
PfamiView protein in Pfam
PF10269 Tmemb_185A, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q8NFB2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLRGLFQDF NPSKFLIYAC LLLFSVLLAL RLDGIIQWSY WAVFAPIWLW
60 70 80 90 100
KLMVIVGASV GTGVWARNPQ YRAEGETCVE FKAMLIAVGI HLLLLMFEVL
110 120 130 140 150
VCDRIERGSH FWLLVFMPLF FVSPVSVAAC VWGFRHDRSL ELEILCSVNI
160 170 180 190 200
LQFIFIALRL DKIIHWPWLV VCVPLWILMS FLCLVVLYYI VWSVLFLRSM
210 220 230 240 250
DVIAEQRRTH ITMALSWMTI VVPLLTFEIL LVHKLDGHNA FSSIPIFVPL
260 270 280 290 300
WLSLITLMAT TFGQKGGNHW WFGIRKDFCQ FLLEIFPFLR EYGNISYDLH
310 320 330 340 350
HEDNEETEET PVPEPPKIAP MFRKKARVVI TQSPGKYVLP PPKLNIEMPD
Length:350
Mass (Da):40,631
Last modified:October 16, 2013 - v2
Checksum:i43F737AF9EC6276F
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B3KY49B3KY49_HUMAN
Family with sequence similarity 11,...
TMEM185A FAM11A, hCG_1999996
172Annotation score:
B7Z4G6B7Z4G6_HUMAN
Transmembrane protein 185A
TMEM185A
291Annotation score:
E7EMM1E7EMM1_HUMAN
Transmembrane protein 185A
TMEM185A
173Annotation score:
E5RGV1E5RGV1_HUMAN
Transmembrane protein 185A
TMEM185A
60Annotation score:
H0YAP3H0YAP3_HUMAN
Transmembrane protein 185A
TMEM185A
223Annotation score:
E5RFI9E5RFI9_HUMAN
Transmembrane protein 185A
TMEM185A
79Annotation score:
H0YBJ6H0YBJ6_HUMAN
Transmembrane protein 185A
TMEM185A
60Annotation score:
A0A087X081A0A087X081_HUMAN
Transmembrane protein 185A
TMEM185A
45Annotation score:

Sequence cautioni

The sequence AAH13793 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033922179M → V. Corresponds to variant dbSNP:rs396058Ensembl.1
Natural variantiVAR_033923243S → C5 PublicationsCorresponds to variant dbSNP:rs609828Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF530473 mRNA Translation: AAM94598.1
AK096308 mRNA Translation: BAG53255.1
AK097391 mRNA Translation: BAC05031.1
AC231844 Genomic DNA No translation available.
AC233288 Genomic DNA No translation available.
CH471169 Genomic DNA Translation: EAW99368.1
BC013793 mRNA Translation: AAH13793.1 Different initiation.
BC103821 mRNA Translation: AAI03822.1
BC103822 mRNA Translation: AAI03823.1
AF353675 mRNA Translation: AAK39521.1
CCDSiCCDS14689.1
RefSeqiNP_001167563.1, NM_001174092.2
NP_001269231.1, NM_001282302.1
NP_115897.1, NM_032508.3
UniGeneiHs.522172

Genome annotation databases

EnsembliENST00000600449; ENSP00000471932; ENSG00000269556
GeneIDi84548
KEGGihsa:84548
UCSCiuc033ezr.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF530473 mRNA Translation: AAM94598.1
AK096308 mRNA Translation: BAG53255.1
AK097391 mRNA Translation: BAC05031.1
AC231844 Genomic DNA No translation available.
AC233288 Genomic DNA No translation available.
CH471169 Genomic DNA Translation: EAW99368.1
BC013793 mRNA Translation: AAH13793.1 Different initiation.
BC103821 mRNA Translation: AAI03822.1
BC103822 mRNA Translation: AAI03823.1
AF353675 mRNA Translation: AAK39521.1
CCDSiCCDS14689.1
RefSeqiNP_001167563.1, NM_001174092.2
NP_001269231.1, NM_001282302.1
NP_115897.1, NM_032508.3
UniGeneiHs.522172

3D structure databases

ProteinModelPortaliQ8NFB2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124133, 61 interactors
STRINGi9606.ENSP00000359449

PTM databases

iPTMnetiQ8NFB2
PhosphoSitePlusiQ8NFB2

Polymorphism and mutation databases

BioMutaiTMEM185A
DMDMi550544296

Proteomic databases

MaxQBiQ8NFB2
PaxDbiQ8NFB2
PeptideAtlasiQ8NFB2
PRIDEiQ8NFB2
ProteomicsDBi73285

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000600449; ENSP00000471932; ENSG00000269556
GeneIDi84548
KEGGihsa:84548
UCSCiuc033ezr.1 human

Organism-specific databases

CTDi84548
DisGeNETi84548
EuPathDBiHostDB:ENSG00000269556.7
GeneCardsiTMEM185A
H-InvDBiHIX0176539
HGNCiHGNC:17125 TMEM185A
HPAiHPA048295
HPA071744
MalaCardsiTMEM185A
MIMi300031 gene
neXtProtiNX_Q8NFB2
Orphaneti100974 FRAXF syndrome
PharmGKBiPA27062
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3879 Eukaryota
ENOG410XURH LUCA
HOGENOMiHOG000231372
HOVERGENiHBG051528
InParanoidiQ8NFB2
OrthoDBiEOG091G0CR4
PhylomeDBiQ8NFB2
TreeFamiTF313829

Miscellaneous databases

ChiTaRSiTMEM185A human
GenomeRNAii84548
PROiPR:Q8NFB2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000269556 Expressed in 183 organ(s), highest expression level in testis
CleanExiHS_TMEM185A
ExpressionAtlasiQ8NFB2 baseline and differential
GenevisibleiQ8NFB2 HS

Family and domain databases

InterProiView protein in InterPro
IPR019396 TM_Fragile-X-F-assoc
PANTHERiPTHR13568 PTHR13568, 1 hit
PfamiView protein in Pfam
PF10269 Tmemb_185A, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT185A_HUMAN
AccessioniPrimary (citable) accession number: Q8NFB2
Secondary accession number(s): B3KTZ3
, Q3SYH1, Q96CW3, Q96KE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 16, 2013
Last modified: October 10, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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