UniProtKB - Q8NFB2 (T185A_HUMAN)

BLAST

>sp|Q8NFB2|T185A_HUMAN Transmembrane protein 185A OS=Homo sapiens OX=9606 GN=TMEM185A PE=1 SV=2
MNLRGLFQDFNPSKFLIYACLLLFSVLLALRLDGIIQWSYWAVFAPIWLWKLMVIVGASV
GTGVWARNPQYRAEGETCVEFKAMLIAVGIHLLLLMFEVLVCDRIERGSHFWLLVFMPLF
FVSPVSVAACVWGFRHDRSLELEILCSVNILQFIFIALRLDKIIHWPWLVVCVPLWILMS
FLCLVVLYYIVWSVLFLRSMDVIAEQRRTHITMALSWMTIVVPLLTFEILLVHKLDGHNA
FSSIPIFVPLWLSLITLMATTFGQKGGNHWWFGIRKDFCQFLLEIFPFLREYGNISYDLH
HEDNEETEETPVPEPPKIAPMFRKKARVVITQSPGKYVLPPPKLNIEMPD

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Entry version 112 (10 Oct 2018)
Sequence version 2 (16 Oct 2013)
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Protein

Transmembrane protein 185A

Gene

TMEM185A

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transmembrane protein 185A Alternative name(s): Protein FAM11A
Gene namesⁱ	Name:TMEM185A Synonyms:CXorf13, FAM11A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000269556.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17125 TMEM185A
MIMⁱ	300031 gene
neXtProtⁱ	NX_Q8NFB2

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	16 – 36	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	41 – 61	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	81 – 101	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	111 – 131	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	177 – 197	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	211 – 231	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	240 – 260	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Cell projection, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	84548
MalaCards human disease database More...MalaCardsⁱ	TMEM185A
Orphanetⁱ	100974 FRAXF syndrome
PharmGKBⁱ	PA27062

Polymorphism and mutation databases

BioMutaⁱ	TMEM185A
DMDMⁱ	550544296

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000188007	1 – 350	Transmembrane protein 185AAdd BLAST		350

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8NFB2
PaxDbⁱ	Q8NFB2
PeptideAtlas More...PeptideAtlasⁱ	Q8NFB2
PRIDEⁱ	Q8NFB2
ProteomicsDBⁱ	73285

PTM databases

iPTMnetⁱ	Q8NFB2
PhosphoSitePlusⁱ	Q8NFB2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000269556 Expressed in 183 organ(s), highest expression level in testis
CleanExⁱ	HS_TMEM185A
ExpressionAtlasⁱ	Q8NFB2 baseline and differential
Genevisibleⁱ	Q8NFB2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA048295 HPA071744

HPAⁱ

HPA048295
HPA071744

Interactionⁱ

Subunit structureⁱ

Interacts with MAP1B.1 Publication

Protein-protein interaction databases

BioGridⁱ	124133, 61 interactors
STRINGⁱ	9606.ENSP00000359449

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NFB2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	298 – 350	Mediates interaction with MAP1B1 PublicationAdd BLAST		53

Sequence similaritiesⁱ

Belongs to the TMEM185 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3879 Eukaryota ENOG410XURH LUCA
HOGENOMⁱ	HOG000231372
HOVERGENⁱ	HBG051528
InParanoidⁱ	Q8NFB2
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CR4
PhylomeDBⁱ	Q8NFB2
TreeFamⁱ	TF313829

Family and domain databases

InterProⁱ	View protein in InterPro IPR019396 TM_Fragile-X-F-assoc
PANTHERⁱ	PTHR13568 PTHR13568, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10269 Tmemb_185A, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show all Align All

Q8NFB2-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MNLRGLFQDF NPSKFLIYAC LLLFSVLLAL RLDGIIQWSY WAVFAPIWLW 
        60         70         80         90        100
KLMVIVGASV GTGVWARNPQ YRAEGETCVE FKAMLIAVGI HLLLLMFEVL 
       110        120        130        140        150
VCDRIERGSH FWLLVFMPLF FVSPVSVAAC VWGFRHDRSL ELEILCSVNI 
       160        170        180        190        200
LQFIFIALRL DKIIHWPWLV VCVPLWILMS FLCLVVLYYI VWSVLFLRSM 
       210        220        230        240        250
DVIAEQRRTH ITMALSWMTI VVPLLTFEIL LVHKLDGHNA FSSIPIFVPL 
       260        270        280        290        300
WLSLITLMAT TFGQKGGNHW WFGIRKDFCQ FLLEIFPFLR EYGNISYDLH 
       310        320        330        340        350
HEDNEETEET PVPEPPKIAP MFRKKARVVI TQSPGKYVLP PPKLNIEMPD

Length:350

Mass (Da):40,631

Last modified:October 16, 2013 - v2

Checksum:ⁱ43F737AF9EC6276F

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B3KY49	B3KY49_HUMAN	Family with sequence similarity 11,... Family with sequence similarity 11, member A, isoform CRA_a (Transmembrane protein 185A) (cDNA FLJ46855 fis, clone UTERU3010029, highly similar to Protein FAM11A)	TMEM185A FAM11A, hCG_1999996	172	Annotation score:
B7Z4G6	B7Z4G6_HUMAN	Transmembrane protein 185A Transmembrane protein 185A (cDNA FLJ52946, highly similar to Protein FAM11A)	TMEM185A	291	Annotation score:
E7EMM1	E7EMM1_HUMAN	Transmembrane protein 185A Transmembrane protein 185A	TMEM185A	173	Annotation score:
E5RGV1	E5RGV1_HUMAN	Transmembrane protein 185A Transmembrane protein 185A	TMEM185A	60	Annotation score:
H0YAP3	H0YAP3_HUMAN	Transmembrane protein 185A Transmembrane protein 185A	TMEM185A	223	Annotation score:
E5RFI9	E5RFI9_HUMAN	Transmembrane protein 185A Transmembrane protein 185A	TMEM185A	79	Annotation score:
H0YBJ6	H0YBJ6_HUMAN	Transmembrane protein 185A Transmembrane protein 185A	TMEM185A	60	Annotation score:
A0A087X081	A0A087X081_HUMAN	Transmembrane protein 185A Transmembrane protein 185A	TMEM185A	45	Annotation score:

Sequence cautionⁱ

The sequence AAH13793 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_033922	179	M → V. Corresponds to variant dbSNP:rs396058Ensembl.		1
Natural variantⁱVAR_033923	243	S → C5 PublicationsCorresponds to variant dbSNP:rs609828Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF530473 mRNA Translation: AAM94598.1 AK096308 mRNA Translation: BAG53255.1 AK097391 mRNA Translation: BAC05031.1 AC231844 Genomic DNA No translation available. AC233288 Genomic DNA No translation available. CH471169 Genomic DNA Translation: EAW99368.1 BC013793 mRNA Translation: AAH13793.1 Different initiation. BC103821 mRNA Translation: AAI03822.1 BC103822 mRNA Translation: AAI03823.1 AF353675 mRNA Translation: AAK39521.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14689.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001167563.1, NM_001174092.2 NP_001269231.1, NM_001282302.1 NP_115897.1, NM_032508.3
UniGeneⁱ	Hs.522172

Genome annotation databases

Ensemblⁱ	ENST00000600449; ENSP00000471932; ENSG00000269556
GeneIDⁱ	84548
KEGGⁱ	hsa:84548
UCSC genome browser More...UCSCⁱ	uc033ezr.1 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8NFB2	Transmembrane protein 185A		PONAB		350	UniRef90_Q8NFB2
Transmembrane protein 185A		MOUSE		350
Transmembrane protein 185A (Fragment)		MUSPF		353
Uncharacterized protein		COLVI		353
Uncharacterized protein		BAMTH		151
+155

Protein	Similar proteins		Species	Score	Length	Source
Q8NFB2	Transmembrane protein 185A		MOUSE		350	UniRef50_Q8NFB2
Transmembrane protein 185A		PONAB		350
Transmembrane protein 185B		BOVIN		350
Transmembrane protein 185B		HUMAN		350
Transmembrane protein 185A (Fragment)		MUSPF		353
+315

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF530473 mRNA Translation: AAM94598.1 AK096308 mRNA Translation: BAG53255.1 AK097391 mRNA Translation: BAC05031.1 AC231844 Genomic DNA No translation available. AC233288 Genomic DNA No translation available. CH471169 Genomic DNA Translation: EAW99368.1 BC013793 mRNA Translation: AAH13793.1 Different initiation. BC103821 mRNA Translation: AAI03822.1 BC103822 mRNA Translation: AAI03823.1 AF353675 mRNA Translation: AAK39521.1
CCDSⁱ	CCDS14689.1
RefSeqⁱ	NP_001167563.1, NM_001174092.2 NP_001269231.1, NM_001282302.1 NP_115897.1, NM_032508.3
UniGeneⁱ	Hs.522172

3D structure databases

ProteinModelPortalⁱ	Q8NFB2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124133, 61 interactors
STRINGⁱ	9606.ENSP00000359449

PTM databases

iPTMnetⁱ	Q8NFB2
PhosphoSitePlusⁱ	Q8NFB2

Polymorphism and mutation databases

BioMutaⁱ	TMEM185A
DMDMⁱ	550544296

Proteomic databases

MaxQBⁱ	Q8NFB2
PaxDbⁱ	Q8NFB2
PeptideAtlasⁱ	Q8NFB2
PRIDEⁱ	Q8NFB2
ProteomicsDBⁱ	73285

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000600449; ENSP00000471932; ENSG00000269556
GeneIDⁱ	84548
KEGGⁱ	hsa:84548
UCSCⁱ	uc033ezr.1 human

Organism-specific databases

CTDⁱ	84548
DisGeNETⁱ	84548
EuPathDBⁱ	HostDB:ENSG00000269556.7
GeneCardsⁱ	TMEM185A
H-InvDBⁱ	HIX0176539
HGNCⁱ	HGNC:17125 TMEM185A
HPAⁱ	HPA048295 HPA071744
MalaCardsⁱ	TMEM185A
MIMⁱ	300031 gene
neXtProtⁱ	NX_Q8NFB2
Orphanetⁱ	100974 FRAXF syndrome
PharmGKBⁱ	PA27062
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3879 Eukaryota ENOG410XURH LUCA
HOGENOMⁱ	HOG000231372
HOVERGENⁱ	HBG051528
InParanoidⁱ	Q8NFB2
OrthoDBⁱ	EOG091G0CR4
PhylomeDBⁱ	Q8NFB2
TreeFamⁱ	TF313829

Miscellaneous databases

ChiTaRSⁱ	TMEM185A human
GenomeRNAiⁱ	84548
Protein Ontology More...PROⁱ	PR:Q8NFB2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000269556 Expressed in 183 organ(s), highest expression level in testis
CleanExⁱ	HS_TMEM185A
ExpressionAtlasⁱ	Q8NFB2 baseline and differential
Genevisibleⁱ	Q8NFB2 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR019396 TM_Fragile-X-F-assoc
PANTHERⁱ	PTHR13568 PTHR13568, 1 hit
Pfamⁱ	View protein in Pfam PF10269 Tmemb_185A, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	T185A_HUMAN
Accessionⁱ	Q8NFB2Primary (citable) accession number: Q8NFB2 Secondary accession number(s): B3KTZ3 , Q3SYH1, Q96CW3, Q96KE8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
	Last sequence update:	October 16, 2013
	Last modified:	October 10, 2018
	This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8NFB2 (T185A_HUMAN)

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Transmembrane protein 185A

TMEM185A

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ