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Protein

Zinc finger protein 397

Gene

ZNF397

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Isoform 3 acts as a DNA-dependent transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri285 – 307C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: UniProtKB

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 397
Alternative name(s):
Zinc finger and SCAN domain-containing protein 15
Zinc finger protein 47
Gene namesi
Name:ZNF397
Synonyms:ZNF47, ZSCAN15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000186812.12
HGNCiHGNC:18818 ZNF397
MIMi609601 gene
neXtProtiNX_Q8NF99

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186812
PharmGKBiPA38694

Polymorphism and mutation databases

BioMutaiZNF397
DMDMi38258943

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475641 – 534Zinc finger protein 397Add BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineCombined sources1
Cross-linki55Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki171Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki202Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki251Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8NF99
MaxQBiQ8NF99
PaxDbiQ8NF99
PeptideAtlasiQ8NF99
PRIDEiQ8NF99
ProteomicsDBi73277
73278 [Q8NF99-2]
73279 [Q8NF99-3]

PTM databases

iPTMnetiQ8NF99
PhosphoSitePlusiQ8NF99

Expressioni

Tissue specificityi

Expressed strongly in testis, moderately in skeletal muscle, pancreas and prostate, and weakly in heart, placenta, liver, kidney, spleen, thymus and small intestine.1 Publication

Gene expression databases

BgeeiENSG00000186812 Expressed in 195 organ(s), highest expression level in corpus callosum
CleanExiHS_ZNF397
ExpressionAtlasiQ8NF99 baseline and differential
GenevisibleiQ8NF99 HS

Organism-specific databases

HPAiHPA026087

Interactioni

Subunit structurei

Isoforms 1 and 3 can both homo- and hetero-associate. Homo-association of isoform 1 is dependent on the presence of the SCAN domain.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124033, 40 interactors
IntActiQ8NF99, 9 interactors
STRINGi9606.ENSP00000331577

Structurei

3D structure databases

ProteinModelPortaliQ8NF99
SMRiQ8NF99
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 132SCAN boxPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri285 – 307C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118881
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ8NF99
KOiK09230
OMAiVIFTHKS
OrthoDBiEOG091G02KC
PhylomeDBiQ8NF99
TreeFamiTF338304

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NF99-1) [UniParc]FASTAAdd to basket
Also known as: ZNF397-fu

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVESGVIST LIPQDPPEQE LILVKVEDNF SWDEKFKQNG STQSCQELFR
60 70 80 90 100
QQFRKFCYQE TPGPREALSR LQELCYQWLM PELHTKEQIL ELLVLEQFLS
110 120 130 140 150
ILPEELQIWV QQHNPESGEE AVTLLEDLER EFDDPGQQVP ASPQGPAVPW
160 170 180 190 200
KDLTCLRASQ ESTDIHLQPL KTQLKSWKPC LSPKSDCENS ETATKEGISE
210 220 230 240 250
EKSQGLPQEP SFRGISEHES NLVWKQGSAT GEKLRSPSQG GSFSQVIFTN
260 270 280 290 300
KSLGKRDLYD EAERCLILTT DSIMCQKVPP EERPYRCDVC GHSFKQHSSL
310 320 330 340 350
TQHQRIHTGE KPYKCNQCGK AFSLRSYLII HQRIHSGEKA YECSECGKAF
360 370 380 390 400
NQSSALIRHR KIHTGEKACK CNECGKAFSQ SSYLIIHQRI HTGEKPYECN
410 420 430 440 450
ECGKTFSQSS KLIRHQRIHT GERPYECNEC GKAFRQSSEL ITHQRIHSGE
460 470 480 490 500
KPYECSECGK AFSLSSNLIR HQRIHSGEEP YQCNECGKTF KRSSALVQHQ
510 520 530
RIHSGDEAYI CNECGKAFRH RSVLMRHQRV HTIK
Length:534
Mass (Da):61,139
Last modified:October 31, 2003 - v2
Checksum:iE990609DABABDE2A
GO
Isoform 2 (identifier: Q8NF99-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-275: SEHESNLVWK...LILTTDSIMC → KLSRPPKASS...SKNVNRKYFS
     276-534: Missing.

Note: No experimental confirmation available.
Show »
Length:275
Mass (Da):31,052
Checksum:iB745896D4FDD142E
GO
Isoform 3 (identifier: Q8NF99-3) [UniParc]FASTAAdd to basket
Also known as: Truncated, ZNF397-nf

The sequence of this isoform differs from the canonical sequence as follows:
     186-207: DCENSETATKEGISEEKSQGLP → GEEWEIIWKLLTLRPLFLRMQN
     208-534: Missing.

Show »
Length:207
Mass (Da):24,141
Checksum:iBC397F169EF9962E
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96K65Q96K65_HUMAN
Zinc finger protein 397, isoform CR...
ZNF397 hCG_1811252
245Annotation score:
K7ERU5K7ERU5_HUMAN
Zinc finger protein 397
ZNF397
188Annotation score:
M0R288M0R288_HUMAN
Zinc finger protein 397
ZNF397
138Annotation score:
K7EIM5K7EIM5_HUMAN
Zinc finger protein 397
ZNF397
201Annotation score:

Sequence cautioni

Isoform 3 : The sequence AAN65175 differs from that shown. Reason: Frameshift at position 194.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042491186 – 207DCENS…SQGLP → GEEWEIIWKLLTLRPLFLRM QN in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_042492208 – 534Missing in isoform 3. 1 PublicationAdd BLAST327
Alternative sequenceiVSP_006924216 – 275SEHES…DSIMC → KLSRPPKASSAIRWECVSPG SFPGDIIAAEATHSTISCFA INTLPATILPSKNVNRKYFS in isoform 2. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_006925276 – 534Missing in isoform 2. 1 PublicationAdd BLAST259

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF533250 mRNA Translation: AAM95991.2
AY157641 mRNA Translation: AAN65175.1 Frameshift.
BC006172 mRNA Translation: AAH06172.1
CCDSiCCDS32814.1 [Q8NF99-2]
CCDS45852.1 [Q8NF99-1]
RefSeqiNP_001128650.1, NM_001135178.2 [Q8NF99-1]
NP_115723.1, NM_032347.2 [Q8NF99-2]
XP_011524533.1, XM_011526231.2 [Q8NF99-1]
XP_016881531.1, XM_017026042.1 [Q8NF99-1]
UniGeneiHs.591061

Genome annotation databases

EnsembliENST00000261333; ENSP00000261333; ENSG00000186812 [Q8NF99-2]
ENST00000330501; ENSP00000331577; ENSG00000186812 [Q8NF99-1]
ENST00000585800; ENSP00000466760; ENSG00000186812 [Q8NF99-3]
ENST00000591206; ENSP00000466317; ENSG00000186812 [Q8NF99-3]
GeneIDi84307
KEGGihsa:84307
UCSCiuc002kyi.4 human [Q8NF99-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF533250 mRNA Translation: AAM95991.2
AY157641 mRNA Translation: AAN65175.1 Frameshift.
BC006172 mRNA Translation: AAH06172.1
CCDSiCCDS32814.1 [Q8NF99-2]
CCDS45852.1 [Q8NF99-1]
RefSeqiNP_001128650.1, NM_001135178.2 [Q8NF99-1]
NP_115723.1, NM_032347.2 [Q8NF99-2]
XP_011524533.1, XM_011526231.2 [Q8NF99-1]
XP_016881531.1, XM_017026042.1 [Q8NF99-1]
UniGeneiHs.591061

3D structure databases

ProteinModelPortaliQ8NF99
SMRiQ8NF99
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124033, 40 interactors
IntActiQ8NF99, 9 interactors
STRINGi9606.ENSP00000331577

PTM databases

iPTMnetiQ8NF99
PhosphoSitePlusiQ8NF99

Polymorphism and mutation databases

BioMutaiZNF397
DMDMi38258943

Proteomic databases

EPDiQ8NF99
MaxQBiQ8NF99
PaxDbiQ8NF99
PeptideAtlasiQ8NF99
PRIDEiQ8NF99
ProteomicsDBi73277
73278 [Q8NF99-2]
73279 [Q8NF99-3]

Protocols and materials databases

DNASUi84307
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261333; ENSP00000261333; ENSG00000186812 [Q8NF99-2]
ENST00000330501; ENSP00000331577; ENSG00000186812 [Q8NF99-1]
ENST00000585800; ENSP00000466760; ENSG00000186812 [Q8NF99-3]
ENST00000591206; ENSP00000466317; ENSG00000186812 [Q8NF99-3]
GeneIDi84307
KEGGihsa:84307
UCSCiuc002kyi.4 human [Q8NF99-1]

Organism-specific databases

CTDi84307
EuPathDBiHostDB:ENSG00000186812.12
GeneCardsiZNF397
HGNCiHGNC:18818 ZNF397
HPAiHPA026087
MIMi609601 gene
neXtProtiNX_Q8NF99
OpenTargetsiENSG00000186812
PharmGKBiPA38694
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118881
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ8NF99
KOiK09230
OMAiVIFTHKS
OrthoDBiEOG091G02KC
PhylomeDBiQ8NF99
TreeFamiTF338304

Miscellaneous databases

ChiTaRSiZNF397 human
GenomeRNAii84307
PROiPR:Q8NF99
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186812 Expressed in 195 organ(s), highest expression level in corpus callosum
CleanExiHS_ZNF397
ExpressionAtlasiQ8NF99 baseline and differential
GenevisibleiQ8NF99 HS

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN397_HUMAN
AccessioniPrimary (citable) accession number: Q8NF99
Secondary accession number(s): Q9BRM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: October 31, 2003
Last modified: November 7, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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