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Entry version 145 (08 May 2019)
Sequence version 2 (07 Dec 2004)
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Protein

Zinc finger MIZ domain-containing protein 2

Gene

ZMIZ2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri585 – 662SP-RING-typePROSITE-ProRule annotationAdd BLAST78

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger MIZ domain-containing protein 2
Alternative name(s):
PIAS-like protein Zimp7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZMIZ2
Synonyms:KIAA1886, ZIMP7
ORF Names:HRIHFB2007
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22229 ZMIZ2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611196 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NF64

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
83637

Open Targets

More...
OpenTargetsi
ENSG00000122515

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162409851

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZMIZ2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
56404909

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002189891 – 920Zinc finger MIZ domain-containing protein 2Add BLAST920

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei111Omega-N-methylarginineBy similarity1
Modified residuei245Asymmetric dimethylarginineCombined sources1
Modified residuei262Asymmetric dimethylarginineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki402Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki457Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki692Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8NF64

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NF64

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NF64

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NF64

PeptideAtlas

More...
PeptideAtlasi
Q8NF64

PRoteomics IDEntifications database

More...
PRIDEi
Q8NF64

ProteomicsDB human proteome resource

More...
ProteomicsDBi
73263
73264 [Q8NF64-2]
73265 [Q8NF64-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NF64

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NF64

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed most abundantly in testis with lower levels in heart, brain, pancreas, prostate and ovary.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000122515 Expressed in 217 organ(s), highest expression level in left lobe of thyroid gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8NF64 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NF64 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040716

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AR, SMARCA4/BRG1 and SMARCE1/BAF57. Interaction with either SMARCA4 and SMARCE1 enhances AR-mediated transcription.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123701, 28 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NF64, 22 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000311778

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8NF64

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni435 – 506Interaction with AR1 PublicationAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi47 – 132Gly-richAdd BLAST86
Compositional biasi147 – 170Ala-richAdd BLAST24
Compositional biasi201 – 403Pro-richAdd BLAST203
Compositional biasi725 – 906Pro-richAdd BLAST182

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri585 – 662SP-RING-typePROSITE-ProRule annotationAdd BLAST78

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2169 Eukaryota
ENOG410XQ2E LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182717

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NF64

KEGG Orthology (KO)

More...
KOi
K22403

Database of Orthologous Groups

More...
OrthoDBi
273193at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NF64

TreeFam database of animal gene trees

More...
TreeFami
TF316952

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004181 Znf_MIZ
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02891 zf-MIZ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51044 ZF_SP_RING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NF64-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSMNPMKPA LPPAPHGDGS FAYESVPWQQ SATQPAGSLS VVTTVWGVGN
60 70 80 90 100
ATQSQVLGNP MGPAGSPSGS SMMPGVAGGS SALTSPQCLG QQAFAEGGAN
110 120 130 140 150
KGYVQQGVYS RGGYPGAPGF TTGYAGGPGG LGLPSHAARP STDFTQAAAA
160 170 180 190 200
AAVAAAAATA TATATATVAA LQEKQSQELS QYGAMGAGQS FNSQFLQHGG
210 220 230 240 250
PRGPSVPAGM NPTGIGGVMG PSGLSPLAMN PTRAAGMTPL YAGQRLPQHG
260 270 280 290 300
YPGPPQAQPL PRQGVKRTYS EVYPGQQYLQ GGQYAPSTAQ FAPSPGQPPA
310 320 330 340 350
PSPSYPGHRL PLQQGMTQSL SVPGPTGLHY KPTEQFNGQG ASFNGGSVSY
360 370 380 390 400
SQPGLSGPTR SIPGYPSSPL PGNPTPPMTP SSSVPYMSPN QEVKSPFLPD
410 420 430 440 450
LKPNLNSLHS SPSGSGPCDE LRLTFPVRDG VVLEPFRLQH NLAVSNHVFQ
460 470 480 490 500
LRDSVYKTLI MRPDLELQFK CYHHEDRQMN TNWPASVQVS VNATPLTIER
510 520 530 540 550
GDNKTSHKPL YLKHVCQPGR NTIQITVTAC CCSHLFVLQL VHRPSVRSVL
560 570 580 590 600
QGLLKKRLLP AEHCITKIKR NFSSGTIPGT PGPNGEDGVE QTAIKVSLKC
610 620 630 640 650
PITFRRIQLP ARGHDCRHIQ CFDLESYLQL NCERGTWRCP VCNKTALLEG
660 670 680 690 700
LEVDQYMLGI LIYIQNSDYE EITIDPTCSW KPVPVKPDMH IKEEPDGPAL
710 720 730 740 750
KRCRTVSPAH VLMPSVMEMI AALGPGAAPF APLQPPSVPA PSDYPGQGSS
760 770 780 790 800
FLGPGTFPES FPPTTPSTPT LAEFTPGPPP ISYQSDIPSS LLTSEKSTAC
810 820 830 840 850
LPSQMAPAGH LDPTHNPGTP GLHTSNLGAP PGPQLHHSNP PPASRQSLGQ
860 870 880 890 900
ASLGPTGELA FSPATGVMGP PSMSGAGEAP EPALDLLPEL TNPDELLSYL
910 920
GPPDLPTNNN DDLLSLFENN
Length:920
Mass (Da):96,537
Last modified:December 7, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC9CE99D0B0798B9F
GO
Isoform 2 (identifier: Q8NF64-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     334-359: Missing.

Show »
Length:894
Mass (Da):93,981
Checksum:i3E9DFD0FD14F5CAE
GO
Isoform 3 (identifier: Q8NF64-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-87: Missing.
     334-359: Missing.

Note: No experimental confirmation available.
Show »
Length:862
Mass (Da):91,112
Checksum:i274013C6083F6D2F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EWM3E7EWM3_HUMAN
Zinc finger MIZ domain-containing p...
ZMIZ2
888Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X127A0A087X127_HUMAN
Zinc finger MIZ domain-containing p...
ZMIZ2
923Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDA5C9JDA5_HUMAN
Zinc finger MIZ domain-containing p...
ZMIZ2
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WC48F8WC48_HUMAN
Zinc finger MIZ domain-containing p...
ZMIZ2
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH21924 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC03396 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB66507 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti127Missing in AAR85526 (PubMed:16051670).Curated1
Sequence conflicti462R → RR in CAH56269 (PubMed:11230166).Curated1
Sequence conflicti568Missing (PubMed:16051670).Curated1
Sequence conflicti765T → M (PubMed:16051670).Curated1
Sequence conflicti765T → M (PubMed:15489334).Curated1
Sequence conflicti765T → M in CAB66507 (PubMed:11230166).Curated1
Sequence conflicti782S → C (PubMed:9853615).Curated1
Sequence conflicti799A → V (PubMed:9853615).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050536408L → F1 PublicationCorresponds to variant dbSNP:rs3735478Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02491856 – 87Missing in isoform 3. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_012190334 – 359Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY426594 mRNA Translation: AAR85526.1
AK090415 mRNA Translation: BAC03396.1 Different initiation.
AC004859 Genomic DNA No translation available.
AC013436 Genomic DNA Translation: AAP22368.1 Sequence problems.
CH236960 Genomic DNA Translation: EAL23750.1
CH471128 Genomic DNA Translation: EAW61083.1
CH471128 Genomic DNA Translation: EAW61084.1
CH471128 Genomic DNA Translation: EAW61085.1
BC021924 mRNA Translation: AAH21924.1 Different initiation.
BC110435 mRNA Translation: AAI10436.1
AB067473 mRNA Translation: BAB67779.1
AL831933 mRNA Translation: CAH56269.1
AL136572 mRNA Translation: CAB66507.1 Different initiation.
AB015330 mRNA Translation: BAA34789.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43576.1 [Q8NF64-1]
CCDS43577.1 [Q8NF64-2]
CCDS75591.1 [Q8NF64-3]

NCBI Reference Sequences

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RefSeqi
NP_001287888.1, NM_001300959.1 [Q8NF64-3]
NP_113637.3, NM_031449.3 [Q8NF64-1]
NP_777589.2, NM_174929.2 [Q8NF64-2]
XP_005249926.1, XM_005249869.2 [Q8NF64-1]
XP_005249929.1, XM_005249872.2 [Q8NF64-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000265346; ENSP00000265346; ENSG00000122515 [Q8NF64-2]
ENST00000309315; ENSP00000311778; ENSG00000122515 [Q8NF64-1]
ENST00000413916; ENSP00000409648; ENSG00000122515 [Q8NF64-3]
ENST00000441627; ENSP00000414723; ENSG00000122515 [Q8NF64-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
83637

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:83637

UCSC genome browser

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UCSCi
uc003tlq.4 human [Q8NF64-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY426594 mRNA Translation: AAR85526.1
AK090415 mRNA Translation: BAC03396.1 Different initiation.
AC004859 Genomic DNA No translation available.
AC013436 Genomic DNA Translation: AAP22368.1 Sequence problems.
CH236960 Genomic DNA Translation: EAL23750.1
CH471128 Genomic DNA Translation: EAW61083.1
CH471128 Genomic DNA Translation: EAW61084.1
CH471128 Genomic DNA Translation: EAW61085.1
BC021924 mRNA Translation: AAH21924.1 Different initiation.
BC110435 mRNA Translation: AAI10436.1
AB067473 mRNA Translation: BAB67779.1
AL831933 mRNA Translation: CAH56269.1
AL136572 mRNA Translation: CAB66507.1 Different initiation.
AB015330 mRNA Translation: BAA34789.1
CCDSiCCDS43576.1 [Q8NF64-1]
CCDS43577.1 [Q8NF64-2]
CCDS75591.1 [Q8NF64-3]
RefSeqiNP_001287888.1, NM_001300959.1 [Q8NF64-3]
NP_113637.3, NM_031449.3 [Q8NF64-1]
NP_777589.2, NM_174929.2 [Q8NF64-2]
XP_005249926.1, XM_005249869.2 [Q8NF64-1]
XP_005249929.1, XM_005249872.2 [Q8NF64-2]

3D structure databases

SMRiQ8NF64
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123701, 28 interactors
IntActiQ8NF64, 22 interactors
STRINGi9606.ENSP00000311778

PTM databases

iPTMnetiQ8NF64
PhosphoSitePlusiQ8NF64

Polymorphism and mutation databases

BioMutaiZMIZ2
DMDMi56404909

Proteomic databases

EPDiQ8NF64
jPOSTiQ8NF64
MaxQBiQ8NF64
PaxDbiQ8NF64
PeptideAtlasiQ8NF64
PRIDEiQ8NF64
ProteomicsDBi73263
73264 [Q8NF64-2]
73265 [Q8NF64-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265346; ENSP00000265346; ENSG00000122515 [Q8NF64-2]
ENST00000309315; ENSP00000311778; ENSG00000122515 [Q8NF64-1]
ENST00000413916; ENSP00000409648; ENSG00000122515 [Q8NF64-3]
ENST00000441627; ENSP00000414723; ENSG00000122515 [Q8NF64-1]
GeneIDi83637
KEGGihsa:83637
UCSCiuc003tlq.4 human [Q8NF64-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
83637
DisGeNETi83637

GeneCards: human genes, protein and diseases

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GeneCardsi
ZMIZ2

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0006652
HGNCiHGNC:22229 ZMIZ2
HPAiHPA040716
MIMi611196 gene
neXtProtiNX_Q8NF64
OpenTargetsiENSG00000122515
PharmGKBiPA162409851

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2169 Eukaryota
ENOG410XQ2E LUCA
GeneTreeiENSGT00950000182717
InParanoidiQ8NF64
KOiK22403
OrthoDBi273193at2759
PhylomeDBiQ8NF64
TreeFamiTF316952

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZMIZ2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ZMIZ2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
83637

Protein Ontology

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PROi
PR:Q8NF64

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000122515 Expressed in 217 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiQ8NF64 baseline and differential
GenevisibleiQ8NF64 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004181 Znf_MIZ
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF02891 zf-MIZ, 1 hit
PROSITEiView protein in PROSITE
PS51044 ZF_SP_RING, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZMIZ2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NF64
Secondary accession number(s): A4D2K7
, D3DVL1, O94790, Q0VGB4, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: May 8, 2019
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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