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Protein

Zinc finger MIZ domain-containing protein 2

Gene

ZMIZ2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri585 – 662SP-RING-typePROSITE-ProRule annotationAdd BLAST78

GO - Molecular functioni

  • nuclear receptor transcription coactivator activity Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MIZ domain-containing protein 2
Alternative name(s):
PIAS-like protein Zimp7
Gene namesi
Name:ZMIZ2
Synonyms:KIAA1886, ZIMP7
ORF Names:HRIHFB2007
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000122515.14
HGNCiHGNC:22229 ZMIZ2
MIMi611196 gene
neXtProtiNX_Q8NF64

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000122515
PharmGKBiPA162409851

Polymorphism and mutation databases

BioMutaiZMIZ2
DMDMi56404909

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002189891 – 920Zinc finger MIZ domain-containing protein 2Add BLAST920

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei111Omega-N-methylarginineBy similarity1
Modified residuei245Asymmetric dimethylarginineCombined sources1
Modified residuei262Asymmetric dimethylarginineCombined sources1
Cross-linki402Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki457Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki692Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

EPDiQ8NF64
MaxQBiQ8NF64
PaxDbiQ8NF64
PeptideAtlasiQ8NF64
PRIDEiQ8NF64
ProteomicsDBi73263
73264 [Q8NF64-2]
73265 [Q8NF64-3]

PTM databases

iPTMnetiQ8NF64
PhosphoSitePlusiQ8NF64

Expressioni

Tissue specificityi

Expressed most abundantly in testis with lower levels in heart, brain, pancreas, prostate and ovary.1 Publication

Gene expression databases

BgeeiENSG00000122515 Expressed in 217 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_ZMIZ2
ExpressionAtlasiQ8NF64 baseline and differential
GenevisibleiQ8NF64 HS

Organism-specific databases

HPAiHPA040716

Interactioni

Subunit structurei

Interacts with AR, SMARCA4/BRG1 and SMARCE1/BAF57. Interaction with either SMARCA4 and SMARCE1 enhances AR-mediated transcription.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi123701, 28 interactors
IntActiQ8NF64, 20 interactors
STRINGi9606.ENSP00000311778

Structurei

3D structure databases

ProteinModelPortaliQ8NF64
SMRiQ8NF64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni435 – 506Interaction with AR1 PublicationAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi47 – 132Gly-richAdd BLAST86
Compositional biasi147 – 170Ala-richAdd BLAST24
Compositional biasi201 – 403Pro-richAdd BLAST203
Compositional biasi725 – 906Pro-richAdd BLAST182

Domaini

The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri585 – 662SP-RING-typePROSITE-ProRule annotationAdd BLAST78

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2169 Eukaryota
ENOG410XQ2E LUCA
GeneTreeiENSGT00550000074410
HOVERGENiHBG056252
InParanoidiQ8NF64
KOiK22403
PhylomeDBiQ8NF64
TreeFamiTF316952

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004181 Znf_MIZ
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF02891 zf-MIZ, 1 hit
PROSITEiView protein in PROSITE
PS51044 ZF_SP_RING, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NF64-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSMNPMKPA LPPAPHGDGS FAYESVPWQQ SATQPAGSLS VVTTVWGVGN
60 70 80 90 100
ATQSQVLGNP MGPAGSPSGS SMMPGVAGGS SALTSPQCLG QQAFAEGGAN
110 120 130 140 150
KGYVQQGVYS RGGYPGAPGF TTGYAGGPGG LGLPSHAARP STDFTQAAAA
160 170 180 190 200
AAVAAAAATA TATATATVAA LQEKQSQELS QYGAMGAGQS FNSQFLQHGG
210 220 230 240 250
PRGPSVPAGM NPTGIGGVMG PSGLSPLAMN PTRAAGMTPL YAGQRLPQHG
260 270 280 290 300
YPGPPQAQPL PRQGVKRTYS EVYPGQQYLQ GGQYAPSTAQ FAPSPGQPPA
310 320 330 340 350
PSPSYPGHRL PLQQGMTQSL SVPGPTGLHY KPTEQFNGQG ASFNGGSVSY
360 370 380 390 400
SQPGLSGPTR SIPGYPSSPL PGNPTPPMTP SSSVPYMSPN QEVKSPFLPD
410 420 430 440 450
LKPNLNSLHS SPSGSGPCDE LRLTFPVRDG VVLEPFRLQH NLAVSNHVFQ
460 470 480 490 500
LRDSVYKTLI MRPDLELQFK CYHHEDRQMN TNWPASVQVS VNATPLTIER
510 520 530 540 550
GDNKTSHKPL YLKHVCQPGR NTIQITVTAC CCSHLFVLQL VHRPSVRSVL
560 570 580 590 600
QGLLKKRLLP AEHCITKIKR NFSSGTIPGT PGPNGEDGVE QTAIKVSLKC
610 620 630 640 650
PITFRRIQLP ARGHDCRHIQ CFDLESYLQL NCERGTWRCP VCNKTALLEG
660 670 680 690 700
LEVDQYMLGI LIYIQNSDYE EITIDPTCSW KPVPVKPDMH IKEEPDGPAL
710 720 730 740 750
KRCRTVSPAH VLMPSVMEMI AALGPGAAPF APLQPPSVPA PSDYPGQGSS
760 770 780 790 800
FLGPGTFPES FPPTTPSTPT LAEFTPGPPP ISYQSDIPSS LLTSEKSTAC
810 820 830 840 850
LPSQMAPAGH LDPTHNPGTP GLHTSNLGAP PGPQLHHSNP PPASRQSLGQ
860 870 880 890 900
ASLGPTGELA FSPATGVMGP PSMSGAGEAP EPALDLLPEL TNPDELLSYL
910 920
GPPDLPTNNN DDLLSLFENN
Length:920
Mass (Da):96,537
Last modified:December 7, 2004 - v2
Checksum:iC9CE99D0B0798B9F
GO
Isoform 2 (identifier: Q8NF64-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     334-359: Missing.

Show »
Length:894
Mass (Da):93,981
Checksum:i3E9DFD0FD14F5CAE
GO
Isoform 3 (identifier: Q8NF64-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-87: Missing.
     334-359: Missing.

Note: No experimental confirmation available.
Show »
Length:862
Mass (Da):91,112
Checksum:i274013C6083F6D2F
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EWM3E7EWM3_HUMAN
Zinc finger MIZ domain-containing p...
ZMIZ2
888Annotation score:
A0A087X127A0A087X127_HUMAN
Zinc finger MIZ domain-containing p...
ZMIZ2
923Annotation score:
F8WC48F8WC48_HUMAN
Zinc finger MIZ domain-containing p...
ZMIZ2
62Annotation score:
C9JDA5C9JDA5_HUMAN
Zinc finger MIZ domain-containing p...
ZMIZ2
89Annotation score:

Sequence cautioni

The sequence AAH21924 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC03396 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB66507 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127Missing in AAR85526 (PubMed:16051670).Curated1
Sequence conflicti462R → RR in CAH56269 (PubMed:11230166).Curated1
Sequence conflicti568Missing (PubMed:16051670).Curated1
Sequence conflicti765T → M (PubMed:16051670).Curated1
Sequence conflicti765T → M (PubMed:15489334).Curated1
Sequence conflicti765T → M in CAB66507 (PubMed:11230166).Curated1
Sequence conflicti782S → C (PubMed:9853615).Curated1
Sequence conflicti799A → V (PubMed:9853615).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050536408L → F1 PublicationCorresponds to variant dbSNP:rs3735478Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02491856 – 87Missing in isoform 3. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_012190334 – 359Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY426594 mRNA Translation: AAR85526.1
AK090415 mRNA Translation: BAC03396.1 Different initiation.
AC004859 Genomic DNA No translation available.
AC013436 Genomic DNA Translation: AAP22368.1 Sequence problems.
CH236960 Genomic DNA Translation: EAL23750.1
CH471128 Genomic DNA Translation: EAW61083.1
CH471128 Genomic DNA Translation: EAW61084.1
CH471128 Genomic DNA Translation: EAW61085.1
BC021924 mRNA Translation: AAH21924.1 Different initiation.
BC110435 mRNA Translation: AAI10436.1
AB067473 mRNA Translation: BAB67779.1
AL831933 mRNA Translation: CAH56269.1
AL136572 mRNA Translation: CAB66507.1 Different initiation.
AB015330 mRNA Translation: BAA34789.1
CCDSiCCDS43576.1 [Q8NF64-1]
CCDS43577.1 [Q8NF64-2]
CCDS75591.1 [Q8NF64-3]
RefSeqiNP_001287888.1, NM_001300959.1 [Q8NF64-3]
NP_113637.3, NM_031449.3 [Q8NF64-1]
NP_777589.2, NM_174929.2 [Q8NF64-2]
XP_005249926.1, XM_005249869.2 [Q8NF64-1]
XP_005249929.1, XM_005249872.2 [Q8NF64-2]
UniGeneiHs.600681
Hs.77978

Genome annotation databases

EnsembliENST00000265346; ENSP00000265346; ENSG00000122515 [Q8NF64-2]
ENST00000309315; ENSP00000311778; ENSG00000122515 [Q8NF64-1]
ENST00000413916; ENSP00000409648; ENSG00000122515 [Q8NF64-3]
ENST00000441627; ENSP00000414723; ENSG00000122515 [Q8NF64-1]
GeneIDi83637
KEGGihsa:83637
UCSCiuc003tlq.4 human [Q8NF64-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY426594 mRNA Translation: AAR85526.1
AK090415 mRNA Translation: BAC03396.1 Different initiation.
AC004859 Genomic DNA No translation available.
AC013436 Genomic DNA Translation: AAP22368.1 Sequence problems.
CH236960 Genomic DNA Translation: EAL23750.1
CH471128 Genomic DNA Translation: EAW61083.1
CH471128 Genomic DNA Translation: EAW61084.1
CH471128 Genomic DNA Translation: EAW61085.1
BC021924 mRNA Translation: AAH21924.1 Different initiation.
BC110435 mRNA Translation: AAI10436.1
AB067473 mRNA Translation: BAB67779.1
AL831933 mRNA Translation: CAH56269.1
AL136572 mRNA Translation: CAB66507.1 Different initiation.
AB015330 mRNA Translation: BAA34789.1
CCDSiCCDS43576.1 [Q8NF64-1]
CCDS43577.1 [Q8NF64-2]
CCDS75591.1 [Q8NF64-3]
RefSeqiNP_001287888.1, NM_001300959.1 [Q8NF64-3]
NP_113637.3, NM_031449.3 [Q8NF64-1]
NP_777589.2, NM_174929.2 [Q8NF64-2]
XP_005249926.1, XM_005249869.2 [Q8NF64-1]
XP_005249929.1, XM_005249872.2 [Q8NF64-2]
UniGeneiHs.600681
Hs.77978

3D structure databases

ProteinModelPortaliQ8NF64
SMRiQ8NF64
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123701, 28 interactors
IntActiQ8NF64, 20 interactors
STRINGi9606.ENSP00000311778

PTM databases

iPTMnetiQ8NF64
PhosphoSitePlusiQ8NF64

Polymorphism and mutation databases

BioMutaiZMIZ2
DMDMi56404909

Proteomic databases

EPDiQ8NF64
MaxQBiQ8NF64
PaxDbiQ8NF64
PeptideAtlasiQ8NF64
PRIDEiQ8NF64
ProteomicsDBi73263
73264 [Q8NF64-2]
73265 [Q8NF64-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265346; ENSP00000265346; ENSG00000122515 [Q8NF64-2]
ENST00000309315; ENSP00000311778; ENSG00000122515 [Q8NF64-1]
ENST00000413916; ENSP00000409648; ENSG00000122515 [Q8NF64-3]
ENST00000441627; ENSP00000414723; ENSG00000122515 [Q8NF64-1]
GeneIDi83637
KEGGihsa:83637
UCSCiuc003tlq.4 human [Q8NF64-1]

Organism-specific databases

CTDi83637
EuPathDBiHostDB:ENSG00000122515.14
GeneCardsiZMIZ2
H-InvDBiHIX0006652
HGNCiHGNC:22229 ZMIZ2
HPAiHPA040716
MIMi611196 gene
neXtProtiNX_Q8NF64
OpenTargetsiENSG00000122515
PharmGKBiPA162409851
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2169 Eukaryota
ENOG410XQ2E LUCA
GeneTreeiENSGT00550000074410
HOVERGENiHBG056252
InParanoidiQ8NF64
KOiK22403
PhylomeDBiQ8NF64
TreeFamiTF316952

Miscellaneous databases

ChiTaRSiZMIZ2 human
GeneWikiiZMIZ2
GenomeRNAii83637
PROiPR:Q8NF64
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122515 Expressed in 217 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_ZMIZ2
ExpressionAtlasiQ8NF64 baseline and differential
GenevisibleiQ8NF64 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004181 Znf_MIZ
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF02891 zf-MIZ, 1 hit
PROSITEiView protein in PROSITE
PS51044 ZF_SP_RING, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZMIZ2_HUMAN
AccessioniPrimary (citable) accession number: Q8NF64
Secondary accession number(s): A4D2K7
, D3DVL1, O94790, Q0VGB4, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: October 10, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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