UniProtKB - Q8NF37 (PCAT1_HUMAN)

BLAST

>sp|Q8NF37|PCAT1_HUMAN Lysophosphatidylcholine acyltransferase 1 OS=Homo sapiens OX=9606 GN=LPCAT1 PE=1 SV=2
MRLRGCGPRAAPASSAGASDARLLAPPGRNPFVHELRLSALQKAQVALMTLTLFPVRLLV
AAAMMLLAWPLALVASLGSAEKEPEQPPALWRKVVDFLLKAIMRTMWFAGGFHRVAVKGR
QALPTEAAILTLAPHSSYFDAIPVTMTMSSIVMKAESRDIPIWGTLIQYIRPVFVSRSDQ
DSRRKTVEEIKRRAQSNGKWPQIMIFPEGTCTNRTCLITFKPGAFIPGAPVQPVVLRYPN
KLDTITWTWQGPGALEILWLTLCQFHNQVEIEFLPVYSPSEEEKRNPALYASNVRRVMAE
ALGVSVTDYTFEDCQLALAEGQLRLPADTCLLEFARLVRGLGLKPEKLEKDLDRYSERAR
MKGGEKIGIAEFAASLEVPVSDLLEDMFSLFDESGSGEVDLRECVVALSVVCRPARTLDT
IQLAFKMYGAQEDGSVGEGDLSCILKTALGVAELTVTDLFRAIDQEEKGKITFADFHRFA
EMYPAFAEEYLYPDQTHFESCAETSPAPIPNGFCADFSPENSDAGRKPVRKKLD

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History
Entry version 137 (07 Nov 2018)
Sequence version 2 (25 Jul 2006)
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Protein

Lysophosphatidylcholine acyltransferase 1

Gene

LPCAT1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Possesses both acyltransferase and acetyltransferase activities (PubMed:16864775, PubMed:21498505). Activity is calcium-independent (By similarity). Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC) (PubMed:21498505). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (PubMed:16704971). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (PubMed:16864775). Involved in the regulation of lipid droplet number and size (PubMed:25491198).By similarity3 Publications

Catalytic activityⁱ

Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.1 Publication

Acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine.1 Publication

Activity regulationⁱ

Not activated by inflammatory stimulation. Inhibited by Cu²⁺ and Fe²⁺. Activity is not affected by Co²⁺, Mg²⁺ or Mn²⁺ (By similarity).By similarity

Pathwayⁱ: phospholipid metabolism

This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Calcium bindingⁱ	392 – 403	1PROSITE-ProRule annotationAdd BLAST		12

GO - Molecular functionⁱ

1-acylglycerol-3-phosphate O-acyltransferase activity Source: Reactome
1-acylglycerophosphocholine O-acyltransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 21498505
1-alkenylglycerophosphocholine O-acyltransferase activity Source: Ensembl
1-alkylglycerophosphocholine O-acetyltransferase activity Source: UniProtKB-EC
1-alkylglycerophosphocholine O-acyltransferase activity Source: Ensembl
2-acylglycerol-3-phosphate O-acyltransferase activity Source: Reactome
calcium ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of phosphatidylcholine biosynthetic process Source: Ensembl
neutrophil degranulation Source: Reactome
phosphatidic acid biosynthetic process Source: Reactome
phosphatidylcholine acyl-chain remodeling
Source: UniProtKB
Inferred from direct assayⁱ
- 21498505
phosphatidylcholine biosynthetic process Source: Reactome
phosphatidylglycerol acyl-chain remodeling Source: Reactome
phospholipid biosynthetic process Source: UniProtKB
positive regulation of protein catabolic process Source: Ensembl
retina development in camera-type eye Source: Ensembl
surfactant homeostasis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Acyltransferase, Transferase
Biological process	Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

BRENDAⁱ	2.3.1.23 2681 2.3.1.51 2681
Reactomeⁱ	R-HSA-1482788 Acyl chain remodelling of PC R-HSA-1482925 Acyl chain remodelling of PG R-HSA-1483166 Synthesis of PA R-HSA-1483191 Synthesis of PC R-HSA-6798695 Neutrophil degranulation
UniPathwayⁱ	UPA00085

Chemistry databases

SwissLipidsⁱ	SLP:000000295

SwissLipidsⁱ

SLP:000000295

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Lysophosphatidylcholine acyltransferase 1 (EC:2.3.1.23) Short name: LPC acyltransferase 1 Short name: LPCAT-1 Short name: LysoPC acyltransferase 1 Alternative name(s): 1-acylglycerophosphocholine O-acyltransferase 1-alkylglycerophosphocholine O-acetyltransferase (EC:2.3.1.67) Acetyl-CoA:lyso-platelet-activating factor acetyltransferase Short name: Acetyl-CoA:lyso-PAF acetyltransferase Short name: Lyso-PAF acetyltransferase Short name: LysoPAFAT Acyltransferase-like 2 Phosphonoformate immuno-associated protein 3
Gene namesⁱ	Name:LPCAT1 Synonyms:AYTL2, PFAAP3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000153395.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25718 LPCAT1
MIMⁱ	610472 gene
neXtProtⁱ	NX_Q8NF37

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 57	CytoplasmicSequence analysisAdd BLAST	57
Transmembraneⁱ	58 – 78	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	79 – 534	LumenalSequence analysisAdd BLAST	456

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Golgi apparatus, Lipid droplet, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79888
Open Targets More...OpenTargetsⁱ	ENSG00000153395
PharmGKBⁱ	PA162394232

Polymorphism and mutation databases

BioMutaⁱ	LPCAT1
DMDMⁱ	110815902

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000247064	1 – 534	Lysophosphatidylcholine acyltransferase 1Add BLAST		534

Proteomic databases

EPDⁱ	Q8NF37
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8NF37
PaxDbⁱ	Q8NF37
PeptideAtlas More...PeptideAtlasⁱ	Q8NF37
PRIDEⁱ	Q8NF37
ProteomicsDBⁱ	73259
TopDownProteomicsⁱ	Q8NF37

PTM databases

iPTMnetⁱ	Q8NF37
PhosphoSitePlusⁱ	Q8NF37
SwissPalmⁱ	Q8NF37

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000153395 Expressed in 192 organ(s), highest expression level in lung
CleanExⁱ	HS_LPCAT1
Genevisibleⁱ	Q8NF37 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA012501 HPA022268

HPAⁱ

HPA012501
HPA022268

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	122973, 26 interactors
IntActⁱ	Q8NF37, 11 interactors
STRINGⁱ	9606.ENSP00000283415

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NF37
SMRⁱ	Q8NF37
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	379 – 414	EF-hand 1PROSITE-ProRule annotationAdd BLAST		36
Domainⁱ	451 – 486	EF-hand 2PROSITE-ProRule annotationAdd BLAST		36

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	135 – 140	HXXXXD motif		6
Motifⁱ	531 – 534	Di-lysine motif		4

Domainⁱ

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine.By similarity

The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.By similarity

Sequence similaritiesⁱ

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.Curated

Keywords - Domainⁱ

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4666 Eukaryota ENOG410XSIQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004914
HOGENOMⁱ	HOG000234374
HOVERGENⁱ	HBG060273
InParanoidⁱ	Q8NF37
KEGG Orthology (KO) More...KOⁱ	K13510
OMAⁱ	ALEILWL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09LH
PhylomeDBⁱ	Q8NF37
TreeFamⁱ	TF323244

Family and domain databases

InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR002048 EF_hand_dom IPR002123 Plipid/glycerol_acylTrfase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01553 Acyltransferase, 1 hit PF13833 EF-hand_8, 1 hit
SMARTⁱ	View protein in SMART SM00054 EFh, 2 hits SM00563 PlsC, 1 hit
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS50222 EF_HAND_2, 2 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q8NF37-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRLRGCGPRA APASSAGASD ARLLAPPGRN PFVHELRLSA LQKAQVALMT 
        60         70         80         90        100
LTLFPVRLLV AAAMMLLAWP LALVASLGSA EKEPEQPPAL WRKVVDFLLK 
       110        120        130        140        150
AIMRTMWFAG GFHRVAVKGR QALPTEAAIL TLAPHSSYFD AIPVTMTMSS 
       160        170        180        190        200
IVMKAESRDI PIWGTLIQYI RPVFVSRSDQ DSRRKTVEEI KRRAQSNGKW 
       210        220        230        240        250
PQIMIFPEGT CTNRTCLITF KPGAFIPGAP VQPVVLRYPN KLDTITWTWQ 
       260        270        280        290        300
GPGALEILWL TLCQFHNQVE IEFLPVYSPS EEEKRNPALY ASNVRRVMAE 
       310        320        330        340        350
ALGVSVTDYT FEDCQLALAE GQLRLPADTC LLEFARLVRG LGLKPEKLEK 
       360        370        380        390        400
DLDRYSERAR MKGGEKIGIA EFAASLEVPV SDLLEDMFSL FDESGSGEVD 
       410        420        430        440        450
LRECVVALSV VCRPARTLDT IQLAFKMYGA QEDGSVGEGD LSCILKTALG 
       460        470        480        490        500
VAELTVTDLF RAIDQEEKGK ITFADFHRFA EMYPAFAEEY LYPDQTHFES 
       510        520        530 
CAETSPAPIP NGFCADFSPE NSDAGRKPVR KKLD

Length:534

Mass (Da):59,151

Last modified:July 25, 2006 - v2

Checksum:ⁱ69A9C3AEC698F6BD

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0G2JQ62	A0A0G2JQ62_HUMAN	Lysophosphatidylcholine acyltransfe... Lysophosphatidylcholine acyltransferase 1	LPCAT1	489	Annotation score:
A0A0G2JRI7	A0A0G2JRI7_HUMAN	Lysophosphatidylcholine acyltransfe... Lysophosphatidylcholine acyltransferase 1	LPCAT1	234	Annotation score:

Sequence cautionⁱ

The sequence BAB14061 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAB14065 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB244719 mRNA Translation: BAE94688.1 AK090444 mRNA Translation: BAC03425.1 BC020166 mRNA Translation: AAH20166.3 AK022505 mRNA Translation: BAB14065.1 Different initiation. AK022499 mRNA Translation: BAB14061.1 Different initiation. AF530061 mRNA Translation: AAQ09945.1 AL831864 mRNA Translation: CAD38556.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3864.1
NCBI Reference Sequences More...RefSeqⁱ	NP_079106.3, NM_024830.4
UniGeneⁱ	Hs.368853

Genome annotation databases

Ensemblⁱ	ENST00000283415; ENSP00000283415; ENSG00000153395 ENST00000475622; ENSP00000423472; ENSG00000153395
GeneIDⁱ	79888
KEGGⁱ	hsa:79888
UCSC genome browser More...UCSCⁱ	uc003jcm.4 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8NF37	LPCAT1 isoform 1		PANTR		534	UniRef90_Q8NF37
LPCAT1 isoform 1		PONAB		534
Uncharacterized protein		MACMU		534
Uncharacterized protein		MACNE		489
Uncharacterized protein		CERAT		534
+27

Protein	Similar proteins		Species	Score	Length	Source
Q8NF37	Uncharacterized protein		CHLSB		534	UniRef50_Q8NF37
Lysophosphatidylcholine acyltransferase 1		GORGO		534
Lysophosphatidylcholine acyltransferase 1		MACMU		534
Uncharacterized protein		MACNE		489
LPCAT1 isoform 1		PONAB		534
+83

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB244719 mRNA Translation: BAE94688.1 AK090444 mRNA Translation: BAC03425.1 BC020166 mRNA Translation: AAH20166.3 AK022505 mRNA Translation: BAB14065.1 Different initiation. AK022499 mRNA Translation: BAB14061.1 Different initiation. AF530061 mRNA Translation: AAQ09945.1 AL831864 mRNA Translation: CAD38556.1
CCDSⁱ	CCDS3864.1
RefSeqⁱ	NP_079106.3, NM_024830.4
UniGeneⁱ	Hs.368853

3D structure databases

ProteinModelPortalⁱ	Q8NF37
SMRⁱ	Q8NF37
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122973, 26 interactors
IntActⁱ	Q8NF37, 11 interactors
STRINGⁱ	9606.ENSP00000283415

Chemistry databases

SwissLipidsⁱ	SLP:000000295

SwissLipidsⁱ

SLP:000000295

PTM databases

iPTMnetⁱ	Q8NF37
PhosphoSitePlusⁱ	Q8NF37
SwissPalmⁱ	Q8NF37

Polymorphism and mutation databases

BioMutaⁱ	LPCAT1
DMDMⁱ	110815902

Proteomic databases

EPDⁱ	Q8NF37
MaxQBⁱ	Q8NF37
PaxDbⁱ	Q8NF37
PeptideAtlasⁱ	Q8NF37
PRIDEⁱ	Q8NF37
ProteomicsDBⁱ	73259
TopDownProteomicsⁱ	Q8NF37

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	79888
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000283415; ENSP00000283415; ENSG00000153395 ENST00000475622; ENSP00000423472; ENSG00000153395
GeneIDⁱ	79888
KEGGⁱ	hsa:79888
UCSCⁱ	uc003jcm.4 human

Organism-specific databases

CTDⁱ	79888
DisGeNETⁱ	79888
EuPathDBⁱ	HostDB:ENSG00000153395.9
GeneCardsⁱ	LPCAT1
HGNCⁱ	HGNC:25718 LPCAT1
HPAⁱ	HPA012501 HPA022268
MIMⁱ	610472 gene
neXtProtⁱ	NX_Q8NF37
OpenTargetsⁱ	ENSG00000153395
PharmGKBⁱ	PA162394232
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4666 Eukaryota ENOG410XSIQ LUCA
GeneTreeⁱ	ENSGT00390000004914
HOGENOMⁱ	HOG000234374
HOVERGENⁱ	HBG060273
InParanoidⁱ	Q8NF37
KOⁱ	K13510
OMAⁱ	ALEILWL
OrthoDBⁱ	EOG091G09LH
PhylomeDBⁱ	Q8NF37
TreeFamⁱ	TF323244

Enzyme and pathway databases

UniPathwayⁱ	UPA00085
BRENDAⁱ	2.3.1.23 2681 2.3.1.51 2681
Reactomeⁱ	R-HSA-1482788 Acyl chain remodelling of PC R-HSA-1482925 Acyl chain remodelling of PG R-HSA-1483166 Synthesis of PA R-HSA-1483191 Synthesis of PC R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSⁱ	LPCAT1 human
GenomeRNAiⁱ	79888
Protein Ontology More...PROⁱ	PR:Q8NF37
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000153395 Expressed in 192 organ(s), highest expression level in lung
CleanExⁱ	HS_LPCAT1
Genevisibleⁱ	Q8NF37 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR002048 EF_hand_dom IPR002123 Plipid/glycerol_acylTrfase
Pfamⁱ	View protein in Pfam PF01553 Acyltransferase, 1 hit PF13833 EF-hand_8, 1 hit
SMARTⁱ	View protein in SMART SM00054 EFh, 2 hits SM00563 PlsC, 1 hit
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS50222 EF_HAND_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PCAT1_HUMAN
Accessionⁱ	Q8NF37Primary (citable) accession number: Q8NF37 Secondary accession number(s): Q1HAQ1 , Q7Z4G6, Q8N3U7, Q8WUL8, Q9GZW6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
	Last sequence update:	July 25, 2006
	Last modified:	November 7, 2018
	This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8NF37 (PCAT1_HUMAN)

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Lysophosphatidylcholine acyltransferase 1

LPCAT1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phospholipid metabolism

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Endoplasmic reticulum

Other locations

Endoplasmic reticulum

Golgi apparatus

Lysosome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: phospholipid metabolism

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ