UniProtKB - Q8NF37 (PCAT1_HUMAN)
Protein
Lysophosphatidylcholine acyltransferase 1
Gene
LPCAT1
Organism
Homo sapiens (Human)
Status
Functioni
Exhibits acyltransferase activity (PubMed:21498505, PubMed:18156367). Exhibits acetyltransferase activity (By similarity). Activity is calcium-independent (By similarity). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:21498505, PubMed:18156367). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (By similarity). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198).By similarity3 Publications
Catalytic activityi
- a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA2 PublicationsEC:2.3.1.232 Publications
- a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoABy similarityEC:2.3.1.51By similarity
- 1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoABy similarityEC:2.3.1.67By similarity
- 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoABy similarityEC:2.3.1.25By similarity
- 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA = 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA = 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA = 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA = 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1ʼ-sn-glycerol) + CoABy similarityThis reaction proceeds in the forwardBy similarity direction.
Kineticsi
- KM=0.6 µM for palmitoyl-CoA (in the presence of 1-palmitoyl-LPC as cosubstrate)1 Publication
- KM=4 µM for oleoyl-CoA (in the presence of 1-palmitoyl-LPC as cosubstrate)1 Publication
- KM=7.8 µM for linoleoyl-CoA (in the presence of 1-palmitoyl-LPC as cosubstrate)1 Publication
- KM=4.3 µM for arachidonyl-CoA (in the presence of 1-palmitoyl-LPC as cosubstrate)1 Publication
- KM=6.8 µM for 1-palmitoyl-LPC (in the presence of palmitoyl-CoA as cosubstrate)1 Publication
- KM=27 µM for 1-palmitoyl-LPC (in the presence of oleoyl-CoA as cosubstrate)1 Publication
- KM=44.5 µM for 1-palmitoyl-LPC (in the presence of linoleoyl-CoA as cosubstrate)1 Publication
- KM=9.2 µM for 1-palmitoyl-LPC (in the presence of arachidonyl-CoA as cosubstrate)1 Publication
- Vmax=2.8 nmol/min/mg enzyme towards palmitoyl-CoA using 1-palmitoyl-LPC as cosubstrate1 Publication
- Vmax=5.6 nmol/min/mg enzyme towards oleoyl-CoA using 1-palmitoyl-LPC as cosubstrate1 Publication
- Vmax=11.3 nmol/min/mg enzyme towards linoleoyl-CoA using 1-palmitoyl-LPC as cosubstrate1 Publication
- Vmax=4.6 nmol/min/mg enzyme towards arachidonyl-CoA using 1-palmitoyl-LPC as cosubstrate1 Publication
- Vmax=1.4 nmol/min/mg enzyme towards 1-palmitoyl-LPC using palmitoyl-CoA as cosubstrate1 Publication
- Vmax=6.8 nmol/min/mg enzyme towards 1-palmitoyl-LPC using oleoyl-CoA as cosubstrate1 Publication
- Vmax=11.8 nmol/min/mg enzyme towards 1-palmitoyl-LPC using linoleoyl-CoA as cosubstrate1 Publication
- Vmax=3.6 nmol/min/mg enzyme with towards 1-palmitoyl-LPC using arachidonyl-CoA as cosubstrate1 Publication
pH dependencei
Optimum pH is 5.5 and 7.5.1 Publication
: phospholipid metabolism Pathwayi
This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 392 – 403 | 1PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- 1-acylglycerol-3-phosphate O-acyltransferase activity Source: UniProtKB
- 1-acylglycerophosphocholine O-acyltransferase activity Source: UniProtKB
- 1-alkenylglycerophosphocholine O-acyltransferase activity Source: UniProtKB
- 1-alkylglycerophosphocholine O-acetyltransferase activity Source: UniProtKB
- 1-alkylglycerophosphocholine O-acyltransferase activity Source: Ensembl
- calcium ion binding Source: InterPro
- plasmalogen synthase activity Source: UniProtKB-EC
GO - Biological processi
- negative regulation of phosphatidylcholine biosynthetic process Source: Ensembl
- neutrophil degranulation Source: Reactome
- phosphatidic acid biosynthetic process Source: Reactome
- phosphatidylcholine acyl-chain remodeling Source: UniProtKB
- phosphatidylcholine biosynthetic process Source: Reactome
- phosphatidylglycerol acyl-chain remodeling Source: Reactome
- phospholipid biosynthetic process Source: UniProtKB
- positive regulation of protein catabolic process Source: Ensembl
- retina development in camera-type eye Source: Ensembl
- surfactant homeostasis Source: Ensembl
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 2.3.1.23, 2681 2.3.1.51, 2681 |
PathwayCommonsi | Q8NF37 |
Reactomei | R-HSA-1482788, Acyl chain remodelling of PC R-HSA-1482925, Acyl chain remodelling of PG R-HSA-1483166, Synthesis of PA R-HSA-1483191, Synthesis of PC R-HSA-6798695, Neutrophil degranulation |
UniPathwayi | UPA00085 |
Chemistry databases
SwissLipidsi | SLP:000000295 |
Names & Taxonomyi
Protein namesi | Recommended name: Lysophosphatidylcholine acyltransferase 1 (EC:2.3.1.232 Publications)Short name: LPC acyltransferase 1 Short name: LPCAT-1 Short name: LysoPC acyltransferase 1 Alternative name(s): 1-acylglycerol-3-phosphate O-acyltransferase (EC:2.3.1.51By similarity) 1-acylglycerophosphocholine O-acyltransferase 1-alkenylglycerophosphocholine O-acyltransferase (EC:2.3.1.25By similarity) 1-alkylglycerophosphocholine O-acetyltransferase (EC:2.3.1.67By similarity) Acetyl-CoA:lyso-platelet-activating factor acetyltransferase Short name: Acetyl-CoA:lyso-PAF acetyltransferase Short name: Lyso-PAF acetyltransferase Short name: LysoPAFAT Acyltransferase-like 2 Phosphonoformate immuno-associated protein 3 |
Gene namesi | Name:LPCAT1 Synonyms:AYTL2, PFAAP3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000153395.9 |
HGNCi | HGNC:25718, LPCAT1 |
MIMi | 610472, gene |
neXtProti | NX_Q8NF37 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Single-pass type II membrane protein 1 Publication
Plasma membrane
- Cell membrane 1 Publication; Single-pass type II membrane protein 1 Publication
Golgi apparatus
- Golgi apparatus membrane By similarity; Single-pass type II membrane protein 1 Publication
Other locations
- Lipid droplet 1 Publication
Note: May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm.1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: Reactome
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- Golgi membrane Source: UniProtKB-SubCell
Lysosome
- azurophil granule membrane Source: Reactome
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
- lipid droplet Source: UniProtKB
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 57 | CytoplasmicSequence analysisAdd BLAST | 57 | |
Transmembranei | 58 – 78 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 79 – 534 | LumenalSequence analysisAdd BLAST | 456 |
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, Golgi apparatus, Lipid droplet, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 79888 |
OpenTargetsi | ENSG00000153395 |
PharmGKBi | PA162394232 |
Miscellaneous databases
Pharosi | Q8NF37, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295903 |
Polymorphism and mutation databases
BioMutai | LPCAT1 |
DMDMi | 110815902 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000247064 | 1 – 534 | Lysophosphatidylcholine acyltransferase 1Add BLAST | 534 |
Proteomic databases
EPDi | Q8NF37 |
jPOSTi | Q8NF37 |
MassIVEi | Q8NF37 |
MaxQBi | Q8NF37 |
PaxDbi | Q8NF37 |
PeptideAtlasi | Q8NF37 |
PRIDEi | Q8NF37 |
ProteomicsDBi | 73259 |
TopDownProteomicsi | Q8NF37 |
PTM databases
iPTMneti | Q8NF37 |
PhosphoSitePlusi | Q8NF37 |
SwissPalmi | Q8NF37 |
Expressioni
Tissue specificityi
Erythrocytes.1 Publication
Gene expression databases
Bgeei | ENSG00000153395, Expressed in lung and 206 other tissues |
Genevisiblei | Q8NF37, HS |
Organism-specific databases
HPAi | ENSG00000153395, Tissue enhanced (lung) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 122973, 41 interactors |
IntActi | Q8NF37, 16 interactors |
STRINGi | 9606.ENSP00000283415 |
Miscellaneous databases
RNActi | Q8NF37, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 379 – 414 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 451 – 486 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 135 – 140 | HXXXXD motifBy similarity | 6 | |
Motifi | 531 – 534 | Di-lysine motif1 Publication | 4 |
Domaini
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine.By similarity
The di-lysine motif may confer endoplasmic reticulum localization.By similarity
Sequence similaritiesi
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.Curated
Keywords - Domaini
Repeat, Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2898, Eukaryota KOG4666, Eukaryota |
GeneTreei | ENSGT01000000214580 |
HOGENOMi | CLU_025017_0_1_1 |
InParanoidi | Q8NF37 |
OMAi | EIEFLPI |
OrthoDBi | 1266853at2759 |
PhylomeDBi | Q8NF37 |
TreeFami | TF323244 |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR002048, EF_hand_dom IPR002123, Plipid/glycerol_acylTrfase |
Pfami | View protein in Pfam PF01553, Acyltransferase, 1 hit PF13833, EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 2 hits SM00563, PlsC, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8NF37-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLRGCGPRA APASSAGASD ARLLAPPGRN PFVHELRLSA LQKAQVALMT
60 70 80 90 100
LTLFPVRLLV AAAMMLLAWP LALVASLGSA EKEPEQPPAL WRKVVDFLLK
110 120 130 140 150
AIMRTMWFAG GFHRVAVKGR QALPTEAAIL TLAPHSSYFD AIPVTMTMSS
160 170 180 190 200
IVMKAESRDI PIWGTLIQYI RPVFVSRSDQ DSRRKTVEEI KRRAQSNGKW
210 220 230 240 250
PQIMIFPEGT CTNRTCLITF KPGAFIPGAP VQPVVLRYPN KLDTITWTWQ
260 270 280 290 300
GPGALEILWL TLCQFHNQVE IEFLPVYSPS EEEKRNPALY ASNVRRVMAE
310 320 330 340 350
ALGVSVTDYT FEDCQLALAE GQLRLPADTC LLEFARLVRG LGLKPEKLEK
360 370 380 390 400
DLDRYSERAR MKGGEKIGIA EFAASLEVPV SDLLEDMFSL FDESGSGEVD
410 420 430 440 450
LRECVVALSV VCRPARTLDT IQLAFKMYGA QEDGSVGEGD LSCILKTALG
460 470 480 490 500
VAELTVTDLF RAIDQEEKGK ITFADFHRFA EMYPAFAEEY LYPDQTHFES
510 520 530
CAETSPAPIP NGFCADFSPE NSDAGRKPVR KKLD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JQ62 | A0A0G2JQ62_HUMAN | Lysophosphatidylcholine acyltransfe... | LPCAT1 | 489 | Annotation score: | ||
A0A0G2JRI7 | A0A0G2JRI7_HUMAN | Lysophosphatidylcholine acyltransfe... | LPCAT1 | 234 | Annotation score: |
Sequence cautioni
The sequence BAB14061 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14065 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB244719 mRNA Translation: BAE94688.1 AK090444 mRNA Translation: BAC03425.1 BC020166 mRNA Translation: AAH20166.3 AK022505 mRNA Translation: BAB14065.1 Different initiation. AK022499 mRNA Translation: BAB14061.1 Different initiation. AF530061 mRNA Translation: AAQ09945.1 AL831864 mRNA Translation: CAD38556.1 |
CCDSi | CCDS3864.1 |
RefSeqi | NP_079106.3, NM_024830.4 |
Genome annotation databases
Ensembli | ENST00000283415; ENSP00000283415; ENSG00000153395 ENST00000475622; ENSP00000423472; ENSG00000153395 |
GeneIDi | 79888 |
KEGGi | hsa:79888 |
UCSCi | uc003jcm.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB244719 mRNA Translation: BAE94688.1 AK090444 mRNA Translation: BAC03425.1 BC020166 mRNA Translation: AAH20166.3 AK022505 mRNA Translation: BAB14065.1 Different initiation. AK022499 mRNA Translation: BAB14061.1 Different initiation. AF530061 mRNA Translation: AAQ09945.1 AL831864 mRNA Translation: CAD38556.1 |
CCDSi | CCDS3864.1 |
RefSeqi | NP_079106.3, NM_024830.4 |
3D structure databases
SMRi | Q8NF37 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122973, 41 interactors |
IntActi | Q8NF37, 16 interactors |
STRINGi | 9606.ENSP00000283415 |
Chemistry databases
ChEMBLi | CHEMBL4295903 |
SwissLipidsi | SLP:000000295 |
PTM databases
iPTMneti | Q8NF37 |
PhosphoSitePlusi | Q8NF37 |
SwissPalmi | Q8NF37 |
Polymorphism and mutation databases
BioMutai | LPCAT1 |
DMDMi | 110815902 |
Proteomic databases
EPDi | Q8NF37 |
jPOSTi | Q8NF37 |
MassIVEi | Q8NF37 |
MaxQBi | Q8NF37 |
PaxDbi | Q8NF37 |
PeptideAtlasi | Q8NF37 |
PRIDEi | Q8NF37 |
ProteomicsDBi | 73259 |
TopDownProteomicsi | Q8NF37 |
Protocols and materials databases
Antibodypediai | 1587, 213 antibodies |
DNASUi | 79888 |
Genome annotation databases
Ensembli | ENST00000283415; ENSP00000283415; ENSG00000153395 ENST00000475622; ENSP00000423472; ENSG00000153395 |
GeneIDi | 79888 |
KEGGi | hsa:79888 |
UCSCi | uc003jcm.4, human |
Organism-specific databases
CTDi | 79888 |
DisGeNETi | 79888 |
EuPathDBi | HostDB:ENSG00000153395.9 |
GeneCardsi | LPCAT1 |
HGNCi | HGNC:25718, LPCAT1 |
HPAi | ENSG00000153395, Tissue enhanced (lung) |
MIMi | 610472, gene |
neXtProti | NX_Q8NF37 |
OpenTargetsi | ENSG00000153395 |
PharmGKBi | PA162394232 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2898, Eukaryota KOG4666, Eukaryota |
GeneTreei | ENSGT01000000214580 |
HOGENOMi | CLU_025017_0_1_1 |
InParanoidi | Q8NF37 |
OMAi | EIEFLPI |
OrthoDBi | 1266853at2759 |
PhylomeDBi | Q8NF37 |
TreeFami | TF323244 |
Enzyme and pathway databases
UniPathwayi | UPA00085 |
BRENDAi | 2.3.1.23, 2681 2.3.1.51, 2681 |
PathwayCommonsi | Q8NF37 |
Reactomei | R-HSA-1482788, Acyl chain remodelling of PC R-HSA-1482925, Acyl chain remodelling of PG R-HSA-1483166, Synthesis of PA R-HSA-1483191, Synthesis of PC R-HSA-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 79888, 11 hits in 843 CRISPR screens |
ChiTaRSi | LPCAT1, human |
GenomeRNAii | 79888 |
Pharosi | Q8NF37, Tbio |
PROi | PR:Q8NF37 |
RNActi | Q8NF37, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000153395, Expressed in lung and 206 other tissues |
Genevisiblei | Q8NF37, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR002048, EF_hand_dom IPR002123, Plipid/glycerol_acylTrfase |
Pfami | View protein in Pfam PF01553, Acyltransferase, 1 hit PF13833, EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 2 hits SM00563, PlsC, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PCAT1_HUMAN | |
Accessioni | Q8NF37Primary (citable) accession number: Q8NF37 Secondary accession number(s): Q1HAQ1 Q9GZW6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 25, 2006 |
Last sequence update: | July 25, 2006 | |
Last modified: | December 2, 2020 | |
This is version 151 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families