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UniProtKB - Q8NF37 (PCAT1_HUMAN)

Entry version 154 (02 Jun 2021)
Sequence version 2 (25 Jul 2006)
Previous versions | rss
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Protein

Lysophosphatidylcholine acyltransferase 1

Gene

LPCAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exhibits acyltransferase activity (PubMed:21498505, PubMed:18156367).

Exhibits acetyltransferase activity (By similarity).

Activity is calcium-independent (By similarity).

Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:21498505, PubMed:18156367).

Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity).

Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity).

Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (By similarity).

May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (By similarity).

Involved in the regulation of lipid droplet number and size (PubMed:25491198).

By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.6 µM for palmitoyl-CoA (in the presence of 1-palmitoyl-LPC as cosubstrate)1 Publication
  2. KM=4 µM for oleoyl-CoA (in the presence of 1-palmitoyl-LPC as cosubstrate)1 Publication
  3. KM=7.8 µM for linoleoyl-CoA (in the presence of 1-palmitoyl-LPC as cosubstrate)1 Publication
  4. KM=4.3 µM for arachidonyl-CoA (in the presence of 1-palmitoyl-LPC as cosubstrate)1 Publication
  5. KM=6.8 µM for 1-palmitoyl-LPC (in the presence of palmitoyl-CoA as cosubstrate)1 Publication
  6. KM=27 µM for 1-palmitoyl-LPC (in the presence of oleoyl-CoA as cosubstrate)1 Publication
  7. KM=44.5 µM for 1-palmitoyl-LPC (in the presence of linoleoyl-CoA as cosubstrate)1 Publication
  8. KM=9.2 µM for 1-palmitoyl-LPC (in the presence of arachidonyl-CoA as cosubstrate)1 Publication
  1. Vmax=2.8 nmol/min/mg enzyme towards palmitoyl-CoA using 1-palmitoyl-LPC as cosubstrate1 Publication
  2. Vmax=5.6 nmol/min/mg enzyme towards oleoyl-CoA using 1-palmitoyl-LPC as cosubstrate1 Publication
  3. Vmax=11.3 nmol/min/mg enzyme towards linoleoyl-CoA using 1-palmitoyl-LPC as cosubstrate1 Publication
  4. Vmax=4.6 nmol/min/mg enzyme towards arachidonyl-CoA using 1-palmitoyl-LPC as cosubstrate1 Publication
  5. Vmax=1.4 nmol/min/mg enzyme towards 1-palmitoyl-LPC using palmitoyl-CoA as cosubstrate1 Publication
  6. Vmax=6.8 nmol/min/mg enzyme towards 1-palmitoyl-LPC using oleoyl-CoA as cosubstrate1 Publication
  7. Vmax=11.8 nmol/min/mg enzyme towards 1-palmitoyl-LPC using linoleoyl-CoA as cosubstrate1 Publication
  8. Vmax=3.6 nmol/min/mg enzyme with towards 1-palmitoyl-LPC using arachidonyl-CoA as cosubstrate1 Publication

pH dependencei

Optimum pH is 5.5 and 7.5.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phospholipid metabolism

This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi392 – 4031PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.3.1.23, 2681
2.3.1.51, 2681
2.3.1.62, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8NF37

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1482788, Acyl chain remodelling of PC
R-HSA-1482925, Acyl chain remodelling of PG
R-HSA-1483166, Synthesis of PA
R-HSA-1483191, Synthesis of PC
R-HSA-6798695, Neutrophil degranulation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00085

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000295

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysophosphatidylcholine acyltransferase 1 (EC:2.3.1.232 Publications)
Short name:
LPC acyltransferase 1
Short name:
LPCAT-1
Short name:
LysoPC acyltransferase 1
Alternative name(s):
1-acylglycerol-3-phosphate O-acyltransferase (EC:2.3.1.51By similarity)
1-acylglycerophosphocholine O-acyltransferase
1-alkenylglycerophosphocholine O-acyltransferase (EC:2.3.1.25By similarity)
1-alkylglycerophosphocholine O-acetyltransferase (EC:2.3.1.67By similarity)
Acetyl-CoA:lyso-platelet-activating factor acetyltransferase
Short name:
Acetyl-CoA:lyso-PAF acetyltransferase
Short name:
Lyso-PAF acetyltransferase
Short name:
LysoPAFAT
Acyltransferase-like 2
Phosphonoformate immuno-associated protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LPCAT1
Synonyms:AYTL2, PFAAP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25718, LPCAT1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610472, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8NF37

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000153395.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 57CytoplasmicSequence analysisAdd BLAST57
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei58 – 78Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini79 – 534LumenalSequence analysisAdd BLAST456

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Lipid droplet, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		79888

Open Targets

More...OpenTargetsi		ENSG00000153395

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162394232

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8NF37, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4295903

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LPCAT1

Domain mapping of disease mutations (DMDM)

More...DMDMi		110815902

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002470641 – 534Lysophosphatidylcholine acyltransferase 1Add BLAST534

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8NF37

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8NF37

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8NF37

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8NF37

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8NF37

PeptideAtlas

More...PeptideAtlasi		Q8NF37

PRoteomics IDEntifications database

More...PRIDEi		Q8NF37

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		73259

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q8NF37

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8NF37

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8NF37

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8NF37

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Erythrocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000153395, Expressed in lung and 206 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8NF37, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000153395, Tissue enhanced (lung)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122973, 55 interactors

Protein interaction database and analysis system

More...IntActi		Q8NF37, 17 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000283415

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8NF37, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8NF37

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini379 – 414EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini451 – 486EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 22DisorderedSequence analysisAdd BLAST22
Regioni512 – 534DisorderedSequence analysisAdd BLAST23

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi135 – 140HXXXXD motifBy similarity6
Motifi531 – 534Di-lysine motif1 Publication4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine.By similarity
The di-lysine motif may confer endoplasmic reticulum localization.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.Curated

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2898, Eukaryota
KOG4666, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234574

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_025017_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8NF37

Identification of Orthologs from Complete Genome Data

More...OMAi		EIEFLPI

Database of Orthologous Groups

More...OrthoDBi		1266853at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8NF37

TreeFam database of animal gene trees

More...TreeFami		TF323244

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR002048, EF_hand_dom
IPR002123, Plipid/glycerol_acylTrfase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01553, Acyltransferase, 1 hit
PF13833, EF-hand_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00054, EFh, 2 hits
SM00563, PlsC, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50222, EF_HAND_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8NF37-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLRGCGPRA APASSAGASD ARLLAPPGRN PFVHELRLSA LQKAQVALMT 
        60         70         80         90        100
LTLFPVRLLV AAAMMLLAWP LALVASLGSA EKEPEQPPAL WRKVVDFLLK 
       110        120        130        140        150
AIMRTMWFAG GFHRVAVKGR QALPTEAAIL TLAPHSSYFD AIPVTMTMSS 
       160        170        180        190        200
IVMKAESRDI PIWGTLIQYI RPVFVSRSDQ DSRRKTVEEI KRRAQSNGKW 
       210        220        230        240        250
PQIMIFPEGT CTNRTCLITF KPGAFIPGAP VQPVVLRYPN KLDTITWTWQ 
       260        270        280        290        300
GPGALEILWL TLCQFHNQVE IEFLPVYSPS EEEKRNPALY ASNVRRVMAE 
       310        320        330        340        350
ALGVSVTDYT FEDCQLALAE GQLRLPADTC LLEFARLVRG LGLKPEKLEK 
       360        370        380        390        400
DLDRYSERAR MKGGEKIGIA EFAASLEVPV SDLLEDMFSL FDESGSGEVD 
       410        420        430        440        450
LRECVVALSV VCRPARTLDT IQLAFKMYGA QEDGSVGEGD LSCILKTALG 
       460        470        480        490        500
VAELTVTDLF RAIDQEEKGK ITFADFHRFA EMYPAFAEEY LYPDQTHFES 
       510        520        530 
CAETSPAPIP NGFCADFSPE NSDAGRKPVR KKLD
Length:534
Mass (Da):59,151
Last modified:July 25, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i69A9C3AEC698F6BD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JQ62A0A0G2JQ62_HUMAN
Lysophosphatidylcholine acyltransfe...
LPCAT1
489Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JRI7A0A0G2JRI7_HUMAN
Lysophosphatidylcholine acyltransfe...
LPCAT1
234Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14061 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14065 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB244719 mRNA Translation: BAE94688.1
AK090444 mRNA Translation: BAC03425.1
BC020166 mRNA Translation: AAH20166.3
AK022505 mRNA Translation: BAB14065.1 Different initiation.
AK022499 mRNA Translation: BAB14061.1 Different initiation.
AF530061 mRNA Translation: AAQ09945.1
AL831864 mRNA Translation: CAD38556.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3864.1

NCBI Reference Sequences

More...RefSeqi		NP_079106.3, NM_024830.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000283415; ENSP00000283415; ENSG00000153395
ENST00000475622; ENSP00000423472; ENSG00000153395

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79888

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79888

UCSC genome browser

More...UCSCi		uc003jcm.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB244719 mRNA Translation: BAE94688.1
AK090444 mRNA Translation: BAC03425.1
BC020166 mRNA Translation: AAH20166.3
AK022505 mRNA Translation: BAB14065.1 Different initiation.
AK022499 mRNA Translation: BAB14061.1 Different initiation.
AF530061 mRNA Translation: AAQ09945.1
AL831864 mRNA Translation: CAD38556.1
CCDSiCCDS3864.1
RefSeqiNP_079106.3, NM_024830.4

3D structure databases

SMRiQ8NF37
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122973, 55 interactors
IntActiQ8NF37, 17 interactors
STRINGi9606.ENSP00000283415

Chemistry databases

ChEMBLiCHEMBL4295903
SwissLipidsiSLP:000000295

PTM databases

iPTMnetiQ8NF37
PhosphoSitePlusiQ8NF37
SwissPalmiQ8NF37

Genetic variation databases

BioMutaiLPCAT1
DMDMi110815902

Proteomic databases

EPDiQ8NF37
jPOSTiQ8NF37
MassIVEiQ8NF37
MaxQBiQ8NF37
PaxDbiQ8NF37
PeptideAtlasiQ8NF37
PRIDEiQ8NF37
ProteomicsDBi73259
TopDownProteomicsiQ8NF37

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1587, 220 antibodies

The DNASU plasmid repository

More...DNASUi		79888

Genome annotation databases

EnsembliENST00000283415; ENSP00000283415; ENSG00000153395
ENST00000475622; ENSP00000423472; ENSG00000153395
GeneIDi79888
KEGGihsa:79888
UCSCiuc003jcm.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79888
DisGeNETi79888

GeneCards: human genes, protein and diseases

More...GeneCardsi		LPCAT1
HGNCiHGNC:25718, LPCAT1
HPAiENSG00000153395, Tissue enhanced (lung)
MIMi610472, gene
neXtProtiNX_Q8NF37
OpenTargetsiENSG00000153395
PharmGKBiPA162394232
VEuPathDBiHostDB:ENSG00000153395.9

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2898, Eukaryota
KOG4666, Eukaryota
GeneTreeiENSGT01030000234574
HOGENOMiCLU_025017_0_1_1
InParanoidiQ8NF37
OMAiEIEFLPI
OrthoDBi1266853at2759
PhylomeDBiQ8NF37
TreeFamiTF323244

Enzyme and pathway databases

UniPathwayiUPA00085
BRENDAi2.3.1.23, 2681
2.3.1.51, 2681
2.3.1.62, 2681
PathwayCommonsiQ8NF37
ReactomeiR-HSA-1482788, Acyl chain remodelling of PC
R-HSA-1482925, Acyl chain remodelling of PG
R-HSA-1483166, Synthesis of PA
R-HSA-1483191, Synthesis of PC
R-HSA-6798695, Neutrophil degranulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79888, 15 hits in 996 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LPCAT1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79888
PharosiQ8NF37, Tbio

Protein Ontology

More...PROi		PR:Q8NF37
RNActiQ8NF37, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000153395, Expressed in lung and 206 other tissues
GenevisibleiQ8NF37, HS

Family and domain databases

InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR002048, EF_hand_dom
IPR002123, Plipid/glycerol_acylTrfase
PfamiView protein in Pfam
PF01553, Acyltransferase, 1 hit
PF13833, EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054, EFh, 2 hits
SM00563, PlsC, 1 hit
SUPFAMiSSF47473, SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222, EF_HAND_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCAT1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NF37
Secondary accession number(s): Q1HAQ1
, Q7Z4G6, Q8N3U7, Q8WUL8, Q9GZW6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: June 2, 2021
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families
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