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Protein

Lysophosphatidylcholine acyltransferase 1

Gene

LPCAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possesses both acyltransferase and acetyltransferase activities (PubMed:16864775, PubMed:21498505). Activity is calcium-independent (By similarity). Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC) (PubMed:21498505). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (PubMed:16704971). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (PubMed:16864775). Involved in the regulation of lipid droplet number and size (PubMed:25491198).By similarity3 Publications

Catalytic activityi

Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.1 Publication
Acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine.1 Publication

Activity regulationi

Not activated by inflammatory stimulation. Inhibited by Cu2+ and Fe2+. Activity is not affected by Co2+, Mg2+ or Mn2+ (By similarity).By similarity

Pathwayi: phospholipid metabolism

This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi392 – 4031PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi2.3.1.23 2681
2.3.1.51 2681
ReactomeiR-HSA-1482788 Acyl chain remodelling of PC
R-HSA-1482925 Acyl chain remodelling of PG
R-HSA-1483166 Synthesis of PA
R-HSA-1483191 Synthesis of PC
R-HSA-6798695 Neutrophil degranulation
UniPathwayi
UPA00085

Chemistry databases

SwissLipidsiSLP:000000295

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidylcholine acyltransferase 1 (EC:2.3.1.23)
Short name:
LPC acyltransferase 1
Short name:
LPCAT-1
Short name:
LysoPC acyltransferase 1
Alternative name(s):
1-acylglycerophosphocholine O-acyltransferase
1-alkylglycerophosphocholine O-acetyltransferase (EC:2.3.1.67)
Acetyl-CoA:lyso-platelet-activating factor acetyltransferase
Short name:
Acetyl-CoA:lyso-PAF acetyltransferase
Short name:
Lyso-PAF acetyltransferase
Short name:
LysoPAFAT
Acyltransferase-like 2
Phosphonoformate immuno-associated protein 3
Gene namesi
Name:LPCAT1
Synonyms:AYTL2, PFAAP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000153395.9
HGNCiHGNC:25718 LPCAT1
MIMi610472 gene
neXtProtiNX_Q8NF37

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57CytoplasmicSequence analysisAdd BLAST57
Transmembranei58 – 78Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini79 – 534LumenalSequence analysisAdd BLAST456

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Lipid droplet, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79888
OpenTargetsiENSG00000153395
PharmGKBiPA162394232

Polymorphism and mutation databases

BioMutaiLPCAT1
DMDMi110815902

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002470641 – 534Lysophosphatidylcholine acyltransferase 1Add BLAST534

Proteomic databases

EPDiQ8NF37
MaxQBiQ8NF37
PaxDbiQ8NF37
PeptideAtlasiQ8NF37
PRIDEiQ8NF37
ProteomicsDBi73259
TopDownProteomicsiQ8NF37

PTM databases

iPTMnetiQ8NF37
PhosphoSitePlusiQ8NF37
SwissPalmiQ8NF37

Expressioni

Gene expression databases

BgeeiENSG00000153395 Expressed in 192 organ(s), highest expression level in lung
CleanExiHS_LPCAT1
GenevisibleiQ8NF37 HS

Organism-specific databases

HPAiHPA012501
HPA022268

Interactioni

Protein-protein interaction databases

BioGridi122973, 26 interactors
IntActiQ8NF37, 11 interactors
STRINGi9606.ENSP00000283415

Structurei

3D structure databases

ProteinModelPortaliQ8NF37
SMRiQ8NF37
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini379 – 414EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini451 – 486EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi135 – 140HXXXXD motif6
Motifi531 – 534Di-lysine motif4

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine.By similarity
The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4666 Eukaryota
ENOG410XSIQ LUCA
GeneTreeiENSGT00390000004914
HOGENOMiHOG000234374
HOVERGENiHBG060273
InParanoidiQ8NF37
KOiK13510
OMAiALEILWL
OrthoDBiEOG091G09LH
PhylomeDBiQ8NF37
TreeFamiTF323244

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR002123 Plipid/glycerol_acylTrfase
PfamiView protein in Pfam
PF01553 Acyltransferase, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SM00563 PlsC, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8NF37-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLRGCGPRA APASSAGASD ARLLAPPGRN PFVHELRLSA LQKAQVALMT
60 70 80 90 100
LTLFPVRLLV AAAMMLLAWP LALVASLGSA EKEPEQPPAL WRKVVDFLLK
110 120 130 140 150
AIMRTMWFAG GFHRVAVKGR QALPTEAAIL TLAPHSSYFD AIPVTMTMSS
160 170 180 190 200
IVMKAESRDI PIWGTLIQYI RPVFVSRSDQ DSRRKTVEEI KRRAQSNGKW
210 220 230 240 250
PQIMIFPEGT CTNRTCLITF KPGAFIPGAP VQPVVLRYPN KLDTITWTWQ
260 270 280 290 300
GPGALEILWL TLCQFHNQVE IEFLPVYSPS EEEKRNPALY ASNVRRVMAE
310 320 330 340 350
ALGVSVTDYT FEDCQLALAE GQLRLPADTC LLEFARLVRG LGLKPEKLEK
360 370 380 390 400
DLDRYSERAR MKGGEKIGIA EFAASLEVPV SDLLEDMFSL FDESGSGEVD
410 420 430 440 450
LRECVVALSV VCRPARTLDT IQLAFKMYGA QEDGSVGEGD LSCILKTALG
460 470 480 490 500
VAELTVTDLF RAIDQEEKGK ITFADFHRFA EMYPAFAEEY LYPDQTHFES
510 520 530
CAETSPAPIP NGFCADFSPE NSDAGRKPVR KKLD
Length:534
Mass (Da):59,151
Last modified:July 25, 2006 - v2
Checksum:i69A9C3AEC698F6BD
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JQ62A0A0G2JQ62_HUMAN
Lysophosphatidylcholine acyltransfe...
LPCAT1
489Annotation score:
A0A0G2JRI7A0A0G2JRI7_HUMAN
Lysophosphatidylcholine acyltransfe...
LPCAT1
234Annotation score:

Sequence cautioni

The sequence BAB14061 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14065 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB244719 mRNA Translation: BAE94688.1
AK090444 mRNA Translation: BAC03425.1
BC020166 mRNA Translation: AAH20166.3
AK022505 mRNA Translation: BAB14065.1 Different initiation.
AK022499 mRNA Translation: BAB14061.1 Different initiation.
AF530061 mRNA Translation: AAQ09945.1
AL831864 mRNA Translation: CAD38556.1
CCDSiCCDS3864.1
RefSeqiNP_079106.3, NM_024830.4
UniGeneiHs.368853

Genome annotation databases

EnsembliENST00000283415; ENSP00000283415; ENSG00000153395
ENST00000475622; ENSP00000423472; ENSG00000153395
GeneIDi79888
KEGGihsa:79888
UCSCiuc003jcm.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB244719 mRNA Translation: BAE94688.1
AK090444 mRNA Translation: BAC03425.1
BC020166 mRNA Translation: AAH20166.3
AK022505 mRNA Translation: BAB14065.1 Different initiation.
AK022499 mRNA Translation: BAB14061.1 Different initiation.
AF530061 mRNA Translation: AAQ09945.1
AL831864 mRNA Translation: CAD38556.1
CCDSiCCDS3864.1
RefSeqiNP_079106.3, NM_024830.4
UniGeneiHs.368853

3D structure databases

ProteinModelPortaliQ8NF37
SMRiQ8NF37
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122973, 26 interactors
IntActiQ8NF37, 11 interactors
STRINGi9606.ENSP00000283415

Chemistry databases

SwissLipidsiSLP:000000295

PTM databases

iPTMnetiQ8NF37
PhosphoSitePlusiQ8NF37
SwissPalmiQ8NF37

Polymorphism and mutation databases

BioMutaiLPCAT1
DMDMi110815902

Proteomic databases

EPDiQ8NF37
MaxQBiQ8NF37
PaxDbiQ8NF37
PeptideAtlasiQ8NF37
PRIDEiQ8NF37
ProteomicsDBi73259
TopDownProteomicsiQ8NF37

Protocols and materials databases

DNASUi79888
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283415; ENSP00000283415; ENSG00000153395
ENST00000475622; ENSP00000423472; ENSG00000153395
GeneIDi79888
KEGGihsa:79888
UCSCiuc003jcm.4 human

Organism-specific databases

CTDi79888
DisGeNETi79888
EuPathDBiHostDB:ENSG00000153395.9
GeneCardsiLPCAT1
HGNCiHGNC:25718 LPCAT1
HPAiHPA012501
HPA022268
MIMi610472 gene
neXtProtiNX_Q8NF37
OpenTargetsiENSG00000153395
PharmGKBiPA162394232
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4666 Eukaryota
ENOG410XSIQ LUCA
GeneTreeiENSGT00390000004914
HOGENOMiHOG000234374
HOVERGENiHBG060273
InParanoidiQ8NF37
KOiK13510
OMAiALEILWL
OrthoDBiEOG091G09LH
PhylomeDBiQ8NF37
TreeFamiTF323244

Enzyme and pathway databases

UniPathwayi
UPA00085

BRENDAi2.3.1.23 2681
2.3.1.51 2681
ReactomeiR-HSA-1482788 Acyl chain remodelling of PC
R-HSA-1482925 Acyl chain remodelling of PG
R-HSA-1483166 Synthesis of PA
R-HSA-1483191 Synthesis of PC
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiLPCAT1 human
GenomeRNAii79888
PROiPR:Q8NF37
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153395 Expressed in 192 organ(s), highest expression level in lung
CleanExiHS_LPCAT1
GenevisibleiQ8NF37 HS

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR002123 Plipid/glycerol_acylTrfase
PfamiView protein in Pfam
PF01553 Acyltransferase, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SM00563 PlsC, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPCAT1_HUMAN
AccessioniPrimary (citable) accession number: Q8NF37
Secondary accession number(s): Q1HAQ1
, Q7Z4G6, Q8N3U7, Q8WUL8, Q9GZW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: November 7, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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