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Protein

F-box only protein 22

Gene

FBXO22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
F-box only protein 22
Alternative name(s):
F-box protein FBX22p44
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FBXO22
Synonyms:FBX22
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000167196.13

Human Gene Nomenclature Database

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HGNCi
HGNC:13593 FBXO22

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609096 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NEZ5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000167196

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA28035

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
FBXO22

Domain mapping of disease mutations (DMDM)

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DMDMi
30580428

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001199061 – 403F-box only protein 22Add BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei128PhosphoserineCombined sources1
Modified residuei194N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8NEZ5

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8NEZ5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NEZ5

PeptideAtlas

More...
PeptideAtlasi
Q8NEZ5

PRoteomics IDEntifications database

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PRIDEi
Q8NEZ5

ProteomicsDB human proteome resource

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ProteomicsDBi
73255
73256 [Q8NEZ5-2]
73257 [Q8NEZ5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8NEZ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8NEZ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in liver, also enriched in cardiac muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167196 Expressed in 199 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

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CleanExi
HS_FBXO22

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8NEZ5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8NEZ5 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Directly interacts with SKP1 and CUL1.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SKP1P632084EBI-2510137,EBI-307486

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
117649, 14 interactors

Protein interaction database and analysis system

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IntActi
Q8NEZ5, 14 interactors

Molecular INTeraction database

More...
MINTi
Q8NEZ5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000307833

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8NEZ5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8NEZ5

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 67F-boxAdd BLAST47

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQPW Eukaryota
ENOG4110X7S LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013049

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000285967

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051570

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8NEZ5

KEGG Orthology (KO)

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KOi
K10302

Identification of Orthologs from Complete Genome Data

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OMAi
RNCARRV

Database of Orthologous Groups

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OrthoDBi
EOG091G08DL

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8NEZ5

TreeFam database of animal gene trees

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TreeFami
TF328809

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR019494 FIST_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00646 F-box, 1 hit
PF10442 FIST_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01204 FIST_C, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF81383 SSF81383, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NEZ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPVGCCGEC RGSSVDPRST FVLSNLAEVV ERVLTFLPAK ALLRVACVCR
60 70 80 90 100
LWRECVRRVL RTHRSVTWIS AGLAEAGHLE GHCLVRVVAE ELENVRILPH
110 120 130 140 150
TVLYMADSET FISLEECRGH KRARKRTSME TALALEKLFP KQCQVLGIVT
160 170 180 190 200
PGIVVTPMGS GSNRPQEIEI GESGFALLFP QIEGIKIQPF HFIKDPKNLT
210 220 230 240 250
LERHQLTEVG LLDNPELRVV LVFGYNCCKV GASNYLQQVV STFSDMNIIL
260 270 280 290 300
AGGQVDNLSS LTSEKNPLDI DASGVVGLSF SGHRIQSATV LLNEDVSDEK
310 320 330 340 350
TAEAAMQRLK AANIPEHNTI GFMFACVGRG FQYYRAKGNV EADAFRKFFP
360 370 380 390 400
SVPLFGFFGN GEIGCDRIVT GNFILRKCNE VKDDDLFHSY TTIMALIHLG

SSK
Length:403
Mass (Da):44,508
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD96712BAA1149D8D
GO
Isoform 2 (identifier: Q8NEZ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-403: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:46
Mass (Da):4,922
Checksum:i1D49258F07775FA2
GO
Isoform 3 (identifier: Q8NEZ5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-276: NPLDIDASGVV → YVLCASDFVCE
     277-403: Missing.

Note: No experimental confirmation available.
Show »
Length:276
Mass (Da):30,589
Checksum:i0E9B0CE3E208358B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BRE0H3BRE0_HUMAN
F-box only protein 22
FBXO22
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTH6H3BTH6_HUMAN
F-box only protein 22
FBXO22
241Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTR7H3BTR7_HUMAN
F-box only protein 22
FBXO22
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BVA4H3BVA4_HUMAN
F-box only protein 22
FBXO22
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUC1H3BUC1_HUMAN
F-box only protein 22
FBXO22
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH39024 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4 – 11VGCCGECR → AGACGGP in AAF04523 (PubMed:10531035).Curated8
Sequence conflicti349F → L in AAH32540 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04182147 – 403Missing in isoform 2. 1 PublicationAdd BLAST357
Alternative sequenceiVSP_013058266 – 276NPLDIDASGVV → YVLCASDFVCE in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_013059277 – 403Missing in isoform 3. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY005144 mRNA Translation: AAF89095.1
AK024048 mRNA Translation: BAB14798.1
AC027104 Genomic DNA No translation available.
BC032540 mRNA Translation: AAH32540.1
BC020204 mRNA Translation: AAH20204.2
BC039024 mRNA Translation: AAH39024.1 Sequence problems.
BC041691 mRNA Translation: AAH41691.1
AF174602 Genomic DNA Translation: AAF04523.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10287.1 [Q8NEZ5-1]
CCDS45310.1 [Q8NEZ5-3]

NCBI Reference Sequences

More...
RefSeqi
NP_036302.1, NM_012170.3 [Q8NEZ5-3]
NP_671717.1, NM_147188.2 [Q8NEZ5-1]
XP_011519749.1, XM_011521447.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.591115

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000308275; ENSP00000307833; ENSG00000167196 [Q8NEZ5-1]
ENST00000453211; ENSP00000396442; ENSG00000167196 [Q8NEZ5-3]
ENST00000569022; ENSP00000457531; ENSG00000167196 [Q8NEZ5-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
26263

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26263

UCSC genome browser

More...
UCSCi
uc002bbj.3 human [Q8NEZ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY005144 mRNA Translation: AAF89095.1
AK024048 mRNA Translation: BAB14798.1
AC027104 Genomic DNA No translation available.
BC032540 mRNA Translation: AAH32540.1
BC020204 mRNA Translation: AAH20204.2
BC039024 mRNA Translation: AAH39024.1 Sequence problems.
BC041691 mRNA Translation: AAH41691.1
AF174602 Genomic DNA Translation: AAF04523.1
CCDSiCCDS10287.1 [Q8NEZ5-1]
CCDS45310.1 [Q8NEZ5-3]
RefSeqiNP_036302.1, NM_012170.3 [Q8NEZ5-3]
NP_671717.1, NM_147188.2 [Q8NEZ5-1]
XP_011519749.1, XM_011521447.2
UniGeneiHs.591115

3D structure databases

ProteinModelPortaliQ8NEZ5
SMRiQ8NEZ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117649, 14 interactors
IntActiQ8NEZ5, 14 interactors
MINTiQ8NEZ5
STRINGi9606.ENSP00000307833

PTM databases

iPTMnetiQ8NEZ5
PhosphoSitePlusiQ8NEZ5

Polymorphism and mutation databases

BioMutaiFBXO22
DMDMi30580428

Proteomic databases

EPDiQ8NEZ5
MaxQBiQ8NEZ5
PaxDbiQ8NEZ5
PeptideAtlasiQ8NEZ5
PRIDEiQ8NEZ5
ProteomicsDBi73255
73256 [Q8NEZ5-2]
73257 [Q8NEZ5-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
26263
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308275; ENSP00000307833; ENSG00000167196 [Q8NEZ5-1]
ENST00000453211; ENSP00000396442; ENSG00000167196 [Q8NEZ5-3]
ENST00000569022; ENSP00000457531; ENSG00000167196 [Q8NEZ5-2]
GeneIDi26263
KEGGihsa:26263
UCSCiuc002bbj.3 human [Q8NEZ5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26263
EuPathDBiHostDB:ENSG00000167196.13

GeneCards: human genes, protein and diseases

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GeneCardsi
FBXO22
HGNCiHGNC:13593 FBXO22
MIMi609096 gene
neXtProtiNX_Q8NEZ5
OpenTargetsiENSG00000167196
PharmGKBiPA28035

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IQPW Eukaryota
ENOG4110X7S LUCA
GeneTreeiENSGT00390000013049
HOGENOMiHOG000285967
HOVERGENiHBG051570
InParanoidiQ8NEZ5
KOiK10302
OMAiRNCARRV
OrthoDBiEOG091G08DL
PhylomeDBiQ8NEZ5
TreeFamiTF328809

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FBXO22 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
26263

Protein Ontology

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PROi
PR:Q8NEZ5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000167196 Expressed in 199 organ(s), highest expression level in liver
CleanExiHS_FBXO22
ExpressionAtlasiQ8NEZ5 baseline and differential
GenevisibleiQ8NEZ5 HS

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR019494 FIST_C
PfamiView protein in Pfam
PF00646 F-box, 1 hit
PF10442 FIST_C, 1 hit
SMARTiView protein in SMART
SM01204 FIST_C, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFBX22_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NEZ5
Secondary accession number(s): Q0D2P8
, Q6PIL5, Q8IXW3, Q9H824, Q9UKC0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: October 1, 2002
Last modified: December 5, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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