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Protein

F-box only protein 22

Gene

FBXO22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 22
Alternative name(s):
F-box protein FBX22p44
Gene namesi
Name:FBXO22
Synonyms:FBX22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000167196.13
HGNCiHGNC:13593 FBXO22
MIMi609096 gene
neXtProtiNX_Q8NEZ5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167196
PharmGKBiPA28035

Polymorphism and mutation databases

BioMutaiFBXO22
DMDMi30580428

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199061 – 403F-box only protein 22Add BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei128PhosphoserineCombined sources1
Modified residuei194N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8NEZ5
MaxQBiQ8NEZ5
PaxDbiQ8NEZ5
PeptideAtlasiQ8NEZ5
PRIDEiQ8NEZ5
ProteomicsDBi73255
73256 [Q8NEZ5-2]
73257 [Q8NEZ5-3]

PTM databases

iPTMnetiQ8NEZ5
PhosphoSitePlusiQ8NEZ5

Expressioni

Tissue specificityi

Predominantly expressed in liver, also enriched in cardiac muscle.1 Publication

Gene expression databases

BgeeiENSG00000167196 Expressed in 199 organ(s), highest expression level in liver
CleanExiHS_FBXO22
ExpressionAtlasiQ8NEZ5 baseline and differential
GenevisibleiQ8NEZ5 HS

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SKP1P632084EBI-2510137,EBI-307486

Protein-protein interaction databases

BioGridi117649, 13 interactors
IntActiQ8NEZ5, 14 interactors
MINTiQ8NEZ5
STRINGi9606.ENSP00000307833

Structurei

3D structure databases

ProteinModelPortaliQ8NEZ5
SMRiQ8NEZ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 67F-boxAdd BLAST47

Phylogenomic databases

eggNOGiENOG410IQPW Eukaryota
ENOG4110X7S LUCA
GeneTreeiENSGT00390000013049
HOGENOMiHOG000285967
HOVERGENiHBG051570
InParanoidiQ8NEZ5
KOiK10302
OMAiCCKVGAS
OrthoDBiEOG091G08DL
PhylomeDBiQ8NEZ5
TreeFamiTF328809

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR019494 FIST_C
PfamiView protein in Pfam
PF00646 F-box, 1 hit
PF10442 FIST_C, 1 hit
SMARTiView protein in SMART
SM01204 FIST_C, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NEZ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPVGCCGEC RGSSVDPRST FVLSNLAEVV ERVLTFLPAK ALLRVACVCR
60 70 80 90 100
LWRECVRRVL RTHRSVTWIS AGLAEAGHLE GHCLVRVVAE ELENVRILPH
110 120 130 140 150
TVLYMADSET FISLEECRGH KRARKRTSME TALALEKLFP KQCQVLGIVT
160 170 180 190 200
PGIVVTPMGS GSNRPQEIEI GESGFALLFP QIEGIKIQPF HFIKDPKNLT
210 220 230 240 250
LERHQLTEVG LLDNPELRVV LVFGYNCCKV GASNYLQQVV STFSDMNIIL
260 270 280 290 300
AGGQVDNLSS LTSEKNPLDI DASGVVGLSF SGHRIQSATV LLNEDVSDEK
310 320 330 340 350
TAEAAMQRLK AANIPEHNTI GFMFACVGRG FQYYRAKGNV EADAFRKFFP
360 370 380 390 400
SVPLFGFFGN GEIGCDRIVT GNFILRKCNE VKDDDLFHSY TTIMALIHLG

SSK
Length:403
Mass (Da):44,508
Last modified:October 1, 2002 - v1
Checksum:iD96712BAA1149D8D
GO
Isoform 2 (identifier: Q8NEZ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-403: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:46
Mass (Da):4,922
Checksum:i1D49258F07775FA2
GO
Isoform 3 (identifier: Q8NEZ5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-276: NPLDIDASGVV → YVLCASDFVCE
     277-403: Missing.

Note: No experimental confirmation available.
Show »
Length:276
Mass (Da):30,589
Checksum:i0E9B0CE3E208358B
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BRE0H3BRE0_HUMAN
F-box only protein 22
FBXO22
93Annotation score:
H3BTH6H3BTH6_HUMAN
F-box only protein 22
FBXO22
241Annotation score:
H3BTR7H3BTR7_HUMAN
F-box only protein 22
FBXO22
78Annotation score:
H3BVA4H3BVA4_HUMAN
F-box only protein 22
FBXO22
153Annotation score:
H3BUC1H3BUC1_HUMAN
F-box only protein 22
FBXO22
160Annotation score:

Sequence cautioni

The sequence AAH39024 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4 – 11VGCCGECR → AGACGGP in AAF04523 (PubMed:10531035).Curated8
Sequence conflicti349F → L in AAH32540 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04182147 – 403Missing in isoform 2. 1 PublicationAdd BLAST357
Alternative sequenceiVSP_013058266 – 276NPLDIDASGVV → YVLCASDFVCE in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_013059277 – 403Missing in isoform 3. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY005144 mRNA Translation: AAF89095.1
AK024048 mRNA Translation: BAB14798.1
AC027104 Genomic DNA No translation available.
BC032540 mRNA Translation: AAH32540.1
BC020204 mRNA Translation: AAH20204.2
BC039024 mRNA Translation: AAH39024.1 Sequence problems.
BC041691 mRNA Translation: AAH41691.1
AF174602 Genomic DNA Translation: AAF04523.1
CCDSiCCDS10287.1 [Q8NEZ5-1]
CCDS45310.1 [Q8NEZ5-3]
RefSeqiNP_036302.1, NM_012170.3 [Q8NEZ5-3]
NP_671717.1, NM_147188.2 [Q8NEZ5-1]
XP_011519749.1, XM_011521447.2
UniGeneiHs.591115

Genome annotation databases

EnsembliENST00000308275; ENSP00000307833; ENSG00000167196 [Q8NEZ5-1]
ENST00000453211; ENSP00000396442; ENSG00000167196 [Q8NEZ5-3]
ENST00000569022; ENSP00000457531; ENSG00000167196 [Q8NEZ5-2]
GeneIDi26263
KEGGihsa:26263
UCSCiuc002bbj.3 human [Q8NEZ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY005144 mRNA Translation: AAF89095.1
AK024048 mRNA Translation: BAB14798.1
AC027104 Genomic DNA No translation available.
BC032540 mRNA Translation: AAH32540.1
BC020204 mRNA Translation: AAH20204.2
BC039024 mRNA Translation: AAH39024.1 Sequence problems.
BC041691 mRNA Translation: AAH41691.1
AF174602 Genomic DNA Translation: AAF04523.1
CCDSiCCDS10287.1 [Q8NEZ5-1]
CCDS45310.1 [Q8NEZ5-3]
RefSeqiNP_036302.1, NM_012170.3 [Q8NEZ5-3]
NP_671717.1, NM_147188.2 [Q8NEZ5-1]
XP_011519749.1, XM_011521447.2
UniGeneiHs.591115

3D structure databases

ProteinModelPortaliQ8NEZ5
SMRiQ8NEZ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117649, 13 interactors
IntActiQ8NEZ5, 14 interactors
MINTiQ8NEZ5
STRINGi9606.ENSP00000307833

PTM databases

iPTMnetiQ8NEZ5
PhosphoSitePlusiQ8NEZ5

Polymorphism and mutation databases

BioMutaiFBXO22
DMDMi30580428

Proteomic databases

EPDiQ8NEZ5
MaxQBiQ8NEZ5
PaxDbiQ8NEZ5
PeptideAtlasiQ8NEZ5
PRIDEiQ8NEZ5
ProteomicsDBi73255
73256 [Q8NEZ5-2]
73257 [Q8NEZ5-3]

Protocols and materials databases

DNASUi26263
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308275; ENSP00000307833; ENSG00000167196 [Q8NEZ5-1]
ENST00000453211; ENSP00000396442; ENSG00000167196 [Q8NEZ5-3]
ENST00000569022; ENSP00000457531; ENSG00000167196 [Q8NEZ5-2]
GeneIDi26263
KEGGihsa:26263
UCSCiuc002bbj.3 human [Q8NEZ5-1]

Organism-specific databases

CTDi26263
EuPathDBiHostDB:ENSG00000167196.13
GeneCardsiFBXO22
HGNCiHGNC:13593 FBXO22
MIMi609096 gene
neXtProtiNX_Q8NEZ5
OpenTargetsiENSG00000167196
PharmGKBiPA28035
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQPW Eukaryota
ENOG4110X7S LUCA
GeneTreeiENSGT00390000013049
HOGENOMiHOG000285967
HOVERGENiHBG051570
InParanoidiQ8NEZ5
KOiK10302
OMAiCCKVGAS
OrthoDBiEOG091G08DL
PhylomeDBiQ8NEZ5
TreeFamiTF328809

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiFBXO22 human
GenomeRNAii26263
PROiPR:Q8NEZ5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167196 Expressed in 199 organ(s), highest expression level in liver
CleanExiHS_FBXO22
ExpressionAtlasiQ8NEZ5 baseline and differential
GenevisibleiQ8NEZ5 HS

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR019494 FIST_C
PfamiView protein in Pfam
PF00646 F-box, 1 hit
PF10442 FIST_C, 1 hit
SMARTiView protein in SMART
SM01204 FIST_C, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFBX22_HUMAN
AccessioniPrimary (citable) accession number: Q8NEZ5
Secondary accession number(s): Q0D2P8
, Q6PIL5, Q8IXW3, Q9H824, Q9UKC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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