UniProtKB - Q8NEZ2 (VP37A_HUMAN)

BLAST

>sp|Q8NEZ2|VP37A_HUMAN Vacuolar protein sorting-associated protein 37A OS=Homo sapiens OX=9606 GN=VPS37A PE=1 SV=1
MSWLFPLTKSASSSAAGSPGGLTSLQQQKQRLIESLRNSHSSIAEIQKDVEYRLPFTINN
LTININILLPPQFPQEKPVISVYPPIRHHLMDKQGVYVTSPLVNNFTMHSDLGKIIQSLL
DEFWKNPPVLAPTSTAFPYLYSNPSGMSPYASQGFPFLPPYPPQEANRSITSLSVADTVS
SSTTSHTTAKPAAPSFGVLSNLPLPIPTVDASIPTSQNGFGYKMPDVPDAFPELSELSVS
QLTDMNEQEEVLLEQFLTLPQLKQIITDKDDLVKSIEELARKNLLLEPSLEAKRQTVLDK
YELLTQMKSTFEKKMQRQHELSESCSASALQARLKVAAHEAEEESDNIAEDFLEGKMEID
DFLSSFMEKRTICHCRRAKEEKLQQAIAMHSQFHAPL

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History
Entry version 136 (12 Sep 2018)
Sequence version 1 (01 Oct 2002)
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Protein

Vacuolar protein sorting-associated protein 37A

Gene

VPS37A

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.1 Publication

GO - Biological processⁱ

endosomal transport Source: Reactome
endosome transport via multivesicular body sorting pathway Source: InterPro
macroautophagy
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 20588296
multivesicular body assembly
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 20588296
protein transport Source: UniProtKB-KW
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21757351
viral budding via host ESCRT complex
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 20588296
viral life cycle Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-162588 Budding and maturation of HIV virion R-HSA-174490 Membrane binding and targetting of GAG proteins R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Reactomeⁱ

R-HSA-162588 Budding and maturation of HIV virion
R-HSA-174490 Membrane binding and targetting of GAG proteins
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Vacuolar protein sorting-associated protein 37A Short name: hVps37A Alternative name(s): ESCRT-I complex subunit VPS37A Hepatocellular carcinoma-related protein 1
Gene namesⁱ	Name:VPS37A Synonyms:HCRP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000155975.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24928 VPS37A
MIMⁱ	609927 gene
neXtProtⁱ	NX_Q8NEZ2

Keywords - Cellular componentⁱ

Endosome, Membrane, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Spastic paraplegia 53, autosomal recessive (SPG53)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. Complicated forms are recognized by additional variable features including spastic quadriparesis, seizures, dementia, amyotrophy, extrapyramidal disturbance, cerebral or cerebellar atrophy, optic atrophy, and peripheral neuropathy, as well as by extra neurological manifestations. SPG53 is characterized by pronounced early onset spastic paraparesis of upper and lower limbs, mild intellectual disability, kyphosis, pectus carinatum and hypertrichosis.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_068424	382	K → N in SPG53; found in patients with complex hereditary spastic paraparesis; hypomorphic mutation; does not affect interaction with TSG101 and VPS28. 1 PublicationCorresponds to variant dbSNP:rs211694394EnsemblClinVar.		1

Keywords - Diseaseⁱ

Disease mutation, Hereditary spastic paraplegia, Neurodegeneration

Organism-specific databases

DisGeNET More...DisGeNETⁱ	137492
MalaCards human disease database More...MalaCardsⁱ	VPS37A
MIMⁱ	614898 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000155975
Orphanetⁱ	319199 Autosomal recessive spastic paraplegia type 53
PharmGKBⁱ	PA142670615

Polymorphism and mutation databases

BioMutaⁱ	VPS37A
DMDMⁱ	74715446

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000287198	1 – 397	Vacuolar protein sorting-associated protein 37AAdd BLAST		397

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	18	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8NEZ2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8NEZ2
PaxDbⁱ	Q8NEZ2
PeptideAtlas More...PeptideAtlasⁱ	Q8NEZ2
PRIDEⁱ	Q8NEZ2
ProteomicsDBⁱ	73247 73248 [Q8NEZ2-2] 73249 [Q8NEZ2-3]

PTM databases

iPTMnetⁱ	Q8NEZ2
PhosphoSitePlusⁱ	Q8NEZ2

Expressionⁱ

Tissue specificityⁱ

Widely expressed. Examined tissues include heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. More abundant in liver. Strongly decreased or undetected in hepatomas.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000155975 Expressed in 199 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_VPS37A
ExpressionAtlasⁱ	Q8NEZ2 baseline and differential
Genevisibleⁱ	Q8NEZ2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA024705 HPA024781

HPAⁱ

HPA024705
HPA024781

Interactionⁱ

Subunit structureⁱ

Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101, VPS28 and HGS. Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoichiometry.4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TRIM42	Q8IWZ5	3	EBI-10270911,EBI-5235829
TSG101	Q99816	5	EBI-2850578,EBI-346882

Protein-protein interaction databases

BioGridⁱ	126479, 15 interactors
IntActⁱ	Q8NEZ2, 9 interactors
Molecular INTeraction database More...MINTⁱ	Q8NEZ2
STRINGⁱ	9606.ENSP00000318629

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NEZ2
SMRⁱ	Q8NEZ2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	308 – 397	VPS37 C-terminalPROSITE-ProRule annotationAdd BLAST		90

Sequence similaritiesⁱ

Belongs to the VPS37 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3270 Eukaryota ENOG4111UJN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063123
HOGENOMⁱ	HOG000008031
HOVERGENⁱ	HBG054793
InParanoidⁱ	Q8NEZ2
KEGG Orthology (KO) More...KOⁱ	K12185
OMAⁱ	PPYASQG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GMF
PhylomeDBⁱ	Q8NEZ2
TreeFamⁱ	TF332146

Family and domain databases

Gene3Dⁱ	1.10.287.660, 1 hit 3.10.110.10, 1 hit
InterProⁱ	View protein in InterPro IPR037202 ESCRT_assembly_dom IPR029012 Helix_hairpin_bin_sf IPR009851 Mod_r IPR016135 UBQ-conjugating_enzyme/RWD IPR037859 Vps37
PANTHERⁱ	PTHR13678 PTHR13678, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07200 Mod_r, 1 hit
SUPFAMⁱ	SSF140111 SSF140111, 1 hit SSF54495 SSF54495, 1 hit
PROSITEⁱ	View protein in PROSITE PS51314 VPS37_C, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q8NEZ2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSWLFPLTKS ASSSAAGSPG GLTSLQQQKQ RLIESLRNSH SSIAEIQKDV 
        60         70         80         90        100
EYRLPFTINN LTININILLP PQFPQEKPVI SVYPPIRHHL MDKQGVYVTS 
       110        120        130        140        150
PLVNNFTMHS DLGKIIQSLL DEFWKNPPVL APTSTAFPYL YSNPSGMSPY 
       160        170        180        190        200
ASQGFPFLPP YPPQEANRSI TSLSVADTVS SSTTSHTTAK PAAPSFGVLS 
       210        220        230        240        250
NLPLPIPTVD ASIPTSQNGF GYKMPDVPDA FPELSELSVS QLTDMNEQEE 
       260        270        280        290        300
VLLEQFLTLP QLKQIITDKD DLVKSIEELA RKNLLLEPSL EAKRQTVLDK 
       310        320        330        340        350
YELLTQMKST FEKKMQRQHE LSESCSASAL QARLKVAAHE AEEESDNIAE 
       360        370        380        390 
DFLEGKMEID DFLSSFMEKR TICHCRRAKE EKLQQAIAMH SQFHAPL

Length:397

Mass (Da):44,314

Last modified:October 1, 2002 - v1

Checksum:ⁱ96EBB670F04A0923

Isoform 2 (identifier: Q8NEZ2-2) [UniParc]FASTA Add to basket

Also known as: beta

The sequence of this isoform differs from the canonical sequence as follows:
42-67: SIAEIQKDVEYRLPFTINNLTININI → R

« Hide

        10         20         30         40         50
MSWLFPLTKS ASSSAAGSPG GLTSLQQQKQ RLIESLRNSH SRLLPPQFPQ 
        60         70         80         90        100
EKPVISVYPP IRHHLMDKQG VYVTSPLVNN FTMHSDLGKI IQSLLDEFWK 
       110        120        130        140        150
NPPVLAPTST AFPYLYSNPS GMSPYASQGF PFLPPYPPQE ANRSITSLSV 
       160        170        180        190        200
ADTVSSSTTS HTTAKPAAPS FGVLSNLPLP IPTVDASIPT SQNGFGYKMP 
       210        220        230        240        250
DVPDAFPELS ELSVSQLTDM NEQEEVLLEQ FLTLPQLKQI ITDKDDLVKS 
       260        270        280        290        300
IEELARKNLL LEPSLEAKRQ TVLDKYELLT QMKSTFEKKM QRQHELSESC 
       310        320        330        340        350
SASALQARLK VAAHEAEEES DNIAEDFLEG KMEIDDFLSS FMEKRTICHC 
       360        370 
RRAKEEKLQQ AIAMHSQFHA PL

Show »

Length:372

Mass (Da):41,456

Checksum:ⁱC0793CE39FC71A49

Isoform 3 (identifier: Q8NEZ2-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
140-185: LYSNPSGMSP...ADTVSSSTTS → QLEIRWHHPH...KQEYHFFICC
186-397: Missing.

« Hide

        10         20         30         40         50
MSWLFPLTKS ASSSAAGSPG GLTSLQQQKQ RLIESLRNSH SSIAEIQKDV 
        60         70         80         90        100
EYRLPFTINN LTININILLP PQFPQEKPVI SVYPPIRHHL MDKQGVYVTS 
       110        120        130        140        150
PLVNNFTMHS DLGKIIQSLL DEFWKNPPVL APTSTAFPYQ LEIRWHHPHC 
       160        170        180 
LEISLARSSN SLGFSISSSI SSTRSKQEYH FFICC

Show »

Length:185

Mass (Da):20,891

Checksum:ⁱAF11A1206F0BCA95

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
H0YBN0	H0YBN0_HUMAN	Vacuolar protein sorting-associated... Vacuolar protein sorting-associated protein 37A	VPS37A	170	Annotation score:
E5RG91	E5RG91_HUMAN	Vacuolar protein sorting-associated... Vacuolar protein sorting-associated protein 37A	VPS37A	317	Annotation score:
E5RHB8	E5RHB8_HUMAN	Vacuolar protein sorting-associated... Vacuolar protein sorting-associated protein 37A	VPS37A	76	Annotation score:
E5RJX6	E5RJX6_HUMAN	Vacuolar protein sorting-associated... Vacuolar protein sorting-associated protein 37A	VPS37A	116	Annotation score:
E5RJ10	E5RJ10_HUMAN	Vacuolar protein sorting-associated... Vacuolar protein sorting-associated protein 37A	VPS37A	53	Annotation score:

Sequence cautionⁱ

The sequence AAH22363 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	313	K → R in BAB71381 (PubMed:14702039).Curated		1
Sequence conflictⁱ	324	S → I in AAH67754 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_032287	206	I → F. Corresponds to variant dbSNP:rs17502618EnsemblClinVar.	1
Natural variantⁱVAR_032288	213	I → V. Corresponds to variant dbSNP:rs17687375EnsemblClinVar.	1
Natural variantⁱVAR_068424	382	K → N in SPG53; found in patients with complex hereditary spastic paraparesis; hypomorphic mutation; does not affect interaction with TSG101 and VPS28. 1 PublicationCorresponds to variant dbSNP:rs211694394EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_025367	42 – 67	SIAEI…ININI → R in isoform 2. 1 PublicationAdd BLAST	26
Alternative sequenceⁱVSP_025368	140 – 185	LYSNP…SSTTS → QLEIRWHHPHCLEISLARSS NSLGFSISSSISSTRSKQEY HFFICC in isoform 3. 1 PublicationAdd BLAST	46
Alternative sequenceⁱVSP_025369	186 – 397	Missing in isoform 3. 1 PublicationAdd BLAST	212

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY033079 mRNA Translation: AAK54349.1 AF547097 mRNA Translation: AAQ12067.1 AK057204 mRNA Translation: BAB71381.1 AL834189 mRNA Translation: CAD38883.1 BC022363 mRNA Translation: AAH22363.1 Different initiation. BC067754 mRNA Translation: AAH67754.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47811.1 [Q8NEZ2-2] CCDS6001.1 [Q8NEZ2-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001138624.1, NM_001145152.1 [Q8NEZ2-2] NP_689628.2, NM_152415.2 [Q8NEZ2-1] XP_016868510.1, XM_017013021.1 [Q8NEZ2-1] XP_016868511.1, XM_017013022.1 [Q8NEZ2-1] XP_016868515.1, XM_017013026.1
UniGeneⁱ	Hs.343873

Genome annotation databases

Ensemblⁱ	ENST00000324849; ENSP00000318629; ENSG00000155975 [Q8NEZ2-1] ENST00000425020; ENSP00000412824; ENSG00000155975 [Q8NEZ2-3] ENST00000521829; ENSP00000429680; ENSG00000155975 [Q8NEZ2-2]
GeneIDⁱ	137492
KEGGⁱ	hsa:137492
UCSC genome browser More...UCSCⁱ	uc003wxj.4 human [Q8NEZ2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8NEZ2	Vacuolar protein sorting-associated protein 37A (Fragment)		HUMAN		170	UniRef100_Q8NEZ2
VPS37A isoform 8 (Fragment)		PONAB		170
UPI000387B266		HUMAN		307

Protein	Similar proteins		Species	Score	Length	Source
Q8NEZ2	Vacuolar protein sorting-associated protein 37A (Fragment)		HUMAN		170	UniRef90_Q8NEZ2
VPS37A isoform 8 (Fragment)		PONAB		170
VPS37A isoform 8		PANTR		408
Vacuolar protein sorting-associated protein 37A isoform 1		MACMU		397
VPS37A, ESCRT-I subunit		CERAT		397
+42
Q8NEZ2-2	VPS37A, ESCRT-I subunit		Cebus capucinus imitator		372	UniRef90_Q8NEZ2-2
VPS37A, ESCRT-I subunit		COLAP		372
vacuolar protein sorting-associated protein 37A isoform X2		ODORO		372
VPS37A isoform 6		PONAB		372
Vacuolar protein sorting 37 homolog A		PANTR		372
+22
Q8NEZ2-3	VPS37A isoform 5		PANTR		185	UniRef90_A0A2J8KIK0
VPS37A isoform 5		PONAB		185

Protein	Similar proteins		Species	Score	Length	Source
Q8NEZ2	Vacuolar protein sorting-associated protein 37A		MOUSE		397	UniRef50_Q8NEZ2
Vacuolar protein sorting-associated protein 37A (Fragment)		HUMAN		170
VPS37A isoform 8 (Fragment)		PONAB		170
VPS37A isoform 8		PANTR		408
VPS37A, ESCRT-I subunit		COLAP		397
+214
Q8NEZ2-2	VPS37A, ESCRT-I subunit		COLAP		372	UniRef50_Q8NEZ2-2
VPS37A, ESCRT-I subunit		PANPA		372
VPS37A, ESCRT-I subunit		AOTNA		372
VPS37A, ESCRT-I subunit		PAPAN		372
VPS37A, ESCRT-I subunit		CERAT		372
+143
Q8NEZ2-3	VPS37A isoform 5		PANTR		185	UniRef50_A0A2J8KIK0
VPS37A isoform 5		PONAB		185

Entry informationⁱ

Entry nameⁱ	VP37A_HUMAN
Accessionⁱ	Q8NEZ2Primary (citable) accession number: Q8NEZ2 Secondary accession number(s): Q336D5 , Q6NW27, Q8N3D7, Q8TBL7, Q96DL9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
	Last sequence update:	October 1, 2002
	Last modified:	September 12, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniParc

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Supporting data

UniProtKB - Q8NEZ2 (VP37A_HUMAN)

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Vacuolar protein sorting-associated protein 37A

VPS37A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Endosome

Cytoskeleton

Cytosol

Endosome

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ