UniProtKB - Q8NEY3 (SPAT4_HUMAN)

BLAST

>sp|Q8NEY3|SPAT4_HUMAN Spermatogenesis-associated protein 4 OS=Homo sapiens OX=9606 GN=SPATA4 PE=1 SV=1
MAAAGQEKGYLTQTAAALDKSPSLSPQLAAPIRGRPKKCLVYPHAPKSSRLSRSVLRWLQ
GLDLSFFPRNINRDFSNGFLIAEIFCIYYPWELELSSFENGTSLKVKLDNWAQLEKFLAR
KKFKLPKELIHGTIHCKAGVPEILIEEVYTLLTHREIKSIQDDFVNFTDYSYQMRLPLVS
RSTVSKSIKDNIRLSELLSNPNMLTNELKAEFLILLHMLQRKLGRKLNPEWFDVKPTVGE
VTLNHLPAQASGRRYNLKVKRGRVVPVLPNIGSGGSSHREIHVKQAGQHSYYSAMKPIRN
MDKKP

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History
Entry version 109 (10 Oct 2018)
Sequence version 1 (01 Oct 2002)
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Protein

Spermatogenesis-associated protein 4

Gene

SPATA4

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May play a role in apoptosis regulation.1 Publication

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Spermatogenesis-associated protein 4 Alternative name(s): Testis and spermatogenesis cell-related protein 2 Testis spermatocyte apoptosis-related gene 2 protein
Gene namesⁱ	Name:SPATA4 Synonyms:TSARG2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000150628.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17333 SPATA4
MIMⁱ	609879 gene
neXtProtⁱ	NX_Q8NEY3

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	132851
Open Targets More...OpenTargetsⁱ	ENSG00000150628
PharmGKBⁱ	PA38232

Polymorphism and mutation databases

BioMutaⁱ	SPATA4
DMDMⁱ	48474486

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000072101	1 – 305	Spermatogenesis-associated protein 4Add BLAST		305

Proteomic databases

PaxDbⁱ	Q8NEY3
PeptideAtlas More...PeptideAtlasⁱ	Q8NEY3
PRIDEⁱ	Q8NEY3
ProteomicsDBⁱ	73237

PTM databases

iPTMnetⁱ	Q8NEY3
PhosphoSitePlusⁱ	Q8NEY3

Expressionⁱ

Tissue specificityⁱ

Highly expressed in testis, the expression is observed precisely in seminiferous tubules.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000150628 Expressed in 93 organ(s), highest expression level in testis
CleanExⁱ	HS_SPATA4
ExpressionAtlasⁱ	Q8NEY3 baseline and differential
Genevisibleⁱ	Q8NEY3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA019220

HPAⁱ

HPA019220

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SIAH1	Q8IUQ4	3	EBI-7067221,EBI-747107

With

Entry

#Exp.

IntAct

Notes

SIAH1

Q8IUQ4

EBI-7067221,EBI-747107

Protein-protein interaction databases

BioGridⁱ	126337, 3 interactors
IntActⁱ	Q8NEY3, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q8NEY3
STRINGⁱ	9606.ENSP00000280191

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NEY3
SMRⁱ	Q8NEY3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	49 – 155	Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST		107

Phylogenomic databases

eggNOGⁱ	ENOG410IJ0V Eukaryota ENOG410ZE7H LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144159
HOGENOMⁱ	HOG000007428
HOVERGENⁱ	HBG054406
InParanoidⁱ	Q8NEY3
OMAⁱ	PKKCLVY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I7I
PhylomeDBⁱ	Q8NEY3
TreeFamⁱ	TF323506

Family and domain databases

Gene3Dⁱ	1.10.418.10, 1 hit
InterProⁱ	View protein in InterPro IPR001715 CH-domain IPR010441 CH_2 IPR036872 CH_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06294 CH_2, 1 hit
PROSITEⁱ	View protein in PROSITE PS50021 CH, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q8NEY3-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAAAGQEKGY LTQTAAALDK SPSLSPQLAA PIRGRPKKCL VYPHAPKSSR 
        60         70         80         90        100
LSRSVLRWLQ GLDLSFFPRN INRDFSNGFL IAEIFCIYYP WELELSSFEN 
       110        120        130        140        150
GTSLKVKLDN WAQLEKFLAR KKFKLPKELI HGTIHCKAGV PEILIEEVYT 
       160        170        180        190        200
LLTHREIKSI QDDFVNFTDY SYQMRLPLVS RSTVSKSIKD NIRLSELLSN 
       210        220        230        240        250
PNMLTNELKA EFLILLHMLQ RKLGRKLNPE WFDVKPTVGE VTLNHLPAQA 
       260        270        280        290        300
SGRRYNLKVK RGRVVPVLPN IGSGGSSHRE IHVKQAGQHS YYSAMKPIRN 

MDKKP

Length:305

Mass (Da):34,751

Last modified:October 1, 2002 - v1

Checksum:ⁱ7A3D1DCDC3FAC976

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G5E9Y6	G5E9Y6_HUMAN	Spermatogenesis associated 4, isofo... Spermatogenesis associated 4, isoform CRA_a (Spermatogenesis-associated protein 4)	SPATA4 hCG_40521	132	Annotation score:
H0YA30	H0YA30_HUMAN	Spermatogenesis-associated protein ... Spermatogenesis-associated protein 4	SPATA4	76	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	70	N → D in AAH21731 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051369	149	Y → C. Corresponds to variant dbSNP:rs17062589Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY040204 mRNA Translation: AAK72463.1 BC021731 mRNA Translation: AAH21731.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3826.1
NCBI Reference Sequences More...RefSeqⁱ	NP_653245.2, NM_144644.3
UniGeneⁱ	Hs.481235

Genome annotation databases

Ensemblⁱ	ENST00000280191; ENSP00000280191; ENSG00000150628
GeneIDⁱ	132851
KEGGⁱ	hsa:132851
UCSC genome browser More...UCSCⁱ	uc003iuo.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8NEY3	Spermatogenesis-associated protein 4		PANTR		305	UniRef90_Q8NEY3
Uncharacterized protein		CERAT		314
Spermatogenesis-associated 4		MACMU		305
Uncharacterized protein		MACFA		305
Uncharacterized protein		RHIRO		305
+26

Protein	Similar proteins		Species	Score	Length	Source
Q8NEY3	Spermatogenesis-associated protein 4		PANTR		305	UniRef50_Q8NEY3
Uncharacterized protein		CERAT		314
Uncharacterized protein		PAPAN		305
Uncharacterized protein		MANLE		305
Uncharacterized protein		NOMLE		305
+87

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY040204 mRNA Translation: AAK72463.1 BC021731 mRNA Translation: AAH21731.1
CCDSⁱ	CCDS3826.1
RefSeqⁱ	NP_653245.2, NM_144644.3
UniGeneⁱ	Hs.481235

3D structure databases

ProteinModelPortalⁱ	Q8NEY3
SMRⁱ	Q8NEY3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126337, 3 interactors
IntActⁱ	Q8NEY3, 2 interactors
MINTⁱ	Q8NEY3
STRINGⁱ	9606.ENSP00000280191

PTM databases

iPTMnetⁱ	Q8NEY3
PhosphoSitePlusⁱ	Q8NEY3

Polymorphism and mutation databases

BioMutaⁱ	SPATA4
DMDMⁱ	48474486

Proteomic databases

PaxDbⁱ	Q8NEY3
PeptideAtlasⁱ	Q8NEY3
PRIDEⁱ	Q8NEY3
ProteomicsDBⁱ	73237

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	132851
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000280191; ENSP00000280191; ENSG00000150628
GeneIDⁱ	132851
KEGGⁱ	hsa:132851
UCSCⁱ	uc003iuo.2 human

Organism-specific databases

CTDⁱ	132851
DisGeNETⁱ	132851
EuPathDBⁱ	HostDB:ENSG00000150628.6
GeneCardsⁱ	SPATA4
HGNCⁱ	HGNC:17333 SPATA4
HPAⁱ	HPA019220
MIMⁱ	609879 gene
neXtProtⁱ	NX_Q8NEY3
OpenTargetsⁱ	ENSG00000150628
PharmGKBⁱ	PA38232
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJ0V Eukaryota ENOG410ZE7H LUCA
GeneTreeⁱ	ENSGT00910000144159
HOGENOMⁱ	HOG000007428
HOVERGENⁱ	HBG054406
InParanoidⁱ	Q8NEY3
OMAⁱ	PKKCLVY
OrthoDBⁱ	EOG091G0I7I
PhylomeDBⁱ	Q8NEY3
TreeFamⁱ	TF323506

Miscellaneous databases

GenomeRNAiⁱ	132851
Protein Ontology More...PROⁱ	PR:Q8NEY3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000150628 Expressed in 93 organ(s), highest expression level in testis
CleanExⁱ	HS_SPATA4
ExpressionAtlasⁱ	Q8NEY3 baseline and differential
Genevisibleⁱ	Q8NEY3 HS

Family and domain databases

Gene3Dⁱ	1.10.418.10, 1 hit
InterProⁱ	View protein in InterPro IPR001715 CH-domain IPR010441 CH_2 IPR036872 CH_dom_sf
Pfamⁱ	View protein in Pfam PF06294 CH_2, 1 hit
PROSITEⁱ	View protein in PROSITE PS50021 CH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SPAT4_HUMAN
Accessionⁱ	Q8NEY3Primary (citable) accession number: Q8NEY3 Secondary accession number(s): Q8NCS5, Q8WW15
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
	Last sequence update:	October 1, 2002
	Last modified:	October 10, 2018
	This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8NEY3 (SPAT4_HUMAN)

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Spermatogenesis-associated protein 4

SPATA4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ