UniProtKB - Q8NEY3 (SPAT4_HUMAN)
Protein
Spermatogenesis-associated protein 4
Gene
SPATA4
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in apoptosis regulation.1 Publication
GO - Molecular functioni
- microtubule binding Source: GO_Central
GO - Biological processi
- regulation of cytoskeleton organization Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q8NEY3 |
Names & Taxonomyi
Protein namesi | Recommended name: Spermatogenesis-associated protein 4Alternative name(s): Testis and spermatogenesis cell-related protein 2 Testis spermatocyte apoptosis-related gene 2 protein |
Gene namesi | Name:SPATA4 Synonyms:TSARG2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000150628.6 |
HGNCi | HGNC:17333, SPATA4 |
MIMi | 609879, gene |
neXtProti | NX_Q8NEY3 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000150628 |
PharmGKBi | PA38232 |
Miscellaneous databases
Pharosi | Q8NEY3, Tbio |
Polymorphism and mutation databases
BioMutai | SPATA4 |
DMDMi | 48474486 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000072101 | 1 – 305 | Spermatogenesis-associated protein 4Add BLAST | 305 |
Proteomic databases
MassIVEi | Q8NEY3 |
PaxDbi | Q8NEY3 |
PeptideAtlasi | Q8NEY3 |
PRIDEi | Q8NEY3 |
ProteomicsDBi | 73237 |
PTM databases
iPTMneti | Q8NEY3 |
PhosphoSitePlusi | Q8NEY3 |
Expressioni
Tissue specificityi
Highly expressed in testis, the expression is observed precisely in seminiferous tubules.1 Publication
Gene expression databases
Bgeei | ENSG00000150628, Expressed in testis and 112 other tissues |
ExpressionAtlasi | Q8NEY3, baseline and differential |
Genevisiblei | Q8NEY3, HS |
Organism-specific databases
HPAi | ENSG00000150628, Tissue enriched (testis) |
Interactioni
Binary interactionsi
Q8NEY3
With | #Exp. | IntAct |
---|---|---|
SIAH1 [Q8IUQ4] | 3 | EBI-7067221,EBI-747107 |
GO - Molecular functioni
- microtubule binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 126337, 4 interactors |
IntActi | Q8NEY3, 2 interactors |
MINTi | Q8NEY3 |
STRINGi | 9606.ENSP00000280191 |
Miscellaneous databases
RNActi | Q8NEY3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 49 – 155 | Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST | 107 |
Phylogenomic databases
eggNOGi | ENOG502QU8V, Eukaryota |
GeneTreei | ENSGT00910000144159 |
HOGENOMi | CLU_077979_1_0_1 |
InParanoidi | Q8NEY3 |
OMAi | DYSYQMH |
OrthoDBi | 1471531at2759 |
PhylomeDBi | Q8NEY3 |
TreeFami | TF323506 |
Family and domain databases
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR001715, CH-domain IPR010441, CH_2 IPR036872, CH_dom_sf |
Pfami | View protein in Pfam PF06294, CH_2, 1 hit |
PROSITEi | View protein in PROSITE PS50021, CH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8NEY3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAAGQEKGY LTQTAAALDK SPSLSPQLAA PIRGRPKKCL VYPHAPKSSR
60 70 80 90 100
LSRSVLRWLQ GLDLSFFPRN INRDFSNGFL IAEIFCIYYP WELELSSFEN
110 120 130 140 150
GTSLKVKLDN WAQLEKFLAR KKFKLPKELI HGTIHCKAGV PEILIEEVYT
160 170 180 190 200
LLTHREIKSI QDDFVNFTDY SYQMRLPLVS RSTVSKSIKD NIRLSELLSN
210 220 230 240 250
PNMLTNELKA EFLILLHMLQ RKLGRKLNPE WFDVKPTVGE VTLNHLPAQA
260 270 280 290 300
SGRRYNLKVK RGRVVPVLPN IGSGGSSHRE IHVKQAGQHS YYSAMKPIRN
MDKKP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG5E9Y6 | G5E9Y6_HUMAN | Spermatogenesis associated 4, isofo... | SPATA4 hCG_40521 | 132 | Annotation score: | ||
H0YA30 | H0YA30_HUMAN | Spermatogenesis-associated protein ... | SPATA4 | 76 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 70 | N → D in AAH21731 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051369 | 149 | Y → C. Corresponds to variant dbSNP:rs17062589Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY040204 mRNA Translation: AAK72463.1 BC021731 mRNA Translation: AAH21731.1 |
CCDSi | CCDS3826.1 |
RefSeqi | NP_653245.2, NM_144644.3 |
Genome annotation databases
Ensembli | ENST00000280191; ENSP00000280191; ENSG00000150628 |
GeneIDi | 132851 |
KEGGi | hsa:132851 |
UCSCi | uc003iuo.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY040204 mRNA Translation: AAK72463.1 BC021731 mRNA Translation: AAH21731.1 |
CCDSi | CCDS3826.1 |
RefSeqi | NP_653245.2, NM_144644.3 |
3D structure databases
SMRi | Q8NEY3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126337, 4 interactors |
IntActi | Q8NEY3, 2 interactors |
MINTi | Q8NEY3 |
STRINGi | 9606.ENSP00000280191 |
PTM databases
iPTMneti | Q8NEY3 |
PhosphoSitePlusi | Q8NEY3 |
Polymorphism and mutation databases
BioMutai | SPATA4 |
DMDMi | 48474486 |
Proteomic databases
MassIVEi | Q8NEY3 |
PaxDbi | Q8NEY3 |
PeptideAtlasi | Q8NEY3 |
PRIDEi | Q8NEY3 |
ProteomicsDBi | 73237 |
Protocols and materials databases
Antibodypediai | 17256, 142 antibodies |
DNASUi | 132851 |
Genome annotation databases
Ensembli | ENST00000280191; ENSP00000280191; ENSG00000150628 |
GeneIDi | 132851 |
KEGGi | hsa:132851 |
UCSCi | uc003iuo.2, human |
Organism-specific databases
CTDi | 132851 |
EuPathDBi | HostDB:ENSG00000150628.6 |
GeneCardsi | SPATA4 |
HGNCi | HGNC:17333, SPATA4 |
HPAi | ENSG00000150628, Tissue enriched (testis) |
MIMi | 609879, gene |
neXtProti | NX_Q8NEY3 |
OpenTargetsi | ENSG00000150628 |
PharmGKBi | PA38232 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QU8V, Eukaryota |
GeneTreei | ENSGT00910000144159 |
HOGENOMi | CLU_077979_1_0_1 |
InParanoidi | Q8NEY3 |
OMAi | DYSYQMH |
OrthoDBi | 1471531at2759 |
PhylomeDBi | Q8NEY3 |
TreeFami | TF323506 |
Enzyme and pathway databases
PathwayCommonsi | Q8NEY3 |
Miscellaneous databases
BioGRID-ORCSi | 132851, 10 hits in 839 CRISPR screens |
ChiTaRSi | SPATA4, human |
GenomeRNAii | 132851 |
Pharosi | Q8NEY3, Tbio |
PROi | PR:Q8NEY3 |
RNActi | Q8NEY3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000150628, Expressed in testis and 112 other tissues |
ExpressionAtlasi | Q8NEY3, baseline and differential |
Genevisiblei | Q8NEY3, HS |
Family and domain databases
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR001715, CH-domain IPR010441, CH_2 IPR036872, CH_dom_sf |
Pfami | View protein in Pfam PF06294, CH_2, 1 hit |
PROSITEi | View protein in PROSITE PS50021, CH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SPAT4_HUMAN | |
Accessioni | Q8NEY3Primary (citable) accession number: Q8NEY3 Secondary accession number(s): Q8NCS5, Q8WW15 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations