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Protein

Spermatogenesis-associated protein 4

Gene

SPATA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in apoptosis regulation.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated protein 4
Alternative name(s):
Testis and spermatogenesis cell-related protein 2
Testis spermatocyte apoptosis-related gene 2 protein
Gene namesi
Name:SPATA4
Synonyms:TSARG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000150628.6
HGNCiHGNC:17333 SPATA4
MIMi609879 gene
neXtProtiNX_Q8NEY3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi132851
OpenTargetsiENSG00000150628
PharmGKBiPA38232

Polymorphism and mutation databases

BioMutaiSPATA4
DMDMi48474486

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000721011 – 305Spermatogenesis-associated protein 4Add BLAST305

Proteomic databases

PaxDbiQ8NEY3
PeptideAtlasiQ8NEY3
PRIDEiQ8NEY3
ProteomicsDBi73237

PTM databases

iPTMnetiQ8NEY3
PhosphoSitePlusiQ8NEY3

Expressioni

Tissue specificityi

Highly expressed in testis, the expression is observed precisely in seminiferous tubules.1 Publication

Gene expression databases

BgeeiENSG00000150628 Expressed in 93 organ(s), highest expression level in testis
CleanExiHS_SPATA4
ExpressionAtlasiQ8NEY3 baseline and differential
GenevisibleiQ8NEY3 HS

Organism-specific databases

HPAiHPA019220

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SIAH1Q8IUQ43EBI-7067221,EBI-747107

Protein-protein interaction databases

BioGridi126337, 3 interactors
IntActiQ8NEY3, 2 interactors
MINTiQ8NEY3
STRINGi9606.ENSP00000280191

Structurei

3D structure databases

ProteinModelPortaliQ8NEY3
SMRiQ8NEY3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 155Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST107

Phylogenomic databases

eggNOGiENOG410IJ0V Eukaryota
ENOG410ZE7H LUCA
GeneTreeiENSGT00910000144159
HOGENOMiHOG000007428
HOVERGENiHBG054406
InParanoidiQ8NEY3
OMAiPKKCLVY
OrthoDBiEOG091G0I7I
PhylomeDBiQ8NEY3
TreeFamiTF323506

Family and domain databases

Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR010441 CH_2
IPR036872 CH_dom_sf
PfamiView protein in Pfam
PF06294 CH_2, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8NEY3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAGQEKGY LTQTAAALDK SPSLSPQLAA PIRGRPKKCL VYPHAPKSSR
60 70 80 90 100
LSRSVLRWLQ GLDLSFFPRN INRDFSNGFL IAEIFCIYYP WELELSSFEN
110 120 130 140 150
GTSLKVKLDN WAQLEKFLAR KKFKLPKELI HGTIHCKAGV PEILIEEVYT
160 170 180 190 200
LLTHREIKSI QDDFVNFTDY SYQMRLPLVS RSTVSKSIKD NIRLSELLSN
210 220 230 240 250
PNMLTNELKA EFLILLHMLQ RKLGRKLNPE WFDVKPTVGE VTLNHLPAQA
260 270 280 290 300
SGRRYNLKVK RGRVVPVLPN IGSGGSSHRE IHVKQAGQHS YYSAMKPIRN

MDKKP
Length:305
Mass (Da):34,751
Last modified:October 1, 2002 - v1
Checksum:i7A3D1DCDC3FAC976
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9Y6G5E9Y6_HUMAN
Spermatogenesis associated 4, isofo...
SPATA4 hCG_40521
132Annotation score:
H0YA30H0YA30_HUMAN
Spermatogenesis-associated protein ...
SPATA4
76Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70N → D in AAH21731 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051369149Y → C. Corresponds to variant dbSNP:rs17062589Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040204 mRNA Translation: AAK72463.1
BC021731 mRNA Translation: AAH21731.1
CCDSiCCDS3826.1
RefSeqiNP_653245.2, NM_144644.3
UniGeneiHs.481235

Genome annotation databases

EnsembliENST00000280191; ENSP00000280191; ENSG00000150628
GeneIDi132851
KEGGihsa:132851
UCSCiuc003iuo.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040204 mRNA Translation: AAK72463.1
BC021731 mRNA Translation: AAH21731.1
CCDSiCCDS3826.1
RefSeqiNP_653245.2, NM_144644.3
UniGeneiHs.481235

3D structure databases

ProteinModelPortaliQ8NEY3
SMRiQ8NEY3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126337, 3 interactors
IntActiQ8NEY3, 2 interactors
MINTiQ8NEY3
STRINGi9606.ENSP00000280191

PTM databases

iPTMnetiQ8NEY3
PhosphoSitePlusiQ8NEY3

Polymorphism and mutation databases

BioMutaiSPATA4
DMDMi48474486

Proteomic databases

PaxDbiQ8NEY3
PeptideAtlasiQ8NEY3
PRIDEiQ8NEY3
ProteomicsDBi73237

Protocols and materials databases

DNASUi132851
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280191; ENSP00000280191; ENSG00000150628
GeneIDi132851
KEGGihsa:132851
UCSCiuc003iuo.2 human

Organism-specific databases

CTDi132851
DisGeNETi132851
EuPathDBiHostDB:ENSG00000150628.6
GeneCardsiSPATA4
HGNCiHGNC:17333 SPATA4
HPAiHPA019220
MIMi609879 gene
neXtProtiNX_Q8NEY3
OpenTargetsiENSG00000150628
PharmGKBiPA38232
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ0V Eukaryota
ENOG410ZE7H LUCA
GeneTreeiENSGT00910000144159
HOGENOMiHOG000007428
HOVERGENiHBG054406
InParanoidiQ8NEY3
OMAiPKKCLVY
OrthoDBiEOG091G0I7I
PhylomeDBiQ8NEY3
TreeFamiTF323506

Miscellaneous databases

GenomeRNAii132851
PROiPR:Q8NEY3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150628 Expressed in 93 organ(s), highest expression level in testis
CleanExiHS_SPATA4
ExpressionAtlasiQ8NEY3 baseline and differential
GenevisibleiQ8NEY3 HS

Family and domain databases

Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR010441 CH_2
IPR036872 CH_dom_sf
PfamiView protein in Pfam
PF06294 CH_2, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPAT4_HUMAN
AccessioniPrimary (citable) accession number: Q8NEY3
Secondary accession number(s): Q8NCS5, Q8WW15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 10, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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