Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Casein kinase II subunit alpha 3

Gene

CSNK2A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei68ATPPROSITE-ProRule annotation1
Active sitei156Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 53ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  • positive regulation of cell growth Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of protein catabolic process Source: UniProtKB
  • protein phosphorylation Source: UniProtKB

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8NEV1

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase II subunit alpha 3 (EC:2.7.11.1)
Short name:
CK II alpha 3
Alternative name(s):
Casein kinase II alpha 1 polypeptide pseudogene
Gene namesi
Name:CSNK2A3
Synonyms:CSNK2A1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000254598.2
HGNCiHGNC:2458 CSNK2A3
neXtProtiNX_Q8NEV1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi283106
OpenTargetsiENSG00000254598

Chemistry databases

ChEMBLiCHEMBL3832943

Polymorphism and mutation databases

BioMutaiCSNK2A3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004221941 – 391Casein kinase II subunit alpha 3Add BLAST391

Proteomic databases

EPDiQ8NEV1
MaxQBiQ8NEV1
PeptideAtlasiQ8NEV1
PRIDEiQ8NEV1

PTM databases

iPTMnetiQ8NEV1
PhosphoSitePlusiQ8NEV1

Expressioni

Tissue specificityi

Detected in blood platelets and megakaryocyte cell lines. Poorly expressed in lung. Highly expressed in lung tumor tissues.2 Publications

Gene expression databases

BgeeiENSG00000254598
GenevisibleiQ8NEV1 HS

Organism-specific databases

HPAiHPA059206
HPA061698

Interactioni

Subunit structurei

Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha' chain) and two regulatory subunits (beta chains) (By similarity). Interacts with PML.By similarity1 Publication

Protein-protein interaction databases

BioGridi129460, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ8NEV1
SMRiQ8NEV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 324Protein kinasePROSITE-ProRule annotationAdd BLAST286

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0668 Eukaryota
ENOG410XNPP LUCA
GeneTreeiENSGT00390000004215
HOVERGENiHBG107282
InParanoidiQ8NEV1
KOiK03097
OMAiNIVRDQQ
OrthoDBiEOG091G0AZY

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NEV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGPVPSRAR VYTDVNTHRP REYWDYESHV VEWGNQDDYQ LVRKLGRGKY
60 70 80 90 100
SEVFEAINIT NNEKVVVKIL KPVKKKKIKR EIKILENLRG GPNIITLADI
110 120 130 140 150
VKDPVSRTPA LVFEHVNNTD FKQLYQTLTD YDIRFYMYEI LKALDYCHSM
160 170 180 190 200
GIMHRDVKPH NVMIDHEHRK LRLIDWGLAE FYHPGQEYNV RVASRYFKGP
210 220 230 240 250
ELLVDYQMYD YSLDMWRLGC MLASMIFRKE PFFHGRDNYD QLVRIAKFLG
260 270 280 290 300
TEDLYGYIDK YNIELDPRFN DILGRHSRKR WERFVHSENQ HLVSPEALDF
310 320 330 340 350
LDKLLRYDHQ SRLTAREAME HPYFYTVVKD QARMGSSSMP GGSTPVSSAN
360 370 380 390
VMSGISSVPT PSPLGPLAGS PVIAAANPLG MPVPAATGAQ Q
Length:391
Mass (Da):45,220
Last modified:May 1, 2013 - v2
Checksum:iD0FA2E3EACB5A064
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti128L → F in X64692 (PubMed:1610905).Curated1
Sequence conflicti128L → F in AAM52224 (PubMed:12102635).Curated1
Sequence conflicti128L → F in EAW68546 (Ref. 5) Curated1
Sequence conflicti217R → S in X64692 (PubMed:1610905).Curated1
Sequence conflicti217R → S in AAM52224 (PubMed:12102635).Curated1
Sequence conflicti217R → S in EAW68546 (Ref. 5) Curated1
Sequence conflicti236R → H in X64692 (PubMed:1610905).Curated1
Sequence conflicti248F → V in X64692 (PubMed:1610905).Curated1
Sequence conflicti248F → V in AAM52224 (PubMed:12102635).Curated1
Sequence conflicti248F → V in EAW68546 (Ref. 5) Curated1
Sequence conflicti287S → R in X64692 (PubMed:1610905).Curated1
Sequence conflicti287S → R in AAM52224 (PubMed:12102635).Curated1
Sequence conflicti287S → R in EAW68546 (Ref. 5) Curated1
Sequence conflicti296Missing in X64692 (PubMed:1610905).Curated1
Sequence conflicti387T → A in X64692 (PubMed:1610905).Curated1
Sequence conflicti387T → A in AAM52224 (PubMed:12102635).Curated1
Sequence conflicti387T → A in EAW68546 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069225133I → T in a lung carcinoma sample; somatic mutation; shows greater kinase activity, provides a cell growth advantage and increases its interaction with the PML tumor suppressor protein and PML degradation. 1 PublicationCorresponds to variant dbSNP:rs2071460Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64692 Genomic DNA No translation available.
AY112721 mRNA Translation: AAM52224.1
CH471064 Genomic DNA Translation: EAW68546.1
RefSeqiNP_001243615.1, NM_001256686.1
UniGeneiHs.654675
Hs.741126

Genome annotation databases

EnsembliENST00000528848; ENSP00000473553; ENSG00000254598
GeneIDi283106
KEGGihsa:283106
UCSCiuc001mjp.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCSK23_HUMAN
AccessioniPrimary (citable) accession number: Q8NEV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: May 1, 2013
Last modified: July 18, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health