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Entry version 146 (22 Apr 2020)
Sequence version 2 (26 Apr 2005)
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Protein

Transient receptor potential cation channel subfamily V member 3

Gene

TRPV3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3295583 TRP channels

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.4.2.9 the transient receptor potential ca(2+) channel (trp-cc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily V member 3
Short name:
TrpV3
Alternative name(s):
Vanilloid receptor-like 3
Short name:
VRL-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRPV3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18084 TRPV3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607066 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NET8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 439CytoplasmicSequence analysisAdd BLAST439
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
Topological domaini461 – 487ExtracellularSequence analysisAdd BLAST27
Transmembranei488 – 508HelicalSequence analysisAdd BLAST21
Topological domaini509 – 523CytoplasmicSequence analysisAdd BLAST15
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21
Topological domaini545ExtracellularSequence analysis1
Transmembranei546 – 566HelicalSequence analysisAdd BLAST21
Topological domaini567 – 589CytoplasmicSequence analysisAdd BLAST23
Transmembranei590 – 610HelicalSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei621 – 637Pore-formingSequence analysisAdd BLAST17
Transmembranei650 – 670HelicalSequence analysisAdd BLAST21
Topological domaini671 – 790CytoplasmicSequence analysisAdd BLAST120

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Olmsted syndrome (OLMS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare congenital disorder characterized by bilateral mutilating palmoplantar keratoderma and periorificial keratotic plaques with severe itching at all lesions. Diffuse alopecia, constriction of digits, and onychodystrophy have also been reported. Infections and squamous cell carcinomas can arise on the keratotic areas. The digital constriction may progress to autoamputation of fingers and toes.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_067920573G → C in OLMS; gain of function mutation; results in constitutive channel activation. 1 PublicationCorresponds to variant dbSNP:rs199473704EnsemblClinVar.1
Natural variantiVAR_067921573G → S in OLMS; gain of function mutation; results in constitutive channel activation. 2 PublicationsCorresponds to variant dbSNP:rs199473704EnsemblClinVar.1
Natural variantiVAR_067922692W → G in OLMS; gain of function mutation; results in constitutive channel activation. 1 PublicationCorresponds to variant dbSNP:rs199473705EnsemblClinVar.1
Palmoplantar keratoderma, non-epidermolytic, focal 2 (FNEPPK2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA dermatological disorder characterized by non-epidermolytic, abnormal thickening of the skin on the palms and soles. Focal palmoplantar keratoderma consists of localized areas of hyperkeratosis located mainly on pressure points and sites of recurrent friction.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073832580Q → P in FNEPPK2; gain of function mutation. 1 PublicationCorresponds to variant dbSNP:rs786205869EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Palmoplantar keratoderma

Organism-specific databases

DisGeNET

More...
DisGeNETi
162514

MalaCards human disease database

More...
MalaCardsi
TRPV3
MIMi614594 phenotype
616400 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000167723

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
448264 Isolated focal non-epidermolytic palmoplantar keratoderma
659 Mutilating palmoplantar keratoderma with periorificial keratotic plaques

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38481

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NET8 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5522

Drug and drug target database

More...
DrugBanki
DB11345 (S)-camphor
DB01744 Camphor
DB09061 Cannabidiol
DB09086 Eugenol
DB00825 Levomenthol
DB14009 Medical Cannabis
DB14011 Nabiximols

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
509

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRPV3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62901456

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002153451 – 790Transient receptor potential cation channel subfamily V member 3Add BLAST790

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NET8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NET8

PeptideAtlas

More...
PeptideAtlasi
Q8NET8

PRoteomics IDEntifications database

More...
PRIDEi
Q8NET8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
73216 [Q8NET8-1]
73217 [Q8NET8-2]
73218 [Q8NET8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NET8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NET8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level). Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles (at protein level).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167723 Expressed in skin of leg and 82 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NET8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NET8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000167723 Tissue enhanced (intestine, skeletal muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form a heteromeric channel with TRPV1.

Interacts with TRPV1.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127821, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000301365

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q8NET8

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NET8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1790
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NET8

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati214 – 243ANK 1Add BLAST30
Repeati261 – 291ANK 2Add BLAST31
Repeati340 – 369ANK 3Add BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3676 Eukaryota
ENOG4110DG4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158281

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012795_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NET8

KEGG Orthology (KO)

More...
KOi
K04972

Identification of Orthologs from Complete Genome Data

More...
OMAi
AHAQGIF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NET8

TreeFam database of animal gene trees

More...
TreeFami
TF314711

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR024862 TRPV
IPR008347 TRPV1-4_channel
IPR024866 TRPV3_channel

The PANTHER Classification System

More...
PANTHERi
PTHR10582 PTHR10582, 1 hit
PTHR10582:SF6 PTHR10582:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01768 TRPVRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NET8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKAHPKEMVP LMGKRVAAPS GNPAILPEKR PAEITPTKKS AHFFLEIEGF
60 70 80 90 100
EPNPTVAKTS PPVFSKPMDS NIRQCISGNC DDMDSPQSPQ DDVTETPSNP
110 120 130 140 150
NSPSAQLAKE EQRRKKRRLK KRIFAAVSEG CVEELVELLV ELQELCRRRH
160 170 180 190 200
DEDVPDFLMH KLTASDTGKT CLMKALLNIN PNTKEIVRIL LAFAEENDIL
210 220 230 240 250
GRFINAEYTE EAYEGQTALN IAIERRQGDI AALLIAAGAD VNAHAKGAFF
260 270 280 290 300
NPKYQHEGFY FGETPLALAA CTNQPEIVQL LMEHEQTDIT SRDSRGNNIL
310 320 330 340 350
HALVTVAEDF KTQNDFVKRM YDMILLRSGN WELETTRNND GLTPLQLAAK
360 370 380 390 400
MGKAEILKYI LSREIKEKRL RSLSRKFTDW AYGPVSSSLY DLTNVDTTTD
410 420 430 440 450
NSVLEITVYN TNIDNRHEML TLEPLHTLLH MKWKKFAKHM FFLSFCFYFF
460 470 480 490 500
YNITLTLVSY YRPREEEAIP HPLALTHKMG WLQLLGRMFV LIWAMCISVK
510 520 530 540 550
EGIAIFLLRP SDLQSILSDA WFHFVFFIQA VLVILSVFLY LFAYKEYLAC
560 570 580 590 600
LVLAMALGWA NMLYYTRGFQ SMGMYSVMIQ KVILHDVLKF LFVYIVFLLG
610 620 630 640 650
FGVALASLIE KCPKDNKDCS SYGSFSDAVL ELFKLTIGLG DLNIQQNSKY
660 670 680 690 700
PILFLFLLIT YVILTFVLLL NMLIALMGET VENVSKESER IWRLQRARTI
710 720 730 740 750
LEFEKMLPEW LRSRFRMGEL CKVAEDDFRL CLRINEVKWT EWKTHVSFLN
760 770 780 790
EDPGPVRRTD FNKIQDSSRN NSKTTLNAFE EVEEFPETSV
Length:790
Mass (Da):90,636
Last modified:April 26, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i31EB9973C015B611
GO
Isoform 2 (identifier: Q8NET8-2) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     759-759: T → TA

Show »
Length:791
Mass (Da):90,707
Checksum:i264D20FFF12791C4
GO
Isoform 3 (identifier: Q8NET8-3) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     760-765: DFNKIQ → GTVAVR
     766-790: Missing.

Show »
Length:765
Mass (Da):87,661
Checksum:i710D3545A7107B73
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X170A0A087X170_HUMAN
Transient receptor potential cation...
TRPV3
775Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KPJ6J3KPJ6_HUMAN
Transient receptor potential cation...
TRPV3
339Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L402I3L402_HUMAN
Transient receptor potential cation...
TRPV3
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L0L5I3L0L5_HUMAN
Transient receptor potential cation...
TRPV3
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti283E → G in AAM80558 (Ref. 3) Curated1
Sequence conflicti283E → G in AAM80559 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05238825I → V1 PublicationCorresponds to variant dbSNP:rs322965EnsemblClinVar.1
Natural variantiVAR_052389117R → G1 PublicationCorresponds to variant dbSNP:rs322937EnsemblClinVar.1
Natural variantiVAR_067920573G → C in OLMS; gain of function mutation; results in constitutive channel activation. 1 PublicationCorresponds to variant dbSNP:rs199473704EnsemblClinVar.1
Natural variantiVAR_067921573G → S in OLMS; gain of function mutation; results in constitutive channel activation. 2 PublicationsCorresponds to variant dbSNP:rs199473704EnsemblClinVar.1
Natural variantiVAR_073832580Q → P in FNEPPK2; gain of function mutation. 1 PublicationCorresponds to variant dbSNP:rs786205869EnsemblClinVar.1
Natural variantiVAR_067922692W → G in OLMS; gain of function mutation; results in constitutive channel activation. 1 PublicationCorresponds to variant dbSNP:rs199473705EnsemblClinVar.1
Natural variantiVAR_052390774T → I. Corresponds to variant dbSNP:rs7212634EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013433759T → TA in isoform 2. 1 Publication1
Alternative sequenceiVSP_013434760 – 765DFNKIQ → GTVAVR in isoform 3. 1 Publication6
Alternative sequenceiVSP_013435766 – 790Missing in isoform 3. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ487035 mRNA Translation: CAD31711.2
AF514998 mRNA Translation: AAM54027.1
AY118267 mRNA Translation: AAM80558.1
AY118268 mRNA Translation: AAM80559.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11029.1 [Q8NET8-1]
CCDS58500.1 [Q8NET8-2]

NCBI Reference Sequences

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RefSeqi
NP_659505.1, NM_145068.3 [Q8NET8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000301365; ENSP00000301365; ENSG00000167723 [Q8NET8-2]
ENST00000572519; ENSP00000460215; ENSG00000167723 [Q8NET8-3]
ENST00000576742; ENSP00000461518; ENSG00000167723 [Q8NET8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
162514

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:162514

UCSC genome browser

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UCSCi
uc002fvr.4 human [Q8NET8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Transient receptor potential cation channel, subfamily V, member 3 (TRPV3)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ487035 mRNA Translation: CAD31711.2
AF514998 mRNA Translation: AAM54027.1
AY118267 mRNA Translation: AAM80558.1
AY118268 mRNA Translation: AAM80559.1
CCDSiCCDS11029.1 [Q8NET8-1]
CCDS58500.1 [Q8NET8-2]
RefSeqiNP_659505.1, NM_145068.3 [Q8NET8-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6H9JX-ray1.83D229-250[»]
6HA6X-ray1.98D220-246[»]
6MHOelectron microscopy3.40A/B/C/D2-790[»]
6MHSelectron microscopy3.20A/B/C/D2-790[»]
6MHVelectron microscopy3.50A/B/C/D2-790[»]
6MHWelectron microscopy4.00A/B/C/D2-790[»]
6MHXelectron microscopy4.00A/B/C/D2-790[»]
6OT2electron microscopy4.10A/B/C/D96-790[»]
6OT5electron microscopy3.60A/B/C/D110-790[»]
SMRiQ8NET8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi127821, 4 interactors
STRINGi9606.ENSP00000301365

Chemistry databases

BindingDBiQ8NET8
ChEMBLiCHEMBL5522
DrugBankiDB11345 (S)-camphor
DB01744 Camphor
DB09061 Cannabidiol
DB09086 Eugenol
DB00825 Levomenthol
DB14009 Medical Cannabis
DB14011 Nabiximols
GuidetoPHARMACOLOGYi509

Protein family/group databases

TCDBi1.A.4.2.9 the transient receptor potential ca(2+) channel (trp-cc) family

PTM databases

iPTMnetiQ8NET8
PhosphoSitePlusiQ8NET8

Polymorphism and mutation databases

BioMutaiTRPV3
DMDMi62901456

Proteomic databases

jPOSTiQ8NET8
PaxDbiQ8NET8
PeptideAtlasiQ8NET8
PRIDEiQ8NET8
ProteomicsDBi73216 [Q8NET8-1]
73217 [Q8NET8-2]
73218 [Q8NET8-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23030 391 antibodies

Genome annotation databases

EnsembliENST00000301365; ENSP00000301365; ENSG00000167723 [Q8NET8-2]
ENST00000572519; ENSP00000460215; ENSG00000167723 [Q8NET8-3]
ENST00000576742; ENSP00000461518; ENSG00000167723 [Q8NET8-1]
GeneIDi162514
KEGGihsa:162514
UCSCiuc002fvr.4 human [Q8NET8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
162514
DisGeNETi162514

GeneCards: human genes, protein and diseases

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GeneCardsi
TRPV3
HGNCiHGNC:18084 TRPV3
HPAiENSG00000167723 Tissue enhanced (intestine, skeletal muscle)
MalaCardsiTRPV3
MIMi607066 gene
614594 phenotype
616400 phenotype
neXtProtiNX_Q8NET8
OpenTargetsiENSG00000167723
Orphaneti448264 Isolated focal non-epidermolytic palmoplantar keratoderma
659 Mutilating palmoplantar keratoderma with periorificial keratotic plaques
PharmGKBiPA38481

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3676 Eukaryota
ENOG4110DG4 LUCA
GeneTreeiENSGT00940000158281
HOGENOMiCLU_012795_0_0_1
InParanoidiQ8NET8
KOiK04972
OMAiAHAQGIF
PhylomeDBiQ8NET8
TreeFamiTF314711

Enzyme and pathway databases

ReactomeiR-HSA-3295583 TRP channels

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TRPV3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TRPV3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
162514
PharosiQ8NET8 Tchem

Protein Ontology

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PROi
PR:Q8NET8
RNActiQ8NET8 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000167723 Expressed in skin of leg and 82 other tissues
ExpressionAtlasiQ8NET8 baseline and differential
GenevisibleiQ8NET8 HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR024862 TRPV
IPR008347 TRPV1-4_channel
IPR024866 TRPV3_channel
PANTHERiPTHR10582 PTHR10582, 1 hit
PTHR10582:SF6 PTHR10582:SF6, 1 hit
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR01768 TRPVRECEPTOR
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRPV3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NET8
Secondary accession number(s): Q8NDW7, Q8NET9, Q8NFH2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: April 22, 2020
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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