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Protein

Beta-defensin 124

Gene

DEFB124

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has antibacterial activity.Curated

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 124
Alternative name(s):
Beta-defensin 24
Short name:
DEFB-24
Defensin, beta 124
Gene namesi
Name:DEFB124
Synonyms:DEFB24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000180383.3
HGNCiHGNC:18104 DEFB124
neXtProtiNX_Q8NES8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180383
PharmGKBiPA38500

Polymorphism and mutation databases

BioMutaiDEFB124
DMDMi84028202

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000004535223 – 71Beta-defensin 124Add BLAST49

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 54By similarity
Disulfide bondi34 ↔ 48By similarity
Disulfide bondi38 ↔ 55By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8NES8
PRIDEiQ8NES8
ProteomicsDBi73211

Expressioni

Gene expression databases

BgeeiENSG00000180383 Expressed in 100 organ(s), highest expression level in right uterine tube
CleanExiHS_DEFB124
GenevisibleiQ8NES8 HS

Organism-specific databases

HPAiHPA051046

Interactioni

Protein-protein interaction databases

IntActiQ8NES8, 2 interactors
STRINGi9606.ENSP00000326309

Structurei

3D structure databases

ProteinModelPortaliQ8NES8
SMRiQ8NES8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J58D Eukaryota
ENOG41117ZI LUCA
GeneTreeiENSGT00530000064308
HOGENOMiHOG000246960
HOVERGENiHBG095630
InParanoidiQ8NES8
OMAiPDASLCC
OrthoDBiEOG091G15V3
PhylomeDBiQ8NES8

Family and domain databases

InterProiView protein in InterPro
IPR025933 Beta_defensin
PANTHERiPTHR15001 PTHR15001, 1 hit
PfamiView protein in Pfam
PF13841 Defensin_beta_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NES8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTQLLLFLVA LLVLGHVPSG RSEFKRCWKG QGACQTYCTR QETYMHLCPD
60 70
ASLCCLSYAL KPPPVPKHEY E
Length:71
Mass (Da):8,058
Last modified:December 20, 2005 - v2
Checksum:i1BF1F37F41E21049
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ119827 mRNA Translation: AAZ81952.1
AL121751 Genomic DNA No translation available.
AY122476 mRNA Translation: AAM93917.1
CCDSiCCDS33457.1
RefSeqiNP_001032589.1, NM_001037500.1
UniGeneiHs.381373

Genome annotation databases

EnsembliENST00000317676; ENSP00000326309; ENSG00000180383
GeneIDi245937
KEGGihsa:245937
UCSCiuc002wvz.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ119827 mRNA Translation: AAZ81952.1
AL121751 Genomic DNA No translation available.
AY122476 mRNA Translation: AAM93917.1
CCDSiCCDS33457.1
RefSeqiNP_001032589.1, NM_001037500.1
UniGeneiHs.381373

3D structure databases

ProteinModelPortaliQ8NES8
SMRiQ8NES8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8NES8, 2 interactors
STRINGi9606.ENSP00000326309

Polymorphism and mutation databases

BioMutaiDEFB124
DMDMi84028202

Proteomic databases

PaxDbiQ8NES8
PRIDEiQ8NES8
ProteomicsDBi73211

Protocols and materials databases

DNASUi245937
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317676; ENSP00000326309; ENSG00000180383
GeneIDi245937
KEGGihsa:245937
UCSCiuc002wvz.1 human

Organism-specific databases

CTDi245937
EuPathDBiHostDB:ENSG00000180383.3
GeneCardsiDEFB124
HGNCiHGNC:18104 DEFB124
HPAiHPA051046
neXtProtiNX_Q8NES8
OpenTargetsiENSG00000180383
PharmGKBiPA38500
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J58D Eukaryota
ENOG41117ZI LUCA
GeneTreeiENSGT00530000064308
HOGENOMiHOG000246960
HOVERGENiHBG095630
InParanoidiQ8NES8
OMAiPDASLCC
OrthoDBiEOG091G15V3
PhylomeDBiQ8NES8

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Miscellaneous databases

GenomeRNAii245937
PROiPR:Q8NES8

Gene expression databases

BgeeiENSG00000180383 Expressed in 100 organ(s), highest expression level in right uterine tube
CleanExiHS_DEFB124
GenevisibleiQ8NES8 HS

Family and domain databases

InterProiView protein in InterPro
IPR025933 Beta_defensin
PANTHERiPTHR15001 PTHR15001, 1 hit
PfamiView protein in Pfam
PF13841 Defensin_beta_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDB124_HUMAN
AccessioniPrimary (citable) accession number: Q8NES8
Secondary accession number(s): Q30E74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: December 20, 2005
Last modified: September 12, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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