UniProtKB - Q8NER1 (TRPV1_HUMAN)
Transient receptor potential cation channel subfamily V member 1
TRPV1
Functioni
Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca2+-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.
By similarity4 PublicationsMiscellaneous
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 116 | ATPBy similarity | 1 | |
Binding sitei | 156 | ATPBy similarity | 1 | |
Binding sitei | 161 | ATPBy similarity | 1 | |
Binding sitei | 165 | ATPBy similarity | 1 | |
Binding sitei | 550 | Resiniferatoxin; agonistBy similarity | 1 | |
Binding sitei | 557 | Resiniferatoxin; agonistBy similarity | 1 | |
Metal bindingi | 647 | Calcium; shared with neighboring subunitsBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 200 – 203 | ATPBy similarity | 4 | |
Nucleotide bindingi | 211 – 212 | ATPBy similarity | 2 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- calcium channel activity Source: GO_Central
- calcium-release channel activity Source: UniProtKB
- calmodulin binding Source: UniProtKB
- chloride channel regulator activity Source: Ensembl
- excitatory extracellular ligand-gated ion channel activity Source: UniProtKB
- extracellular ligand-gated ion channel activity Source: UniProtKB
- identical protein binding Source: Ensembl
- ion channel activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- phosphatidylinositol binding Source: UniProtKB
- phosphoprotein binding Source: UniProtKB
- temperature-gated ion channel activity Source: Ensembl
- transmembrane signaling receptor activity Source: UniProtKB
- voltage-gated calcium channel activity Source: Reactome
GO - Biological processi
- behavioral response to pain Source: Ensembl
- calcium ion import across plasma membrane Source: UniProtKB
- calcium ion transmembrane transport Source: UniProtKB
- cell surface receptor signaling pathway Source: ProtInc
- cellular response to acidic pH Source: UniProtKB
- cellular response to alkaloid Source: UniProtKB
- cellular response to ATP Source: UniProtKB
- cellular response to heat Source: UniProtKB
- cellular response to nerve growth factor stimulus Source: Ensembl
- cellular response to temperature stimulus Source: Ensembl
- cellular response to tumor necrosis factor Source: Ensembl
- chemosensory behavior Source: ProtInc
- detection of chemical stimulus involved in sensory perception of pain Source: Ensembl
- detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
- detection of temperature stimulus involved in thermoception Source: Ensembl
- diet induced thermogenesis Source: Ensembl
- fever generation Source: Ensembl
- glutamate secretion Source: Ensembl
- lipid metabolic process Source: Ensembl
- microglial cell activation Source: Ensembl
- negative regulation of establishment of blood-brain barrier Source: Ensembl
- negative regulation of heart rate Source: Ensembl
- negative regulation of mitochondrial membrane potential Source: Ensembl
- negative regulation of systemic arterial blood pressure Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- peptide secretion Source: Ensembl
- positive regulation of apoptotic process Source: Ensembl
- positive regulation of gastric acid secretion Source: Ensembl
- positive regulation of nitric oxide biosynthetic process Source: Ensembl
- protein homotetramerization Source: UniProtKB
- response to capsazepine Source: UniProtKB
- response to peptide hormone Source: Ensembl
- sensory perception of mechanical stimulus Source: Ensembl
- smooth muscle contraction involved in micturition Source: Ensembl
- thermoception Source: MGI
Keywordsi
Molecular function | Calcium channel, Calmodulin-binding, Ion channel |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | ATP-binding, Calcium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8NER1 |
Reactomei | R-HSA-3295583, TRP channels |
SignaLinki | Q8NER1 |
SIGNORi | Q8NER1 |
Protein family/group databases
TCDBi | 1.A.4.2.13, the transient receptor potential ca(2+) channel (trp-cc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Transient receptor potential cation channel subfamily V member 1Short name: TrpV1 Alternative name(s): Capsaicin receptor Osm-9-like TRP channel 1 Short name: OTRPC1 Vanilloid receptor 1 |
Gene namesi | Name:TRPV1 Synonyms:VR1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12716, TRPV1 |
MIMi | 602076, gene |
neXtProti | NX_Q8NER1 |
VEuPathDBi | HostDB:ENSG00000196689 |
Subcellular locationi
Plasma membrane
- postsynaptic cell membrane By similarity; Multi-pass membrane protein By similarity
- dendritic spine membrane By similarity; Multi-pass membrane protein By similarity
- Cell membrane 3 Publications; Multi-pass membrane protein By similarity
Note: Mostly, but not exclusively expressed in postsynaptic dendritic spines.By similarity
Cytosol
- cytosol Source: Ensembl
Mitochondrion
- mitochondrion Source: Ensembl
Plasma Membrane
- dendritic spine membrane Source: UniProtKB-SubCell
- external side of plasma membrane Source: Ensembl
- integral component of plasma membrane Source: UniProtKB
- intrinsic component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
- postsynaptic membrane Source: UniProtKB
Other locations
- integral component of membrane Source: MGI
- neuronal cell body Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 433 | CytoplasmicBy similarityAdd BLAST | 433 | |
Transmembranei | 434 – 454 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 455 – 471 | ExtracellularBy similarityAdd BLAST | 17 | |
Transmembranei | 472 – 497 | HelicalBy similarityAdd BLAST | 26 | |
Topological domaini | 498 – 510 | CytoplasmicBy similarityAdd BLAST | 13 | |
Transmembranei | 511 – 531 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 532 – 535 | ExtracellularBy similarity | 4 | |
Transmembranei | 536 – 556 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 557 – 571 | CytoplasmicBy similarityAdd BLAST | 15 | |
Transmembranei | 572 – 599 | HelicalBy similarityAdd BLAST | 28 | |
Topological domaini | 600 – 658 | ExtracellularBy similarityAdd BLAST | 59 | |
Transmembranei | 659 – 687 | HelicalBy similarityAdd BLAST | 29 | |
Topological domaini | 688 – 839 | CytoplasmicBy similarityAdd BLAST | 152 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 511 | Y → A: Loss of sensitivity to capsaicin. 1 Publication | 1 | |
Mutagenesisi | 550 | T → I: Reduces sensitivity to capsaicin 40-fold. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 7442 |
OpenTargetsi | ENSG00000196689 |
PharmGKBi | PA37329 |
Miscellaneous databases
Pharosi | Q8NER1, Tclin |
Chemistry databases
ChEMBLi | CHEMBL4794 |
DrugBanki | DB11345, (S)-camphor DB00316, Acetaminophen DB00132, alpha-Linolenic acid DB00168, Aspartame DB01744, Camphor DB09061, Cannabidiol DB14050, Cannabidivarin DB06774, Capsaicin DB11131, Capsicum oleoresin DB00159, Icosapent DB14009, Medical Cannabis DB14011, Nabiximols DB11324, Nonivamide DB09288, Propacetamol DB06515, Resiniferatoxin DB02955, Ricinoleic Acid DB00193, Tramadol DB09120, Zucapsaicin |
DrugCentrali | Q8NER1 |
GuidetoPHARMACOLOGYi | 507 |
Genetic variation databases
BioMutai | TRPV1 |
DMDMi | 296452849 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215338 | 1 – 839 | Transient receptor potential cation channel subfamily V member 1Add BLAST | 839 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 117 | Phosphoserine; by PKA and PKDBy similarity | 1 | |
Modified residuei | 145 | Phosphothreonine; by PKA; in vitroBy similarity | 1 | |
Modified residuei | 371 | Phosphothreonine; by PKA; in vitroBy similarity | 1 | |
Modified residuei | 502 | Phosphoserine; by PKC/PRKCEBy similarity | 1 | |
Glycosylationi | 604 | N-linked (GlcNAc...) asparagineBy similarity | 1 | |
Modified residuei | 705 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 775 | PhosphoserineBy similarity | 1 | |
Modified residuei | 801 | Phosphoserine; by PKC/PRKCE and PKC/PRKCZBy similarity | 1 | |
Modified residuei | 821 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | Q8NER1 |
PaxDbi | Q8NER1 |
PeptideAtlasi | Q8NER1 |
PRIDEi | Q8NER1 |
ProteomicsDBi | 73202 [Q8NER1-1] |
PTM databases
GlyGeni | Q8NER1, 1 site |
iPTMneti | Q8NER1 |
PhosphoSitePlusi | Q8NER1 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000196689, Expressed in brain and 157 other tissues |
ExpressionAtlasi | Q8NER1, baseline and differential |
Genevisiblei | Q8NER1, HS |
Organism-specific databases
HPAi | ENSG00000196689, Tissue enhanced (liver) |
Interactioni
Subunit structurei
Interacts with PIRT (By similarity). Homotetramer (By similarity).
Interacts with TRPV3 and may also form a heteromeric channel with TRPV3 (PubMed:12077606).
Interacts with CALM, PRKCM and CSK.
Interacts with PRKCG and NTRK1, probably by forming a trimeric complex (By similarity).
Interacts with the Scolopendra mutilans RhTx toxin (By similarity).
Interacts with TMEM100 (By similarity).
Interacts with PACS2 (PubMed:29656858).
By similarity2 PublicationsGO - Molecular functioni
- calmodulin binding Source: UniProtKB
- identical protein binding Source: Ensembl
- phosphoprotein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 113281, 9 interactors |
STRINGi | 9606.ENSP00000459962 |
Chemistry databases
BindingDBi | Q8NER1 |
Miscellaneous databases
RNActi | Q8NER1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 111 – 153 | ANK 1Add BLAST | 43 | |
Repeati | 154 – 200 | ANK 2Add BLAST | 47 | |
Repeati | 201 – 247 | ANK 3Add BLAST | 47 | |
Repeati | 248 – 283 | ANK 4Add BLAST | 36 | |
Repeati | 284 – 332 | ANK 5Add BLAST | 49 | |
Repeati | 333 – 359 | ANK 6Add BLAST | 27 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 58 | DisorderedSequence analysisAdd BLAST | 58 | |
Regioni | 511 – 512 | Resiniferatoxin binding; agonistBy similarity | 2 | |
Regioni | 685 – 713 | ADBy similarityAdd BLAST | 29 | |
Regioni | 768 – 802 | Interaction with calmodulinBy similarityAdd BLAST | 35 | |
Regioni | 778 – 793 | Required for PIP2-mediated channel inhibitionBy similarityAdd BLAST | 16 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 644 – 647 | Selectivity filterBy similarity | 4 |
Domaini
Sequence similaritiesi
Keywords - Domaini
ANK repeat, Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3676, Eukaryota |
GeneTreei | ENSGT00940000160870 |
HOGENOMi | CLU_012795_1_0_1 |
InParanoidi | Q8NER1 |
OrthoDBi | 693004at2759 |
PhylomeDBi | Q8NER1 |
TreeFami | TF314711 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR005821, Ion_trans_dom IPR024862, TRPV IPR024863, TRPV1 IPR008347, TRPV1-4_channel |
PANTHERi | PTHR10582, PTHR10582, 1 hit PTHR10582:SF17, PTHR10582:SF17, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF00520, Ion_trans, 1 hit |
PRINTSi | PR01768, TRPVRECEPTOR |
SMARTi | View protein in SMART SM00248, ANK, 4 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKKWSSTDLG AAADPLQKDT CPDPLDGDPN SRPPPAKPQL STAKSRTRLF
60 70 80 90 100
GKGDSEEAFP VDCPHEEGEL DSCPTITVSP VITIQRPGDG PTGARLLSQD
110 120 130 140 150
SVAASTEKTL RLYDRRSIFE AVAQNNCQDL ESLLLFLQKS KKHLTDNEFK
160 170 180 190 200
DPETGKTCLL KAMLNLHDGQ NTTIPLLLEI ARQTDSLKEL VNASYTDSYY
210 220 230 240 250
KGQTALHIAI ERRNMALVTL LVENGADVQA AAHGDFFKKT KGRPGFYFGE
260 270 280 290 300
LPLSLAACTN QLGIVKFLLQ NSWQTADISA RDSVGNTVLH ALVEVADNTA
310 320 330 340 350
DNTKFVTSMY NEILMLGAKL HPTLKLEELT NKKGMTPLAL AAGTGKIGVL
360 370 380 390 400
AYILQREIQE PECRHLSRKF TEWAYGPVHS SLYDLSCIDT CEKNSVLEVI
410 420 430 440 450
AYSSSETPNR HDMLLVEPLN RLLQDKWDRF VKRIFYFNFL VYCLYMIIFT
460 470 480 490 500
MAAYYRPVDG LPPFKMEKTG DYFRVTGEIL SVLGGVYFFF RGIQYFLQRR
510 520 530 540 550
PSMKTLFVDS YSEMLFFLQS LFMLATVVLY FSHLKEYVAS MVFSLALGWT
560 570 580 590 600
NMLYYTRGFQ QMGIYAVMIE KMILRDLCRF MFVYIVFLFG FSTAVVTLIE
610 620 630 640 650
DGKNDSLPSE STSHRWRGPA CRPPDSSYNS LYSTCLELFK FTIGMGDLEF
660 670 680 690 700
TENYDFKAVF IILLLAYVIL TYILLLNMLI ALMGETVNKI AQESKNIWKL
710 720 730 740 750
QRAITILDTE KSFLKCMRKA FRSGKLLQVG YTPDGKDDYR WCFRVDEVNW
760 770 780 790 800
TTWNTNVGII NEDPGNCEGV KRTLSFSLRS SRVSGRHWKN FALVPLLREA
810 820 830
SARDRQSAQP EEVYLRQFSG SLKPEDAEVF KSPAASGEK
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EQ78 | E7EQ78_HUMAN | Osm-9-like TRP channel 1 | TRPV1 | 850 | Annotation score: | ||
I3L1R6 | I3L1R6_HUMAN | Osm-9-like TRP channel 1 | TRPV1 | 829 | Annotation score: | ||
E7ESJ2 | E7ESJ2_HUMAN | Osm-9-like TRP channel 1 | TRPV1 | 779 | Annotation score: | ||
A0A3B3ISI9 | A0A3B3ISI9_HUMAN | Transient receptor potential cation... | TRPV1 | 521 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 336 | T → M in CAB89866 (PubMed:11226139).Curated | 1 | |
Sequence conflicti | 552 | M → V in ABA06605 (Ref. 5) 1 Publication | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057307 | 91 | P → S1 PublicationCorresponds to variant dbSNP:rs222749Ensembl. | 1 | |
Natural variantiVAR_071244 | 315 | M → I8 PublicationsCorresponds to variant dbSNP:rs222747Ensembl. | 1 | |
Natural variantiVAR_057308 | 469 | T → I2 PublicationsCorresponds to variant dbSNP:rs224534Ensembl. | 1 | |
Natural variantiVAR_057309 | 505 | T → A. Corresponds to variant dbSNP:rs17633288EnsemblClinVar. | 1 | |
Natural variantiVAR_022246 | 585 | I → V2 PublicationsCorresponds to variant dbSNP:rs8065080Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056862 | 1 – 150 | MKKWS…DNEFK → METLTPGHLQPSPSSPRPRA APGSLGRVTRRRLSRWIALT RKVSWTPARPSQSALLSPSR GQETAPPVPGCCPRTLSPPA PRRPSGSMIAGVSLKPLLRI TARIWRACCSSCRRARSTSQ TTSSKVAPALGSGRAPALAC PDPPLCLS in isoform 2. 1 PublicationAdd BLAST | 150 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ277028 mRNA Translation: CAB95729.1 AF196175 mRNA Translation: AAG43466.1 AF196176 mRNA Translation: AAG43467.1 Frameshift. AJ272063 mRNA Translation: CAB89866.2 AY131289 mRNA Translation: AAM89472.1 DQ177332 mRNA Translation: ABA06605.1 AL136801 mRNA Translation: CAB66735.1 AC027796 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90497.1 BC132820 mRNA Translation: AAI32821.1 BC136633 mRNA Translation: AAI36634.1 |
CCDSi | CCDS45576.1 [Q8NER1-1] |
PIRi | JC7621 |
RefSeqi | NP_061197.4, NM_018727.5 [Q8NER1-1] NP_542435.2, NM_080704.3 [Q8NER1-1] NP_542436.2, NM_080705.3 [Q8NER1-1] NP_542437.2, NM_080706.3 [Q8NER1-1] |
Genome annotation databases
Ensembli | ENST00000399756; ENSP00000382659; ENSG00000196689 ENST00000399759; ENSP00000382661; ENSG00000196689 ENST00000571088; ENSP00000461007; ENSG00000196689 ENST00000572705; ENSP00000459962; ENSG00000196689 |
GeneIDi | 7442 |
KEGGi | hsa:7442 |
MANE-Selecti | ENST00000572705.2; ENSP00000459962.1; NM_080704.4; NP_542435.2 |
UCSCi | uc010vrr.3, human [Q8NER1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ277028 mRNA Translation: CAB95729.1 AF196175 mRNA Translation: AAG43466.1 AF196176 mRNA Translation: AAG43467.1 Frameshift. AJ272063 mRNA Translation: CAB89866.2 AY131289 mRNA Translation: AAM89472.1 DQ177332 mRNA Translation: ABA06605.1 AL136801 mRNA Translation: CAB66735.1 AC027796 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90497.1 BC132820 mRNA Translation: AAI32821.1 BC136633 mRNA Translation: AAI36634.1 |
CCDSi | CCDS45576.1 [Q8NER1-1] |
PIRi | JC7621 |
RefSeqi | NP_061197.4, NM_018727.5 [Q8NER1-1] NP_542435.2, NM_080704.3 [Q8NER1-1] NP_542436.2, NM_080705.3 [Q8NER1-1] NP_542437.2, NM_080706.3 [Q8NER1-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6L93 | X-ray | 4.47 | A/B/C/D/E/F | 101-365 | [»] | |
SMRi | Q8NER1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113281, 9 interactors |
STRINGi | 9606.ENSP00000459962 |
Chemistry databases
BindingDBi | Q8NER1 |
ChEMBLi | CHEMBL4794 |
DrugBanki | DB11345, (S)-camphor DB00316, Acetaminophen DB00132, alpha-Linolenic acid DB00168, Aspartame DB01744, Camphor DB09061, Cannabidiol DB14050, Cannabidivarin DB06774, Capsaicin DB11131, Capsicum oleoresin DB00159, Icosapent DB14009, Medical Cannabis DB14011, Nabiximols DB11324, Nonivamide DB09288, Propacetamol DB06515, Resiniferatoxin DB02955, Ricinoleic Acid DB00193, Tramadol DB09120, Zucapsaicin |
DrugCentrali | Q8NER1 |
GuidetoPHARMACOLOGYi | 507 |
Protein family/group databases
TCDBi | 1.A.4.2.13, the transient receptor potential ca(2+) channel (trp-cc) family |
PTM databases
GlyGeni | Q8NER1, 1 site |
iPTMneti | Q8NER1 |
PhosphoSitePlusi | Q8NER1 |
Genetic variation databases
BioMutai | TRPV1 |
DMDMi | 296452849 |
Proteomic databases
MassIVEi | Q8NER1 |
PaxDbi | Q8NER1 |
PeptideAtlasi | Q8NER1 |
PRIDEi | Q8NER1 |
ProteomicsDBi | 73202 [Q8NER1-1] |
Protocols and materials databases
Antibodypediai | 5472, 547 antibodies from 39 providers |
DNASUi | 7442 |
Genome annotation databases
Ensembli | ENST00000399756; ENSP00000382659; ENSG00000196689 ENST00000399759; ENSP00000382661; ENSG00000196689 ENST00000571088; ENSP00000461007; ENSG00000196689 ENST00000572705; ENSP00000459962; ENSG00000196689 |
GeneIDi | 7442 |
KEGGi | hsa:7442 |
MANE-Selecti | ENST00000572705.2; ENSP00000459962.1; NM_080704.4; NP_542435.2 |
UCSCi | uc010vrr.3, human [Q8NER1-1] |
Organism-specific databases
CTDi | 7442 |
DisGeNETi | 7442 |
GeneCardsi | TRPV1 |
HGNCi | HGNC:12716, TRPV1 |
HPAi | ENSG00000196689, Tissue enhanced (liver) |
MIMi | 602076, gene |
neXtProti | NX_Q8NER1 |
OpenTargetsi | ENSG00000196689 |
PharmGKBi | PA37329 |
VEuPathDBi | HostDB:ENSG00000196689 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3676, Eukaryota |
GeneTreei | ENSGT00940000160870 |
HOGENOMi | CLU_012795_1_0_1 |
InParanoidi | Q8NER1 |
OrthoDBi | 693004at2759 |
PhylomeDBi | Q8NER1 |
TreeFami | TF314711 |
Enzyme and pathway databases
PathwayCommonsi | Q8NER1 |
Reactomei | R-HSA-3295583, TRP channels |
SignaLinki | Q8NER1 |
SIGNORi | Q8NER1 |
Miscellaneous databases
BioGRID-ORCSi | 7442, 4 hits in 1028 CRISPR screens |
ChiTaRSi | TRPV1, human |
GeneWikii | TRPV1 |
GenomeRNAii | 7442 |
Pharosi | Q8NER1, Tclin |
PROi | PR:Q8NER1 |
RNActi | Q8NER1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196689, Expressed in brain and 157 other tissues |
ExpressionAtlasi | Q8NER1, baseline and differential |
Genevisiblei | Q8NER1, HS |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR005821, Ion_trans_dom IPR024862, TRPV IPR024863, TRPV1 IPR008347, TRPV1-4_channel |
PANTHERi | PTHR10582, PTHR10582, 1 hit PTHR10582:SF17, PTHR10582:SF17, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF00520, Ion_trans, 1 hit |
PRINTSi | PR01768, TRPVRECEPTOR |
SMARTi | View protein in SMART SM00248, ANK, 4 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TRPV1_HUMAN | |
Accessioni | Q8NER1Primary (citable) accession number: Q8NER1 Secondary accession number(s): A2RUA9 Q9NY22 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2005 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 23, 2022 | |
This is version 168 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families