TRPV1

Functionⁱ

Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca²⁺-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.By similarity4 Publications

Miscellaneous

Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine.

Activity regulationⁱ

Channel activity is activated via the interaction with PIRT and phosphatidylinositol 4,5-bisphosphate (PIP2). Both PIRT and PIP2 are required to activate channel activity (By similarity). The channel is sensitized by ATP binding. Repeated stimulation with capsaicin gives rise to progressively smaller responses, due to desensitization. This desensitization is triggered by the influx of calcium ions and is inhibited by elevated ATP levels. Ca²⁺ and CALM displace ATP from its binding site and trigger a conformation change that leads to a closed, desensitized channel. Intracellular PIP2 inhibits desensitization. The double-knot toxin (DkTx) from the Chinese earth tiger tarantula activates the channel and traps it in an open conformation (By similarity). The Scolopendra mutilans RhTx toxin potentiates the heat activation pathway mediated by this channel by binding to the charge-rich outer pore region (in an activated state) (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	116	ATPBy similarity	1
Binding siteⁱ	156	ATPBy similarity	1
Binding siteⁱ	161	ATPBy similarity	1
Binding siteⁱ	165	ATPBy similarity	1
Binding siteⁱ	512	AgonistBy similarity	1
Binding siteⁱ	550	AgonistBy similarity	1
Siteⁱ	557	Important for agonist bindingBy similarity	1
Metal bindingⁱ	647	Calcium; shared with neighboring subunitsBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	200 – 203	ATPBy similarity		4
Nucleotide bindingⁱ	211 – 212	ATPBy similarity		2

GO - Molecular functionⁱ

ATP binding Source: UniProtKB
calcium channel activity Source: GO_Central
calcium-release channel activity Source: UniProtKB
calmodulin binding Source: UniProtKB
chloride channel regulator activity Source: Ensembl
excitatory extracellular ligand-gated ion channel activity Source: UniProtKB
extracellular ligand-gated ion channel activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11226139
identical protein binding Source: Ensembl
metal ion binding Source: UniProtKB-KW
phosphatidylinositol binding Source: UniProtKB
phosphoprotein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19801576
temperature-gated ion channel activity Source: Ensembl
transmembrane signaling receptor activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

behavioral response to pain Source: Ensembl
calcium ion import across plasma membrane
Source: UniProtKB
Inferred from direct assayⁱ
- 11226139
calcium ion transmembrane transport Source: UniProtKB
cell surface receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 9349813
cellular response to acidic pH
Source: UniProtKB
Inferred from direct assayⁱ
- 11226139
cellular response to alkaloid Source: UniProtKB
cellular response to ATP Source: UniProtKB
cellular response to heat
Source: UniProtKB
Inferred from direct assayⁱ
- 11226139
cellular response to nerve growth factor stimulus Source: Ensembl
cellular response to temperature stimulus Source: Ensembl
cellular response to tumor necrosis factor Source: Ensembl
chemosensory behavior
Source: ProtInc
Traceable author statementⁱ
- 9349813
detection of chemical stimulus involved in sensory perception of pain Source: Ensembl
detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
detection of temperature stimulus involved in thermoception Source: Ensembl
diet induced thermogenesis Source: Ensembl
fever generation Source: Ensembl
glutamate secretion Source: Ensembl
lipid metabolic process Source: Ensembl
microglial cell activation Source: Ensembl
negative regulation of establishment of blood-brain barrier Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
peptide secretion Source: Ensembl
positive regulation of apoptotic process Source: Ensembl
positive regulation of gastric acid secretion Source: Ensembl
positive regulation of nitric oxide biosynthetic process Source: Ensembl
protein homotetramerization Source: UniProtKB
response to capsazepine
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11226139
response to peptide hormone Source: Ensembl
sensory perception of mechanical stimulus Source: Ensembl
smooth muscle contraction involved in micturition Source: Ensembl
thermoception
Source: MGI
Inferred from direct assayⁱ
- 10201375

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Calcium channel, Calmodulin-binding, Ion channel
Biological process	Calcium transport, Ion transport, Transport
Ligand	ATP-binding, Calcium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3295583 TRP channels
SIGNORⁱ	Q8NER1

Protein family/group databases

TCDBⁱ	1.A.4.2.13 the transient receptor potential ca(2+) channel (trp-cc) family

TCDBⁱ

1.A.4.2.13 the transient receptor potential ca(2+) channel (trp-cc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transient receptor potential cation channel subfamily V member 1 Short name: TrpV1 Alternative name(s): Capsaicin receptor Osm-9-like TRP channel 1 Short name: OTRPC1 Vanilloid receptor 1
Gene namesⁱ	Name:TRPV1 Synonyms:VR1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000196689.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12716 TRPV1
MIMⁱ	602076 gene
neXtProtⁱ	NX_Q8NER1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 433	CytoplasmicBy similarityAdd BLAST	433
Transmembraneⁱ	434 – 454	HelicalBy similarityAdd BLAST	21
Topological domainⁱ	455 – 471	ExtracellularBy similarityAdd BLAST	17
Transmembraneⁱ	472 – 497	HelicalBy similarityAdd BLAST	26
Topological domainⁱ	498 – 510	CytoplasmicBy similarityAdd BLAST	13
Transmembraneⁱ	511 – 531	HelicalBy similarityAdd BLAST	21
Topological domainⁱ	532 – 535	ExtracellularBy similarity	4
Transmembraneⁱ	536 – 556	HelicalBy similarityAdd BLAST	21
Topological domainⁱ	557 – 571	CytoplasmicBy similarityAdd BLAST	15
Transmembraneⁱ	572 – 599	HelicalBy similarityAdd BLAST	28
Topological domainⁱ	600 – 658	ExtracellularBy similarityAdd BLAST	59
Transmembraneⁱ	659 – 687	HelicalBy similarityAdd BLAST	29
Topological domainⁱ	688 – 839	CytoplasmicBy similarityAdd BLAST	152

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	511	Y → A: Loss of sensitivity to capsaicin. 1 Publication		1
Mutagenesisⁱ	550	T → I: Reduces sensitivity to capsaicin 40-fold. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7442
Open Targets More...OpenTargetsⁱ	ENSG00000196689
PharmGKBⁱ	PA37329

Chemistry databases

ChEMBLⁱ	CHEMBL4794
Drug and drug target database More...DrugBankⁱ	DB00316 Acetaminophen DB00132 Alpha-Linolenic Acid DB00168 Aspartame DB06774 Capsaicin DB00159 Icosapent
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	507

Polymorphism and mutation databases

BioMutaⁱ	TRPV1
DMDMⁱ	296452849

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000215338	1 – 839	Transient receptor potential cation channel subfamily V member 1Add BLAST		839

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	117	Phosphoserine; by PKA and PKDBy similarity	1
Modified residueⁱ	145	Phosphothreonine; by PKA; in vitroBy similarity	1
Modified residueⁱ	371	Phosphothreonine; by PKA; in vitroBy similarity	1
Modified residueⁱ	502	Phosphoserine; by PKC/PRKCEBy similarity	1
Glycosylationⁱ	604	N-linked (GlcNAc...) asparagineBy similarity	1
Modified residueⁱ	705	PhosphothreonineBy similarity	1
Modified residueⁱ	775	PhosphoserineBy similarity	1
Modified residueⁱ	801	Phosphoserine; by PKC/PRKCE and PKC/PRKCZBy similarity	1
Modified residueⁱ	821	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phosphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PRKCE, PRKCM and probably PRKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity.By similarity

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q8NER1
PeptideAtlas More...PeptideAtlasⁱ	Q8NER1
PRIDEⁱ	Q8NER1
ProteomicsDBⁱ	73202

PTM databases

iPTMnetⁱ	Q8NER1
PhosphoSitePlusⁱ	Q8NER1

Expressionⁱ

Tissue specificityⁱ

Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000196689 Expressed in 140 organ(s), highest expression level in brain
CleanExⁱ	HS_TRPV1
ExpressionAtlasⁱ	Q8NER1 baseline and differential
Genevisibleⁱ	Q8NER1 HS

Interactionⁱ

Subunit structureⁱ

Interacts with PIRT (By similarity). Homotetramer (By similarity). Interacts with TRPV3 and may also form a heteromeric channel with TRPV3 (PubMed:12077606). Interacts with CALM, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex (By similarity). Interacts with the Scolopendra mutilans RhTx toxin (By similarity). Interacts with TMEM100 (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

calmodulin binding Source: UniProtKB
identical protein binding Source: Ensembl
phosphoprotein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19801576

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113281, 8 interactors
STRINGⁱ	9606.ENSP00000459962

Chemistry databases

BindingDBⁱ

Q8NER1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NER1
SMRⁱ	Q8NER1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	111 – 153	ANK 1Add BLAST	43
Repeatⁱ	154 – 200	ANK 2Add BLAST	47
Repeatⁱ	201 – 247	ANK 3Add BLAST	47
Repeatⁱ	248 – 283	ANK 4Add BLAST	36
Repeatⁱ	284 – 332	ANK 5Add BLAST	49
Repeatⁱ	333 – 359	ANK 6Add BLAST	27

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	115 – 116	Important for channel activation by agonists and heatBy similarity	2
Regionⁱ	685 – 713	ADBy similarityAdd BLAST	29
Regionⁱ	768 – 802	Interaction with calmodulinBy similarityAdd BLAST	35
Regionⁱ	778 – 793	Required for PIP2-mediated channel inhibitionBy similarityAdd BLAST	16

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	644 – 647	Selectivity filterBy similarity		4

Domainⁱ

The association domain (AD) is necessary for self-association.By similarity

Sequence similaritiesⁱ

Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily. [View classification]Curated

Keywords - Domainⁱ

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3676 Eukaryota ENOG4110DG4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074425
HOGENOMⁱ	HOG000234630
HOVERGENⁱ	HBG054085
InParanoidⁱ	Q8NER1
KEGG Orthology (KO) More...KOⁱ	K05222
PhylomeDBⁱ	Q8NER1
TreeFamⁱ	TF314711

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR005821 Ion_trans_dom IPR004729 TRP_channel IPR024862 TRPV IPR024863 TRPV1 IPR008347 TRPV1-4_channel
PANTHERⁱ	PTHR10582 PTHR10582, 1 hit PTHR10582:SF17 PTHR10582:SF17, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit PF00520 Ion_trans, 1 hit
PRINTSⁱ	PR01768 TRPVRECEPTOR
SMARTⁱ	View protein in SMART SM00248 ANK, 4 hits
SUPFAMⁱ	SSF48403 SSF48403, 1 hit
TIGRFAMsⁱ	TIGR00870 trp, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8NER1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKWSSTDLG AAADPLQKDT CPDPLDGDPN SRPPPAKPQL STAKSRTRLF 
        60         70         80         90        100
GKGDSEEAFP VDCPHEEGEL DSCPTITVSP VITIQRPGDG PTGARLLSQD 
       110        120        130        140        150
SVAASTEKTL RLYDRRSIFE AVAQNNCQDL ESLLLFLQKS KKHLTDNEFK 
       160        170        180        190        200
DPETGKTCLL KAMLNLHDGQ NTTIPLLLEI ARQTDSLKEL VNASYTDSYY 
       210        220        230        240        250
KGQTALHIAI ERRNMALVTL LVENGADVQA AAHGDFFKKT KGRPGFYFGE 
       260        270        280        290        300
LPLSLAACTN QLGIVKFLLQ NSWQTADISA RDSVGNTVLH ALVEVADNTA 
       310        320        330        340        350
DNTKFVTSMY NEILMLGAKL HPTLKLEELT NKKGMTPLAL AAGTGKIGVL 
       360        370        380        390        400
AYILQREIQE PECRHLSRKF TEWAYGPVHS SLYDLSCIDT CEKNSVLEVI 
       410        420        430        440        450
AYSSSETPNR HDMLLVEPLN RLLQDKWDRF VKRIFYFNFL VYCLYMIIFT 
       460        470        480        490        500
MAAYYRPVDG LPPFKMEKTG DYFRVTGEIL SVLGGVYFFF RGIQYFLQRR 
       510        520        530        540        550
PSMKTLFVDS YSEMLFFLQS LFMLATVVLY FSHLKEYVAS MVFSLALGWT 
       560        570        580        590        600
NMLYYTRGFQ QMGIYAVMIE KMILRDLCRF MFVYIVFLFG FSTAVVTLIE 
       610        620        630        640        650
DGKNDSLPSE STSHRWRGPA CRPPDSSYNS LYSTCLELFK FTIGMGDLEF 
       660        670        680        690        700
TENYDFKAVF IILLLAYVIL TYILLLNMLI ALMGETVNKI AQESKNIWKL 
       710        720        730        740        750
QRAITILDTE KSFLKCMRKA FRSGKLLQVG YTPDGKDDYR WCFRVDEVNW 
       760        770        780        790        800
TTWNTNVGII NEDPGNCEGV KRTLSFSLRS SRVSGRHWKN FALVPLLREA 
       810        820        830 
SARDRQSAQP EEVYLRQFSG SLKPEDAEVF KSPAASGEK

Length:839

Mass (Da):94,956

Last modified:May 18, 2010 - v2

Checksum:ⁱ7142F59D428827FB

GO

Isoform 2 (identifier: Q8NER1-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-150: MKKWSSTDLG...KKHLTDNEFK → METLTPGHLQ...ACPDPPLCLS

« Hide

        10         20         30         40         50
METLTPGHLQ PSPSSPRPRA APGSLGRVTR RRLSRWIALT RKVSWTPARP 
        60         70         80         90        100
SQSALLSPSR GQETAPPVPG CCPRTLSPPA PRRPSGSMIA GVSLKPLLRI 
       110        120        130        140        150
TARIWRACCS SCRRARSTSQ TTSSKVAPAL GSGRAPALAC PDPPLCLSDP 
       160        170        180        190        200
ETGKTCLLKA MLNLHDGQNT TIPLLLEIAR QTDSLKELVN ASYTDSYYKG 
       210        220        230        240        250
QTALHIAIER RNMALVTLLV ENGADVQAAA HGDFFKKTKG RPGFYFGELP 
       260        270        280        290        300
LSLAACTNQL GIVKFLLQNS WQTADISARD SVGNTVLHAL VEVADNTADN 
       310        320        330        340        350
TKFVTSMYNE ILMLGAKLHP TLKLEELTNK KGMTPLALAA GTGKIGVLAY 
       360        370        380        390        400
ILQREIQEPE CRHLSRKFTE WAYGPVHSSL YDLSCIDTCE KNSVLEVIAY 
       410        420        430        440        450
SSSETPNRHD MLLVEPLNRL LQDKWDRFVK RIFYFNFLVY CLYMIIFTMA 
       460        470        480        490        500
AYYRPVDGLP PFKMEKTGDY FRVTGEILSV LGGVYFFFRG IQYFLQRRPS 
       510        520        530        540        550
MKTLFVDSYS EMLFFLQSLF MLATVVLYFS HLKEYVASMV FSLALGWTNM 
       560        570        580        590        600
LYYTRGFQQM GIYAVMIEKM ILRDLCRFMF VYIVFLFGFS TAVVTLIEDG 
       610        620        630        640        650
KNDSLPSEST SHRWRGPACR PPDSSYNSLY STCLELFKFT IGMGDLEFTE 
       660        670        680        690        700
NYDFKAVFII LLLAYVILTY ILLLNMLIAL MGETVNKIAQ ESKNIWKLQR 
       710        720        730        740        750
AITILDTEKS FLKCMRKAFR SGKLLQVGYT PDGKDDYRWC FRVDEVNWTT 
       760        770        780        790        800
WNTNVGIINE DPGNCEGVKR TLSFSLRSSR VSGRHWKNFA LVPLLREASA 
       810        820        830 
RDRQSAQPEE VYLRQFSGSL KPEDAEVFKS PAASGEK

Show »

Length:837

Mass (Da):94,211

Checksum:ⁱD662DD6094BDCA56

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E7EQ78	E7EQ78_HUMAN	Transient receptor potential cation... Transient receptor potential cation channel subfamily V member 1	TRPV1	850	Annotation score:
I3L1R6	I3L1R6_HUMAN	Transient receptor potential cation... Transient receptor potential cation channel subfamily V member 1	TRPV1	829	Annotation score:
E7ESJ2	E7ESJ2_HUMAN	Transient receptor potential cation... Transient receptor potential cation channel subfamily V member 1	TRPV1	779	Annotation score:

Sequence cautionⁱ

The sequence AAG43467 differs from that shown. Reason: Frameshift at position 498.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	336	T → M in CAB89866 (PubMed:11226139).Curated		1
Sequence conflictⁱ	552	M → V in ABA06605 (Ref. 5) 1 Publication		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_057307	91	P → S1 PublicationCorresponds to variant dbSNP:rs222749Ensembl.	1
Natural variantⁱVAR_071244	315	M → I8 PublicationsCorresponds to variant dbSNP:rs222747Ensembl.	1
Natural variantⁱVAR_057308	469	T → I2 PublicationsCorresponds to variant dbSNP:rs224534Ensembl.	1
Natural variantⁱVAR_057309	505	T → A. Corresponds to variant dbSNP:rs17633288Ensembl.	1
Natural variantⁱVAR_022246	585	I → V2 PublicationsCorresponds to variant dbSNP:rs8065080Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056862	1 – 150	MKKWS…DNEFK → METLTPGHLQPSPSSPRPRA APGSLGRVTRRRLSRWIALT RKVSWTPARPSQSALLSPSR GQETAPPVPGCCPRTLSPPA PRRPSGSMIAGVSLKPLLRI TARIWRACCSSCRRARSTSQ TTSSKVAPALGSGRAPALAC PDPPLCLS in isoform 2. 1 PublicationAdd BLAST		150

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ277028 mRNA Translation: CAB95729.1 AF196175 mRNA Translation: AAG43466.1 AF196176 mRNA Translation: AAG43467.1 Frameshift. AJ272063 mRNA Translation: CAB89866.2 AY131289 mRNA Translation: AAM89472.1 DQ177332 mRNA Translation: ABA06605.1 AL136801 mRNA Translation: CAB66735.1 AC027796 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90497.1 BC132820 mRNA Translation: AAI32821.1 BC136633 mRNA Translation: AAI36634.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45576.1 [Q8NER1-1]
PIRⁱ	JC7621
NCBI Reference Sequences More...RefSeqⁱ	NP_061197.4, NM_018727.5 [Q8NER1-1] NP_542435.2, NM_080704.3 [Q8NER1-1] NP_542436.2, NM_080705.3 [Q8NER1-1] NP_542437.2, NM_080706.3 [Q8NER1-1]
UniGeneⁱ	Hs.579217 Hs.655380

Genome annotation databases

Ensemblⁱ	ENST00000399756; ENSP00000382659; ENSG00000196689 [Q8NER1-1] ENST00000399759; ENSP00000382661; ENSG00000196689 [Q8NER1-1] ENST00000571088; ENSP00000461007; ENSG00000196689 [Q8NER1-1] ENST00000572705; ENSP00000459962; ENSG00000196689 [Q8NER1-1]
GeneIDⁱ	7442
KEGGⁱ	hsa:7442
UCSC genome browser More...UCSCⁱ	uc010vrr.3 human [Q8NER1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8NER1	Uncharacterized protein		RHIRO		853	UniRef90_Q8NER1
Transient receptor potential cation channel subfamily V member 1		HUMAN		850
Uncharacterized protein		COLAP		850
Uncharacterized protein		PAPAN		850
Uncharacterized protein		NOMLE		850
+34

Protein	Similar proteins		Species	Score	Length	Source
Q8NER1	Transient receptor potential cation channel subfamily V member 1	)	RAT		838	UniRef50_O35433
Transient receptor potential cation channel subfamily V member 1		MOUSE		839
Transient receptor potential cation channel subfamily V member 1		RABIT		842
Transient receptor potential cation channel subfamily V member 1		CAVPO		839
Transient receptor potential cation channel subfamily V member 1		CANLF		840
+374

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ277028 mRNA Translation: CAB95729.1 AF196175 mRNA Translation: AAG43466.1 AF196176 mRNA Translation: AAG43467.1 Frameshift. AJ272063 mRNA Translation: CAB89866.2 AY131289 mRNA Translation: AAM89472.1 DQ177332 mRNA Translation: ABA06605.1 AL136801 mRNA Translation: CAB66735.1 AC027796 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90497.1 BC132820 mRNA Translation: AAI32821.1 BC136633 mRNA Translation: AAI36634.1
CCDSⁱ	CCDS45576.1 [Q8NER1-1]
PIRⁱ	JC7621
RefSeqⁱ	NP_061197.4, NM_018727.5 [Q8NER1-1] NP_542435.2, NM_080704.3 [Q8NER1-1] NP_542436.2, NM_080705.3 [Q8NER1-1] NP_542437.2, NM_080706.3 [Q8NER1-1]
UniGeneⁱ	Hs.579217 Hs.655380

3D structure databases

ProteinModelPortalⁱ	Q8NER1
SMRⁱ	Q8NER1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113281, 8 interactors
STRINGⁱ	9606.ENSP00000459962

Chemistry databases

BindingDBⁱ	Q8NER1
ChEMBLⁱ	CHEMBL4794
DrugBankⁱ	DB00316 Acetaminophen DB00132 Alpha-Linolenic Acid DB00168 Aspartame DB06774 Capsaicin DB00159 Icosapent
GuidetoPHARMACOLOGYⁱ	507

Protein family/group databases

TCDBⁱ	1.A.4.2.13 the transient receptor potential ca(2+) channel (trp-cc) family

TCDBⁱ

1.A.4.2.13 the transient receptor potential ca(2+) channel (trp-cc) family

PTM databases

iPTMnetⁱ	Q8NER1
PhosphoSitePlusⁱ	Q8NER1

Polymorphism and mutation databases

BioMutaⁱ	TRPV1
DMDMⁱ	296452849

Proteomic databases

PaxDbⁱ	Q8NER1
PeptideAtlasⁱ	Q8NER1
PRIDEⁱ	Q8NER1
ProteomicsDBⁱ	73202

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7442
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000399756; ENSP00000382659; ENSG00000196689 [Q8NER1-1] ENST00000399759; ENSP00000382661; ENSG00000196689 [Q8NER1-1] ENST00000571088; ENSP00000461007; ENSG00000196689 [Q8NER1-1] ENST00000572705; ENSP00000459962; ENSG00000196689 [Q8NER1-1]
GeneIDⁱ	7442
KEGGⁱ	hsa:7442
UCSCⁱ	uc010vrr.3 human [Q8NER1-1]

Organism-specific databases

CTDⁱ	7442
DisGeNETⁱ	7442
EuPathDBⁱ	HostDB:ENSG00000196689.11
GeneCardsⁱ	TRPV1
H-InvDBⁱ	HIX0013428 HIX0079948
HGNCⁱ	HGNC:12716 TRPV1
MIMⁱ	602076 gene
neXtProtⁱ	NX_Q8NER1
OpenTargetsⁱ	ENSG00000196689
PharmGKBⁱ	PA37329
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3676 Eukaryota ENOG4110DG4 LUCA
GeneTreeⁱ	ENSGT00550000074425
HOGENOMⁱ	HOG000234630
HOVERGENⁱ	HBG054085
InParanoidⁱ	Q8NER1
KOⁱ	K05222
PhylomeDBⁱ	Q8NER1
TreeFamⁱ	TF314711

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3295583 TRP channels
SIGNORⁱ	Q8NER1

Miscellaneous databases

GeneWikiⁱ	TRPV1
GenomeRNAiⁱ	7442
Protein Ontology More...PROⁱ	PR:Q8NER1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000196689 Expressed in 140 organ(s), highest expression level in brain
CleanExⁱ	HS_TRPV1
ExpressionAtlasⁱ	Q8NER1 baseline and differential
Genevisibleⁱ	Q8NER1 HS

Family and domain databases

CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR005821 Ion_trans_dom IPR004729 TRP_channel IPR024862 TRPV IPR024863 TRPV1 IPR008347 TRPV1-4_channel
PANTHERⁱ	PTHR10582 PTHR10582, 1 hit PTHR10582:SF17 PTHR10582:SF17, 1 hit
Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit PF00520 Ion_trans, 1 hit
PRINTSⁱ	PR01768 TRPVRECEPTOR
SMARTⁱ	View protein in SMART SM00248 ANK, 4 hits
SUPFAMⁱ	SSF48403 SSF48403, 1 hit
TIGRFAMsⁱ	TIGR00870 trp, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TRPV1_HUMAN
Accessionⁱ	Q8NER1Primary (citable) accession number: Q8NER1 Secondary accession number(s): A2RUA9 Q9NY22
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
	Last sequence update:	May 18, 2010
	Last modified:	September 12, 2018
	This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

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UniProtKB - Q8NER1 (TRPV1_HUMAN)

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Transient receptor potential cation channel subfamily V member 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

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Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Keywords - Cellular componenti

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Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

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GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

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3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

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Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ