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Entry version 162 (02 Jun 2021)
Sequence version 4 (20 Jan 2009)
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Protein

Zinc finger protein 555

Gene

ZNF555

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri172 – 194C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri536 – 558C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri564 – 586C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8NEP9

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 555
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF555
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28382, ZNF555

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NEP9

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000186300.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
148254

Open Targets

More...
OpenTargetsi
ENSG00000186300

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134956715

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NEP9, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF555

Domain mapping of disease mutations (DMDM)

More...
DMDMi
221222537

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002345881 – 628Zinc finger protein 555Add BLAST628

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NEP9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NEP9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NEP9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NEP9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NEP9

PeptideAtlas

More...
PeptideAtlasi
Q8NEP9

PRoteomics IDEntifications database

More...
PRIDEi
Q8NEP9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
73197 [Q8NEP9-1]
73198 [Q8NEP9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NEP9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NEP9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186300, Expressed in amniotic fluid and 206 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NEP9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NEP9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000186300, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127136, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NEP9, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000334853

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NEP9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NEP9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 77KRABPROSITE-ProRule annotationAdd BLAST74

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 194C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri536 – 558C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri564 – 586C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163425

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_44_5_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NEP9

Identification of Orthologs from Complete Genome Data

More...
OMAi
HVRMHPG

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NEP9

TreeFam database of animal gene trees

More...
TreeFami
TF338854

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 11 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 15 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 15 hits
PS50157, ZINC_FINGER_C2H2_2, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NEP9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSVVFEDVA VDFTLEEWAL LDSAQRDLYR DVMLETFQNL ASVDDETQFK
60 70 80 90 100
ASGSVSQQDI YGEKIPKESK IATFTRNVSW ASVLGKIWDS LSIEDQTTNQ
110 120 130 140 150
GRNLSRNHGL ERLCESNDQC GEALSQIPHL NLYKKIPPGV KQYEYNTYGK
160 170 180 190 200
VFMHRRTSLK SPITVHTGHK PYQCQECGQA YSCRSHLRMH VRTHNGERPY
210 220 230 240 250
VCKLCGKTFP RTSSLNRHVR IHTAEKTYEC KQCGKAFIDF SSLTSHLRSH
260 270 280 290 300
TGEKPYKCKE CGKAFSYSST FRRHTITHTG EKPYKCKECA EAFSYSSTFR
310 320 330 340 350
RHMISHTGEK PHKCKECGEA FSYSSAFRRH MITHTGEKPY ECKQCGKTFI
360 370 380 390 400
YLQSFRRHER IHTGEKPYEC KQCGKTFIYP QSFRRHERTH GGEKPYECNQ
410 420 430 440 450
CGKAFSHPSS FRGHMRVHTG EKPYECKQCG KTFNWPISLR KHMRTHTREK
460 470 480 490 500
PYECKQCGKA FSLSACFREH VRMHPEDKSY ECKLCGKAFY CHISLQKHMR
510 520 530 540 550
RHTAEKLYKC KQCGKAFSWP ELLQQHVRTH TVEKPYECKE CGKVFKWPSS
560 570 580 590 600
LPIHMRLHTG EKPYQCKHCG KAFNCSSSLR RHVRIHTTEK QYKCNVGHPP
610 620
ANEFMCSASE KSHQERDLIK VVNMVLPL
Length:628
Mass (Da):73,084
Last modified:January 20, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9C3B651D0B2FDE0
GO
Isoform 2 (identifier: Q8NEP9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-105: Missing.
     451-453: PYE → LYK
     460-543: Missing.

Show »
Length:543
Mass (Da):63,040
Checksum:i370044FF6CA635E0
GO
Isoform 3 (identifier: Q8NEP9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-105: Missing.

Show »
Length:627
Mass (Da):72,997
Checksum:i0582DBDDF4E31B7E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ENK0K7ENK0_HUMAN
Zinc finger protein 555
ZNF555
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti304I → T in BAF85643 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054223107N → D1 PublicationCorresponds to variant dbSNP:rs17856649Ensembl.1
Natural variantiVAR_054224137P → L. Corresponds to variant dbSNP:rs36012545Ensembl.1
Natural variantiVAR_054225194H → N1 PublicationCorresponds to variant dbSNP:rs17851955Ensembl.1
Natural variantiVAR_026295515K → T1 PublicationCorresponds to variant dbSNP:rs17856648Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_018382105Missing in isoform 2 and isoform 3. 1 Publication1
Alternative sequenceiVSP_018383451 – 453PYE → LYK in isoform 2. 1 Publication3
Alternative sequenceiVSP_018384460 – 543Missing in isoform 2. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK093163 mRNA Translation: BAC04082.1
AK292954 mRNA Translation: BAF85643.1
BX647423 mRNA No translation available.
AC006130 Genomic DNA No translation available.
BC022022 mRNA Translation: AAH22022.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12096.1 [Q8NEP9-1]
CCDS59329.1 [Q8NEP9-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001166246.1, NM_001172775.1 [Q8NEP9-4]
NP_690004.4, NM_152791.4 [Q8NEP9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000334241; ENSP00000334853; ENSG00000186300 [Q8NEP9-1]
ENST00000591539; ENSP00000467893; ENSG00000186300 [Q8NEP9-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
148254

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:148254

UCSC genome browser

More...
UCSCi
uc002lwn.5, human [Q8NEP9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093163 mRNA Translation: BAC04082.1
AK292954 mRNA Translation: BAF85643.1
BX647423 mRNA No translation available.
AC006130 Genomic DNA No translation available.
BC022022 mRNA Translation: AAH22022.2
CCDSiCCDS12096.1 [Q8NEP9-1]
CCDS59329.1 [Q8NEP9-4]
RefSeqiNP_001166246.1, NM_001172775.1 [Q8NEP9-4]
NP_690004.4, NM_152791.4 [Q8NEP9-1]

3D structure databases

SMRiQ8NEP9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127136, 8 interactors
IntActiQ8NEP9, 6 interactors
STRINGi9606.ENSP00000334853

PTM databases

iPTMnetiQ8NEP9
PhosphoSitePlusiQ8NEP9

Genetic variation databases

BioMutaiZNF555
DMDMi221222537

Proteomic databases

EPDiQ8NEP9
jPOSTiQ8NEP9
MassIVEiQ8NEP9
MaxQBiQ8NEP9
PaxDbiQ8NEP9
PeptideAtlasiQ8NEP9
PRIDEiQ8NEP9
ProteomicsDBi73197 [Q8NEP9-1]
73198 [Q8NEP9-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
10850, 162 antibodies

The DNASU plasmid repository

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DNASUi
148254

Genome annotation databases

EnsembliENST00000334241; ENSP00000334853; ENSG00000186300 [Q8NEP9-1]
ENST00000591539; ENSP00000467893; ENSG00000186300 [Q8NEP9-4]
GeneIDi148254
KEGGihsa:148254
UCSCiuc002lwn.5, human [Q8NEP9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
148254
DisGeNETi148254

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF555
HGNCiHGNC:28382, ZNF555
HPAiENSG00000186300, Low tissue specificity
neXtProtiNX_Q8NEP9
OpenTargetsiENSG00000186300
PharmGKBiPA134956715
VEuPathDBiHostDB:ENSG00000186300.11

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000163425
HOGENOMiCLU_002678_44_5_1
InParanoidiQ8NEP9
OMAiHVRMHPG
OrthoDBi1318335at2759
PhylomeDBiQ8NEP9
TreeFamiTF338854

Enzyme and pathway databases

PathwayCommonsiQ8NEP9
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
148254, 7 hits in 1010 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
148254
PharosiQ8NEP9, Tdark

Protein Ontology

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PROi
PR:Q8NEP9
RNActiQ8NEP9, protein

Gene expression databases

BgeeiENSG00000186300, Expressed in amniotic fluid and 206 other tissues
ExpressionAtlasiQ8NEP9, baseline and differential
GenevisibleiQ8NEP9, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 15 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 15 hits
PS50157, ZINC_FINGER_C2H2_2, 15 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN555_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NEP9
Secondary accession number(s): A8KA89
, K7EQM2, Q8NA46, Q96MP1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: January 20, 2009
Last modified: June 2, 2021
This is version 162 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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