Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 136 (12 Aug 2020)
Sequence version 2 (04 Jan 2005)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Kelch domain-containing protein 9

Gene

KLHDC9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8NEP7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kelch domain-containing protein 9
Alternative name(s):
Kelch/ankyrin repeat-containing cyclin A1-interacting protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KLHDC9
Synonyms:KARCA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000162755.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28489, KLHDC9

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617375, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NEP7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000162755

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162393459

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NEP7, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KLHDC9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751256

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003004641 – 349Kelch domain-containing protein 9Add BLAST349

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NEP7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NEP7

PeptideAtlas

More...
PeptideAtlasi
Q8NEP7

PRoteomics IDEntifications database

More...
PRIDEi
Q8NEP7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
73194 [Q8NEP7-1]
73195 [Q8NEP7-2]
73196 [Q8NEP7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NEP7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NEP7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162755, Expressed in testis and 186 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NEP7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000162755, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CCNA1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
126019, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NEP7, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356990

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NEP7, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati39 – 89Kelch 1Add BLAST51
Repeati91 – 137Kelch 2Add BLAST47
Repeati325 – 349Kelch 3Add BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0379, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011582

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_068365_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NEP7

Identification of Orthologs from Complete Genome Data

More...
OMAi
GWAWRPV

Database of Orthologous Groups

More...
OrthoDBi
933937at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NEP7

TreeFam database of animal gene trees

More...
TreeFami
TF337916

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.80, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011043, Gal_Oxase/kelch_b-propeller
IPR015915, Kelch-typ_b-propeller
IPR042941, KLDC9

The PANTHER Classification System

More...
PANTHERi
PTHR47196, PTHR47196, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50965, SSF50965, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8NEP7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVAVPPGRA AGSGWAWRPV ARDALLARAF HSCTELRGRF YLVGGLLAGG
60 70 80 90 100
AREPSSDTVV FDPARGQAVR LGARGSPPRS HHDAAPVDGR WLCVVGGWDG
110 120 130 140 150
SRRLATVTAL DTERGVWEAW TGTPGDCPPA GLSSHTCTRI SDRELQVAGR
160 170 180 190 200
EGGIHTQRRY GSIYTLRLDP SARTYCYKQE GCHTASRSGH CAALLQTPGP
210 220 230 240 250
HPGHQLLLFG GCNLAEPEVA GHWSHGKIKE EPPVAPHLME QLARLVSSGQ
260 270 280 290 300
GSQKGPHGLR HHSCSVVGPF AVLFGGETLT RARDTICNDL YIYDTRTSPP
310 320 330 340
LWFHFPCADR GMKRMGHRTC LWNDQLYLVG GFGEDGRTAS PQVCILDFI
Length:349
Mass (Da):37,754
Last modified:January 4, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i034F41898BDE0BBB
GO
Isoform 2 (identifier: Q8NEP7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-288: EEPPVAPHLM...LTRARDTICN → SFLSPQGGTT...AVWWRNSDQS
     289-349: Missing.

Show »
Length:288
Mass (Da):30,682
Checksum:iF3D681F077396E10
GO
Isoform 3 (identifier: Q8NEP7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-263: CYKQEGCHTA...KGPHGLRHHS → WYGTLRPKPF...LTFSRKPTQP
     264-349: Missing.

Show »
Length:263
Mass (Da):28,527
Checksum:i1788E87659EF9F18
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti83D → G in BAC04114 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034873171S → R. Corresponds to variant dbSNP:rs11576830Ensembl.1
Natural variantiVAR_050056282A → T1 PublicationCorresponds to variant dbSNP:rs1128750Ensembl.1
Natural variantiVAR_034874288N → S. Corresponds to variant dbSNP:rs1128750Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027807176 – 263CYKQE…LRHHS → WYGTLRPKPFTLIHTLEKQK PKQISQAIYPPPHSSTLLPG EPTMFKLAELSTVLPSLLSH LPHCPMPLLHPSLARAVALT FSRKPTQP in isoform 3. 2 PublicationsAdd BLAST88
Alternative sequenceiVSP_027808230 – 288EEPPV…DTICN → SFLSPQGGTTCCSSFDGTAC KACEQWAGVPEGAPWTTASL MFCGRALCCAVWWRNSDQS in isoform 2. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_027809264 – 349Missing in isoform 3. 2 PublicationsAdd BLAST86
Alternative sequenceiVSP_027810289 – 349Missing in isoform 2. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY601914 mRNA Translation: AAT09158.1
AK093268 mRNA Translation: BAC04114.1
AL591806 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52659.1
CH471121 Genomic DNA Translation: EAW52662.1
BC022077 mRNA Translation: AAH22077.2
BC032482 mRNA Translation: AAH32482.1
BC066896 mRNA Translation: AAH66896.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30919.1 [Q8NEP7-1]
CCDS41425.1 [Q8NEP7-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001007256.1, NM_001007255.2 [Q8NEP7-2]
NP_689579.3, NM_152366.4 [Q8NEP7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368011; ENSP00000356990; ENSG00000162755 [Q8NEP7-1]
ENST00000392192; ENSP00000376030; ENSG00000162755 [Q8NEP7-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
126823

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:126823

UCSC genome browser

More...
UCSCi
uc001fxr.4, human [Q8NEP7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY601914 mRNA Translation: AAT09158.1
AK093268 mRNA Translation: BAC04114.1
AL591806 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52659.1
CH471121 Genomic DNA Translation: EAW52662.1
BC022077 mRNA Translation: AAH22077.2
BC032482 mRNA Translation: AAH32482.1
BC066896 mRNA Translation: AAH66896.1
CCDSiCCDS30919.1 [Q8NEP7-1]
CCDS41425.1 [Q8NEP7-2]
RefSeqiNP_001007256.1, NM_001007255.2 [Q8NEP7-2]
NP_689579.3, NM_152366.4 [Q8NEP7-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi126019, 7 interactors
IntActiQ8NEP7, 6 interactors
STRINGi9606.ENSP00000356990

PTM databases

iPTMnetiQ8NEP7
PhosphoSitePlusiQ8NEP7

Polymorphism and mutation databases

BioMutaiKLHDC9
DMDMi74751256

Proteomic databases

MassIVEiQ8NEP7
PaxDbiQ8NEP7
PeptideAtlasiQ8NEP7
PRIDEiQ8NEP7
ProteomicsDBi73194 [Q8NEP7-1]
73195 [Q8NEP7-2]
73196 [Q8NEP7-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34288, 76 antibodies

The DNASU plasmid repository

More...
DNASUi
126823

Genome annotation databases

EnsembliENST00000368011; ENSP00000356990; ENSG00000162755 [Q8NEP7-1]
ENST00000392192; ENSP00000376030; ENSG00000162755 [Q8NEP7-2]
GeneIDi126823
KEGGihsa:126823
UCSCiuc001fxr.4, human [Q8NEP7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
126823
EuPathDBiHostDB:ENSG00000162755.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KLHDC9
HGNCiHGNC:28489, KLHDC9
HPAiENSG00000162755, Tissue enhanced (testis)
MIMi617375, gene
neXtProtiNX_Q8NEP7
OpenTargetsiENSG00000162755
PharmGKBiPA162393459

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0379, Eukaryota
GeneTreeiENSGT00390000011582
HOGENOMiCLU_068365_0_0_1
InParanoidiQ8NEP7
OMAiGWAWRPV
OrthoDBi933937at2759
PhylomeDBiQ8NEP7
TreeFamiTF337916

Enzyme and pathway databases

PathwayCommonsiQ8NEP7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
126823, 4 hits in 862 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KLHDC9, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
126823
PharosiQ8NEP7, Tbio

Protein Ontology

More...
PROi
PR:Q8NEP7
RNActiQ8NEP7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000162755, Expressed in testis and 186 other tissues
GenevisibleiQ8NEP7, HS

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR011043, Gal_Oxase/kelch_b-propeller
IPR015915, Kelch-typ_b-propeller
IPR042941, KLDC9
PANTHERiPTHR47196, PTHR47196, 1 hit
SUPFAMiSSF50965, SSF50965, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKLDC9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NEP7
Secondary accession number(s): Q5SY56
, Q6NXT9, Q6PKN4, Q8N5E1, Q8NA16
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 4, 2005
Last modified: August 12, 2020
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again