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UniProtKB - Q8NEM7 (SP20H_HUMAN)

Protein

Transcription factor SPT20 homolog

Gene

SUPT20H

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy.By similarity1 Publication

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDevelopmental protein
Biological processAutophagy, Gastrulation

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SPT20 homolog
Alternative name(s):
p38-interacting protein
Short name:
p38IP
Gene namesi
Name:SUPT20H
Synonyms:C13orf19, FAM48A
ORF Names:FP757
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000102710.19
HGNCiHGNC:20596 SUPT20H
MIMi613417 gene
neXtProtiNX_Q8NEM7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55578
OpenTargetsiENSG00000102710
PharmGKBiPA134985241

Polymorphism and mutation databases

BioMutaiSUPT20H
DMDMi334302791

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001870391 – 779Transcription factor SPT20 homologAdd BLAST779

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei296PhosphoserineBy similarity1
Modified residuei494PhosphothreonineCombined sources1
Modified residuei519PhosphoserineCombined sources1
Modified residuei524PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8NEM7
MaxQBiQ8NEM7
PaxDbiQ8NEM7
PeptideAtlasiQ8NEM7
PRIDEiQ8NEM7
ProteomicsDBi73182
73183 [Q8NEM7-2]

PTM databases

iPTMnetiQ8NEM7
PhosphoSitePlusiQ8NEM7

Expressioni

Tissue specificityi

Highly expressed in testis, moderately in brain and pituitary gland. Expressed in several fetal tissues, including lung, brain, thymus and kidney. Expression is down-regulated in malignant prostate tissues.1 Publication

Gene expression databases

BgeeiENSG00000102710 Expressed in 226 organ(s), highest expression level in kidney
CleanExiHS_FAM48A
ExpressionAtlasiQ8NEM7 baseline and differential
GenevisibleiQ8NEM7 HS

Organism-specific databases

HPAiHPA038906
HPA038907

Interactioni

Subunit structurei

Interacts with MAPK14. Interacts with ATG9A.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi120729, 34 interactors
ComplexPortaliCPX-900 SAGA complex
CORUMiQ8NEM7
IntActiQ8NEM7, 13 interactors
STRINGi9606.ENSP00000218894

Structurei

3D structure databases

ProteinModelPortaliQ8NEM7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi636 – 754Gln-richAdd BLAST119

Sequence similaritiesi

Belongs to the SPT20 family.Curated

Phylogenomic databases

eggNOGiENOG410IJ9A Eukaryota
ENOG410YRYS LUCA
GeneTreeiENSGT00390000013549
HOGENOMiHOG000168361
HOVERGENiHBG081509
InParanoidiQ8NEM7
KOiK21245
OMAiFECEAGN
OrthoDBiEOG091G0VSR
TreeFamiTF329155

Family and domain databases

InterProiView protein in InterPro
IPR021950 Spt20
PANTHERiPTHR13526 PTHR13526, 1 hit
PfamiView protein in Pfam
PF12090 Spt20, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NEM7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQQALELALD RAEYVIESAR QRPPKRKYLS SGRKSVFQKL YDLYIEECEK 
        60         70         80         90        100
EPEVKKLRRN VNLLEKLVMQ ETLSCLVVNL YPGNEGYSLM LRGKNGSDSE 
       110        120        130        140        150
TIRLPYEEGE LLEYLDAEEL PPILVDLLEK SQVNIFHCGC VIAEIRDYRQ 
       160        170        180        190        200
SSNMKSPGYQ SRHILLRPTM QTLICDVHSI TSDNHKWTQE DKLLLESQLI 
       210        220        230        240        250
LATAEPLCLD PSIAVTCTAN RLLYNKQKMN TRPMKRCFKR YSRSSLNRQQ 
       260        270        280        290        300
DLSHCPPPPQ LRLLDFLQKR KERKAGQHYD LKISKAGNCV DMWKRSPCNL 
       310        320        330        340        350
AIPSEVDVEK YAKVEKSIKS DDSQPTVWPA HDVKDDYVFE CEAGTQYQKT 
       360        370        380        390        400
KLTILQSLGD PLYYGKIQPC KADEESDSQM SPSHSSTDDH SNWFIIGSKT 
       410        420        430        440        450
DAERVVNQYQ ELVQNEAKCP VKMSHSSSGS ASLSQVSPGK ETDQTETVSV 
       460        470        480        490        500
QSSVLGKGVK HRPPPIKLPS SSGNSSSGNY FTPQQTSSFL KSPTPPPSSK 
       510        520        530        540        550
PSSIPRKSSV DLNQVSMLSP AALSPASSSQ RTTATQVMAN SAGLNFINVV 
       560        570        580        590        600
GSVCGAQALM SGSNPMLGCN TGAITPAGIN LSGLLPSGGL LPNALPSAMQ 
       610        620        630        640        650
AASQAGVPFG LKNTSSLRPL NLLQLPGGSL IFNTLQQQQQ QLSQFTPQQP 
       660        670        680        690        700
QQPTTCSPQQ PGEQGSEQGS TSQEQALSAQ QAAVINLTGV GSFMQSQAAV 
       710        720        730        740        750
LSQLGSAENR PEQSLPQQRF QLSSAFQQQQ QQIQQLRFLQ HQMAMAAAAA 
       760        770 
QTAQLHHHRH TGSQSKSKMK RGTPTTPKF
Length:779
Mass (Da):85,789
Last modified:May 31, 2011 - v2
Checksum:i4CD7DFD8719F621C
GO
Isoform 2 (identifier: Q8NEM7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-55: K → KQ
     700-732: VLSQLGSAENRPEQSLPQQRFQLSSAFQQQQQQ → AVAILAASNGYGSSSSTNSSATSSSAYRQPVKK
     733-779: Missing.

Show »
Length:733
Mass (Da):80,102
Checksum:i7FC9A980B6FF1935
GO
Isoform 3 (identifier: Q8NEM7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     531-531: R → RSGTPKPSTP...STMVTSITPG
     700-732: VLSQLGSAENRPEQSLPQQRFQLSSAFQQQQQQ → AVAILAASNGYGSSSSTNSSATSSSAYRQPVKK
     733-779: Missing.

Note: No experimental confirmation available.
Show »
Length:811
Mass (Da):88,041
Checksum:i110B9040C3B5C8A3
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6S7C4F6S7C4_HUMAN
Transcription factor SPT20 homolog
SUPT20H
736Annotation score:
C9JQS2C9JQS2_HUMAN
Transcription factor SPT20 homolog
SUPT20H
190Annotation score:
B4E2D5B4E2D5_HUMAN
Transcription factor SPT20 homolog
SUPT20H
498Annotation score:
H7C5F9H7C5F9_HUMAN
Transcription factor SPT20 homolog
SUPT20H
378Annotation score:
R4GND2R4GND2_HUMAN
Transcription factor SPT20 homolog
SUPT20H
522Annotation score:

Sequence cautioni

The sequence AAQ15220 differs from that shown. Intron retention.Curated
The sequence AAQ15220 differs from that shown. Reason: Frameshift at position 562.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti707A → V in AAH30686 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055798154M → V. Corresponds to variant dbSNP:rs7324275Ensembl.1
Natural variantiVAR_055799773T → M1 PublicationCorresponds to variant dbSNP:rs9469Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01487755K → KQ in isoform 2. 2 Publications1
Alternative sequenceiVSP_055621531R → RSGTPKPSTPTPTPSSTPHP PDAQSSTPSTPSATPTPQDS GFTPQPTLLTQFAQQQRSLS QAMPVTTIPLSTMVTSITPG in isoform 3. 1 Publication1
Alternative sequenceiVSP_014878700 – 732VLSQL…QQQQQ → AVAILAASNGYGSSSSTNSS ATSSSAYRQPVKK in isoform 2 and isoform 3. 3 PublicationsAdd BLAST33
Alternative sequenceiVSP_014879733 – 779Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ130894 mRNA Translation: CAB62207.1
AF093250 mRNA Translation: AAD40550.1
AK225376 mRNA No translation available.
AL138706 Genomic DNA No translation available.
AL391383 Genomic DNA No translation available.
BC030686 mRNA Translation: AAH30686.1
AF370384 mRNA Translation: AAQ15220.1 Sequence problems.
CCDSiCCDS31959.1 [Q8NEM7-1]
CCDS61311.1 [Q8NEM7-3]
CCDS9362.1 [Q8NEM7-2]
RefSeqiNP_001014308.2, NM_001014286.2 [Q8NEM7-1]
NP_001265409.1, NM_001278480.1 [Q8NEM7-3]
NP_001265410.1, NM_001278481.1 [Q8NEM7-2]
NP_001265411.1, NM_001278482.1 [Q8NEM7-2]
NP_060039.1, NM_017569.3 [Q8NEM7-2]
UniGeneiHs.435815

Genome annotation databases

EnsembliENST00000350612; ENSP00000218894; ENSG00000102710 [Q8NEM7-1]
ENST00000356185; ENSP00000348512; ENSG00000102710 [Q8NEM7-2]
ENST00000360252; ENSP00000353388; ENSG00000102710 [Q8NEM7-2]
ENST00000464744; ENSP00000419754; ENSG00000102710 [Q8NEM7-2]
ENST00000475892; ENSP00000417510; ENSG00000102710 [Q8NEM7-3]
GeneIDi55578
KEGGihsa:55578
UCSCiuc001uwg.4 human [Q8NEM7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ130894 mRNA Translation: CAB62207.1
AF093250 mRNA Translation: AAD40550.1
AK225376 mRNA No translation available.
AL138706 Genomic DNA No translation available.
AL391383 Genomic DNA No translation available.
BC030686 mRNA Translation: AAH30686.1
AF370384 mRNA Translation: AAQ15220.1 Sequence problems.
CCDSiCCDS31959.1 [Q8NEM7-1]
CCDS61311.1 [Q8NEM7-3]
CCDS9362.1 [Q8NEM7-2]
RefSeqiNP_001014308.2, NM_001014286.2 [Q8NEM7-1]
NP_001265409.1, NM_001278480.1 [Q8NEM7-3]
NP_001265410.1, NM_001278481.1 [Q8NEM7-2]
NP_001265411.1, NM_001278482.1 [Q8NEM7-2]
NP_060039.1, NM_017569.3 [Q8NEM7-2]
UniGeneiHs.435815

3D structure databases

ProteinModelPortaliQ8NEM7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120729, 34 interactors
ComplexPortaliCPX-900 SAGA complex
CORUMiQ8NEM7
IntActiQ8NEM7, 13 interactors
STRINGi9606.ENSP00000218894

PTM databases

iPTMnetiQ8NEM7
PhosphoSitePlusiQ8NEM7

Polymorphism and mutation databases

BioMutaiSUPT20H
DMDMi334302791

Proteomic databases

EPDiQ8NEM7
MaxQBiQ8NEM7
PaxDbiQ8NEM7
PeptideAtlasiQ8NEM7
PRIDEiQ8NEM7
ProteomicsDBi73182
73183 [Q8NEM7-2]

Protocols and materials databases

DNASUi55578
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350612; ENSP00000218894; ENSG00000102710 [Q8NEM7-1]
ENST00000356185; ENSP00000348512; ENSG00000102710 [Q8NEM7-2]
ENST00000360252; ENSP00000353388; ENSG00000102710 [Q8NEM7-2]
ENST00000464744; ENSP00000419754; ENSG00000102710 [Q8NEM7-2]
ENST00000475892; ENSP00000417510; ENSG00000102710 [Q8NEM7-3]
GeneIDi55578
KEGGihsa:55578
UCSCiuc001uwg.4 human [Q8NEM7-1]

Organism-specific databases

CTDi55578
DisGeNETi55578
EuPathDBiHostDB:ENSG00000102710.19
GeneCardsiSUPT20H
HGNCiHGNC:20596 SUPT20H
HPAiHPA038906
HPA038907
MIMi613417 gene
neXtProtiNX_Q8NEM7
OpenTargetsiENSG00000102710
PharmGKBiPA134985241
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ9A Eukaryota
ENOG410YRYS LUCA
GeneTreeiENSGT00390000013549
HOGENOMiHOG000168361
HOVERGENiHBG081509
InParanoidiQ8NEM7
KOiK21245
OMAiFECEAGN
OrthoDBiEOG091G0VSR
TreeFamiTF329155

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones

Miscellaneous databases

ChiTaRSiSUPT20H human
GeneWikiiFAM48A
GenomeRNAii55578
PROiPR:Q8NEM7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102710 Expressed in 226 organ(s), highest expression level in kidney
CleanExiHS_FAM48A
ExpressionAtlasiQ8NEM7 baseline and differential
GenevisibleiQ8NEM7 HS

Family and domain databases

InterProiView protein in InterPro
IPR021950 Spt20
PANTHERiPTHR13526 PTHR13526, 1 hit
PfamiView protein in Pfam
PF12090 Spt20, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSP20H_HUMAN
AccessioniPrimary (citable) accession number: Q8NEM7
Secondary accession number(s): E7ER46, Q71RF3, Q9Y6A6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 31, 2011
Last modified: November 7, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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