SHCBP1

Functionⁱ

May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.By similarity

GO - Molecular functionⁱ

SH2 domain binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fibroblast growth factor receptor signaling pathway Source: UniProtKB
regulation of neural precursor cell proliferation Source: UniProtKB

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: SHC SH2 domain-binding protein 1
Gene namesⁱ	Name:SHCBP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000171241.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29547 SHCBP1
MIMⁱ	611027 gene
neXtProtⁱ	NX_Q8NEM2

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79801
Open Targets More...OpenTargetsⁱ	ENSG00000171241
PharmGKBⁱ	PA134931125

Polymorphism and mutation databases

BioMutaⁱ	SHCBP1
DMDMⁱ	296452958

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000076315	2 – 672	SHC SH2 domain-binding protein 1Add BLAST		671

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	5	PhosphoserineCombined sources	1
Modified residueⁱ	7	PhosphothreonineCombined sources	1
Modified residueⁱ	31	PhosphoserineCombined sources	1
Modified residueⁱ	42	PhosphoserineCombined sources	1
Modified residueⁱ	44	PhosphoserineCombined sources	1
Modified residueⁱ	47	PhosphoserineCombined sources	1
Modified residueⁱ	273	PhosphoserineCombined sources	1
Modified residueⁱ	634	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q8NEM2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8NEM2
PaxDbⁱ	Q8NEM2
PeptideAtlas More...PeptideAtlasⁱ	Q8NEM2
PRIDEⁱ	Q8NEM2
ProteomicsDBⁱ	73181

PTM databases

iPTMnetⁱ	Q8NEM2
PhosphoSitePlusⁱ	Q8NEM2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000171241 Expressed in 140 organ(s), highest expression level in liver
CleanExⁱ	HS_SHCBP1
ExpressionAtlasⁱ	Q8NEM2 baseline and differential
Genevisibleⁱ	Q8NEM2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA048876

HPAⁱ

HPA048876

Interactionⁱ

Subunit structureⁱ

Interacts directly with isoform p52shc of SHC1 via its SH2 domain (By similarity). Interacts with TRIM71; leading to enhanced SHCBP1 protein stability (By similarity). Interacts with both members of the centralspindlin complex, KIF23 and RACGAP1 (PubMed:21187330).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PRKCB	P05771	2	EBI-744700,EBI-706216

With

Entry

#Exp.

IntAct

Notes

PRKCB

P05771

2

EBI-744700,EBI-706216

GO - Molecular functionⁱ

SH2 domain binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	122898, 36 interactors
CORUMⁱ	Q8NEM2
IntActⁱ	Q8NEM2, 15 interactors
Molecular INTeraction database More...MINTⁱ	Q8NEM2
STRINGⁱ	9606.ENSP00000306473

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NEM2
SMRⁱ	Q8NEM2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	428 – 451	PbH1 1Add BLAST	24
Repeatⁱ	452 – 473	PbH1 2Add BLAST	22
Repeatⁱ	474 – 496	PbH1 3Add BLAST	23
Repeatⁱ	497 – 518	PbH1 4Add BLAST	22
Repeatⁱ	526 – 548	PbH1 5Add BLAST	23

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	211 – 216	Poly-Glu		6

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IIV2 Eukaryota ENOG410XXTE LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063807
HOGENOMⁱ	HOG000154313
HOVERGENⁱ	HBG060212
InParanoidⁱ	Q8NEM2
OMAⁱ	LMCLHLR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0UP6
PhylomeDBⁱ	Q8NEM2
TreeFamⁱ	TF329196

Family and domain databases

Gene3Dⁱ	2.160.20.10, 1 hit
InterProⁱ	View protein in InterPro IPR039448 Beta_helix IPR006626 PbH1 IPR012334 Pectin_lyas_fold IPR011050 Pectin_lyase_fold/virulence
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13229 Beta_helix, 1 hit
SMARTⁱ	View protein in SMART SM00710 PbH1, 5 hits
SUPFAMⁱ	SSF51126 SSF51126, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q8NEM2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MADGSLTGGG LEAAAMAPER MGWAVEQELA SLEKGLFQDE DSCSDCSYRD 
        60         70         80         90        100
KPGSSLQSFM PEGKTFFPEI FQTNQLLFYE RFRAYQDYIL ADCKASEVQE 
       110        120        130        140        150
FTAEFLEKVL EPSGWRAVWH TNVFKVLVEI TDVDFAALKA VVRLAEPYLC 
       160        170        180        190        200
DSQVSTFTME CMKELLDLKE HRLPLQELWV VFDDSGVFDQ TALAIEHVRF 
       210        220        230        240        250
FYQNIWRSWD EEEEDEYDYF VRCVEPRLRL HYDILEDRVP SGLIVDYHNL 
       260        270        280        290        300
LSQCEESYRK FLNLRSSLSN CNSDSEQENI SMVEGLKLYS EMEQLKQKLK 
       310        320        330        340        350
LIENPLLRYV FGYQKNSNIQ AKGVRSSGQK ITHVVSSTMM AGLLRSLLTD 
       360        370        380        390        400
RLCQEPGEEE REIQFHSDPL SAINACFEGD TVIVCPGHYV VHGTFSIADS 
       410        420        430        440        450
IELEGYGLPD DIVIEKRGKG DTFVDCTGAD IKISGIKFVQ HDAVEGILIV 
       460        470        480        490        500
HRGKTTLENC VLQCETTGVT VRTSAEFLMK NSDLYGAKGA GIEIYPGSQC 
       510        520        530        540        550
TLSDNGIHHC KEGILIKDFL DEHYDIPKIS MVNNIIHNNE GYGVVLVKPT 
       560        570        580        590        600
IFSDLQENAE DGTEENKALK IQTSGEPDVA ERVDLEELIE CATGKMELCA 
       610        620        630        640        650
RTDPSEQVEG NCEIVNELIA ASTQKGQIKK KRLSELGITQ ADDNLMSQEM 
       660        670 
FVGIVGNQFK WNGKGSFGTF LF

Length:672

Mass (Da):75,690

Last modified:May 18, 2010 - v3

Checksum:ⁱF3BF0210D5413376

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	I3L3Z1	I3L3Z1_HUMAN		SHC SH2 domain-binding protein 1 SHC SH2 domain-binding protein 1	SHCBP1	155	Annotation score:

Sequence cautionⁱ

The sequence BAB15208 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	118	V → A in BAB71049 (PubMed:14702039).Curated	1
Sequence conflictⁱ	329	Q → R in BAB71049 (PubMed:14702039).Curated	1
Sequence conflictⁱ	437	K → R in BAB15208 (PubMed:14702039).Curated	1
Sequence conflictⁱ	450	V → A in BAB15208 (PubMed:14702039).Curated	1
Sequence conflictⁱ	558	N → S in AAH30699 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051354	21	M → TCombined sources2 PublicationsCorresponds to variant dbSNP:rs6598679Ensembl.		1
Natural variantⁱVAR_051355	60	M → R. Corresponds to variant dbSNP:rs11545690Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK025662 mRNA Translation: BAB15208.1 Different initiation. AK055931 mRNA Translation: BAB71049.1 AC092368 Genomic DNA No translation available. BC000960 mRNA Translation: AAH00960.1 BC030699 mRNA Translation: AAH30699.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10720.1
NCBI Reference Sequences More...RefSeqⁱ	NP_079021.3, NM_024745.4
UniGeneⁱ	Hs.123253

Genome annotation databases

Ensemblⁱ	ENST00000303383; ENSP00000306473; ENSG00000171241
GeneIDⁱ	79801
KEGGⁱ	hsa:79801
UCSC genome browser More...UCSCⁱ	uc002eec.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8NEM2	Uncharacterized protein		PIG		712	UniRef90_Q8NEM2
SHC binding and spindle associated 1		BOVIN		674
SHC SH2 domain-binding protein 1		Yangtze finless porpoise		674
SHC SH2 domain-binding protein 1-like		LIPVE		674
SHC SH2 domain-binding protein 1		TURTR		674
+41

Protein	Similar proteins		Species	Score	Length	Source
Q8NEM2	SHC SH2 domain-binding protein 1		MOUSE		668	UniRef50_Q9Z179
SHC SH2 domain-binding protein 1 homolog B		XENLA		698
SHC-binding and spindle-associated 1		RAT		661
SHC binding and spindle associated 1		FICAL		643
SHC binding and spindle associated 1		SARHA		652
+250

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK025662 mRNA Translation: BAB15208.1 Different initiation. AK055931 mRNA Translation: BAB71049.1 AC092368 Genomic DNA No translation available. BC000960 mRNA Translation: AAH00960.1 BC030699 mRNA Translation: AAH30699.1
CCDSⁱ	CCDS10720.1
RefSeqⁱ	NP_079021.3, NM_024745.4
UniGeneⁱ	Hs.123253

3D structure databases

ProteinModelPortalⁱ	Q8NEM2
SMRⁱ	Q8NEM2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122898, 36 interactors
CORUMⁱ	Q8NEM2
IntActⁱ	Q8NEM2, 15 interactors
MINTⁱ	Q8NEM2
STRINGⁱ	9606.ENSP00000306473

PTM databases

iPTMnetⁱ	Q8NEM2
PhosphoSitePlusⁱ	Q8NEM2

Polymorphism and mutation databases

BioMutaⁱ	SHCBP1
DMDMⁱ	296452958

Proteomic databases

EPDⁱ	Q8NEM2
MaxQBⁱ	Q8NEM2
PaxDbⁱ	Q8NEM2
PeptideAtlasⁱ	Q8NEM2
PRIDEⁱ	Q8NEM2
ProteomicsDBⁱ	73181

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	79801
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000303383; ENSP00000306473; ENSG00000171241
GeneIDⁱ	79801
KEGGⁱ	hsa:79801
UCSCⁱ	uc002eec.5 human

Organism-specific databases

CTDⁱ	79801
DisGeNETⁱ	79801
EuPathDBⁱ	HostDB:ENSG00000171241.8
GeneCardsⁱ	SHCBP1
HGNCⁱ	HGNC:29547 SHCBP1
HPAⁱ	HPA048876
MIMⁱ	611027 gene
neXtProtⁱ	NX_Q8NEM2
OpenTargetsⁱ	ENSG00000171241
PharmGKBⁱ	PA134931125
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IIV2 Eukaryota ENOG410XXTE LUCA
GeneTreeⁱ	ENSGT00530000063807
HOGENOMⁱ	HOG000154313
HOVERGENⁱ	HBG060212
InParanoidⁱ	Q8NEM2
OMAⁱ	LMCLHLR
OrthoDBⁱ	EOG091G0UP6
PhylomeDBⁱ	Q8NEM2
TreeFamⁱ	TF329196

Miscellaneous databases

ChiTaRSⁱ	SHCBP1 human
GeneWikiⁱ	SHCBP1
GenomeRNAiⁱ	79801
Protein Ontology More...PROⁱ	PR:Q8NEM2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000171241 Expressed in 140 organ(s), highest expression level in liver
CleanExⁱ	HS_SHCBP1
ExpressionAtlasⁱ	Q8NEM2 baseline and differential
Genevisibleⁱ	Q8NEM2 HS

Family and domain databases

Gene3Dⁱ	2.160.20.10, 1 hit
InterProⁱ	View protein in InterPro IPR039448 Beta_helix IPR006626 PbH1 IPR012334 Pectin_lyas_fold IPR011050 Pectin_lyase_fold/virulence
Pfamⁱ	View protein in Pfam PF13229 Beta_helix, 1 hit
SMARTⁱ	View protein in SMART SM00710 PbH1, 5 hits
SUPFAMⁱ	SSF51126 SSF51126, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SHCBP_HUMAN
Accessionⁱ	Q8NEM2Primary (citable) accession number: Q8NEM2 Secondary accession number(s): Q96N60, Q9BVS0, Q9H6P6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
	Last sequence update:	May 18, 2010
	Last modified:	October 10, 2018
	This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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UniProtKB - Q8NEM2 (SHCBP_HUMAN)

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SHC SH2 domain-binding protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ