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UniProtKB - Q8NEM2 (SHCBP_HUMAN)

Entry version 150 (10 Feb 2021)
Sequence version 3 (18 May 2010)
Previous versions | rss
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Protein

SHC SH2 domain-binding protein 1

Gene

SHCBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8NEM2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SHC SH2 domain-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SHCBP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29547, SHCBP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611027, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8NEM2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000171241.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		79801

Open Targets

More...OpenTargetsi		ENSG00000171241

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134931125

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8NEM2, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SHCBP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		296452958

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000763152 – 672SHC SH2 domain-binding protein 1Add BLAST671

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei5PhosphoserineCombined sources1
Modified residuei7PhosphothreonineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei42PhosphoserineCombined sources1
Modified residuei44PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei273PhosphoserineCombined sources1
Modified residuei634PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8NEM2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8NEM2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8NEM2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8NEM2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8NEM2

PeptideAtlas

More...PeptideAtlasi		Q8NEM2

PRoteomics IDEntifications database

More...PRIDEi		Q8NEM2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		73181

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8NEM2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8NEM2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000171241, Expressed in liver and 160 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8NEM2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8NEM2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000171241, Tissue enhanced (bone marrow, lymphoid tissue, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts directly with isoform p52shc of SHC1 via its SH2 domain (By similarity).

Interacts with TRIM71; leading to enhanced SHCBP1 protein stability (By similarity).

Interacts with both members of the centralspindlin complex, KIF23 and RACGAP1 (PubMed:21187330).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122898, 40 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q8NEM2

Protein interaction database and analysis system

More...IntActi		Q8NEM2, 31 interactors

Molecular INTeraction database

More...MINTi		Q8NEM2

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000306473

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8NEM2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8NEM2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati428 – 451PbH1 1Add BLAST24
Repeati452 – 473PbH1 2Add BLAST22
Repeati474 – 496PbH1 3Add BLAST23
Repeati497 – 518PbH1 4Add BLAST22
Repeati526 – 548PbH1 5Add BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi211 – 216Poly-Glu6

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QUQ2, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161310

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_022717_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8NEM2

Identification of Orthologs from Complete Genome Data

More...OMAi		TDLMCLH

Database of Orthologous Groups

More...OrthoDBi		1276823at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8NEM2

TreeFam database of animal gene trees

More...TreeFami		TF329196

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.160.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039448, Beta_helix
IPR006626, PbH1
IPR012334, Pectin_lyas_fold
IPR011050, Pectin_lyase_fold/virulence

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13229, Beta_helix, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00710, PbH1, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51126, SSF51126, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8NEM2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADGSLTGGG LEAAAMAPER MGWAVEQELA SLEKGLFQDE DSCSDCSYRD 
        60         70         80         90        100
KPGSSLQSFM PEGKTFFPEI FQTNQLLFYE RFRAYQDYIL ADCKASEVQE 
       110        120        130        140        150
FTAEFLEKVL EPSGWRAVWH TNVFKVLVEI TDVDFAALKA VVRLAEPYLC 
       160        170        180        190        200
DSQVSTFTME CMKELLDLKE HRLPLQELWV VFDDSGVFDQ TALAIEHVRF 
       210        220        230        240        250
FYQNIWRSWD EEEEDEYDYF VRCVEPRLRL HYDILEDRVP SGLIVDYHNL 
       260        270        280        290        300
LSQCEESYRK FLNLRSSLSN CNSDSEQENI SMVEGLKLYS EMEQLKQKLK 
       310        320        330        340        350
LIENPLLRYV FGYQKNSNIQ AKGVRSSGQK ITHVVSSTMM AGLLRSLLTD 
       360        370        380        390        400
RLCQEPGEEE REIQFHSDPL SAINACFEGD TVIVCPGHYV VHGTFSIADS 
       410        420        430        440        450
IELEGYGLPD DIVIEKRGKG DTFVDCTGAD IKISGIKFVQ HDAVEGILIV 
       460        470        480        490        500
HRGKTTLENC VLQCETTGVT VRTSAEFLMK NSDLYGAKGA GIEIYPGSQC 
       510        520        530        540        550
TLSDNGIHHC KEGILIKDFL DEHYDIPKIS MVNNIIHNNE GYGVVLVKPT 
       560        570        580        590        600
IFSDLQENAE DGTEENKALK IQTSGEPDVA ERVDLEELIE CATGKMELCA 
       610        620        630        640        650
RTDPSEQVEG NCEIVNELIA ASTQKGQIKK KRLSELGITQ ADDNLMSQEM 
       660        670 
FVGIVGNQFK WNGKGSFGTF LF
Length:672
Mass (Da):75,690
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3BF0210D5413376
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L3Z1I3L3Z1_HUMAN
SHC SH2 domain-binding protein 1
SHCBP1
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15208 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti118V → A in BAB71049 (PubMed:14702039).Curated1
Sequence conflicti329Q → R in BAB71049 (PubMed:14702039).Curated1
Sequence conflicti437K → R in BAB15208 (PubMed:14702039).Curated1
Sequence conflicti450V → A in BAB15208 (PubMed:14702039).Curated1
Sequence conflicti558N → S in AAH30699 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05135421M → TCombined sources2 PublicationsCorresponds to variant dbSNP:rs6598679Ensembl.1
Natural variantiVAR_05135560M → R. Corresponds to variant dbSNP:rs11545690Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK025662 mRNA Translation: BAB15208.1 Different initiation.
AK055931 mRNA Translation: BAB71049.1
AC092368 Genomic DNA No translation available.
BC000960 mRNA Translation: AAH00960.1
BC030699 mRNA Translation: AAH30699.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10720.1

NCBI Reference Sequences

More...RefSeqi		NP_079021.3, NM_024745.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000303383; ENSP00000306473; ENSG00000171241

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79801

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79801

UCSC genome browser

More...UCSCi		uc002eec.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025662 mRNA Translation: BAB15208.1 Different initiation.
AK055931 mRNA Translation: BAB71049.1
AC092368 Genomic DNA No translation available.
BC000960 mRNA Translation: AAH00960.1
BC030699 mRNA Translation: AAH30699.1
CCDSiCCDS10720.1
RefSeqiNP_079021.3, NM_024745.4

3D structure databases

SMRiQ8NEM2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122898, 40 interactors
CORUMiQ8NEM2
IntActiQ8NEM2, 31 interactors
MINTiQ8NEM2
STRINGi9606.ENSP00000306473

PTM databases

iPTMnetiQ8NEM2
PhosphoSitePlusiQ8NEM2

Genetic variation databases

BioMutaiSHCBP1
DMDMi296452958

Proteomic databases

EPDiQ8NEM2
jPOSTiQ8NEM2
MassIVEiQ8NEM2
MaxQBiQ8NEM2
PaxDbiQ8NEM2
PeptideAtlasiQ8NEM2
PRIDEiQ8NEM2
ProteomicsDBi73181

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		43856, 109 antibodies

The DNASU plasmid repository

More...DNASUi		79801

Genome annotation databases

EnsembliENST00000303383; ENSP00000306473; ENSG00000171241
GeneIDi79801
KEGGihsa:79801
UCSCiuc002eec.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79801
DisGeNETi79801

GeneCards: human genes, protein and diseases

More...GeneCardsi		SHCBP1
HGNCiHGNC:29547, SHCBP1
HPAiENSG00000171241, Tissue enhanced (bone marrow, lymphoid tissue, testis)
MIMi611027, gene
neXtProtiNX_Q8NEM2
OpenTargetsiENSG00000171241
PharmGKBiPA134931125
VEuPathDBiHostDB:ENSG00000171241.8

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QUQ2, Eukaryota
GeneTreeiENSGT00940000161310
HOGENOMiCLU_022717_2_0_1
InParanoidiQ8NEM2
OMAiTDLMCLH
OrthoDBi1276823at2759
PhylomeDBiQ8NEM2
TreeFamiTF329196

Enzyme and pathway databases

PathwayCommonsiQ8NEM2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79801, 7 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SHCBP1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SHCBP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79801
PharosiQ8NEM2, Tbio

Protein Ontology

More...PROi		PR:Q8NEM2
RNActiQ8NEM2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000171241, Expressed in liver and 160 other tissues
ExpressionAtlasiQ8NEM2, baseline and differential
GenevisibleiQ8NEM2, HS

Family and domain databases

Gene3Di2.160.20.10, 1 hit
InterProiView protein in InterPro
IPR039448, Beta_helix
IPR006626, PbH1
IPR012334, Pectin_lyas_fold
IPR011050, Pectin_lyase_fold/virulence
PfamiView protein in Pfam
PF13229, Beta_helix, 1 hit
SMARTiView protein in SMART
SM00710, PbH1, 5 hits
SUPFAMiSSF51126, SSF51126, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHCBP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NEM2
Secondary accession number(s): Q96N60, Q9BVS0, Q9H6P6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 18, 2010
Last modified: February 10, 2021
This is version 150 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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