UniProtKB - Q8NEM2 (SHCBP_HUMAN)
Protein
SHC SH2 domain-binding protein 1
Gene
SHCBP1
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.By similarity
GO - Molecular functioni
- SH2 domain binding Source: Ensembl
GO - Biological processi
- fibroblast growth factor receptor signaling pathway Source: UniProtKB
- regulation of neural precursor cell proliferation Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q8NEM2 |
Names & Taxonomyi
Protein namesi | Recommended name: SHC SH2 domain-binding protein 1 |
Gene namesi | Name:SHCBP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29547, SHCBP1 |
MIMi | 611027, gene |
neXtProti | NX_Q8NEM2 |
VEuPathDBi | HostDB:ENSG00000171241.8 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 79801 |
OpenTargetsi | ENSG00000171241 |
PharmGKBi | PA134931125 |
Miscellaneous databases
Pharosi | Q8NEM2, Tbio |
Genetic variation databases
BioMutai | SHCBP1 |
DMDMi | 296452958 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000076315 | 2 – 672 | SHC SH2 domain-binding protein 1Add BLAST | 671 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 5 | PhosphoserineCombined sources | 1 | |
Modified residuei | 7 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 31 | PhosphoserineCombined sources | 1 | |
Modified residuei | 42 | PhosphoserineCombined sources | 1 | |
Modified residuei | 44 | PhosphoserineCombined sources | 1 | |
Modified residuei | 47 | PhosphoserineCombined sources | 1 | |
Modified residuei | 273 | PhosphoserineCombined sources | 1 | |
Modified residuei | 634 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q8NEM2 |
jPOSTi | Q8NEM2 |
MassIVEi | Q8NEM2 |
MaxQBi | Q8NEM2 |
PaxDbi | Q8NEM2 |
PeptideAtlasi | Q8NEM2 |
PRIDEi | Q8NEM2 |
ProteomicsDBi | 73181 |
PTM databases
iPTMneti | Q8NEM2 |
PhosphoSitePlusi | Q8NEM2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000171241, Expressed in liver and 160 other tissues |
ExpressionAtlasi | Q8NEM2, baseline and differential |
Genevisiblei | Q8NEM2, HS |
Organism-specific databases
HPAi | ENSG00000171241, Tissue enhanced (bone marrow, lymphoid tissue, testis) |
Interactioni
Subunit structurei
Interacts directly with isoform p52shc of SHC1 via its SH2 domain (By similarity).
Interacts with TRIM71; leading to enhanced SHCBP1 protein stability (By similarity).
Interacts with both members of the centralspindlin complex, KIF23 and RACGAP1 (PubMed:21187330).
By similarity1 PublicationBinary interactionsi
Q8NEM2
With | #Exp. | IntAct |
---|---|---|
PRKCB [P05771] | 2 | EBI-744700,EBI-706216 |
GO - Molecular functioni
- SH2 domain binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 122898, 40 interactors |
CORUMi | Q8NEM2 |
IntActi | Q8NEM2, 31 interactors |
MINTi | Q8NEM2 |
STRINGi | 9606.ENSP00000306473 |
Miscellaneous databases
RNActi | Q8NEM2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 428 – 451 | PbH1 1Add BLAST | 24 | |
Repeati | 452 – 473 | PbH1 2Add BLAST | 22 | |
Repeati | 474 – 496 | PbH1 3Add BLAST | 23 | |
Repeati | 497 – 518 | PbH1 4Add BLAST | 22 | |
Repeati | 526 – 548 | PbH1 5Add BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 211 – 216 | Poly-Glu | 6 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QUQ2, Eukaryota |
GeneTreei | ENSGT00940000161310 |
HOGENOMi | CLU_022717_2_0_1 |
InParanoidi | Q8NEM2 |
OMAi | TDLMCLH |
OrthoDBi | 1276823at2759 |
PhylomeDBi | Q8NEM2 |
TreeFami | TF329196 |
Family and domain databases
Gene3Di | 2.160.20.10, 1 hit |
InterProi | View protein in InterPro IPR039448, Beta_helix IPR006626, PbH1 IPR012334, Pectin_lyas_fold IPR011050, Pectin_lyase_fold/virulence |
Pfami | View protein in Pfam PF13229, Beta_helix, 1 hit |
SMARTi | View protein in SMART SM00710, PbH1, 5 hits |
SUPFAMi | SSF51126, SSF51126, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8NEM2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADGSLTGGG LEAAAMAPER MGWAVEQELA SLEKGLFQDE DSCSDCSYRD
60 70 80 90 100
KPGSSLQSFM PEGKTFFPEI FQTNQLLFYE RFRAYQDYIL ADCKASEVQE
110 120 130 140 150
FTAEFLEKVL EPSGWRAVWH TNVFKVLVEI TDVDFAALKA VVRLAEPYLC
160 170 180 190 200
DSQVSTFTME CMKELLDLKE HRLPLQELWV VFDDSGVFDQ TALAIEHVRF
210 220 230 240 250
FYQNIWRSWD EEEEDEYDYF VRCVEPRLRL HYDILEDRVP SGLIVDYHNL
260 270 280 290 300
LSQCEESYRK FLNLRSSLSN CNSDSEQENI SMVEGLKLYS EMEQLKQKLK
310 320 330 340 350
LIENPLLRYV FGYQKNSNIQ AKGVRSSGQK ITHVVSSTMM AGLLRSLLTD
360 370 380 390 400
RLCQEPGEEE REIQFHSDPL SAINACFEGD TVIVCPGHYV VHGTFSIADS
410 420 430 440 450
IELEGYGLPD DIVIEKRGKG DTFVDCTGAD IKISGIKFVQ HDAVEGILIV
460 470 480 490 500
HRGKTTLENC VLQCETTGVT VRTSAEFLMK NSDLYGAKGA GIEIYPGSQC
510 520 530 540 550
TLSDNGIHHC KEGILIKDFL DEHYDIPKIS MVNNIIHNNE GYGVVLVKPT
560 570 580 590 600
IFSDLQENAE DGTEENKALK IQTSGEPDVA ERVDLEELIE CATGKMELCA
610 620 630 640 650
RTDPSEQVEG NCEIVNELIA ASTQKGQIKK KRLSELGITQ ADDNLMSQEM
660 670
FVGIVGNQFK WNGKGSFGTF LF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketI3L3Z1 | I3L3Z1_HUMAN | SHC SH2 domain-binding protein 1 | SHCBP1 | 155 | Annotation score: |
Sequence cautioni
The sequence BAB15208 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 118 | V → A in BAB71049 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 329 | Q → R in BAB71049 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 437 | K → R in BAB15208 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 450 | V → A in BAB15208 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 558 | N → S in AAH30699 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051354 | 21 | M → TCombined sources2 PublicationsCorresponds to variant dbSNP:rs6598679Ensembl. | 1 | |
Natural variantiVAR_051355 | 60 | M → R. Corresponds to variant dbSNP:rs11545690Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK025662 mRNA Translation: BAB15208.1 Different initiation. AK055931 mRNA Translation: BAB71049.1 AC092368 Genomic DNA No translation available. BC000960 mRNA Translation: AAH00960.1 BC030699 mRNA Translation: AAH30699.1 |
CCDSi | CCDS10720.1 |
RefSeqi | NP_079021.3, NM_024745.4 |
Genome annotation databases
Ensembli | ENST00000303383; ENSP00000306473; ENSG00000171241 |
GeneIDi | 79801 |
KEGGi | hsa:79801 |
UCSCi | uc002eec.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK025662 mRNA Translation: BAB15208.1 Different initiation. AK055931 mRNA Translation: BAB71049.1 AC092368 Genomic DNA No translation available. BC000960 mRNA Translation: AAH00960.1 BC030699 mRNA Translation: AAH30699.1 |
CCDSi | CCDS10720.1 |
RefSeqi | NP_079021.3, NM_024745.4 |
3D structure databases
SMRi | Q8NEM2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122898, 40 interactors |
CORUMi | Q8NEM2 |
IntActi | Q8NEM2, 31 interactors |
MINTi | Q8NEM2 |
STRINGi | 9606.ENSP00000306473 |
PTM databases
iPTMneti | Q8NEM2 |
PhosphoSitePlusi | Q8NEM2 |
Genetic variation databases
BioMutai | SHCBP1 |
DMDMi | 296452958 |
Proteomic databases
EPDi | Q8NEM2 |
jPOSTi | Q8NEM2 |
MassIVEi | Q8NEM2 |
MaxQBi | Q8NEM2 |
PaxDbi | Q8NEM2 |
PeptideAtlasi | Q8NEM2 |
PRIDEi | Q8NEM2 |
ProteomicsDBi | 73181 |
Protocols and materials databases
Antibodypediai | 43856, 109 antibodies |
DNASUi | 79801 |
Genome annotation databases
Ensembli | ENST00000303383; ENSP00000306473; ENSG00000171241 |
GeneIDi | 79801 |
KEGGi | hsa:79801 |
UCSCi | uc002eec.5, human |
Organism-specific databases
CTDi | 79801 |
DisGeNETi | 79801 |
GeneCardsi | SHCBP1 |
HGNCi | HGNC:29547, SHCBP1 |
HPAi | ENSG00000171241, Tissue enhanced (bone marrow, lymphoid tissue, testis) |
MIMi | 611027, gene |
neXtProti | NX_Q8NEM2 |
OpenTargetsi | ENSG00000171241 |
PharmGKBi | PA134931125 |
VEuPathDBi | HostDB:ENSG00000171241.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUQ2, Eukaryota |
GeneTreei | ENSGT00940000161310 |
HOGENOMi | CLU_022717_2_0_1 |
InParanoidi | Q8NEM2 |
OMAi | TDLMCLH |
OrthoDBi | 1276823at2759 |
PhylomeDBi | Q8NEM2 |
TreeFami | TF329196 |
Enzyme and pathway databases
PathwayCommonsi | Q8NEM2 |
Miscellaneous databases
BioGRID-ORCSi | 79801, 7 hits in 873 CRISPR screens |
ChiTaRSi | SHCBP1, human |
GeneWikii | SHCBP1 |
GenomeRNAii | 79801 |
Pharosi | Q8NEM2, Tbio |
PROi | PR:Q8NEM2 |
RNActi | Q8NEM2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171241, Expressed in liver and 160 other tissues |
ExpressionAtlasi | Q8NEM2, baseline and differential |
Genevisiblei | Q8NEM2, HS |
Family and domain databases
Gene3Di | 2.160.20.10, 1 hit |
InterProi | View protein in InterPro IPR039448, Beta_helix IPR006626, PbH1 IPR012334, Pectin_lyas_fold IPR011050, Pectin_lyase_fold/virulence |
Pfami | View protein in Pfam PF13229, Beta_helix, 1 hit |
SMARTi | View protein in SMART SM00710, PbH1, 5 hits |
SUPFAMi | SSF51126, SSF51126, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SHCBP_HUMAN | |
Accessioni | Q8NEM2Primary (citable) accession number: Q8NEM2 Secondary accession number(s): Q96N60, Q9BVS0, Q9H6P6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 10, 2021 | |
This is version 150 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot