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Protein

Terminal nucleotidyltransferase 5D

Gene

TENT5D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase.2 Publications

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).1 Publication

GO - Molecular functioni

  • RNA adenylyltransferase activity Source: UniProtKB

Keywordsi

Molecular functionNucleotidyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Terminal nucleotidyltransferase 5DCurated (EC:2.7.7.191 Publication1 Publication)
Alternative name(s):
Non-canonical poly(A) polymerase FAM46D1 Publication
Gene namesi
Name:TENT5DImported
Synonyms:FAM46DImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000174016.11
HGNCiHGNC:28399 TENT5D
MIMi300976 gene
neXtProtiNX_Q8NEK8

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174016
PharmGKBiPA134947605

Polymorphism and mutation databases

BioMutaiFAM46D
DMDMi74751253

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002599391 – 389Terminal nucleotidyltransferase 5DAdd BLAST389

Proteomic databases

PaxDbiQ8NEK8
PeptideAtlasiQ8NEK8
PRIDEiQ8NEK8
ProteomicsDBi73173

PTM databases

iPTMnetiQ8NEK8
PhosphoSitePlusiQ8NEK8

Expressioni

Tissue specificityi

restricted to testis.1 Publication

Gene expression databases

BgeeiENSG00000174016 Expressed in 8 organ(s), highest expression level in sperm
CleanExiHS_FAM46D
GenevisibleiQ8NEK8 HS

Organism-specific databases

HPAiHPA059362

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi127991, 2 interactors
IntActiQ8NEK8, 13 interactors
STRINGi9606.ENSP00000308575

Structurei

3D structure databases

ProteinModelPortaliQ8NEK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TENT family.Curated

Phylogenomic databases

eggNOGiKOG3852 Eukaryota
ENOG410XTG4 LUCA
GeneTreeiENSGT00500000044785
HOGENOMiHOG000234733
HOVERGENiHBG057969
InParanoidiQ8NEK8
OMAiFQPYHPL
OrthoDBiEOG091G06T9
PhylomeDBiQ8NEK8
TreeFamiTF315239

Family and domain databases

InterProiView protein in InterPro
IPR012937 TET5
PANTHERiPTHR12974 PTHR12974, 1 hit
PfamiView protein in Pfam
PF07984 NTP_transf_7, 1 hit
SMARTiView protein in SMART
SM01153 DUF1693, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NEK8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEIRFTNLT WDQVITLDQV LDEVIPIHGK GNFPTMEVKP KDIIHVVKDQ
60 70 80 90 100
LIGQGIIVKD ARLNGSVASY ILASHNGISY KDLDVIFGVE LPGNEEFQVV
110 120 130 140 150
KDAVLDCLLD FLPKDVKKEK LSPDIMKDAY VQKLVKVCNG HDCWSLISLS
160 170 180 190 200
NNTGKNLELK FVSSLRRQFE FSVDSFQIVL DPMLDFYSDK NAKLTKESYP
210 220 230 240 250
VVVAESMYGD FQEAMTHLQH KLICTRKPEE IRGGGLLKYC SLLVHGFKPA
260 270 280 290 300
CMSEIKNLER YMCSRFFIDF PHIEEQQKKI ESYLHNHFIG EGMTKYDYLM
310 320 330 340 350
TLHGVVNEST VCLMSYERRQ ILHLITMMAL KVLGELNILP NTQKVTCFYQ
360 370 380
PAPYFAAEAR YPIYVIPEPP PVSFQPYHPL HFRGSNGMS
Length:389
Mass (Da):44,500
Last modified:October 1, 2002 - v1
Checksum:iF7E117DF03203418
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10T → A in AAH28710 (PubMed:15489334).Curated1
Sequence conflicti382F → L in AAH28710 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028980185D → E2 PublicationsCorresponds to variant dbSNP:rs1113265Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128147 mRNA Translation: BAG54638.1
AK313875 mRNA Translation: BAG36603.1
BX537938 mRNA Translation: CAD97909.1
AL591431 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98586.1
BC028710 mRNA Translation: AAH28710.1
BC030784 mRNA Translation: AAH30784.1
BC034979 mRNA Translation: AAH34979.1
CCDSiCCDS14446.1
RefSeqiNP_001164045.1, NM_001170574.1
NP_689843.1, NM_152630.4
UniGeneiHs.367959

Genome annotation databases

EnsembliENST00000308293; ENSP00000308575; ENSG00000174016
ENST00000538312; ENSP00000443410; ENSG00000174016
GeneIDi169966
KEGGihsa:169966
UCSCiuc004edl.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128147 mRNA Translation: BAG54638.1
AK313875 mRNA Translation: BAG36603.1
BX537938 mRNA Translation: CAD97909.1
AL591431 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98586.1
BC028710 mRNA Translation: AAH28710.1
BC030784 mRNA Translation: AAH30784.1
BC034979 mRNA Translation: AAH34979.1
CCDSiCCDS14446.1
RefSeqiNP_001164045.1, NM_001170574.1
NP_689843.1, NM_152630.4
UniGeneiHs.367959

3D structure databases

ProteinModelPortaliQ8NEK8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127991, 2 interactors
IntActiQ8NEK8, 13 interactors
STRINGi9606.ENSP00000308575

PTM databases

iPTMnetiQ8NEK8
PhosphoSitePlusiQ8NEK8

Polymorphism and mutation databases

BioMutaiFAM46D
DMDMi74751253

Proteomic databases

PaxDbiQ8NEK8
PeptideAtlasiQ8NEK8
PRIDEiQ8NEK8
ProteomicsDBi73173

Protocols and materials databases

DNASUi169966
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308293; ENSP00000308575; ENSG00000174016
ENST00000538312; ENSP00000443410; ENSG00000174016
GeneIDi169966
KEGGihsa:169966
UCSCiuc004edl.1 human

Organism-specific databases

CTDi169966
EuPathDBiHostDB:ENSG00000174016.11
GeneCardsiTENT5D
H-InvDBiHIX0016895
HGNCiHGNC:28399 TENT5D
HPAiHPA059362
MIMi300976 gene
neXtProtiNX_Q8NEK8
OpenTargetsiENSG00000174016
PharmGKBiPA134947605
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3852 Eukaryota
ENOG410XTG4 LUCA
GeneTreeiENSGT00500000044785
HOGENOMiHOG000234733
HOVERGENiHBG057969
InParanoidiQ8NEK8
OMAiFQPYHPL
OrthoDBiEOG091G06T9
PhylomeDBiQ8NEK8
TreeFamiTF315239

Miscellaneous databases

GenomeRNAii169966
PROiPR:Q8NEK8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174016 Expressed in 8 organ(s), highest expression level in sperm
CleanExiHS_FAM46D
GenevisibleiQ8NEK8 HS

Family and domain databases

InterProiView protein in InterPro
IPR012937 TET5
PANTHERiPTHR12974 PTHR12974, 1 hit
PfamiView protein in Pfam
PF07984 NTP_transf_7, 1 hit
SMARTiView protein in SMART
SM01153 DUF1693, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTET5D_HUMAN
AccessioniPrimary (citable) accession number: Q8NEK8
Secondary accession number(s): B2R9Q6, Q7Z3F6, Q8NHU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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