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Entry version 126 (12 Aug 2020)
Sequence version 1 (01 Oct 2002)
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Protein

Terminal nucleotidyltransferase 5D

Gene

TENT5D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • mRNA stabilization Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8NEK8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Terminal nucleotidyltransferase 5DCurated (EC:2.7.7.191 Publication1 Publication)
Alternative name(s):
Non-canonical poly(A) polymerase FAM46D1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TENT5DImported
Synonyms:FAM46DImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000174016.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28399, TENT5D

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300976, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NEK8

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
169966

Open Targets

More...
OpenTargetsi
ENSG00000174016

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134947605

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NEK8, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM46D

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751253

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002599391 – 389Terminal nucleotidyltransferase 5DAdd BLAST389

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NEK8

PeptideAtlas

More...
PeptideAtlasi
Q8NEK8

PRoteomics IDEntifications database

More...
PRIDEi
Q8NEK8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
73173

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NEK8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NEK8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

restricted to testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000174016, Expressed in sperm and 9 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NEK8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000174016, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127991, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NEK8, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000443410

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NEK8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NEK8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TENT family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3852, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162488

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008115_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NEK8

KEGG Orthology (KO)

More...
KOi
K23035

Identification of Orthologs from Complete Genome Data

More...
OMAi
FQPYHPL

Database of Orthologous Groups

More...
OrthoDBi
612201at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NEK8

TreeFam database of animal gene trees

More...
TreeFami
TF315239

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012937, TET5

The PANTHER Classification System

More...
PANTHERi
PTHR12974, PTHR12974, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07984, NTP_transf_7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01153, DUF1693, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8NEK8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEIRFTNLT WDQVITLDQV LDEVIPIHGK GNFPTMEVKP KDIIHVVKDQ
60 70 80 90 100
LIGQGIIVKD ARLNGSVASY ILASHNGISY KDLDVIFGVE LPGNEEFQVV
110 120 130 140 150
KDAVLDCLLD FLPKDVKKEK LSPDIMKDAY VQKLVKVCNG HDCWSLISLS
160 170 180 190 200
NNTGKNLELK FVSSLRRQFE FSVDSFQIVL DPMLDFYSDK NAKLTKESYP
210 220 230 240 250
VVVAESMYGD FQEAMTHLQH KLICTRKPEE IRGGGLLKYC SLLVHGFKPA
260 270 280 290 300
CMSEIKNLER YMCSRFFIDF PHIEEQQKKI ESYLHNHFIG EGMTKYDYLM
310 320 330 340 350
TLHGVVNEST VCLMSYERRQ ILHLITMMAL KVLGELNILP NTQKVTCFYQ
360 370 380
PAPYFAAEAR YPIYVIPEPP PVSFQPYHPL HFRGSNGMS
Length:389
Mass (Da):44,500
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7E117DF03203418
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10T → A in AAH28710 (PubMed:15489334).Curated1
Sequence conflicti382F → L in AAH28710 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028980185D → E2 PublicationsCorresponds to variant dbSNP:rs1113265Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK128147 mRNA Translation: BAG54638.1
AK313875 mRNA Translation: BAG36603.1
BX537938 mRNA Translation: CAD97909.1
AL591431 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98586.1
BC028710 mRNA Translation: AAH28710.1
BC030784 mRNA Translation: AAH30784.1
BC034979 mRNA Translation: AAH34979.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14446.1

NCBI Reference Sequences

More...
RefSeqi
NP_001164045.1, NM_001170574.1
NP_689843.1, NM_152630.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000308293; ENSP00000308575; ENSG00000174016
ENST00000538312; ENSP00000443410; ENSG00000174016

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
169966

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:169966

UCSC genome browser

More...
UCSCi
uc004edl.1, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128147 mRNA Translation: BAG54638.1
AK313875 mRNA Translation: BAG36603.1
BX537938 mRNA Translation: CAD97909.1
AL591431 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98586.1
BC028710 mRNA Translation: AAH28710.1
BC030784 mRNA Translation: AAH30784.1
BC034979 mRNA Translation: AAH34979.1
CCDSiCCDS14446.1
RefSeqiNP_001164045.1, NM_001170574.1
NP_689843.1, NM_152630.4

3D structure databases

SMRiQ8NEK8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127991, 3 interactors
IntActiQ8NEK8, 14 interactors
STRINGi9606.ENSP00000443410

PTM databases

iPTMnetiQ8NEK8
PhosphoSitePlusiQ8NEK8

Polymorphism and mutation databases

BioMutaiFAM46D
DMDMi74751253

Proteomic databases

PaxDbiQ8NEK8
PeptideAtlasiQ8NEK8
PRIDEiQ8NEK8
ProteomicsDBi73173

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
56143, 72 antibodies

The DNASU plasmid repository

More...
DNASUi
169966

Genome annotation databases

EnsembliENST00000308293; ENSP00000308575; ENSG00000174016
ENST00000538312; ENSP00000443410; ENSG00000174016
GeneIDi169966
KEGGihsa:169966
UCSCiuc004edl.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
169966
DisGeNETi169966
EuPathDBiHostDB:ENSG00000174016.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TENT5D
HGNCiHGNC:28399, TENT5D
HPAiENSG00000174016, Tissue enriched (testis)
MIMi300976, gene
neXtProtiNX_Q8NEK8
OpenTargetsiENSG00000174016
PharmGKBiPA134947605

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3852, Eukaryota
GeneTreeiENSGT00940000162488
HOGENOMiCLU_008115_2_0_1
InParanoidiQ8NEK8
KOiK23035
OMAiFQPYHPL
OrthoDBi612201at2759
PhylomeDBiQ8NEK8
TreeFamiTF315239

Enzyme and pathway databases

PathwayCommonsiQ8NEK8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
169966, 11 hits in 500 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
169966
PharosiQ8NEK8, Tbio

Protein Ontology

More...
PROi
PR:Q8NEK8
RNActiQ8NEK8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000174016, Expressed in sperm and 9 other tissues
GenevisibleiQ8NEK8, HS

Family and domain databases

InterProiView protein in InterPro
IPR012937, TET5
PANTHERiPTHR12974, PTHR12974, 1 hit
PfamiView protein in Pfam
PF07984, NTP_transf_7, 1 hit
SMARTiView protein in SMART
SM01153, DUF1693, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTET5D_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NEK8
Secondary accession number(s): B2R9Q6, Q7Z3F6, Q8NHU1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2002
Last modified: August 12, 2020
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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