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Protein

Zinc finger protein 548

Gene

ZNF548

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri197 – 219C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 548
Gene namesi
Name:ZNF548
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000188785.11
HGNCiHGNC:26561 ZNF548
neXtProtiNX_Q8NEK5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188785
PharmGKBiPA134889718

Polymorphism and mutation databases

BioMutaiZNF548
DMDMi296453046

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002421601 – 533Zinc finger protein 548Add BLAST533

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki516Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8NEK5
MaxQBiQ8NEK5
PaxDbiQ8NEK5
PeptideAtlasiQ8NEK5
PRIDEiQ8NEK5
ProteomicsDBi73171
73172 [Q8NEK5-2]

PTM databases

iPTMnetiQ8NEK5
PhosphoSitePlusiQ8NEK5

Expressioni

Gene expression databases

BgeeiENSG00000188785 Expressed in 205 organ(s), highest expression level in gingival epithelium
CleanExiHS_ZNF548
ExpressionAtlasiQ8NEK5 baseline and differential
GenevisibleiQ8NEK5 HS

Organism-specific databases

HPAiHPA066042

Interactioni

Protein-protein interaction databases

BioGridi127076, 2 interactors
STRINGi9606.ENSP00000337555

Structurei

3D structure databases

ProteinModelPortaliQ8NEK5
SMRiQ8NEK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri197 – 219C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119107
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8NEK5
KOiK09228
OMAiFMKHQTV
OrthoDBiEOG091G02KC
PhylomeDBiQ8NEK5
TreeFamiTF339848

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q8NEK5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNLTEGRVVF EDVAIYFSQE EWGHLDEAQR LLYRDVMLEN LALLSSLGSW
60 70 80 90 100
HGAEDEEAPS QQGFSVGVSE VTASKPCLSS QKVHPSETCG PPLKDILCLV
110 120 130 140 150
EHNGIHPEQH IYICEAELFQ HPKQQIGENL SRGDDWIPSF GKNHRVHMAE
160 170 180 190 200
EIFTCMEGWK DLPATSCLLQ HQGPQSEWKP YRDTEDREAF QTGQNDYKCS
210 220 230 240 250
ECGKTFTCSY SFVEHQKIHT GERSYECNKC GKFFKYSANF MKHQTVHTSE
260 270 280 290 300
RTYECRECGK SFMYNYRLMR HKRVHTGERP YECNTCGKFF RYSSTFVRHQ
310 320 330 340 350
RVHTGERPYE CRECGKFFMD SSTLIKHQRV HTGERPYKCN DCGKFFRYIS
360 370 380 390 400
TLIRHQRIHT GERPYECSVC GELFRYNSSL VKHWRNHTGE RPYKCSECGK
410 420 430 440 450
SFRYHCRLIR HQRVHTGERP YECSECGKFF RYNSNLIKHW RNHTGERPYE
460 470 480 490 500
CRECGKAFSH KHILVEHQKI HSGERPYECS ECQKAFIRKS HLVHHQKIHS
510 520 530
EERLVCSMNV GNSLAKTPTS LNIRDFTMEK VYH
Length:533
Mass (Da):62,728
Last modified:May 18, 2010 - v2
Checksum:iBFC3DDE9C74E0C98
GO
Isoform 2 (identifier: Q8NEK5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     6-6: G → GPLAMAEMDPTQG

Note: No experimental confirmation available.
Show »
Length:545
Mass (Da):63,970
Checksum:i9C46D313C634DFF5
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QX17M0QX17_HUMAN
Zinc finger protein 548
ZNF548
57Annotation score:
M0R3F2M0R3F2_HUMAN
Zinc finger protein 548
ZNF548
63Annotation score:
M0QXE2M0QXE2_HUMAN
Zinc finger protein 548
ZNF548
87Annotation score:
M0R354M0R354_HUMAN
Zinc finger protein 548
ZNF548
44Annotation score:
M0R041M0R041_HUMAN
Zinc finger protein 548
ZNF548
114Annotation score:
M0QY53M0QY53_HUMAN
Zinc finger protein 548
ZNF548
75Annotation score:
M0R2J6M0R2J6_HUMAN
Zinc finger protein 548
ZNF548
47Annotation score:
M0QYA3M0QYA3_HUMAN
Zinc finger protein 548
ZNF548
56Annotation score:
M0R1K1M0R1K1_HUMAN
Zinc finger protein 548
ZNF548
63Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti377N → S in BAB71509 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02684558A → S1 PublicationCorresponds to variant dbSNP:rs17856896Ensembl.1
Natural variantiVAR_02684673A → T2 PublicationsCorresponds to variant dbSNP:rs4801478Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0194536G → GPLAMAEMDPTQG in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003002 Genomic DNA No translation available.
BC030788 mRNA Translation: AAH30788.1
AK057494 mRNA Translation: BAB71509.1
CCDSiCCDS46209.1 [Q8NEK5-1]
CCDS54324.1 [Q8NEK5-2]
RefSeqiNP_001166244.1, NM_001172773.1 [Q8NEK5-2]
NP_690873.2, NM_152909.3 [Q8NEK5-1]
UniGeneiHs.126905

Genome annotation databases

EnsembliENST00000336128; ENSP00000337555; ENSG00000188785 [Q8NEK5-2]
ENST00000366197; ENSP00000379482; ENSG00000188785 [Q8NEK5-1]
GeneIDi147694
KEGGihsa:147694
UCSCiuc002qom.4 human [Q8NEK5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN548_HUMAN
AccessioniPrimary (citable) accession number: Q8NEK5
Secondary accession number(s): Q96M05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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