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Protein

Neuroguidin

Gene

NGDN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranslation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroguidin
Alternative name(s):
Centromere accumulated nuclear protein 1
Short name:
CANu1
EIF4E-binding protein
Gene namesi
Name:NGDN
Synonyms:C14orf120
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000129460.15
HGNCiHGNC:20271 NGDN
MIMi610777 gene
neXtProtiNX_Q8NEJ9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Centromere, Chromosome, Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi25983
OpenTargetsiENSG00000129460
PharmGKBiPA134957933

Polymorphism and mutation databases

BioMutaiNGDN
DMDMi46395905

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001143312 – 315NeuroguidinAdd BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei121PhosphoserineCombined sources1
Modified residuei142PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei204PhosphoserineCombined sources1
Modified residuei214PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8NEJ9
MaxQBiQ8NEJ9
PaxDbiQ8NEJ9
PeptideAtlasiQ8NEJ9
PRIDEiQ8NEJ9
ProteomicsDBi73169
73170 [Q8NEJ9-2]
TopDownProteomicsiQ8NEJ9-1 [Q8NEJ9-1]

PTM databases

iPTMnetiQ8NEJ9
PhosphoSitePlusiQ8NEJ9

Expressioni

Gene expression databases

BgeeiENSG00000129460
CleanExiHS_NGDN
ExpressionAtlasiQ8NEJ9 baseline and differential
GenevisibleiQ8NEJ9 HS

Organism-specific databases

HPAiHPA000944

Interactioni

Subunit structurei

Interacts with CPEB1 and EIF4E.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AATFQ9NY613EBI-9995414,EBI-372428

Protein-protein interaction databases

BioGridi117466, 30 interactors
CORUMiQ8NEJ9
IntActiQ8NEJ9, 9 interactors
STRINGi9606.ENSP00000386134

Structurei

3D structure databases

ProteinModelPortaliQ8NEJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 174Necessary for interaction with EIF4EBy similarityAdd BLAST134

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili13 – 41Sequence analysisAdd BLAST29
Coiled coili181 – 205Sequence analysisAdd BLAST25

Sequence similaritiesi

Belongs to the SAS10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3117 Eukaryota
ENOG4111F0Z LUCA
GeneTreeiENSGT00500000044922
HOGENOMiHOG000013129
HOVERGENiHBG082025
InParanoidiQ8NEJ9
KOiK14765
OMAiHRINYEE
OrthoDBiEOG091G0I9S
PhylomeDBiQ8NEJ9
TreeFamiTF313713

Family and domain databases

InterProiView protein in InterPro
IPR007146 Sas10/Utp3/C1D
PfamiView protein in Pfam
PF04000 Sas10_Utp3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NEJ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALGVLESD LPSAVTLLKN LQEQVMAVTA QVKSLTQKVQ AGAYPTEKGL
60 70 80 90 100
SFLEVKDQLL LMYLMDLTHL ILDKASGGSL QGHDAVLRLV EIRTVLEKLR
110 120 130 140 150
PLDQKLKYQI DKLIKTAVTG SLSENDPLRF KPHPSNMMSK LSSEDEEEDE
160 170 180 190 200
AEDDQSEASG KKSVKGVSKK YVPPRLVPVH YDETEAEREK KRLERAKRRA
210 220 230 240 250
LSSSVIRELK EQYSDAPEEI RDARHPHVTR QSQEDQHRIN YEESMMVRLS
260 270 280 290 300
VSKREKGRRK RANVMSSQLH SLTHFSDISA LTGGTVHLDE DQNPIKKRKK
310
IPQKGRKKKG FRRRR
Length:315
Mass (Da):35,894
Last modified:October 1, 2002 - v1
Checksum:iF5B26C3C2EDDC840
GO
Isoform 2 (identifier: Q8NEJ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     311-311: F → Q
     312-315: Missing.

Note: May be due to a competing donor splice site.
Show »
Length:311
Mass (Da):35,250
Checksum:iF1CDC840E2968036
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05189815V → L. Corresponds to variant dbSNP:rs10149626Ensembl.1
Natural variantiVAR_051899308K → I. Corresponds to variant dbSNP:rs17093050Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009935311F → Q in isoform 2. 1 Publication1
Alternative sequenceiVSP_009936312 – 315Missing in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291875 mRNA Translation: BAF84564.1
AL050003 mRNA Translation: CAB43232.2
CH471078 Genomic DNA Translation: EAW66149.1
BC030817 mRNA Translation: AAH30817.1
CCDSiCCDS32051.1 [Q8NEJ9-2]
CCDS41926.1 [Q8NEJ9-1]
PIRiT08694
RefSeqiNP_001036100.1, NM_001042635.1 [Q8NEJ9-1]
NP_056329.1, NM_015514.1 [Q8NEJ9-2]
UniGeneiHs.9043

Genome annotation databases

EnsembliENST00000397154; ENSP00000380340; ENSG00000129460 [Q8NEJ9-2]
ENST00000408901; ENSP00000386134; ENSG00000129460 [Q8NEJ9-1]
GeneIDi25983
KEGGihsa:25983
UCSCiuc001wjy.4 human [Q8NEJ9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNGDN_HUMAN
AccessioniPrimary (citable) accession number: Q8NEJ9
Secondary accession number(s): A8K760, Q9Y400
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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