UniProtKB - Q8NEJ9 (NGDN_HUMAN)
Protein
Neuroguidin
Gene
NGDN
Organism
Homo sapiens (Human)
Status
Functioni
Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs.By similarity
GO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
- regulation of translation Source: UniProtKB-KW
Keywordsi
Molecular function | Repressor |
Biological process | Translation regulation |
Enzyme and pathway databases
PathwayCommonsi | Q8NEJ9 |
Names & Taxonomyi
Protein namesi | Recommended name: NeuroguidinAlternative name(s): Centromere accumulated nuclear protein 1 Short name: CANu1 EIF4E-binding protein |
Gene namesi | Name:NGDN Synonyms:C14orf120 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20271, NGDN |
MIMi | 610777, gene |
neXtProti | NX_Q8NEJ9 |
VEuPathDBi | HostDB:ENSG00000129460.15 |
Subcellular locationi
Nucleus
Other locations
- centromere 1 Publication
- Cytoplasm By similarity
- axon By similarity
- dendrite By similarity
- filopodium By similarity
Note: Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites (By similarity). Translocated from nucleolus to nuclear foci in response to UV damage.By similarity
Mitochondrion
- mitochondrion Source: HPA
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
Other locations
- axon Source: UniProtKB-SubCell
- chromosome, centromeric region Source: UniProtKB-SubCell
- dendrite Source: UniProtKB-SubCell
- filopodium Source: UniProtKB-SubCell
- small-subunit processome Source: GO_Central
Keywords - Cellular componenti
Cell projection, Centromere, Chromosome, Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 25983 |
OpenTargetsi | ENSG00000129460 |
PharmGKBi | PA134957933 |
Miscellaneous databases
Pharosi | Q8NEJ9, Tbio |
Genetic variation databases
BioMutai | NGDN |
DMDMi | 46395905 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000114331 | 2 – 315 | NeuroguidinAdd BLAST | 314 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 121 | PhosphoserineCombined sources | 1 | |
Modified residuei | 142 | PhosphoserineCombined sources | 1 | |
Modified residuei | 143 | PhosphoserineCombined sources | 1 | |
Modified residuei | 204 | PhosphoserineCombined sources | 1 | |
Modified residuei | 214 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q8NEJ9 |
jPOSTi | Q8NEJ9 |
MassIVEi | Q8NEJ9 |
MaxQBi | Q8NEJ9 |
PaxDbi | Q8NEJ9 |
PeptideAtlasi | Q8NEJ9 |
PRIDEi | Q8NEJ9 |
ProteomicsDBi | 73169 [Q8NEJ9-1] 73170 [Q8NEJ9-2] |
TopDownProteomicsi | Q8NEJ9-1 [Q8NEJ9-1] |
PTM databases
iPTMneti | Q8NEJ9 |
PhosphoSitePlusi | Q8NEJ9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000129460, Expressed in oocyte and 241 other tissues |
ExpressionAtlasi | Q8NEJ9, baseline and differential |
Genevisiblei | Q8NEJ9, HS |
Organism-specific databases
HPAi | ENSG00000129460, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with CPEB1 and EIF4E.
By similarityBinary interactionsi
Hide detailsQ8NEJ9
Protein-protein interaction databases
BioGRIDi | 117466, 50 interactors |
CORUMi | Q8NEJ9 |
IntActi | Q8NEJ9, 29 interactors |
MINTi | Q8NEJ9 |
STRINGi | 9606.ENSP00000386134 |
Miscellaneous databases
RNActi | Q8NEJ9, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 41 – 174 | Necessary for interaction with EIF4EBy similarityAdd BLAST | 134 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 13 – 41 | Sequence analysisAdd BLAST | 29 | |
Coiled coili | 181 – 205 | Sequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the SAS10 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3117, Eukaryota |
GeneTreei | ENSGT00500000044922 |
HOGENOMi | CLU_031901_0_0_1 |
InParanoidi | Q8NEJ9 |
OMAi | FGGEEWH |
OrthoDBi | 1511802at2759 |
PhylomeDBi | Q8NEJ9 |
TreeFami | TF313713 |
Family and domain databases
InterProi | View protein in InterPro IPR007146, Sas10/Utp3/C1D |
PANTHERi | PTHR13237, PTHR13237, 1 hit |
Pfami | View protein in Pfam PF04000, Sas10_Utp3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8NEJ9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAALGVLESD LPSAVTLLKN LQEQVMAVTA QVKSLTQKVQ AGAYPTEKGL
60 70 80 90 100
SFLEVKDQLL LMYLMDLTHL ILDKASGGSL QGHDAVLRLV EIRTVLEKLR
110 120 130 140 150
PLDQKLKYQI DKLIKTAVTG SLSENDPLRF KPHPSNMMSK LSSEDEEEDE
160 170 180 190 200
AEDDQSEASG KKSVKGVSKK YVPPRLVPVH YDETEAEREK KRLERAKRRA
210 220 230 240 250
LSSSVIRELK EQYSDAPEEI RDARHPHVTR QSQEDQHRIN YEESMMVRLS
260 270 280 290 300
VSKREKGRRK RANVMSSQLH SLTHFSDISA LTGGTVHLDE DQNPIKKRKK
310
IPQKGRKKKG FRRRR
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YJ17 | H0YJ17_HUMAN | Neuroguidin | NGDN | 263 | Annotation score: | ||
G3V4G1 | G3V4G1_HUMAN | Neuroguidin | NGDN | 141 | Annotation score: | ||
H0YJQ1 | H0YJQ1_HUMAN | Neuroguidin | NGDN | 74 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051898 | 15 | V → L. Corresponds to variant dbSNP:rs10149626Ensembl. | 1 | |
Natural variantiVAR_051899 | 308 | K → I. Corresponds to variant dbSNP:rs17093050Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009935 | 311 | F → Q in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_009936 | 312 – 315 | Missing in isoform 2. 1 Publication | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK291875 mRNA Translation: BAF84564.1 AL050003 mRNA Translation: CAB43232.2 CH471078 Genomic DNA Translation: EAW66149.1 BC030817 mRNA Translation: AAH30817.1 |
CCDSi | CCDS32051.1 [Q8NEJ9-2] CCDS41926.1 [Q8NEJ9-1] |
PIRi | T08694 |
RefSeqi | NP_001036100.1, NM_001042635.1 [Q8NEJ9-1] NP_056329.1, NM_015514.1 [Q8NEJ9-2] |
Genome annotation databases
Ensembli | ENST00000397154; ENSP00000380340; ENSG00000129460 [Q8NEJ9-2] ENST00000408901; ENSP00000386134; ENSG00000129460 [Q8NEJ9-1] |
GeneIDi | 25983 |
KEGGi | hsa:25983 |
UCSCi | uc001wjy.4, human [Q8NEJ9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK291875 mRNA Translation: BAF84564.1 AL050003 mRNA Translation: CAB43232.2 CH471078 Genomic DNA Translation: EAW66149.1 BC030817 mRNA Translation: AAH30817.1 |
CCDSi | CCDS32051.1 [Q8NEJ9-2] CCDS41926.1 [Q8NEJ9-1] |
PIRi | T08694 |
RefSeqi | NP_001036100.1, NM_001042635.1 [Q8NEJ9-1] NP_056329.1, NM_015514.1 [Q8NEJ9-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 117466, 50 interactors |
CORUMi | Q8NEJ9 |
IntActi | Q8NEJ9, 29 interactors |
MINTi | Q8NEJ9 |
STRINGi | 9606.ENSP00000386134 |
PTM databases
iPTMneti | Q8NEJ9 |
PhosphoSitePlusi | Q8NEJ9 |
Genetic variation databases
BioMutai | NGDN |
DMDMi | 46395905 |
Proteomic databases
EPDi | Q8NEJ9 |
jPOSTi | Q8NEJ9 |
MassIVEi | Q8NEJ9 |
MaxQBi | Q8NEJ9 |
PaxDbi | Q8NEJ9 |
PeptideAtlasi | Q8NEJ9 |
PRIDEi | Q8NEJ9 |
ProteomicsDBi | 73169 [Q8NEJ9-1] 73170 [Q8NEJ9-2] |
TopDownProteomicsi | Q8NEJ9-1 [Q8NEJ9-1] |
Protocols and materials databases
Antibodypediai | 89, 154 antibodies |
DNASUi | 25983 |
Genome annotation databases
Ensembli | ENST00000397154; ENSP00000380340; ENSG00000129460 [Q8NEJ9-2] ENST00000408901; ENSP00000386134; ENSG00000129460 [Q8NEJ9-1] |
GeneIDi | 25983 |
KEGGi | hsa:25983 |
UCSCi | uc001wjy.4, human [Q8NEJ9-1] |
Organism-specific databases
CTDi | 25983 |
DisGeNETi | 25983 |
GeneCardsi | NGDN |
HGNCi | HGNC:20271, NGDN |
HPAi | ENSG00000129460, Low tissue specificity |
MIMi | 610777, gene |
neXtProti | NX_Q8NEJ9 |
OpenTargetsi | ENSG00000129460 |
PharmGKBi | PA134957933 |
VEuPathDBi | HostDB:ENSG00000129460.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3117, Eukaryota |
GeneTreei | ENSGT00500000044922 |
HOGENOMi | CLU_031901_0_0_1 |
InParanoidi | Q8NEJ9 |
OMAi | FGGEEWH |
OrthoDBi | 1511802at2759 |
PhylomeDBi | Q8NEJ9 |
TreeFami | TF313713 |
Enzyme and pathway databases
PathwayCommonsi | Q8NEJ9 |
Miscellaneous databases
BioGRID-ORCSi | 25983, 412 hits in 883 CRISPR screens |
ChiTaRSi | NGDN, human |
GenomeRNAii | 25983 |
Pharosi | Q8NEJ9, Tbio |
PROi | PR:Q8NEJ9 |
RNActi | Q8NEJ9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000129460, Expressed in oocyte and 241 other tissues |
ExpressionAtlasi | Q8NEJ9, baseline and differential |
Genevisiblei | Q8NEJ9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007146, Sas10/Utp3/C1D |
PANTHERi | PTHR13237, PTHR13237, 1 hit |
Pfami | View protein in Pfam PF04000, Sas10_Utp3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NGDN_HUMAN | |
Accessioni | Q8NEJ9Primary (citable) accession number: Q8NEJ9 Secondary accession number(s): A8K760, Q9Y400 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families