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Protein

Meiosis-specific nuclear structural protein 1

Gene

MNS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis.By similarity

GO - Molecular functioni

  • identical protein binding Source: MGI

GO - Biological processi

Keywordsi

Biological processMeiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Meiosis-specific nuclear structural protein 1
Gene namesi
Name:MNS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000138587.5
HGNCiHGNC:29636 MNS1
MIMi610766 gene
neXtProtiNX_Q8NEH6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55329
OpenTargetsiENSG00000138587
PharmGKBiPA142671346

Polymorphism and mutation databases

BioMutaiMNS1
DMDMi156632590

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002989211 – 495Meiosis-specific nuclear structural protein 1Add BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei188PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8NEH6
PaxDbiQ8NEH6
PeptideAtlasiQ8NEH6
PRIDEiQ8NEH6
ProteomicsDBi73166

PTM databases

iPTMnetiQ8NEH6
PhosphoSitePlusiQ8NEH6

Expressioni

Gene expression databases

BgeeiENSG00000138587 Expressed in 172 organ(s), highest expression level in testis
CleanExiHS_MNS1
GenevisibleiQ8NEH6 HS

Organism-specific databases

HPAiHPA039975
HPA040382

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120610, 9 interactors
IntActiQ8NEH6, 27 interactors
MINTiQ8NEH6
STRINGi9606.ENSP00000260453

Structurei

3D structure databases

ProteinModelPortaliQ8NEH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili28 – 410Sequence analysisAdd BLAST383

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 373Glu-richAdd BLAST311

Sequence similaritiesi

Belongs to the MNS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFU7 Eukaryota
ENOG410YXPQ LUCA
GeneTreeiENSGT00730000111210
HOGENOMiHOG000006500
HOVERGENiHBG108140
InParanoidiQ8NEH6
OMAiNAQKQRM
OrthoDBiEOG091G0CNW
PhylomeDBiQ8NEH6
TreeFamiTF329219

Family and domain databases

InterProiView protein in InterPro
IPR026504 MNS1
PANTHERiPTHR19265 PTHR19265, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NEH6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSKRRNLSC SERHQKLVDE NYCKKLHVQA LKNVNSQIRN QMVQNENDNR
60 70 80 90 100
VQRKQFLRLL QNEQFELDME EAIQKAEENK RLKELQLKQE EKLAMELAKL
110 120 130 140 150
KHESLKDEKM RQQVRENSIE LRELEKKLKA AYMNKERAAQ IAEKDAIKYE
160 170 180 190 200
QMKRDAEIAK TMMEEHKRII KEENAAEDKR NKAKAQYYLD LEKQLEEQEK
210 220 230 240 250
KKQEAYEQLL KEKLMIDEIV RKIYEEDQLE KQQKLEKMNA MRRYIEEFQK
260 270 280 290 300
EQALWRKKKR EEMEEENRKI IEFANMQQQR EEDRMAKVQE NEEKRLQLQN
310 320 330 340 350
ALTQKLEEML RQREDLEQVR QELYQEEQAE IYKSKLKEEA EKKLRKQKEM
360 370 380 390 400
KQDFEEQMAL KELVLQAAKE EEENFRKTML AKFAEDDRIE LMNAQKQRMK
410 420 430 440 450
QLEHRRAVEK LIEERRQQFL ADKQRELEEW QLQQRRQGFI NAIIEEERLK
460 470 480 490
LLKEHATNLL GYLPKGVFKK EDDIDLLGEE FRKVYQQRSE ICEEK
Length:495
Mass (Da):60,571
Last modified:August 21, 2007 - v2
Checksum:i85EF33C9A659FBD1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03473710C → Y. Corresponds to variant dbSNP:rs34807682Ensembl.1
Natural variantiVAR_03473855Q → P. Corresponds to variant dbSNP:rs1715919Ensembl.1
Natural variantiVAR_034739216I → T. Corresponds to variant dbSNP:rs35775595Ensembl.1
Natural variantiVAR_034740244Y → H1 PublicationCorresponds to variant dbSNP:rs17852882Ensembl.1
Natural variantiVAR_034741426E → G1 PublicationCorresponds to variant dbSNP:rs17853357Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002084 mRNA Translation: BAA92077.1
BC031046 mRNA Translation: AAH31046.1
BC034991 mRNA Translation: AAH34991.1
CCDSiCCDS10158.1
RefSeqiNP_060835.1, NM_018365.2
UniGeneiHs.444483

Genome annotation databases

EnsembliENST00000260453; ENSP00000260453; ENSG00000138587
GeneIDi55329
KEGGihsa:55329
UCSCiuc002adr.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002084 mRNA Translation: BAA92077.1
BC031046 mRNA Translation: AAH31046.1
BC034991 mRNA Translation: AAH34991.1
CCDSiCCDS10158.1
RefSeqiNP_060835.1, NM_018365.2
UniGeneiHs.444483

3D structure databases

ProteinModelPortaliQ8NEH6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120610, 9 interactors
IntActiQ8NEH6, 27 interactors
MINTiQ8NEH6
STRINGi9606.ENSP00000260453

PTM databases

iPTMnetiQ8NEH6
PhosphoSitePlusiQ8NEH6

Polymorphism and mutation databases

BioMutaiMNS1
DMDMi156632590

Proteomic databases

EPDiQ8NEH6
PaxDbiQ8NEH6
PeptideAtlasiQ8NEH6
PRIDEiQ8NEH6
ProteomicsDBi73166

Protocols and materials databases

DNASUi55329
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260453; ENSP00000260453; ENSG00000138587
GeneIDi55329
KEGGihsa:55329
UCSCiuc002adr.2 human

Organism-specific databases

CTDi55329
DisGeNETi55329
EuPathDBiHostDB:ENSG00000138587.5
GeneCardsiMNS1
HGNCiHGNC:29636 MNS1
HPAiHPA039975
HPA040382
MIMi610766 gene
neXtProtiNX_Q8NEH6
OpenTargetsiENSG00000138587
PharmGKBiPA142671346
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFU7 Eukaryota
ENOG410YXPQ LUCA
GeneTreeiENSGT00730000111210
HOGENOMiHOG000006500
HOVERGENiHBG108140
InParanoidiQ8NEH6
OMAiNAQKQRM
OrthoDBiEOG091G0CNW
PhylomeDBiQ8NEH6
TreeFamiTF329219

Miscellaneous databases

GenomeRNAii55329
PROiPR:Q8NEH6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138587 Expressed in 172 organ(s), highest expression level in testis
CleanExiHS_MNS1
GenevisibleiQ8NEH6 HS

Family and domain databases

InterProiView protein in InterPro
IPR026504 MNS1
PANTHERiPTHR19265 PTHR19265, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMNS1_HUMAN
AccessioniPrimary (citable) accession number: Q8NEH6
Secondary accession number(s): Q8IYT6, Q9NUP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: November 7, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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