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Entry version 110 (18 Sep 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Protein DENND6B

Gene

DENND6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35.1 Publication

Caution

Identified as having similarity to the core DENN family and referred to as DENN6B (PubMed:21330364). Prediction methods do not indicate a DENN domain for this sequence and, the exact role of the DENN or this DENN-like domain in GEF activity needs to be clarified.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein DENND6B
Alternative name(s):
DENN domain-containing protein 6B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DENND6B
Synonyms:FAM116B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:32690 DENND6B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NEG7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000205593

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA144596432

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DENND6B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74760209

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002649901 – 585Protein DENND6BAdd BLAST585

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NEG7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NEG7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NEG7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NEG7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NEG7

PeptideAtlas

More...
PeptideAtlasi
Q8NEG7

PRoteomics IDEntifications database

More...
PRIDEi
Q8NEG7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
73165

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NEG7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NEG7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000205593 Expressed in 132 organ(s), highest expression level in right uterine tube

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NEG7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NEG7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA018934
HPA021653
HPA029570

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
136098, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NEG7, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000391524

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NEG7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 214uDENNPROSITE-ProRule annotationAdd BLAST172
Domaini246 – 373cDENNPROSITE-ProRule annotationAdd BLAST128
Domaini375 – 499dDENNPROSITE-ProRule annotationAdd BLAST125

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DENND6 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2432 Eukaryota
ENOG410XP3F LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005529

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000000674

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NEG7

Identification of Orthologs from Complete Genome Data

More...
OMAi
QCDQENL

Database of Orthologous Groups

More...
OrthoDBi
252077at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NEG7

TreeFam database of animal gene trees

More...
TreeFami
TF320228

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018307 ABL9/DENND6_dom
IPR024224 DENND6
IPR037516 Tripartite_DENN

The PANTHER Classification System

More...
PANTHERi
PTHR13677 PTHR13677, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09794 Avl9, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50211 DENN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8NEG7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDALLGTGPR RARGCLGAAG PTSSGRAART PAAPWARFSA WLECVCVVTF
60 70 80 90 100
DLELGQALEL VYPNDFRLTD KEKSSICYLS FPDSHSGCLG DTQFSFRMRQ
110 120 130 140 150
CGGQRSPWHA DDRHYNSRAP VALQREPAHY FGYVYFRQVK DSSVKRGYFQ
160 170 180 190 200
KSLVLVSRLP FVRLFQALLS LIAPEYFDKL APCLEAVCSE IDQWPAPAPG
210 220 230 240 250
QTLNLPVMGV VVQVRIPSRV DKSESSPPKQ FDQENLLPAP VVLASVHELD
260 270 280 290 300
LFRCFRPVLT HMQTLWELML LGEPLLVLAP SPDVSSEMVL ALTSCLQPLR
310 320 330 340 350
FCCDFRPYFT IHDSEFKEFT TRTQAPPNVV LGVTNPFFIK TLQHWPHILR
360 370 380 390 400
VGEPKMSGDL PKQVKLKKPS RLKTLDTKPG LYTAYTAHLH RDKALLKRLL
410 420 430 440 450
KGVQKKRPSD VQSALLRRHL LELTQSFIIP LEHYMASLMP LQKSITPWKT
460 470 480 490 500
PPQIQPFSQD DFLRSLEHAG PQLTCILKGD WLGLYRRFFK SPHFDGWYRQ
510 520 530 540 550
RHKEMALKLE ALHLEAICEA NIETWMKDKS EVEVVDLVLK LREKLVRAQG
560 570 580
HQLPVKEATL QRAQLYIETV IGSLPKDLQA VLCPP
Length:585
Mass (Da):66,464
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B2D5F46647D448C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y7N0H0Y7N0_HUMAN
Protein DENND6B
DENND6B
298Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CT009622
, CR559946, CR759740, CR932343, CR932344 Genomic DNA Translation: CAO03304.1
CR932344
, CR559946, CR759740, CR932343, CT009622 Genomic DNA Translation: CAO03484.1
CR559946
, CR759740, CR932343, CR932344, CT009622 Genomic DNA Translation: CAO03525.1
CR932343
, CR559946, CR759740, CR932344, CT009622 Genomic DNA Translation: CAO03579.1
CR759740
, CR559946, CR932343, CR932344, CT009622 Genomic DNA Translation: CAO03621.1
BC031069 mRNA Translation: AAH31069.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46732.1

NCBI Reference Sequences

More...
RefSeqi
NP_001001794.3, NM_001001794.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000413817; ENSP00000391524; ENSG00000205593

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
414918

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:414918

UCSC genome browser

More...
UCSCi
uc011arv.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT009622
, CR559946, CR759740, CR932343, CR932344 Genomic DNA Translation: CAO03304.1
CR932344
, CR559946, CR759740, CR932343, CT009622 Genomic DNA Translation: CAO03484.1
CR559946
, CR759740, CR932343, CR932344, CT009622 Genomic DNA Translation: CAO03525.1
CR932343
, CR559946, CR759740, CR932344, CT009622 Genomic DNA Translation: CAO03579.1
CR759740
, CR559946, CR932343, CR932344, CT009622 Genomic DNA Translation: CAO03621.1
BC031069 mRNA Translation: AAH31069.1
CCDSiCCDS46732.1
RefSeqiNP_001001794.3, NM_001001794.3

3D structure databases

SMRiQ8NEG7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi136098, 3 interactors
IntActiQ8NEG7, 7 interactors
STRINGi9606.ENSP00000391524

PTM databases

iPTMnetiQ8NEG7
PhosphoSitePlusiQ8NEG7

Polymorphism and mutation databases

BioMutaiDENND6B
DMDMi74760209

Proteomic databases

EPDiQ8NEG7
jPOSTiQ8NEG7
MassIVEiQ8NEG7
MaxQBiQ8NEG7
PaxDbiQ8NEG7
PeptideAtlasiQ8NEG7
PRIDEiQ8NEG7
ProteomicsDBi73165

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000413817; ENSP00000391524; ENSG00000205593
GeneIDi414918
KEGGihsa:414918
UCSCiuc011arv.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
414918

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DENND6B
HGNCiHGNC:32690 DENND6B
HPAiHPA018934
HPA021653
HPA029570
neXtProtiNX_Q8NEG7
OpenTargetsiENSG00000205593
PharmGKBiPA144596432

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2432 Eukaryota
ENOG410XP3F LUCA
GeneTreeiENSGT00390000005529
HOGENOMiHOG000000674
InParanoidiQ8NEG7
OMAiQCDQENL
OrthoDBi252077at2759
PhylomeDBiQ8NEG7
TreeFamiTF320228

Enzyme and pathway databases

ReactomeiR-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
414918

Pharos

More...
Pharosi
Q8NEG7

Protein Ontology

More...
PROi
PR:Q8NEG7

Gene expression databases

BgeeiENSG00000205593 Expressed in 132 organ(s), highest expression level in right uterine tube
ExpressionAtlasiQ8NEG7 baseline and differential
GenevisibleiQ8NEG7 HS

Family and domain databases

InterProiView protein in InterPro
IPR018307 ABL9/DENND6_dom
IPR024224 DENND6
IPR037516 Tripartite_DENN
PANTHERiPTHR13677 PTHR13677, 1 hit
PfamiView protein in Pfam
PF09794 Avl9, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDEN6B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NEG7
Secondary accession number(s): A6X8I5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: September 18, 2019
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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