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Entry version 141 (12 Aug 2020)
Sequence version 2 (30 Nov 2010)
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Protein

E3 ubiquitin-protein ligase ZSWIM2

Gene

ZSWIM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri54 – 87SWIM-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri147 – 198RING-type 1PROSITE-ProRule annotationAdd BLAST52
Zinc fingeri228 – 277ZZ-typePROSITE-ProRule annotationAdd BLAST50
Zinc fingeri344 – 388RING-type 2PROSITE-ProRule annotationAdd BLAST45

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processApoptosis, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8NEG5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase ZSWIM2 (EC:2.3.2.27)
Alternative name(s):
MEKK1-related protein X
Short name:
MEX
RING-type E3 ubiquitin transferase ZSWIM2
ZZ-type zinc finger-containing protein 2
Zinc finger SWIM domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZSWIM2
Synonyms:ZZZ2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000163012.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30990, ZSWIM2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NEG5

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
151112

Open Targets

More...
OpenTargetsi
ENSG00000163012

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134900131

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NEG5, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZSWIM2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104068

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002230971 – 633E3 ubiquitin-protein ligase ZSWIM2Add BLAST633

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Polyubiquitinated. Polyubiquitination is followed by degradation via the proteasome (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NEG5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NEG5

PeptideAtlas

More...
PeptideAtlasi
Q8NEG5

PRoteomics IDEntifications database

More...
PRIDEi
Q8NEG5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
73164

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NEG5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NEG5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163012, Expressed in testis and 44 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NEG5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NEG5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000163012, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Dimer.

Interacts with UBE2D1.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127342, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NEG5, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000295131

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NEG5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1633
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NEG5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8NEG5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SWIM-type zinc finger is required for ubiquitination activity.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri54 – 87SWIM-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri147 – 198RING-type 1PROSITE-ProRule annotationAdd BLAST52
Zinc fingeri228 – 277ZZ-typePROSITE-ProRule annotationAdd BLAST50
Zinc fingeri344 – 388RING-type 2PROSITE-ProRule annotationAdd BLAST45

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0800, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006826

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_029121_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NEG5

KEGG Orthology (KO)

More...
KOi
K15716

Identification of Orthologs from Complete Genome Data

More...
OMAi
CNSCPID

Database of Orthologous Groups

More...
OrthoDBi
797346at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NEG5

TreeFam database of animal gene trees

More...
TreeFami
TF333237

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 2 hits
3.30.60.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR007527, Znf_SWIM
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
IPR039903, Zswim2

The PANTHER Classification System

More...
PANTHERi
PTHR21540, PTHR21540, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04434, SWIM, 1 hit
PF13639, zf-RING_2, 1 hit
PF00569, ZZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00184, RING, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50089, ZF_RING_2, 2 hits
PS50966, ZF_SWIM, 1 hit
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8NEG5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRRGYKASE RRRHLSERLS WHQDQALSSS IYLLREMGPT GFLLREEEPE
60 70 80 90 100
YMDFRVFLGN PHVCNCSTFP KGGELCKHIC WVLLKKFKLP RNHESALQLG
110 120 130 140 150
LGEREISDLL RGIHRVQTPQ PGTNDENEHV EEDGYIKQKE IDSEDICSIC
160 170 180 190 200
QELLLEKKLP VTFCRFGCGN SIHIKCMKIL ANYQSTSNTS MLKCPLCRKE
210 220 230 240 250
FAPLKLILEE FKNSSKLVAA AEKERLDKHL GIPCNNCKQF PIEGKCYKCT
260 270 280 290 300
ECIEYHLCQE CFDSCCHLSH TFTFREKRNQ KWRSLEKRAD EVVKYIDTKN
310 320 330 340 350
EIEEKMSHFQ EKQGQVYTPK HIVRSLPLQL ITKNSKLLAP GYQCLLCLKA
360 370 380 390 400
FHLGQHTRLL PCTHKFHRKC IDNWLFHKCN SCPIDGQVIY NPLTWKNSAV
410 420 430 440 450
NGQAHQSVSN RDIIHLSKQK EPDLFIPGTG LVLKQNRLGI LPSIPQCNFD
460 470 480 490 500
ELNTPQSPKD AYENTTIDNL CSIKLDNSNS KKLTYDYKIS QHFPRYLQDL
510 520 530 540 550
PTVSFGKIPS QTLLPPIVHK NIVCPTAMES PCISGKFHTS LSRMTKGCKC
560 570 580 590 600
NNHNLKKTPA TKIREDNKRS TLLPEDFNLI VNWSTAKLSL SKRYSNCMGE
610 620 630
ITRKCSHLSR QPVSHSVNTK STELSLIIEG VQL
Length:633
Mass (Da):72,732
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB5B74E5E7FA625C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WCC6F8WCC6_HUMAN
E3 ubiquitin-protein ligase ZSWIM2
ZSWIM2
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti88K → E in AAH31094 (PubMed:15489334).Curated1
Sequence conflicti265C → Y in AAH31094 (PubMed:15489334).Curated1
Sequence conflicti302I → T in AAH31094 (PubMed:15489334).Curated1
Sequence conflicti385D → G in AAH31094 (PubMed:15489334).Curated1
Sequence conflicti486D → E in AAH31094 (PubMed:15489334).Curated1
Sequence conflicti537F → Y in AAH31094 (PubMed:15489334).Curated1
Sequence conflicti544M → V in AAH31094 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK128006 mRNA Translation: BAG54618.1
AC018735 Genomic DNA Translation: AAY14907.1
AC103914 Genomic DNA Translation: AAX82016.1
CH471058 Genomic DNA Translation: EAX10929.1
BC031094 mRNA Translation: AAH31094.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33348.1

NCBI Reference Sequences

More...
RefSeqi
NP_872327.2, NM_182521.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000295131; ENSP00000295131; ENSG00000163012

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
151112

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:151112

UCSC genome browser

More...
UCSCi
uc002upu.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128006 mRNA Translation: BAG54618.1
AC018735 Genomic DNA Translation: AAY14907.1
AC103914 Genomic DNA Translation: AAX82016.1
CH471058 Genomic DNA Translation: EAX10929.1
BC031094 mRNA Translation: AAH31094.1
CCDSiCCDS33348.1
RefSeqiNP_872327.2, NM_182521.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DIPNMR-A208-292[»]
SMRiQ8NEG5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi127342, 9 interactors
IntActiQ8NEG5, 8 interactors
STRINGi9606.ENSP00000295131

PTM databases

iPTMnetiQ8NEG5
PhosphoSitePlusiQ8NEG5

Polymorphism and mutation databases

BioMutaiZSWIM2
DMDMi313104068

Proteomic databases

jPOSTiQ8NEG5
PaxDbiQ8NEG5
PeptideAtlasiQ8NEG5
PRIDEiQ8NEG5
ProteomicsDBi73164

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34014, 99 antibodies

The DNASU plasmid repository

More...
DNASUi
151112

Genome annotation databases

EnsembliENST00000295131; ENSP00000295131; ENSG00000163012
GeneIDi151112
KEGGihsa:151112
UCSCiuc002upu.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
151112
DisGeNETi151112
EuPathDBiHostDB:ENSG00000163012.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZSWIM2
HGNCiHGNC:30990, ZSWIM2
HPAiENSG00000163012, Tissue enriched (testis)
neXtProtiNX_Q8NEG5
OpenTargetsiENSG00000163012
PharmGKBiPA134900131

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0800, Eukaryota
GeneTreeiENSGT00390000006826
HOGENOMiCLU_029121_0_0_1
InParanoidiQ8NEG5
KOiK15716
OMAiCNSCPID
OrthoDBi797346at2759
PhylomeDBiQ8NEG5
TreeFamiTF333237

Enzyme and pathway databases

PathwayCommonsiQ8NEG5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
151112, 4 hits in 868 CRISPR screens
EvolutionaryTraceiQ8NEG5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
151112
PharosiQ8NEG5, Tbio

Protein Ontology

More...
PROi
PR:Q8NEG5
RNActiQ8NEG5, protein

Gene expression databases

BgeeiENSG00000163012, Expressed in testis and 44 other tissues
ExpressionAtlasiQ8NEG5, baseline and differential
GenevisibleiQ8NEG5, HS

Family and domain databases

Gene3Di3.30.40.10, 2 hits
3.30.60.90, 1 hit
InterProiView protein in InterPro
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR007527, Znf_SWIM
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
IPR039903, Zswim2
PANTHERiPTHR21540, PTHR21540, 1 hit
PfamiView protein in Pfam
PF04434, SWIM, 1 hit
PF13639, zf-RING_2, 1 hit
PF00569, ZZ, 1 hit
SMARTiView protein in SMART
SM00184, RING, 2 hits
PROSITEiView protein in PROSITE
PS50089, ZF_RING_2, 2 hits
PS50966, ZF_SWIM, 1 hit
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZSWM2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NEG5
Secondary accession number(s): B3KXV6, Q53SI3, Q57ZY3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 30, 2010
Last modified: August 12, 2020
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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