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Entry version 145 (16 Oct 2019)
Sequence version 3 (02 Nov 2010)
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Protein

Dynein regulatory complex subunit 6

Gene

FBXL13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein regulatory complex subunit 6By similarity
Alternative name(s):
F-box and leucine-rich repeat protein 13
F-box/LRR-repeat protein 13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FBXL13
Synonyms:DRC6By similarity, FBL13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21658 FBXL13

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609080 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NEE6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
222235

Open Targets

More...
OpenTargetsi
ENSG00000161040

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134938720

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NEE6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FBXL13

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033450

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001198591 – 735Dynein regulatory complex subunit 6Add BLAST735

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NEE6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NEE6

PRoteomics IDEntifications database

More...
PRIDEi
Q8NEE6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
73152 [Q8NEE6-1]
73153 [Q8NEE6-2]
73154 [Q8NEE6-3]
73155 [Q8NEE6-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NEE6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NEE6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8NEE6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000161040 Expressed in 108 organ(s), highest expression level in sperm

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NEE6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NEE6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA057232

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the nexin-dynein regulatory complex (N-DRC). Directly interacts with SKP1 and CUL1.

Interacts with TCTE1/DRC5.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128792, 39 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NEE6, 4 interactors

Molecular INTeraction database

More...
MINTi
Q8NEE6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000321927

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini152 – 198F-boxPROSITE-ProRule annotationAdd BLAST47
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati230 – 254LRR 1Add BLAST25
Repeati255 – 280LRR 2Add BLAST26
Repeati281 – 305LRR 3Add BLAST25
Repeati306 – 333LRR 4Add BLAST28
Repeati334 – 359LRR 5Add BLAST26
Repeati360 – 385LRR 6Add BLAST26
Repeati386 – 406LRR 7Add BLAST21
Repeati410 – 435LRR 8Add BLAST26
Repeati436 – 460LRR 9Add BLAST25
Repeati461 – 488LRR 10Add BLAST28
Repeati489 – 514LRR 11Add BLAST26
Repeati515 – 538LRR 12Add BLAST24
Repeati539 – 563LRR 13Add BLAST25
Repeati564 – 589LRR 14Add BLAST26
Repeati590 – 615LRR 15Add BLAST26
Repeati616 – 641LRR 16Add BLAST26
Repeati642 – 667LRR 17Add BLAST26

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DRC6 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IT20 Eukaryota
ENOG410XPA4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160224

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NEE6

KEGG Orthology (KO)

More...
KOi
K10279

Identification of Orthologs from Complete Genome Data

More...
OMAi
CIHLGDA

Database of Orthologous Groups

More...
OrthoDBi
1282076at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NEE6

TreeFam database of animal gene trees

More...
TreeFami
TF329711

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13516 LRR_6, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00367 LRR_CC, 14 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81383 SSF81383, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50181 FBOX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NEE6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTPELMIKAC SFYTGHLVKT HFCTWRDIAR TNENVVLAEK MNRAVTCYNF
60 70 80 90 100
RLQKSVFHHW HSYMEDQKEK LKNILLRIQQ IIYCHKLTII LTKWRNTARH
110 120 130 140 150
KSKKKEDELI LKHELQLKKW KNRLILKRAA AEESNFPERS SSEVFLVDET
160 170 180 190 200
LKCDISLLPE RAILQIFFYL SLKDVIICGQ VNHAWMLMTQ LNSLWNAIDF
210 220 230 240 250
SSVKNVIPDK YIVSTLQRWR LNVLRLNFRG CLLRPKTFRS VSHCRNLQEL
260 270 280 290 300
NVSDCPTFTD ESMRHISEGC PGVLCLNLSN TTITNRTMRL LPRHFHNLQN
310 320 330 340 350
LSLAYCRRFT DKGLQYLNLG NGCHKLIYLD LSGCTQISVQ GFRYIANSCT
360 370 380 390 400
GIMHLTINDM PTLTDNCVKA LVEKCSRITS LVFTGAPHIS DCTFRALSAC
410 420 430 440 450
KLRKIRFEGN KRVTDASFKF IDKNYPNLSH IYMADCKGIT DSSLRSLSPL
460 470 480 490 500
KQLTVLNLAN CVRIGDMGLK QFLDGPASMR IRELNLSNCV RLSDASVMKL
510 520 530 540 550
SERCPNLNYL SLRNCEHLTA QGIGYIVNIF SLVSIDLSGT DISNEGLNVL
560 570 580 590 600
SRHKKLKELS VSECYRITDD GIQAFCKSSL ILEHLDVSYC SQLSDMIIKA
610 620 630 640 650
LAIYCINLTS LSIAGCPKIT DSAMEMLSAK CHYLHILDIS GCVLLTDQIL
660 670 680 690 700
EDLQIGCKQL RILKMQYCTN ISKKAAQRMS SKVQQQEYNT NDPPRWFGYD
710 720 730
REGNPVTELD NITSSKGALE LTVKKSTYSS EDQAA
Length:735
Mass (Da):83,924
Last modified:November 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i27F92DC4693C2581
GO
Isoform 2 (identifier: Q8NEE6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     546-573: Missing.

Note: No experimental confirmation available.
Show »
Length:707
Mass (Da):80,739
Checksum:i2C5A4F17C11B7734
GO
Isoform 3 (identifier: Q8NEE6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     574-618: Missing.

Show »
Length:690
Mass (Da):79,064
Checksum:iA9C6D44C07E0CBD7
GO
Isoform 4 (identifier: Q8NEE6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     337-618: Missing.

Show »
Length:453
Mass (Da):52,734
Checksum:iE3E226E465BF54C9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ERH8E7ERH8_HUMAN
Dynein regulatory complex subunit 6
FBXL13
684Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRW5A0A0A0MRW5_HUMAN
Dynein regulatory complex subunit 6
FBXL13
683Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JI88C9JI88_HUMAN
Dynein regulatory complex subunit 6
FBXL13
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD28506 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti110I → V in AAR13262 (PubMed:15820312).Curated1
Sequence conflicti337I → V in AAR13263 (PubMed:15820312).Curated1
Sequence conflicti496S → F in CAD28506 (PubMed:17974005).Curated1
Sequence conflicti674K → E in AAR13263 (PubMed:15820312).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02148074I → M2 PublicationsCorresponds to variant dbSNP:rs7805950Ensembl.1
Natural variantiVAR_031426313G → A. Corresponds to variant dbSNP:rs17135923Ensembl.1
Natural variantiVAR_031427535I → V. Corresponds to variant dbSNP:rs17135873Ensembl.1
Natural variantiVAR_031428565Y → C. Corresponds to variant dbSNP:rs17136118Ensembl.1
Natural variantiVAR_031429692D → G1 PublicationCorresponds to variant dbSNP:rs17852944Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013003337 – 618Missing in isoform 4. 1 PublicationAdd BLAST282
Alternative sequenceiVSP_013004546 – 573Missing in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_013005574 – 618Missing in isoform 3. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY359238 mRNA Translation: AAR13262.1
AY359239 mRNA Translation: AAR13263.1
AK097537 mRNA Translation: BAC05092.1
AC005250 Genomic DNA Translation: AAP22333.1
AC006477 Genomic DNA Translation: AAS00354.1
AC073127 Genomic DNA No translation available.
BC020572 mRNA Translation: AAH20572.2
BC020575 mRNA Translation: AAH20575.2
BC031285 mRNA Translation: AAH31285.1
AL713709 mRNA Translation: CAD28506.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47678.1 [Q8NEE6-3]
CCDS5726.1 [Q8NEE6-1]
CCDS75649.1 [Q8NEE6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001104508.1, NM_001111038.1 [Q8NEE6-3]
NP_001274079.1, NM_001287150.1 [Q8NEE6-2]
NP_659469.3, NM_145032.3 [Q8NEE6-1]
XP_005250266.1, XM_005250209.2 [Q8NEE6-1]
XP_011514232.1, XM_011515930.2 [Q8NEE6-1]
XP_016867342.1, XM_017011853.1 [Q8NEE6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000313221; ENSP00000321927; ENSG00000161040 [Q8NEE6-1]
ENST00000379305; ENSP00000368607; ENSG00000161040 [Q8NEE6-2]
ENST00000436908; ENSP00000388608; ENSG00000161040 [Q8NEE6-1]
ENST00000455112; ENSP00000391550; ENSG00000161040 [Q8NEE6-3]
ENST00000456695; ENSP00000409716; ENSG00000161040 [Q8NEE6-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
222235

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:222235

UCSC genome browser

More...
UCSCi
uc003vaq.3 human [Q8NEE6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359238 mRNA Translation: AAR13262.1
AY359239 mRNA Translation: AAR13263.1
AK097537 mRNA Translation: BAC05092.1
AC005250 Genomic DNA Translation: AAP22333.1
AC006477 Genomic DNA Translation: AAS00354.1
AC073127 Genomic DNA No translation available.
BC020572 mRNA Translation: AAH20572.2
BC020575 mRNA Translation: AAH20575.2
BC031285 mRNA Translation: AAH31285.1
AL713709 mRNA Translation: CAD28506.1 Different initiation.
CCDSiCCDS47678.1 [Q8NEE6-3]
CCDS5726.1 [Q8NEE6-1]
CCDS75649.1 [Q8NEE6-2]
RefSeqiNP_001104508.1, NM_001111038.1 [Q8NEE6-3]
NP_001274079.1, NM_001287150.1 [Q8NEE6-2]
NP_659469.3, NM_145032.3 [Q8NEE6-1]
XP_005250266.1, XM_005250209.2 [Q8NEE6-1]
XP_011514232.1, XM_011515930.2 [Q8NEE6-1]
XP_016867342.1, XM_017011853.1 [Q8NEE6-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi128792, 39 interactors
IntActiQ8NEE6, 4 interactors
MINTiQ8NEE6
STRINGi9606.ENSP00000321927

PTM databases

iPTMnetiQ8NEE6
PhosphoSitePlusiQ8NEE6
SwissPalmiQ8NEE6

Polymorphism and mutation databases

BioMutaiFBXL13
DMDMi311033450

Proteomic databases

MaxQBiQ8NEE6
PaxDbiQ8NEE6
PRIDEiQ8NEE6
ProteomicsDBi73152 [Q8NEE6-1]
73153 [Q8NEE6-2]
73154 [Q8NEE6-3]
73155 [Q8NEE6-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
222235

Genome annotation databases

EnsembliENST00000313221; ENSP00000321927; ENSG00000161040 [Q8NEE6-1]
ENST00000379305; ENSP00000368607; ENSG00000161040 [Q8NEE6-2]
ENST00000436908; ENSP00000388608; ENSG00000161040 [Q8NEE6-1]
ENST00000455112; ENSP00000391550; ENSG00000161040 [Q8NEE6-3]
ENST00000456695; ENSP00000409716; ENSG00000161040 [Q8NEE6-4]
GeneIDi222235
KEGGihsa:222235
UCSCiuc003vaq.3 human [Q8NEE6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
222235
DisGeNETi222235

GeneCards: human genes, protein and diseases

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GeneCardsi
FBXL13
HGNCiHGNC:21658 FBXL13
HPAiHPA057232
MIMi609080 gene
neXtProtiNX_Q8NEE6
OpenTargetsiENSG00000161040
PharmGKBiPA134938720

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IT20 Eukaryota
ENOG410XPA4 LUCA
GeneTreeiENSGT00940000160224
InParanoidiQ8NEE6
KOiK10279
OMAiCIHLGDA
OrthoDBi1282076at2759
PhylomeDBiQ8NEE6
TreeFamiTF329711

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FBXL13 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
222235
PharosiQ8NEE6

Protein Ontology

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PROi
PR:Q8NEE6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000161040 Expressed in 108 organ(s), highest expression level in sperm
ExpressionAtlasiQ8NEE6 baseline and differential
GenevisibleiQ8NEE6 HS

Family and domain databases

Gene3Di3.80.10.10, 4 hits
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13516 LRR_6, 5 hits
SMARTiView protein in SMART
SM00367 LRR_CC, 14 hits
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDRC6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NEE6
Secondary accession number(s): C9J565
, C9J566, Q6UVW7, Q6UVW8, Q75MN5, Q86UJ5, Q8N7Y4, Q8TCL2, Q8WUF9, Q8WUG0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 2, 2010
Last modified: October 16, 2019
This is version 145 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
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