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Protein

Phospholipid phosphatase 5

Gene

PLPP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma.2 Publications

Catalytic activityi

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.1 Publication

Activity regulationi

Inhibited by N-ethylmaleimide.1 Publication

Kineticsi

  1. KM=41 µM for diacylglycerol pyrophosphate1 Publication
  2. KM=277 µM for phosphatidate1 Publication
  3. KM=295 µM for lysophosphatidate1 Publication

    GO - Molecular functioni

    • phosphatase activity Source: GO_Central
    • phosphatidate phosphatase activity Source: UniProtKB

    GO - Biological processi

    Keywordsi

    Molecular functionHydrolase

    Enzyme and pathway databases

    BRENDAi3.1.3.4 2681
    3.1.3.81 2681
    ReactomeiR-HSA-2029485 Role of phospholipids in phagocytosis

    Chemistry databases

    SwissLipidsiSLP:000000604

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phospholipid phosphatase 5Imported (EC:3.1.3.4)
    Alternative name(s):
    Phosphatidic acid phosphatase type 2 domain-containing protein 1B
    Gene namesi
    Name:PLPP5Imported
    Synonyms:DPPL1, HTPAP, PPAPDC1B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 8

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000147535.16
    HGNCiHGNC:25026 PLPP5
    MIMi610626 gene
    neXtProtiNX_Q8NEB5

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
    Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
    Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
    Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
    Transmembranei209 – 228HelicalSequence analysisAdd BLAST20

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi115R → A: Loss of phosphatase activity; when associated with A-152 and with A-208. 1 Publication1
    Mutagenesisi152H → A: Loss of phosphatase activity; when associated with A-115 and with A-208. 1 Publication1
    Mutagenesisi208H → A: Loss of phosphatase activity; when associated with A-115 and with A-152. 1 Publication1

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    DisGeNETi84513
    OpenTargetsiENSG00000147535
    PharmGKBiPA142671154

    Polymorphism and mutation databases

    BioMutaiPPAPDC1B
    DMDMi313104170

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00002869451 – 264Phospholipid phosphatase 5Add BLAST264

    Proteomic databases

    EPDiQ8NEB5
    MaxQBiQ8NEB5
    PaxDbiQ8NEB5
    PeptideAtlasiQ8NEB5
    PRIDEiQ8NEB5
    ProteomicsDBi73143
    73144 [Q8NEB5-2]
    73145 [Q8NEB5-3]

    PTM databases

    DEPODiQ8NEB5
    iPTMnetiQ8NEB5
    PhosphoSitePlusiQ8NEB5

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    BgeeiENSG00000147535 Expressed in 178 organ(s), highest expression level in body of pancreas
    CleanExiHS_PPAPDC1B
    ExpressionAtlasiQ8NEB5 baseline and differential
    GenevisibleiQ8NEB5 HS

    Organism-specific databases

    HPAiHPA055777

    Interactioni

    Protein-protein interaction databases

    IntActiQ8NEB5, 2 interactors
    STRINGi9606.ENSP00000392553

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NEB5
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni108 – 116Phosphatase sequence motif I9
    Regioni149 – 152Phosphatase sequence motif II4
    Regioni201 – 211Phosphatase sequence motif IIIAdd BLAST11

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG3030 Eukaryota
    COG0671 LUCA
    GeneTreeiENSGT00510000046723
    HOGENOMiHOG000206608
    HOVERGENiHBG056764
    InParanoidiQ8NEB5
    KOiK18693
    OMAiEMWLYKF
    OrthoDBiEOG091G0O0I
    PhylomeDBiQ8NEB5
    TreeFamiTF323722

    Family and domain databases

    InterProiView protein in InterPro
    IPR036938 P_Acid_Pase_2/haloperoxi_sf
    IPR000326 P_Acid_Pase_2/haloperoxidase
    IPR032462 PPAPDC1B
    PANTHERiPTHR10165:SF87 PTHR10165:SF87, 1 hit
    PfamiView protein in Pfam
    PF01569 PAP2, 1 hit
    SMARTiView protein in SMART
    SM00014 acidPPc, 1 hit
    SUPFAMiSSF48317 SSF48317, 1 hit

    Sequences (4+)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q8NEB5-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MGKAAAAVAF GAEVGVRLAL FAAFLVTELL PPFQRLIQPE EMWLYRNPYV
    60 70 80 90 100
    EAEYFPTKPM FVIAFLSPLS LIFLAKFLKK ADTRDSRQAC LAASLALALN
    110 120 130 140 150
    GVFTNTIKLI VGRPRPDFFY RCFPDGLAHS DLMCTGDKDV VNEGRKSFPS
    160 170 180 190 200
    GHSSFAFAGL AFASFYLAGK LHCFTPQGRG KSWRFCAFLS PLLFAAVIAL
    210 220 230 240 250
    SRTCDYKHHW QDVLVGSMIG MTFAYVCYRQ YYPPLTDAEC HKPFQDKLVL
    260
    STAQKPGDSY CFDI
    Length:264
    Mass (Da):29,484
    Last modified:November 30, 2010 - v2
    Checksum:i3682DA52B6F3C65B
    GO
    Isoform 2 (identifier: Q8NEB5-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         212-216: DVLVG → GPFKW
         217-264: Missing.

    Show »
    Length:216
    Mass (Da):24,091
    Checksum:i64D0637A9E546E5A
    GO
    Isoform 3 (identifier: Q8NEB5-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-41: Missing.

    Show »
    Length:223
    Mass (Da):25,159
    Checksum:i72B01C9A0DBBA1BA
    GO
    Isoform 4 (identifier: Q8NEB5-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         155-176: FAFAGLAFASFYLAGKLHCFTP → CMNIIWTLPYACFHIIEFNLES
         177-264: Missing.

    Note: No experimental confirmation available. Gene prediction based on EST data.
    Show »
    Length:176
    Mass (Da):19,677
    Checksum:iC0D4D05D0E7BE789
    GO

    Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    E9PNB1E9PNB1_HUMAN
    Phospholipid phosphatase 5
    PLPP5
    132Annotation score:
    H0YCK0H0YCK0_HUMAN
    Phospholipid phosphatase 5
    PLPP5
    244Annotation score:
    H0YCQ3H0YCQ3_HUMAN
    Phospholipid phosphatase 5
    PLPP5
    245Annotation score:
    H0YDY2H0YDY2_HUMAN
    Phospholipid phosphatase 5
    PLPP5
    60Annotation score:

    Sequence cautioni

    The sequence AAI06015 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
    The sequence AAK14924 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0400551 – 41Missing in isoform 3. 1 PublicationAdd BLAST41
    Alternative sequenceiVSP_054076155 – 176FAFAG…HCFTP → CMNIIWTLPYACFHIIEFNL ES in isoform 4. CuratedAdd BLAST22
    Alternative sequenceiVSP_054077177 – 264Missing in isoform 4. CuratedAdd BLAST88
    Alternative sequenceiVSP_025241212 – 216DVLVG → GPFKW in isoform 2. 2 Publications5
    Alternative sequenceiVSP_025242217 – 264Missing in isoform 2. 2 PublicationsAdd BLAST48

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    BD418664 mRNA No translation available.
    AC087362 Genomic DNA No translation available.
    BC033025 mRNA Translation: AAH33025.1
    BC106014 mRNA Translation: AAI06015.2 Different initiation.
    AF212238 mRNA Translation: AAK14924.1 Different initiation.
    CCDSiCCDS47841.1 [Q8NEB5-1]
    CCDS47842.1 [Q8NEB5-2]
    CCDS47843.1 [Q8NEB5-4]
    RefSeqiNP_001096029.1, NM_001102559.1 [Q8NEB5-1]
    NP_001096030.1, NM_001102560.1 [Q8NEB5-4]
    NP_115872.2, NM_032483.3 [Q8NEB5-2]
    XP_011542973.1, XM_011544671.1 [Q8NEB5-3]
    UniGeneiHs.567619

    Genome annotation databases

    EnsembliENST00000419686; ENSP00000414522; ENSG00000147535 [Q8NEB5-4]
    ENST00000422581; ENSP00000390622; ENSG00000147535 [Q8NEB5-2]
    ENST00000424479; ENSP00000392553; ENSG00000147535 [Q8NEB5-1]
    ENST00000529359; ENSP00000434916; ENSG00000147535 [Q8NEB5-3]
    GeneIDi84513
    KEGGihsa:84513
    UCSCiuc003xle.5 human [Q8NEB5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Similar proteinsi

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    BD418664 mRNA No translation available.
    AC087362 Genomic DNA No translation available.
    BC033025 mRNA Translation: AAH33025.1
    BC106014 mRNA Translation: AAI06015.2 Different initiation.
    AF212238 mRNA Translation: AAK14924.1 Different initiation.
    CCDSiCCDS47841.1 [Q8NEB5-1]
    CCDS47842.1 [Q8NEB5-2]
    CCDS47843.1 [Q8NEB5-4]
    RefSeqiNP_001096029.1, NM_001102559.1 [Q8NEB5-1]
    NP_001096030.1, NM_001102560.1 [Q8NEB5-4]
    NP_115872.2, NM_032483.3 [Q8NEB5-2]
    XP_011542973.1, XM_011544671.1 [Q8NEB5-3]
    UniGeneiHs.567619

    3D structure databases

    ProteinModelPortaliQ8NEB5
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    IntActiQ8NEB5, 2 interactors
    STRINGi9606.ENSP00000392553

    Chemistry databases

    SwissLipidsiSLP:000000604

    PTM databases

    DEPODiQ8NEB5
    iPTMnetiQ8NEB5
    PhosphoSitePlusiQ8NEB5

    Polymorphism and mutation databases

    BioMutaiPPAPDC1B
    DMDMi313104170

    Proteomic databases

    EPDiQ8NEB5
    MaxQBiQ8NEB5
    PaxDbiQ8NEB5
    PeptideAtlasiQ8NEB5
    PRIDEiQ8NEB5
    ProteomicsDBi73143
    73144 [Q8NEB5-2]
    73145 [Q8NEB5-3]

    Protocols and materials databases

    DNASUi84513
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000419686; ENSP00000414522; ENSG00000147535 [Q8NEB5-4]
    ENST00000422581; ENSP00000390622; ENSG00000147535 [Q8NEB5-2]
    ENST00000424479; ENSP00000392553; ENSG00000147535 [Q8NEB5-1]
    ENST00000529359; ENSP00000434916; ENSG00000147535 [Q8NEB5-3]
    GeneIDi84513
    KEGGihsa:84513
    UCSCiuc003xle.5 human [Q8NEB5-1]

    Organism-specific databases

    CTDi84513
    DisGeNETi84513
    EuPathDBiHostDB:ENSG00000147535.16
    GeneCardsiPLPP5
    H-InvDBiHIX0201275
    HGNCiHGNC:25026 PLPP5
    HPAiHPA055777
    MIMi610626 gene
    neXtProtiNX_Q8NEB5
    OpenTargetsiENSG00000147535
    PharmGKBiPA142671154
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG3030 Eukaryota
    COG0671 LUCA
    GeneTreeiENSGT00510000046723
    HOGENOMiHOG000206608
    HOVERGENiHBG056764
    InParanoidiQ8NEB5
    KOiK18693
    OMAiEMWLYKF
    OrthoDBiEOG091G0O0I
    PhylomeDBiQ8NEB5
    TreeFamiTF323722

    Enzyme and pathway databases

    BRENDAi3.1.3.4 2681
    3.1.3.81 2681
    ReactomeiR-HSA-2029485 Role of phospholipids in phagocytosis

    Miscellaneous databases

    ChiTaRSiPLPP5 human
    GenomeRNAii84513
    PROiPR:Q8NEB5
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000147535 Expressed in 178 organ(s), highest expression level in body of pancreas
    CleanExiHS_PPAPDC1B
    ExpressionAtlasiQ8NEB5 baseline and differential
    GenevisibleiQ8NEB5 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR036938 P_Acid_Pase_2/haloperoxi_sf
    IPR000326 P_Acid_Pase_2/haloperoxidase
    IPR032462 PPAPDC1B
    PANTHERiPTHR10165:SF87 PTHR10165:SF87, 1 hit
    PfamiView protein in Pfam
    PF01569 PAP2, 1 hit
    SMARTiView protein in SMART
    SM00014 acidPPc, 1 hit
    SUPFAMiSSF48317 SSF48317, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiPLPP5_HUMAN
    AccessioniPrimary (citable) accession number: Q8NEB5
    Secondary accession number(s): C9JKF5, Q3KQX6, Q9BY45
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: November 30, 2010
    Last modified: November 7, 2018
    This is version 115 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
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