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Entry version 118 (13 Feb 2019)
Sequence version 2 (30 Nov 2010)
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Protein

Phospholipid phosphatase 5

Gene

PLPP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by N-ethylmaleimide.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=41 µM for diacylglycerol pyrophosphate1 Publication
  2. KM=277 µM for phosphatidate1 Publication
  3. KM=295 µM for lysophosphatidate1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • phosphatase activity Source: GO_Central
    • phosphatidate phosphatase activity Source: UniProtKB

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.1.3.4 2681
    3.1.3.81 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-2029485 Role of phospholipids in phagocytosis

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000000604

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Phospholipid phosphatase 5Imported (EC:3.1.3.4)
    Alternative name(s):
    Phosphatidic acid phosphatase type 2 domain-containing protein 1B
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PLPP5Imported
    Synonyms:DPPL1, HTPAP, PPAPDC1B
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000147535.16

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:25026 PLPP5

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    610626 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q8NEB5

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
    Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
    Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
    Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
    Transmembranei209 – 228HelicalSequence analysisAdd BLAST20

    Keywords - Cellular componenti

    Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi115R → A: Loss of phosphatase activity; when associated with A-152 and with A-208. 1 Publication1
    Mutagenesisi152H → A: Loss of phosphatase activity; when associated with A-115 and with A-208. 1 Publication1
    Mutagenesisi208H → A: Loss of phosphatase activity; when associated with A-115 and with A-152. 1 Publication1

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    84513

    Open Targets

    More...
    OpenTargetsi
    ENSG00000147535

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA142671154

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    PLPP5

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    313104170

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002869451 – 264Phospholipid phosphatase 5Add BLAST264

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q8NEB5

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q8NEB5

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q8NEB5

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8NEB5

    PeptideAtlas

    More...
    PeptideAtlasi
    Q8NEB5

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8NEB5

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    73143
    73144 [Q8NEB5-2]
    73145 [Q8NEB5-3]

    PTM databases

    DEPOD human dephosphorylation database

    More...
    DEPODi
    Q8NEB5

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q8NEB5

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8NEB5

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000147535 Expressed in 178 organ(s), highest expression level in body of pancreas

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q8NEB5 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q8NEB5 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA055777

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    Protein interaction database and analysis system

    More...
    IntActi
    Q8NEB5, 2 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000392553

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q8NEB5

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni108 – 116Phosphatase sequence motif I9
    Regioni149 – 152Phosphatase sequence motif II4
    Regioni201 – 211Phosphatase sequence motif IIIAdd BLAST11

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3030 Eukaryota
    COG0671 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000159772

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000206608

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG056764

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8NEB5

    KEGG Orthology (KO)

    More...
    KOi
    K18693

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    EMWLYKF

    Database of Orthologous Groups

    More...
    OrthoDBi
    1621899at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q8NEB5

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF323722

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR036938 P_Acid_Pase_2/haloperoxi_sf
    IPR000326 P_Acid_Pase_2/haloperoxidase
    IPR032462 PPAPDC1B

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR10165:SF87 PTHR10165:SF87, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01569 PAP2, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00014 acidPPc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF48317 SSF48317, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q8NEB5-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MGKAAAAVAF GAEVGVRLAL FAAFLVTELL PPFQRLIQPE EMWLYRNPYV
    60 70 80 90 100
    EAEYFPTKPM FVIAFLSPLS LIFLAKFLKK ADTRDSRQAC LAASLALALN
    110 120 130 140 150
    GVFTNTIKLI VGRPRPDFFY RCFPDGLAHS DLMCTGDKDV VNEGRKSFPS
    160 170 180 190 200
    GHSSFAFAGL AFASFYLAGK LHCFTPQGRG KSWRFCAFLS PLLFAAVIAL
    210 220 230 240 250
    SRTCDYKHHW QDVLVGSMIG MTFAYVCYRQ YYPPLTDAEC HKPFQDKLVL
    260
    STAQKPGDSY CFDI
    Length:264
    Mass (Da):29,484
    Last modified:November 30, 2010 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3682DA52B6F3C65B
    GO
    Isoform 2 (identifier: Q8NEB5-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         212-216: DVLVG → GPFKW
         217-264: Missing.

    Show »
    Length:216
    Mass (Da):24,091
    Checksum:i64D0637A9E546E5A
    GO
    Isoform 3 (identifier: Q8NEB5-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-41: Missing.

    Show »
    Length:223
    Mass (Da):25,159
    Checksum:i72B01C9A0DBBA1BA
    GO
    Isoform 4 (identifier: Q8NEB5-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         155-176: FAFAGLAFASFYLAGKLHCFTP → CMNIIWTLPYACFHIIEFNLES
         177-264: Missing.

    Note: No experimental confirmation available. Gene prediction based on EST data.
    Show »
    Length:176
    Mass (Da):19,677
    Checksum:iC0D4D05D0E7BE789
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    E9PNB1E9PNB1_HUMAN
    Phospholipid phosphatase 5
    PLPP5
    132Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YCQ3H0YCQ3_HUMAN
    Phospholipid phosphatase 5
    PLPP5
    245Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YCK0H0YCK0_HUMAN
    Phospholipid phosphatase 5
    PLPP5
    244Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YDY2H0YDY2_HUMAN
    Phospholipid phosphatase 5
    PLPP5
    60Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAI06015 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
    The sequence AAK14924 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0400551 – 41Missing in isoform 3. 1 PublicationAdd BLAST41
    Alternative sequenceiVSP_054076155 – 176FAFAG…HCFTP → CMNIIWTLPYACFHIIEFNL ES in isoform 4. CuratedAdd BLAST22
    Alternative sequenceiVSP_054077177 – 264Missing in isoform 4. CuratedAdd BLAST88
    Alternative sequenceiVSP_025241212 – 216DVLVG → GPFKW in isoform 2. 2 Publications5
    Alternative sequenceiVSP_025242217 – 264Missing in isoform 2. 2 PublicationsAdd BLAST48

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    BD418664 mRNA No translation available.
    AC087362 Genomic DNA No translation available.
    BC033025 mRNA Translation: AAH33025.1
    BC106014 mRNA Translation: AAI06015.2 Different initiation.
    AF212238 mRNA Translation: AAK14924.1 Different initiation.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS47841.1 [Q8NEB5-1]
    CCDS47842.1 [Q8NEB5-2]
    CCDS47843.1 [Q8NEB5-4]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001096029.1, NM_001102559.1 [Q8NEB5-1]
    NP_001096030.1, NM_001102560.1 [Q8NEB5-4]
    NP_115872.2, NM_032483.3 [Q8NEB5-2]
    XP_011542973.1, XM_011544671.1 [Q8NEB5-3]

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.567619

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000419686; ENSP00000414522; ENSG00000147535 [Q8NEB5-4]
    ENST00000422581; ENSP00000390622; ENSG00000147535 [Q8NEB5-2]
    ENST00000424479; ENSP00000392553; ENSG00000147535 [Q8NEB5-1]
    ENST00000529359; ENSP00000434916; ENSG00000147535 [Q8NEB5-3]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    84513

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:84513

    UCSC genome browser

    More...
    UCSCi
    uc003xle.5 human [Q8NEB5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    BD418664 mRNA No translation available.
    AC087362 Genomic DNA No translation available.
    BC033025 mRNA Translation: AAH33025.1
    BC106014 mRNA Translation: AAI06015.2 Different initiation.
    AF212238 mRNA Translation: AAK14924.1 Different initiation.
    CCDSiCCDS47841.1 [Q8NEB5-1]
    CCDS47842.1 [Q8NEB5-2]
    CCDS47843.1 [Q8NEB5-4]
    RefSeqiNP_001096029.1, NM_001102559.1 [Q8NEB5-1]
    NP_001096030.1, NM_001102560.1 [Q8NEB5-4]
    NP_115872.2, NM_032483.3 [Q8NEB5-2]
    XP_011542973.1, XM_011544671.1 [Q8NEB5-3]
    UniGeneiHs.567619

    3D structure databases

    ProteinModelPortaliQ8NEB5
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    IntActiQ8NEB5, 2 interactors
    STRINGi9606.ENSP00000392553

    Chemistry databases

    SwissLipidsiSLP:000000604

    PTM databases

    DEPODiQ8NEB5
    iPTMnetiQ8NEB5
    PhosphoSitePlusiQ8NEB5

    Polymorphism and mutation databases

    BioMutaiPLPP5
    DMDMi313104170

    Proteomic databases

    EPDiQ8NEB5
    jPOSTiQ8NEB5
    MaxQBiQ8NEB5
    PaxDbiQ8NEB5
    PeptideAtlasiQ8NEB5
    PRIDEiQ8NEB5
    ProteomicsDBi73143
    73144 [Q8NEB5-2]
    73145 [Q8NEB5-3]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    84513
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000419686; ENSP00000414522; ENSG00000147535 [Q8NEB5-4]
    ENST00000422581; ENSP00000390622; ENSG00000147535 [Q8NEB5-2]
    ENST00000424479; ENSP00000392553; ENSG00000147535 [Q8NEB5-1]
    ENST00000529359; ENSP00000434916; ENSG00000147535 [Q8NEB5-3]
    GeneIDi84513
    KEGGihsa:84513
    UCSCiuc003xle.5 human [Q8NEB5-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    84513
    DisGeNETi84513
    EuPathDBiHostDB:ENSG00000147535.16

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    PLPP5

    H-Invitational Database, human transcriptome db

    More...
    H-InvDBi
    HIX0201275
    HGNCiHGNC:25026 PLPP5
    HPAiHPA055777
    MIMi610626 gene
    neXtProtiNX_Q8NEB5
    OpenTargetsiENSG00000147535
    PharmGKBiPA142671154

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG3030 Eukaryota
    COG0671 LUCA
    GeneTreeiENSGT00940000159772
    HOGENOMiHOG000206608
    HOVERGENiHBG056764
    InParanoidiQ8NEB5
    KOiK18693
    OMAiEMWLYKF
    OrthoDBi1621899at2759
    PhylomeDBiQ8NEB5
    TreeFamiTF323722

    Enzyme and pathway databases

    BRENDAi3.1.3.4 2681
    3.1.3.81 2681
    ReactomeiR-HSA-2029485 Role of phospholipids in phagocytosis

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    PLPP5 human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    84513

    Protein Ontology

    More...
    PROi
    PR:Q8NEB5

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000147535 Expressed in 178 organ(s), highest expression level in body of pancreas
    ExpressionAtlasiQ8NEB5 baseline and differential
    GenevisibleiQ8NEB5 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR036938 P_Acid_Pase_2/haloperoxi_sf
    IPR000326 P_Acid_Pase_2/haloperoxidase
    IPR032462 PPAPDC1B
    PANTHERiPTHR10165:SF87 PTHR10165:SF87, 1 hit
    PfamiView protein in Pfam
    PF01569 PAP2, 1 hit
    SMARTiView protein in SMART
    SM00014 acidPPc, 1 hit
    SUPFAMiSSF48317 SSF48317, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLPP5_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NEB5
    Secondary accession number(s): C9JKF5, Q3KQX6, Q9BY45
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: November 30, 2010
    Last modified: February 13, 2019
    This is version 118 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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