PLPP5

Functionⁱ

Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma.2 Publications

Catalytic activityⁱ

A 1,2-diacylglycerol 3-phosphate + H₂O = a 1,2-diacyl-sn-glycerol + phosphate.1 Publication

Activity regulationⁱ

Inhibited by N-ethylmaleimide.1 Publication

Keywordsⁱ

Molecular function	Hydrolase

Molecular function

Hydrolase

Enzyme and pathway databases

BRENDAⁱ	3.1.3.4 2681 3.1.3.81 2681
Reactomeⁱ	R-HSA-2029485 Role of phospholipids in phagocytosis

Chemistry databases

SwissLipidsⁱ	SLP:000000604

SwissLipidsⁱ

SLP:000000604

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Phospholipid phosphatase 5Imported (EC:3.1.3.4) Alternative name(s): Phosphatidic acid phosphatase type 2 domain-containing protein 1B
Gene namesⁱ	Name:PLPP5Imported Synonyms:DPPL1, HTPAP, PPAPDC1B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000147535.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25026 PLPP5
MIMⁱ	610626 gene
neXtProtⁱ	NX_Q8NEB5

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	55 – 75	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	91 – 111	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	155 – 175	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	180 – 200	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	209 – 228	HelicalSequence analysisAdd BLAST	20

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	115	R → A: Loss of phosphatase activity; when associated with A-152 and with A-208. 1 Publication	1
Mutagenesisⁱ	152	H → A: Loss of phosphatase activity; when associated with A-115 and with A-208. 1 Publication	1
Mutagenesisⁱ	208	H → A: Loss of phosphatase activity; when associated with A-115 and with A-152. 1 Publication	1

Keywords - Diseaseⁱ

Tumor suppressor

Organism-specific databases

DisGeNET More...DisGeNETⁱ	84513
Open Targets More...OpenTargetsⁱ	ENSG00000147535
PharmGKBⁱ	PA142671154

Polymorphism and mutation databases

BioMutaⁱ	PPAPDC1B
DMDMⁱ	313104170

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000286945	1 – 264	Phospholipid phosphatase 5Add BLAST		264

Proteomic databases

EPDⁱ	Q8NEB5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8NEB5
PaxDbⁱ	Q8NEB5
PeptideAtlas More...PeptideAtlasⁱ	Q8NEB5
PRIDEⁱ	Q8NEB5
ProteomicsDBⁱ	73143 73144 [Q8NEB5-2] 73145 [Q8NEB5-3]

PTM databases

DEPODⁱ	Q8NEB5
iPTMnetⁱ	Q8NEB5
PhosphoSitePlusⁱ	Q8NEB5

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000147535 Expressed in 178 organ(s), highest expression level in body of pancreas
CleanExⁱ	HS_PPAPDC1B
ExpressionAtlasⁱ	Q8NEB5 baseline and differential
Genevisibleⁱ	Q8NEB5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA055777

HPAⁱ

HPA055777

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q8NEB5, 2 interactors
STRINGⁱ	9606.ENSP00000392553

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NEB5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	108 – 116	Phosphatase sequence motif I	9
Regionⁱ	149 – 152	Phosphatase sequence motif II	4
Regionⁱ	201 – 211	Phosphatase sequence motif IIIAdd BLAST	11

Sequence similaritiesⁱ

Belongs to the PA-phosphatase related phosphoesterase family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3030 Eukaryota COG0671 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046723
HOGENOMⁱ	HOG000206608
HOVERGENⁱ	HBG056764
InParanoidⁱ	Q8NEB5
KEGG Orthology (KO) More...KOⁱ	K18693
OMAⁱ	EMWLYKF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0O0I
PhylomeDBⁱ	Q8NEB5
TreeFamⁱ	TF323722

Family and domain databases

InterProⁱ	View protein in InterPro IPR036938 P_Acid_Pase_2/haloperoxi_sf IPR000326 P_Acid_Pase_2/haloperoxidase IPR032462 PPAPDC1B
PANTHERⁱ	PTHR10165:SF87 PTHR10165:SF87, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01569 PAP2, 1 hit
SMARTⁱ	View protein in SMART SM00014 acidPPc, 1 hit
SUPFAMⁱ	SSF48317 SSF48317, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8NEB5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKAAAAVAF GAEVGVRLAL FAAFLVTELL PPFQRLIQPE EMWLYRNPYV 
        60         70         80         90        100
EAEYFPTKPM FVIAFLSPLS LIFLAKFLKK ADTRDSRQAC LAASLALALN 
       110        120        130        140        150
GVFTNTIKLI VGRPRPDFFY RCFPDGLAHS DLMCTGDKDV VNEGRKSFPS 
       160        170        180        190        200
GHSSFAFAGL AFASFYLAGK LHCFTPQGRG KSWRFCAFLS PLLFAAVIAL 
       210        220        230        240        250
SRTCDYKHHW QDVLVGSMIG MTFAYVCYRQ YYPPLTDAEC HKPFQDKLVL 
       260 
STAQKPGDSY CFDI

Length:264

Mass (Da):29,484

Last modified:November 30, 2010 - v2

Checksum:ⁱ3682DA52B6F3C65B

GO

Isoform 2 (identifier: Q8NEB5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
212-216: DVLVG → GPFKW
217-264: Missing.

« Hide

        10         20         30         40         50
MGKAAAAVAF GAEVGVRLAL FAAFLVTELL PPFQRLIQPE EMWLYRNPYV 
        60         70         80         90        100
EAEYFPTKPM FVIAFLSPLS LIFLAKFLKK ADTRDSRQAC LAASLALALN 
       110        120        130        140        150
GVFTNTIKLI VGRPRPDFFY RCFPDGLAHS DLMCTGDKDV VNEGRKSFPS 
       160        170        180        190        200
GHSSFAFAGL AFASFYLAGK LHCFTPQGRG KSWRFCAFLS PLLFAAVIAL 
       210 
SRTCDYKHHW QGPFKW

Show »

Length:216

Mass (Da):24,091

Checksum:ⁱ64D0637A9E546E5A

GO

Isoform 3 (identifier: Q8NEB5-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-41: Missing.

« Hide

        10         20         30         40         50
MWLYRNPYVE AEYFPTKPMF VIAFLSPLSL IFLAKFLKKA DTRDSRQACL 
        60         70         80         90        100
AASLALALNG VFTNTIKLIV GRPRPDFFYR CFPDGLAHSD LMCTGDKDVV 
       110        120        130        140        150
NEGRKSFPSG HSSFAFAGLA FASFYLAGKL HCFTPQGRGK SWRFCAFLSP 
       160        170        180        190        200
LLFAAVIALS RTCDYKHHWQ DVLVGSMIGM TFAYVCYRQY YPPLTDAECH 
       210        220 
KPFQDKLVLS TAQKPGDSYC FDI

Show »

Length:223

Mass (Da):25,159

Checksum:ⁱ72B01C9A0DBBA1BA

GO

Isoform 4 (identifier: Q8NEB5-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
155-176: FAFAGLAFASFYLAGKLHCFTP → CMNIIWTLPYACFHIIEFNLES
177-264: Missing.

« Hide

        10         20         30         40         50
MGKAAAAVAF GAEVGVRLAL FAAFLVTELL PPFQRLIQPE EMWLYRNPYV 
        60         70         80         90        100
EAEYFPTKPM FVIAFLSPLS LIFLAKFLKK ADTRDSRQAC LAASLALALN 
       110        120        130        140        150
GVFTNTIKLI VGRPRPDFFY RCFPDGLAHS DLMCTGDKDV VNEGRKSFPS 
       160        170 
GHSSCMNIIW TLPYACFHII EFNLES

Note: No experimental confirmation available. Gene prediction based on EST data.

Show »

Length:176

Mass (Da):19,677

Checksum:ⁱC0D4D05D0E7BE789

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PNB1	E9PNB1_HUMAN	Phospholipid phosphatase 5 Phospholipid phosphatase 5	PLPP5	132	Annotation score:
H0YCK0	H0YCK0_HUMAN	Phospholipid phosphatase 5 Phospholipid phosphatase 5	PLPP5	244	Annotation score:
H0YCQ3	H0YCQ3_HUMAN	Phospholipid phosphatase 5 Phospholipid phosphatase 5	PLPP5	245	Annotation score:
H0YDY2	H0YDY2_HUMAN	Phospholipid phosphatase 5 Phospholipid phosphatase 5	PLPP5	60	Annotation score:

Sequence cautionⁱ

The sequence AAI06015 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAK14924 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_040055	1 – 41	Missing in isoform 3. 1 PublicationAdd BLAST	41
Alternative sequenceⁱVSP_054076	155 – 176	FAFAG…HCFTP → CMNIIWTLPYACFHIIEFNL ES in isoform 4. CuratedAdd BLAST	22
Alternative sequenceⁱVSP_054077	177 – 264	Missing in isoform 4. CuratedAdd BLAST	88
Alternative sequenceⁱVSP_025241	212 – 216	DVLVG → GPFKW in isoform 2. 2 Publications	5
Alternative sequenceⁱVSP_025242	217 – 264	Missing in isoform 2. 2 PublicationsAdd BLAST	48

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BD418664 mRNA No translation available. AC087362 Genomic DNA No translation available. BC033025 mRNA Translation: AAH33025.1 BC106014 mRNA Translation: AAI06015.2 Different initiation. AF212238 mRNA Translation: AAK14924.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47841.1 [Q8NEB5-1] CCDS47842.1 [Q8NEB5-2] CCDS47843.1 [Q8NEB5-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001096029.1, NM_001102559.1 [Q8NEB5-1] NP_001096030.1, NM_001102560.1 [Q8NEB5-4] NP_115872.2, NM_032483.3 [Q8NEB5-2] XP_011542973.1, XM_011544671.1 [Q8NEB5-3]
UniGeneⁱ	Hs.567619

Genome annotation databases

Ensemblⁱ	ENST00000419686; ENSP00000414522; ENSG00000147535 [Q8NEB5-4] ENST00000422581; ENSP00000390622; ENSG00000147535 [Q8NEB5-2] ENST00000424479; ENSP00000392553; ENSG00000147535 [Q8NEB5-1] ENST00000529359; ENSP00000434916; ENSG00000147535 [Q8NEB5-3]
GeneIDⁱ	84513
KEGGⁱ	hsa:84513
UCSC genome browser More...UCSCⁱ	uc003xle.5 human [Q8NEB5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8NEB5	Testicular secretory protein Li 38		HUMAN		264	UniRef100_Q8NEB5
PLPP5 isoform 3		PANTR		264
Uncharacterized protein		PANPA		264
Phospholipid phosphatase 5		GORGO		264
PLPP5 isoform 10		PANTR		223
+2
Q8NEB5-2	PLPP5 isoform 4		PANTR		216	UniRef100_H2QW16
Uncharacterized protein		MANLE		191
Uncharacterized protein		MACMU		216
Uncharacterized protein		COLAP		216
Uncharacterized protein		CERAT		216
+8
Q8NEB5-4	PLPP5 isoform 1		PANTR		176	UniRef100_K7CBM9

Protein	Similar proteins		Species	Score	Length	Source
Q8NEB5	Testicular secretory protein Li 38		HUMAN		264	UniRef90_Q8NEB5
PLPP5 isoform 3		PANTR		264
Uncharacterized protein		PANPA		264
Phospholipid phosphatase 5		GORGO		264
Uncharacterized protein		RHIBE		314
+75
Q8NEB5-4	Uncharacterized protein		PAPAN		177	UniRef90_A0A2I3LZ71
Uncharacterized protein		MANLE		151
PLPP5 isoform 1		PONAB		177
PLPP5 isoform 1		PANTR		176
Uncharacterized protein		COLAP		176
+10

Protein	Similar proteins		Species	Score	Length	Source
Q8NEB5	Phospholipid phosphatase 5		MOUSE		260	UniRef50_Q8NEB5
Testicular secretory protein Li 38		HUMAN		264
PLPP5 isoform 3		PANTR		264
Uncharacterized protein		PANPA		264
Phospholipid phosphatase 5		GORGO		264
+187
Q8NEB5-4	Uncharacterized protein		PAPAN		177	UniRef50_A0A2I3LZ71
Uncharacterized protein		MANLE		151
PLPP5 isoform 1		PONAB		177
Uncharacterized protein		AOTNA		176
Uncharacterized protein		COLAP		176
+15

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BD418664 mRNA No translation available. AC087362 Genomic DNA No translation available. BC033025 mRNA Translation: AAH33025.1 BC106014 mRNA Translation: AAI06015.2 Different initiation. AF212238 mRNA Translation: AAK14924.1 Different initiation.
CCDSⁱ	CCDS47841.1 [Q8NEB5-1] CCDS47842.1 [Q8NEB5-2] CCDS47843.1 [Q8NEB5-4]
RefSeqⁱ	NP_001096029.1, NM_001102559.1 [Q8NEB5-1] NP_001096030.1, NM_001102560.1 [Q8NEB5-4] NP_115872.2, NM_032483.3 [Q8NEB5-2] XP_011542973.1, XM_011544671.1 [Q8NEB5-3]
UniGeneⁱ	Hs.567619

3D structure databases

ProteinModelPortalⁱ	Q8NEB5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q8NEB5, 2 interactors
STRINGⁱ	9606.ENSP00000392553

Chemistry databases

SwissLipidsⁱ	SLP:000000604

SwissLipidsⁱ

SLP:000000604

PTM databases

DEPODⁱ	Q8NEB5
iPTMnetⁱ	Q8NEB5
PhosphoSitePlusⁱ	Q8NEB5

Polymorphism and mutation databases

BioMutaⁱ	PPAPDC1B
DMDMⁱ	313104170

Proteomic databases

EPDⁱ	Q8NEB5
MaxQBⁱ	Q8NEB5
PaxDbⁱ	Q8NEB5
PeptideAtlasⁱ	Q8NEB5
PRIDEⁱ	Q8NEB5
ProteomicsDBⁱ	73143 73144 [Q8NEB5-2] 73145 [Q8NEB5-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	84513
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000419686; ENSP00000414522; ENSG00000147535 [Q8NEB5-4] ENST00000422581; ENSP00000390622; ENSG00000147535 [Q8NEB5-2] ENST00000424479; ENSP00000392553; ENSG00000147535 [Q8NEB5-1] ENST00000529359; ENSP00000434916; ENSG00000147535 [Q8NEB5-3]
GeneIDⁱ	84513
KEGGⁱ	hsa:84513
UCSCⁱ	uc003xle.5 human [Q8NEB5-1]

Organism-specific databases

CTDⁱ	84513
DisGeNETⁱ	84513
EuPathDBⁱ	HostDB:ENSG00000147535.16
GeneCardsⁱ	PLPP5
H-InvDBⁱ	HIX0201275
HGNCⁱ	HGNC:25026 PLPP5
HPAⁱ	HPA055777
MIMⁱ	610626 gene
neXtProtⁱ	NX_Q8NEB5
OpenTargetsⁱ	ENSG00000147535
PharmGKBⁱ	PA142671154
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3030 Eukaryota COG0671 LUCA
GeneTreeⁱ	ENSGT00510000046723
HOGENOMⁱ	HOG000206608
HOVERGENⁱ	HBG056764
InParanoidⁱ	Q8NEB5
KOⁱ	K18693
OMAⁱ	EMWLYKF
OrthoDBⁱ	EOG091G0O0I
PhylomeDBⁱ	Q8NEB5
TreeFamⁱ	TF323722

Enzyme and pathway databases

BRENDAⁱ	3.1.3.4 2681 3.1.3.81 2681
Reactomeⁱ	R-HSA-2029485 Role of phospholipids in phagocytosis

Miscellaneous databases

ChiTaRSⁱ	PLPP5 human
GenomeRNAiⁱ	84513
Protein Ontology More...PROⁱ	PR:Q8NEB5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000147535 Expressed in 178 organ(s), highest expression level in body of pancreas
CleanExⁱ	HS_PPAPDC1B
ExpressionAtlasⁱ	Q8NEB5 baseline and differential
Genevisibleⁱ	Q8NEB5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036938 P_Acid_Pase_2/haloperoxi_sf IPR000326 P_Acid_Pase_2/haloperoxidase IPR032462 PPAPDC1B
PANTHERⁱ	PTHR10165:SF87 PTHR10165:SF87, 1 hit
Pfamⁱ	View protein in Pfam PF01569 PAP2, 1 hit
SMARTⁱ	View protein in SMART SM00014 acidPPc, 1 hit
SUPFAMⁱ	SSF48317 SSF48317, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PLPP5_HUMAN
Accessionⁱ	Q8NEB5Primary (citable) accession number: Q8NEB5 Secondary accession number(s): C9JKF5, Q3KQX6, Q9BY45
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
	Last sequence update:	November 30, 2010
	Last modified:	November 7, 2018
	This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM

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UniProtKB - Q8NEB5 (PLPP5_HUMAN)

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Phospholipid phosphatase 5

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

Kineticsⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ