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UniProtKB - Q8NEB5 (PLPP5_HUMAN)

Entry version 130 (10 Feb 2021)
Sequence version 2 (30 Nov 2010)
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Protein

Phospholipid phosphatase 5

Gene

PLPP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Magnesium-independent phospholipid phosphatase with broad substrate specificity (PubMed:17590538). Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate (PubMed:17590538). Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules (PubMed:17590538).1 Publication1 Publication

Miscellaneous

May be a metastatic suppressor for hepatocellular carcinoma.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Magnesium-independent phospholipid phosphatase (PubMed:17590538). Inhibited by N-ethylmaleimide (PubMed:17590538).1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=41 µM for 1,2-dioctanoyl-sn-glycero-3-diphosphate/diacylglycerol pyrophosphate1 Publication
  2. KM=277 µM for 1,2-dioctanoyl-sn-glycero-3-phosphate/phosphatidate1 Publication
  3. KM=295 µM for 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate/lysophosphatidate1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phospholipid metabolism

    This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.1 Publication
    View all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei152Proton donorsBy similarity1
    Active sitei208NucleophileBy similarity1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei212Stabilizes the active site histidine for nucleophilic attackBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    Biological processLipid metabolism

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		3.1.3.4, 2681
    3.1.3.81, 2681

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		Q8NEB5

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-2029485, Role of phospholipids in phagocytosis

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...    UniPathwayi    		UPA00085

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...    SwissLipidsi    		SLP:000000604

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Phospholipid phosphatase 5Imported (EC:3.1.3.41 Publication, EC:3.1.3.811 Publication)
    Alternative name(s):
    Phosphatidic acid phosphatase type 2 domain-containing protein 1BImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PLPP5Imported
    Synonyms:DPPL11 Publication, HTPAP1 Publication, PPAPDC1BImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:25026, PLPP5

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		610626, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_Q8NEB5

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...    VEuPathDBi    		HostDB:ENSG00000147535.16

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 5CytoplasmicCurated5
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
    Topological domaini27 – 54ExtracellularBy similarityAdd BLAST28
    Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
    Topological domaini76 – 90CytoplasmicBy similarityAdd BLAST15
    Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
    Topological domaini112 – 154ExtracellularBy similarityAdd BLAST43
    Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
    Topological domaini176 – 179CytoplasmicBy similarity4
    Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
    Topological domaini201 – 208ExtracellularBy similarity8
    Transmembranei209 – 228HelicalSequence analysisAdd BLAST20
    Topological domaini229 – 264CytoplasmicBy similarityAdd BLAST36

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi115R → A: Loss of phosphatase activity; when associated with A-152 and with A-208. 1 Publication1
    Mutagenesisi152H → A: Loss of phosphatase activity; when associated with A-115 and with A-208. 1 Publication1
    Mutagenesisi208H → A: Loss of phosphatase activity; when associated with A-115 and with A-152. 1 Publication1

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		84513

    Open Targets

    More...    OpenTargetsi    		ENSG00000147535

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA142671154

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		Q8NEB5, Tbio

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		PLPP5

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		313104170

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002869451 – 264Phospholipid phosphatase 5Add BLAST264

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		Q8NEB5

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		Q8NEB5

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		Q8NEB5

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		Q8NEB5

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q8NEB5

    PeptideAtlas

    More...    PeptideAtlasi    		Q8NEB5

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q8NEB5

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		10577
    73143 [Q8NEB5-1]
    73144 [Q8NEB5-2]
    73145 [Q8NEB5-3]

    PTM databases

    DEPOD human dephosphorylation database

    More...    DEPODi    		PLPP5

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q8NEB5

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q8NEB5

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000147535, Expressed in body of pancreas and 194 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		Q8NEB5, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q8NEB5, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000147535, Tissue enhanced (pancreas)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Hide details

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		124107, 3 interactors

    Protein interaction database and analysis system

    More...    IntActi    		Q8NEB5, 3 interactors

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000392553

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		Q8NEB5, protein

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni108 – 116Phosphatase sequence motif I1 Publication9
    Regioni149 – 152Phosphatase sequence motif II1 Publication4
    Regioni201 – 211Phosphatase sequence motif III1 PublicationAdd BLAST11

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the PA-phosphatase related phosphoesterase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG3030, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000159772

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q8NEB5

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		SWAWTLA

    Database of Orthologous Groups

    More...    OrthoDBi    		1621899at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q8NEB5

    TreeFam database of animal gene trees

    More...    TreeFami    		TF323722

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR036938, P_Acid_Pase_2/haloperoxi_sf
    IPR000326, P_Acid_Pase_2/haloperoxidase
    IPR043216, PLPP
    IPR028668, PLPP4/5

    The PANTHER Classification System

    More...    PANTHERi    		PTHR10165, PTHR10165, 1 hit
    PTHR10165:SF87, PTHR10165:SF87, 1 hit

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF01569, PAP2, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...    SMARTi    		View protein in SMART
    SM00014, acidPPc, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF48317, SSF48317, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q8NEB5-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MGKAAAAVAF GAEVGVRLAL FAAFLVTELL PPFQRLIQPE EMWLYRNPYV 
            60         70         80         90        100
    EAEYFPTKPM FVIAFLSPLS LIFLAKFLKK ADTRDSRQAC LAASLALALN 
           110        120        130        140        150
    GVFTNTIKLI VGRPRPDFFY RCFPDGLAHS DLMCTGDKDV VNEGRKSFPS 
           160        170        180        190        200
    GHSSFAFAGL AFASFYLAGK LHCFTPQGRG KSWRFCAFLS PLLFAAVIAL 
           210        220        230        240        250
    SRTCDYKHHW QDVLVGSMIG MTFAYVCYRQ YYPPLTDAEC HKPFQDKLVL 
           260 
    STAQKPGDSY CFDI
    Length:264
    Mass (Da):29,484
    Last modified:November 30, 2010 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3682DA52B6F3C65B
    GO
    Isoform 2 (identifier: Q8NEB5-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         212-216: DVLVG → GPFKW
         217-264: Missing.

    Show »
    Length:216
    Mass (Da):24,091
    Checksum:i64D0637A9E546E5A
    GO
    Isoform 3 (identifier: Q8NEB5-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-41: Missing.

    Show »
    Length:223
    Mass (Da):25,159
    Checksum:i72B01C9A0DBBA1BA
    GO
    Isoform 4 (identifier: Q8NEB5-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         155-176: FAFAGLAFASFYLAGKLHCFTP → CMNIIWTLPYACFHIIEFNLES
         177-264: Missing.

    Show »
    Length:176
    Mass (Da):19,677
    Checksum:iC0D4D05D0E7BE789
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    E9PNB1E9PNB1_HUMAN
    Phospholipid phosphatase 5
    PLPP5
    		132Annotation score:

    Annotation score:3 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YCQ3H0YCQ3_HUMAN
    Phospholipid phosphatase 5
    PLPP5
    		245Annotation score:

    Annotation score:3 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YCK0H0YCK0_HUMAN
    Phospholipid phosphatase 5
    PLPP5
    		244Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YDY2H0YDY2_HUMAN
    Phospholipid phosphatase 5
    PLPP5
    		60Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAI06015 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
    The sequence AAK14924 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0400551 – 41Missing in isoform 3. 1 PublicationAdd BLAST41
    Alternative sequenceiVSP_054076155 – 176FAFAG…HCFTP → CMNIIWTLPYACFHIIEFNL ES in isoform 4. CuratedAdd BLAST22
    Alternative sequenceiVSP_054077177 – 264Missing in isoform 4. CuratedAdd BLAST88
    Alternative sequenceiVSP_025241212 – 216DVLVG → GPFKW in isoform 2. 2 Publications5
    Alternative sequenceiVSP_025242217 – 264Missing in isoform 2. 2 PublicationsAdd BLAST48

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		BD418664 mRNA No translation available.
    AC087362 Genomic DNA No translation available.
    BC033025 mRNA Translation: AAH33025.1
    BC106014 mRNA Translation: AAI06015.2 Different initiation.
    AF212238 mRNA Translation: AAK14924.1 Different initiation.

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS47841.1 [Q8NEB5-1]
    CCDS47842.1 [Q8NEB5-2]
    CCDS47843.1 [Q8NEB5-4]

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001096029.1, NM_001102559.1 [Q8NEB5-1]
    NP_001096030.1, NM_001102560.1 [Q8NEB5-4]
    NP_115872.2, NM_032483.3 [Q8NEB5-2]
    XP_011542973.1, XM_011544671.1 [Q8NEB5-3]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000419686; ENSP00000414522; ENSG00000147535 [Q8NEB5-4]
    ENST00000422581; ENSP00000390622; ENSG00000147535 [Q8NEB5-2]
    ENST00000424479; ENSP00000392553; ENSG00000147535 [Q8NEB5-1]
    ENST00000529359; ENSP00000434916; ENSG00000147535 [Q8NEB5-3]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		84513

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:84513

    UCSC genome browser

    More...    UCSCi    		uc003xle.5, human [Q8NEB5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		BD418664 mRNA No translation available.
    AC087362 Genomic DNA No translation available.
    BC033025 mRNA Translation: AAH33025.1
    BC106014 mRNA Translation: AAI06015.2 Different initiation.
    AF212238 mRNA Translation: AAK14924.1 Different initiation.
    CCDSiCCDS47841.1 [Q8NEB5-1]
    CCDS47842.1 [Q8NEB5-2]
    CCDS47843.1 [Q8NEB5-4]
    RefSeqiNP_001096029.1, NM_001102559.1 [Q8NEB5-1]
    NP_001096030.1, NM_001102560.1 [Q8NEB5-4]
    NP_115872.2, NM_032483.3 [Q8NEB5-2]
    XP_011542973.1, XM_011544671.1 [Q8NEB5-3]

    3D structure databases

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    SWISS-MODEL Interactive Workspace

    More...    SWISS-MODEL-Workspacei    		Submit a new modelling project...

    Protein-protein interaction databases

    BioGRIDi124107, 3 interactors
    IntActiQ8NEB5, 3 interactors
    STRINGi9606.ENSP00000392553

    Chemistry databases

    SwissLipidsiSLP:000000604

    PTM databases

    DEPODiPLPP5
    iPTMnetiQ8NEB5
    PhosphoSitePlusiQ8NEB5

    Genetic variation databases

    BioMutaiPLPP5
    DMDMi313104170

    Proteomic databases

    EPDiQ8NEB5
    jPOSTiQ8NEB5
    MassIVEiQ8NEB5
    MaxQBiQ8NEB5
    PaxDbiQ8NEB5
    PeptideAtlasiQ8NEB5
    PRIDEiQ8NEB5
    ProteomicsDBi10577
    73143 [Q8NEB5-1]
    73144 [Q8NEB5-2]
    73145 [Q8NEB5-3]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		23567, 98 antibodies

    The DNASU plasmid repository

    More...    DNASUi    		84513

    Genome annotation databases

    EnsembliENST00000419686; ENSP00000414522; ENSG00000147535 [Q8NEB5-4]
    ENST00000422581; ENSP00000390622; ENSG00000147535 [Q8NEB5-2]
    ENST00000424479; ENSP00000392553; ENSG00000147535 [Q8NEB5-1]
    ENST00000529359; ENSP00000434916; ENSG00000147535 [Q8NEB5-3]
    GeneIDi84513
    KEGGihsa:84513
    UCSCiuc003xle.5, human [Q8NEB5-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		84513
    DisGeNETi84513

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		PLPP5
    HGNCiHGNC:25026, PLPP5
    HPAiENSG00000147535, Tissue enhanced (pancreas)
    MIMi610626, gene
    neXtProtiNX_Q8NEB5
    OpenTargetsiENSG00000147535
    PharmGKBiPA142671154
    VEuPathDBiHostDB:ENSG00000147535.16

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG3030, Eukaryota
    GeneTreeiENSGT00940000159772
    InParanoidiQ8NEB5
    OMAiSWAWTLA
    OrthoDBi1621899at2759
    PhylomeDBiQ8NEB5
    TreeFamiTF323722

    Enzyme and pathway databases

    UniPathwayiUPA00085
    BRENDAi3.1.3.4, 2681
    3.1.3.81, 2681
    PathwayCommonsiQ8NEB5
    ReactomeiR-HSA-2029485, Role of phospholipids in phagocytosis

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		84513, 6 hits in 870 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		PLPP5, human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		84513
    PharosiQ8NEB5, Tbio

    Protein Ontology

    More...    PROi    		PR:Q8NEB5
    RNActiQ8NEB5, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000147535, Expressed in body of pancreas and 194 other tissues
    ExpressionAtlasiQ8NEB5, baseline and differential
    GenevisibleiQ8NEB5, HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR036938, P_Acid_Pase_2/haloperoxi_sf
    IPR000326, P_Acid_Pase_2/haloperoxidase
    IPR043216, PLPP
    IPR028668, PLPP4/5
    PANTHERiPTHR10165, PTHR10165, 1 hit
    PTHR10165:SF87, PTHR10165:SF87, 1 hit
    PfamiView protein in Pfam
    PF01569, PAP2, 1 hit
    SMARTiView protein in SMART
    SM00014, acidPPc, 1 hit
    SUPFAMiSSF48317, SSF48317, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLPP5_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NEB5
    Secondary accession number(s): C9JKF5, Q3KQX6, Q9BY45
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: November 30, 2010
    Last modified: February 10, 2021
    This is version 130 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families
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