UniProtKB - Q8NEA9 (GMCL2_HUMAN)
Protein
Germ cell-less protein-like 2
Gene
GMCL2
Organism
Homo sapiens (Human)
Status
Functioni
Possible function in spermatogenesis. Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312).By similarity1 Publication
Miscellaneous
According to some authors, GMCL2 is a GMCL retrogene on chromosome 5 which is likely to be functional.1 Publication
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.1 PublicationView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Molecular functioni
- cullin family protein binding Source: UniProtKB
GO - Biological processi
- germ cell development Source: InterPro
- multicellular organism development Source: UniProtKB-KW
- protein ubiquitination Source: UniProtKB-UniPathway
- spermatogenesis Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Spermatogenesis, Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q8NEA9 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Germ cell-less protein-like 2CuratedAlternative name(s): Germ cell-less protein-like 1-like |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19717, GMCL2 |
MIMi | 618629, gene |
neXtProti | NX_Q8NEA9 |
Subcellular locationi
Nucleus
- Nucleus matrix By similarity
Nucleus
- nuclear matrix Source: UniProtKB-SubCell
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Miscellaneous databases
Pharosi | Q8NEA9, Tdark |
Polymorphism and mutation databases
BioMutai | HGNC:19717 |
DMDMi | 47605713 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000087523 | 1 – 526 | Germ cell-less protein-like 2Add BLAST | 526 |
Proteomic databases
MassIVEi | Q8NEA9 |
PeptideAtlasi | Q8NEA9 |
PRIDEi | Q8NEA9 |
ProteomicsDBi | 73142 |
PTM databases
iPTMneti | Q8NEA9 |
PhosphoSitePlusi | Q8NEA9 |
Expressioni
Tissue specificityi
Expressed predominantly in testis.1 Publication
Interactioni
Subunit structurei
Interacts with CUL3.
1 PublicationBinary interactionsi
Hide detailsQ8NEA9
GO - Molecular functioni
- cullin family protein binding Source: UniProtKB
Protein-protein interaction databases
IntActi | Q8NEA9, 21 interactors |
Miscellaneous databases
RNActi | Q8NEA9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 108 – 178 | BTBPROSITE-ProRule annotationAdd BLAST | 71 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 49 – 55 | Nuclear localization signalSequence analysis | 7 | |
Motifi | 85 – 91 | Nuclear localization signalSequence analysis | 7 |
Phylogenomic databases
GeneTreei | ENSGT00940000156185 |
InParanoidi | Q8NEA9 |
PhylomeDBi | Q8NEA9 |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR043380, Gcl-like IPR011333, SKP1/BTB/POZ_sf |
PANTHERi | PTHR23231, PTHR23231, 1 hit |
Pfami | View protein in Pfam PF00651, BTB, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NEA9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSSSSRVLG QPRRALAQQE QGARARGSAR RPDTGDDAAS YGFCYCPGSH
60 70 80 90 100
KRKRSSGACR YCDPDSHREE HEEEGDKQQP LLNTPARKKL RSTSKYIYQT
110 120 130 140 150
LFLNGENSDI KICALGEEWR LHKIYLCQSG YFSSMFSGSW KESSMNIIEL
160 170 180 190 200
EIPDQNIDVD ALQVAFGSLY RDDVLIKPSR VVAILAAACM LQLDGLIQQC
210 220 230 240 250
GETMKETINV KTVCGYYTSV EIYGLDSVKK KCLEWLLNNL MTHQNVKLFK
260 270 280 290 300
ELGINVMKQL IGSSNLFVMQ VEMDVYTTLK KWMFLQLVPS WNGSLKQLLT
310 320 330 340 350
ETDVWFSKQR KDFEGMAFLE TEPGKPFVSV FRHLRLQYII SDLASARIIE
360 370 380 390 400
QDGIVPSEWL SSVYKQQWFA MLRAEQDREV GPQEINKEDL EGNSMRCGRK
410 420 430 440 450
LAKDGEYYWC WTGFNFGFDL LVIYTNGYII FKRNTLNQPR SGSVSLRPRR
460 470 480 490 500
SIAFRLRLAS FDSSGKLVCS RTTGYQILIL KKDQEQVVMN LDSRFLTFPL
510 520
YICCNFLYIS PEKGIENNRH PENPEN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 40 | S → G in ABB92410 (PubMed:16201836).Curated | 1 | |
Sequence conflicti | 47 | P → Q in BC024184 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 230 | K → E in BC024184 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 230 | K → E in BC024185 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 378 | R → H in BAG38063 (PubMed:14702039). | 1 | |
Sequence conflicti | 378 | R → H in BC024184 (PubMed:15489334). | 1 | |
Sequence conflicti | 378 | R → H in BC024185 (PubMed:15489334). | 1 | |
Sequence conflicti | 378 | R → H in BC033886 (PubMed:15489334). | 1 | |
Sequence conflicti | 393 | N → S in BAG38063 (PubMed:14702039). | 1 | |
Sequence conflicti | 393 | N → S in BC024184 (PubMed:15489334). | 1 | |
Sequence conflicti | 393 | N → S in BC024185 (PubMed:15489334). | 1 | |
Sequence conflicti | 393 | N → S in BC033886 (PubMed:15489334). | 1 | |
Sequence conflicti | 393 | N → S in ABB92410 (PubMed:16201836). | 1 | |
Sequence conflicti | 440 | R → C in BAG38063 (PubMed:14702039). | 1 | |
Sequence conflicti | 440 | R → C in BC024184 (PubMed:15489334). | 1 | |
Sequence conflicti | 440 | R → C in BC024185 (PubMed:15489334). | 1 | |
Sequence conflicti | 440 | R → C in BC033886 (PubMed:15489334). | 1 | |
Sequence conflicti | 440 | R → C in ABB92410 (PubMed:16201836). | 1 | |
Sequence conflicti | 523 | N → D in BAG38063 (PubMed:14702039). | 1 | |
Sequence conflicti | 523 | N → D in BC024184 (PubMed:15489334). | 1 | |
Sequence conflicti | 523 | N → D in BC024185 (PubMed:15489334). | 1 | |
Sequence conflicti | 523 | N → D in BC033886 (PubMed:15489334). | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035924 | 275 | V → A in a colorectal cancer sample; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK315701 mRNA Translation: BAG38063.1 AC136632 Genomic DNA No translation available. BC024184 mRNA No translation available. BC024185 mRNA No translation available. BC033886 mRNA No translation available. DQ120624 Genomic DNA Translation: ABB92410.1 |
Genome annotation databases
Ensembli | ENST00000463439; ENSP00000497178; ENSG00000244234 |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK315701 mRNA Translation: BAG38063.1 AC136632 Genomic DNA No translation available. BC024184 mRNA No translation available. BC024185 mRNA No translation available. BC033886 mRNA No translation available. DQ120624 Genomic DNA Translation: ABB92410.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q8NEA9, 21 interactors |
PTM databases
iPTMneti | Q8NEA9 |
PhosphoSitePlusi | Q8NEA9 |
Polymorphism and mutation databases
BioMutai | HGNC:19717 |
DMDMi | 47605713 |
Proteomic databases
MassIVEi | Q8NEA9 |
PeptideAtlasi | Q8NEA9 |
PRIDEi | Q8NEA9 |
ProteomicsDBi | 73142 |
Protocols and materials databases
Antibodypediai | 79002, 24 antibodies |
Genome annotation databases
Ensembli | ENST00000463439; ENSP00000497178; ENSG00000244234 |
Organism-specific databases
GeneCardsi | GMCL2 |
HGNCi | HGNC:19717, GMCL2 |
MIMi | 618629, gene |
neXtProti | NX_Q8NEA9 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156185 |
InParanoidi | Q8NEA9 |
PhylomeDBi | Q8NEA9 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q8NEA9 |
Miscellaneous databases
Pharosi | Q8NEA9, Tdark |
PROi | PR:Q8NEA9 |
RNActi | Q8NEA9, protein |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR043380, Gcl-like IPR011333, SKP1/BTB/POZ_sf |
PANTHERi | PTHR23231, PTHR23231, 1 hit |
Pfami | View protein in Pfam PF00651, BTB, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GMCL2_HUMAN | |
Accessioni | Q8NEA9Primary (citable) accession number: Q8NEA9 Secondary accession number(s): B2RDW6 Q8TC89 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2004 |
Last sequence update: | February 28, 2018 | |
Last modified: | August 12, 2020 | |
This is version 142 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations