UniProtKB - Q8NEA6 (GLIS3_HUMAN)

BLAST

>sp|Q8NEA6|GLIS3_HUMAN Zinc finger protein GLIS3 OS=Homo sapiens OX=9606 GN=GLIS3 PE=2 SV=5
MMVQRLGLISPPASQVSTACNQISPSLQRAMNAANLNIPPSDTRSLISRESLASTTLSLT
ESQSASSMKQEWSQGYRALPSLSNHGSQNGLDLGDLLSLPPGTSMSSNSVSNSLPSYLFG
TESSHSPYPSPRHSSTRSHSARSKKRALSLSPLSDGIGIDFNTIIRTSPTSLVAYINGSR
ASPANLSPQPEVYGHFLGVRGSCIPQPRPVPGSQKGVLVAPGGLALPAYGEDGALEHERM
QQLEHGGLQPGLVNHMVVQHGLPGPDSQSAGLFKTERLEEFPGSTVDLPPAPPLPPLPPP
PGPPPPYHAHAHLHHPELGPHAQQLALPQATLDDDGEMDGIGGKHCCRWIDCSALYDQQE
ELVRHIEKVHIDQRKGEDFTCFWAGCPRRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCE
KAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCT
KRYTDPSSLRKHVKAHSSKEQQARKKLRSSTELHPDLLTDCLTVQSLQPATSPRDAAAEG
TVGRSPGPGPDLYSAPIFSSNYSSRSGTAAGAVPPPHPVSHPSPGHNVQGSPHNPSSQLP
PLTAVDAGAERFAPSAPSPHHISPRRVPAPSSILQRTQPPYTQQPSGSHLKSYQPETNSS
FQPNGIHVHGFYGQLQKFCPPHYPDSQRIVPPVSSCSVVPSFEDCLVPTSMGQASFDVFH
RAFSTHSGITVYDLPSSSSSLFGESLRSGAEDATFLQISTVDRCPSQLSSVYTEG

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History
Entry version 139 (07 Nov 2018)
Sequence version 5 (08 Feb 2011)
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Protein

Zinc finger protein GLIS3

Gene

GLIS3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	345 – 370	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	26
Zinc fingerⁱ	379 – 406	C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST	28
Zinc fingerⁱ	412 – 436	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	442 – 466	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	472 – 496	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of transcription by RNA polymerase II Source: UniProtKB
positive regulation of transcription by RNA polymerase II Source: UniProtKB
transcription by RNA polymerase II Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

SIGNORⁱ	Q8NEA6

SIGNORⁱ

Q8NEA6

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein GLIS3 Alternative name(s): GLI-similar 3 Zinc finger protein 515
Gene namesⁱ	Name:GLIS3 Synonyms:ZNF515
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000107249.21
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28510 GLIS3
MIMⁱ	610192 gene
neXtProtⁱ	NX_Q8NEA6

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Diabetes mellitus, neonatal, with congenital hypothyroidism (NDH)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA syndrome of neonatal diabetes syndrome associated with congenital hypothyroidism, congenital glaucoma, hepatic fibrosis and polycystic kidneys.

Keywords - Diseaseⁱ

Congenital hypothyroidism

Organism-specific databases

DisGeNET More...DisGeNETⁱ	169792
MalaCards human disease database More...MalaCardsⁱ	GLIS3
MIMⁱ	610199 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000107249
Orphanetⁱ	79118 Neonatal diabetes-congenital hypothyroidism-congenital glaucoma-hepatic fibrosis-polycystic kidneys syndrome
PharmGKBⁱ	PA134878768

Polymorphism and mutation databases

BioMutaⁱ	GLIS3
DMDMⁱ	322510143

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047211	1 – 775	Zinc finger protein GLIS3Add BLAST		775

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8NEA6
PaxDbⁱ	Q8NEA6
PeptideAtlas More...PeptideAtlasⁱ	Q8NEA6
PRIDEⁱ	Q8NEA6
ProteomicsDBⁱ	73140 73141 [Q8NEA6-2]

PTM databases

iPTMnetⁱ	Q8NEA6
PhosphoSitePlusⁱ	Q8NEA6

Expressionⁱ

Tissue specificityⁱ

In the adult, expressed at high levels in the kidney and at lower levels in the brain, skeletal muscle, pancreas, liver, lung, thymus and ovary.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000107249 Expressed in 156 organ(s), highest expression level in buccal mucosa cell
CleanExⁱ	HS_GLIS3
ExpressionAtlasⁱ	Q8NEA6 baseline and differential
Genevisibleⁱ	Q8NEA6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA056426

HPAⁱ

HPA056426

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	127988, 19 interactors
CORUMⁱ	Q8NEA6
IntActⁱ	Q8NEA6, 7 interactors
STRINGⁱ	9606.ENSP00000371398

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NEA6
SMRⁱ	Q8NEA6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	491 – 507	Bipartite nuclear localization signalSequence analysisAdd BLAST		17

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	41 – 154	Ser-richAdd BLAST		114
Compositional biasⁱ	289 – 306	Pro-richAdd BLAST		18

Sequence similaritiesⁱ

Belongs to the GLI C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	345 – 370	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	26
Zinc fingerⁱ	379 – 406	C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST	28
Zinc fingerⁱ	412 – 436	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	442 – 466	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	472 – 496	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	25

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140802
HOGENOMⁱ	HOG000231136
HOVERGENⁱ	HBG107950
InParanoidⁱ	Q8NEA6
KEGG Orthology (KO) More...KOⁱ	K09232
OMAⁱ	HIQGFYG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IZP
PhylomeDBⁱ	Q8NEA6
TreeFamⁱ	TF350216

Family and domain databases

InterProⁱ	View protein in InterPro IPR030405 GLIS3 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR19818:SF123 PTHR19818:SF123, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8NEA6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMVQRLGLIS PPASQVSTAC NQISPSLQRA MNAANLNIPP SDTRSLISRE 
        60         70         80         90        100
SLASTTLSLT ESQSASSMKQ EWSQGYRALP SLSNHGSQNG LDLGDLLSLP 
       110        120        130        140        150
PGTSMSSNSV SNSLPSYLFG TESSHSPYPS PRHSSTRSHS ARSKKRALSL 
       160        170        180        190        200
SPLSDGIGID FNTIIRTSPT SLVAYINGSR ASPANLSPQP EVYGHFLGVR 
       210        220        230        240        250
GSCIPQPRPV PGSQKGVLVA PGGLALPAYG EDGALEHERM QQLEHGGLQP 
       260        270        280        290        300
GLVNHMVVQH GLPGPDSQSA GLFKTERLEE FPGSTVDLPP APPLPPLPPP 
       310        320        330        340        350
PGPPPPYHAH AHLHHPELGP HAQQLALPQA TLDDDGEMDG IGGKHCCRWI 
       360        370        380        390        400
DCSALYDQQE ELVRHIEKVH IDQRKGEDFT CFWAGCPRRY KPFNARYKLL 
       410        420        430        440        450
IHMRVHSGEK PNKCTFEGCE KAFSRLENLK IHLRSHTGEK PYLCQHPGCQ 
       460        470        480        490        500
KAFSNSSDRA KHQRTHLDTK PYACQIPGCT KRYTDPSSLR KHVKAHSSKE 
       510        520        530        540        550
QQARKKLRSS TELHPDLLTD CLTVQSLQPA TSPRDAAAEG TVGRSPGPGP 
       560        570        580        590        600
DLYSAPIFSS NYSSRSGTAA GAVPPPHPVS HPSPGHNVQG SPHNPSSQLP 
       610        620        630        640        650
PLTAVDAGAE RFAPSAPSPH HISPRRVPAP SSILQRTQPP YTQQPSGSHL 
       660        670        680        690        700
KSYQPETNSS FQPNGIHVHG FYGQLQKFCP PHYPDSQRIV PPVSSCSVVP 
       710        720        730        740        750
SFEDCLVPTS MGQASFDVFH RAFSTHSGIT VYDLPSSSSS LFGESLRSGA 
       760        770 
EDATFLQIST VDRCPSQLSS VYTEG

Length:775

Mass (Da):83,636

Last modified:February 8, 2011 - v5

Checksum:ⁱ1C8519AFCDF6C813

Isoform 2 (identifier: Q8NEA6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MNGRSCSMSL...NNLVVTSSPM

« Hide

        10         20         30         40         50
MNGRSCSMSL HRTSGTPQGP RMVSGHHIPA IRAHSGTPGP SPCGSTSSPT 
        60         70         80         90        100
MASLANNLHL KMPSGGGMAP QNNVAESRIH LPALSPRRQM LTNGKPRFQV 
       110        120        130        140        150
TQAGGMSGSH TLKPKQQEFG SPFPPNPGKG ALGFGPQCKS IGKGSCNNLV 
       160        170        180        190        200
VTSSPMMVQR LGLISPPASQ VSTACNQISP SLQRAMNAAN LNIPPSDTRS 
       210        220        230        240        250
LISRESLAST TLSLTESQSA SSMKQEWSQG YRALPSLSNH GSQNGLDLGD 
       260        270        280        290        300
LLSLPPGTSM SSNSVSNSLP SYLFGTESSH SPYPSPRHSS TRSHSARSKK 
       310        320        330        340        350
RALSLSPLSD GIGIDFNTII RTSPTSLVAY INGSRASPAN LSPQPEVYGH 
       360        370        380        390        400
FLGVRGSCIP QPRPVPGSQK GVLVAPGGLA LPAYGEDGAL EHERMQQLEH 
       410        420        430        440        450
GGLQPGLVNH MVVQHGLPGP DSQSAGLFKT ERLEEFPGST VDLPPAPPLP 
       460        470        480        490        500
PLPPPPGPPP PYHAHAHLHH PELGPHAQQL ALPQATLDDD GEMDGIGGKH 
       510        520        530        540        550
CCRWIDCSAL YDQQEELVRH IEKVHIDQRK GEDFTCFWAG CPRRYKPFNA 
       560        570        580        590        600
RYKLLIHMRV HSGEKPNKCT FEGCEKAFSR LENLKIHLRS HTGEKPYLCQ 
       610        620        630        640        650
HPGCQKAFSN SSDRAKHQRT HLDTKPYACQ IPGCTKRYTD PSSLRKHVKA 
       660        670        680        690        700
HSSKEQQARK KLRSSTELHP DLLTDCLTVQ SLQPATSPRD AAAEGTVGRS 
       710        720        730        740        750
PGPGPDLYSA PIFSSNYSSR SGTAAGAVPP PHPVSHPSPG HNVQGSPHNP 
       760        770        780        790        800
SSQLPPLTAV DAGAERFAPS APSPHHISPR RVPAPSSILQ RTQPPYTQQP 
       810        820        830        840        850
SGSHLKSYQP ETNSSFQPNG IHVHGFYGQL QKFCPPHYPD SQRIVPPVSS 
       860        870        880        890        900
CSVVPSFEDC LVPTSMGQAS FDVFHRAFST HSGITVYDLP SSSSSLFGES 
       910        920        930
LRSGAEDATF LQISTVDRCP SQLSSVYTEG

Show »

Length:930

Mass (Da):99,605

Checksum:ⁱB31E78045EB5C953

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q1PHJ8	Q1PHJ8_HUMAN	GLIS family zinc finger 3 transcrip... GLIS family zinc finger 3 transcript variant TS2 (GLIS family zinc finger 3 transcript variant TS3) (GLIS family zinc finger 3 transcript variant TS4) (GLIS family zinc finger 3 transcript variant TS5) (Zinc finger protein GLIS3)	GLIS3	244	Annotation score:
Q1PHJ2	Q1PHJ2_HUMAN	GLIS family zinc finger 3 transcrip... GLIS family zinc finger 3 transcript variant TS10 (GLIS family zinc finger 3 transcript variant TS11) (GLIS family zinc finger 3 transcript variant TS7) (GLIS family zinc finger 3 transcript variant TS8) (GLIS family zinc finger 3 transcript variant TS9) (Zinc finger protein GLIS3)	GLIS3	89	Annotation score:
F8WEV9	F8WEV9_HUMAN	Zinc finger protein GLIS3 Zinc finger protein GLIS3	GLIS3	142	Annotation score:
A0A2R8YEK9	A0A2R8YEK9_HUMAN	Zinc finger protein GLIS3 Zinc finger protein GLIS3	GLIS3	56	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	347	C → Y in AAH33899 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_047148	269	S → P1 PublicationCorresponds to variant dbSNP:rs806052EnsemblClinVar.	1
Natural variantⁱVAR_031062	301	P → Q1 PublicationCorresponds to variant dbSNP:rs6415788EnsemblClinVar.	1
Natural variantⁱVAR_047149	578	P → L. Corresponds to variant dbSNP:rs10973986Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_038299	1	M → MNGRSCSMSLHRTSGTPQGP RMVSGHHIPAIRAHSGTPGP SPCGSTSSPTMASLANNLHL KMPSGGGMAPQNNVAESRIH LPALSPRRQMLTNGKPRFQV TQAGGMSGSHTLKPKQQEFG SPFPPNPGKGALGFGPQCKS IGKGSCNNLVVTSSPM in isoform 2. Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL158012 Genomic DNA No translation available. AL133283 Genomic DNA No translation available. AL137071 Genomic DNA No translation available. BC033899 mRNA Translation: AAH33899.2 DQ438877 mRNA Translation: ABE66434.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43784.1 [Q8NEA6-2] CCDS6451.1 [Q8NEA6-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001035878.1, NM_001042413.1 [Q8NEA6-2] NP_689842.3, NM_152629.3 [Q8NEA6-1] XP_005251443.1, XM_005251386.4 [Q8NEA6-1] XP_011516065.1, XM_011517763.2 [Q8NEA6-2] XP_011516066.1, XM_011517764.2 [Q8NEA6-2] XP_011516068.1, XM_011517766.2 [Q8NEA6-1] XP_016869850.1, XM_017014361.1 [Q8NEA6-1]
UniGeneⁱ	Hs.162125 Hs.644570

Genome annotation databases

Ensemblⁱ	ENST00000324333; ENSP00000325494; ENSG00000107249 [Q8NEA6-1] ENST00000381971; ENSP00000371398; ENSG00000107249 [Q8NEA6-2]
GeneIDⁱ	169792
KEGGⁱ	hsa:169792
UCSC genome browser More...UCSCⁱ	uc003zhw.2 human [Q8NEA6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8NEA6	Isoform 2 of Zinc finger protein GLIS3		HUMAN		930	UniRef100_Q8NEA6
GLIS family zinc finger 3 isoform 1 (Fragment)		HUMAN		775
GLIS family zinc finger 3 transcript variant TS6 (Fragment)		HUMAN		194
GLIS family zinc finger 3 transcript variant TS1		HUMAN		438
GLIS family zinc finger 3 transcript variant TS2 (Fragment)		HUMAN		244
+1

Protein	Similar proteins		Species	Score	Length	Source
Q8NEA6	Isoform 2 of Zinc finger protein GLIS3		HUMAN		930	UniRef90_Q8NEA6
Uncharacterized protein		SHEEP		932
zinc finger protein GLIS3 isoform X1		DELLE		931
zinc finger protein GLIS3 isoform X1		TARSY		931
Uncharacterized protein		OTOGA		931
+44

Protein	Similar proteins		Species	Score	Length	Source
Q8NEA6	Zinc finger protein GLIS3		MOUSE		780	UniRef50_Q6XP49
GLIS family zinc finger 3		RAT		935
Uncharacterized protein (Fragment)		NEOLE		91
GLIS family zinc finger 3 isoform 2		HUMAN		738
Uncharacterized protein		PAPAN		838
+336

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL158012 Genomic DNA No translation available. AL133283 Genomic DNA No translation available. AL137071 Genomic DNA No translation available. BC033899 mRNA Translation: AAH33899.2 DQ438877 mRNA Translation: ABE66434.1
CCDSⁱ	CCDS43784.1 [Q8NEA6-2] CCDS6451.1 [Q8NEA6-1]
RefSeqⁱ	NP_001035878.1, NM_001042413.1 [Q8NEA6-2] NP_689842.3, NM_152629.3 [Q8NEA6-1] XP_005251443.1, XM_005251386.4 [Q8NEA6-1] XP_011516065.1, XM_011517763.2 [Q8NEA6-2] XP_011516066.1, XM_011517764.2 [Q8NEA6-2] XP_011516068.1, XM_011517766.2 [Q8NEA6-1] XP_016869850.1, XM_017014361.1 [Q8NEA6-1]
UniGeneⁱ	Hs.162125 Hs.644570

3D structure databases

ProteinModelPortalⁱ	Q8NEA6
SMRⁱ	Q8NEA6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127988, 19 interactors
CORUMⁱ	Q8NEA6
IntActⁱ	Q8NEA6, 7 interactors
STRINGⁱ	9606.ENSP00000371398

PTM databases

iPTMnetⁱ	Q8NEA6
PhosphoSitePlusⁱ	Q8NEA6

Polymorphism and mutation databases

BioMutaⁱ	GLIS3
DMDMⁱ	322510143

Proteomic databases

MaxQBⁱ	Q8NEA6
PaxDbⁱ	Q8NEA6
PeptideAtlasⁱ	Q8NEA6
PRIDEⁱ	Q8NEA6
ProteomicsDBⁱ	73140 73141 [Q8NEA6-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	169792
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000324333; ENSP00000325494; ENSG00000107249 [Q8NEA6-1] ENST00000381971; ENSP00000371398; ENSG00000107249 [Q8NEA6-2]
GeneIDⁱ	169792
KEGGⁱ	hsa:169792
UCSCⁱ	uc003zhw.2 human [Q8NEA6-1]

Organism-specific databases

CTDⁱ	169792
DisGeNETⁱ	169792
EuPathDBⁱ	HostDB:ENSG00000107249.21
GeneCardsⁱ	GLIS3
HGNCⁱ	HGNC:28510 GLIS3
HPAⁱ	HPA056426
MalaCardsⁱ	GLIS3
MIMⁱ	610192 gene 610199 phenotype
neXtProtⁱ	NX_Q8NEA6
OpenTargetsⁱ	ENSG00000107249
Orphanetⁱ	79118 Neonatal diabetes-congenital hypothyroidism-congenital glaucoma-hepatic fibrosis-polycystic kidneys syndrome
PharmGKBⁱ	PA134878768
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00900000140802
HOGENOMⁱ	HOG000231136
HOVERGENⁱ	HBG107950
InParanoidⁱ	Q8NEA6
KOⁱ	K09232
OMAⁱ	HIQGFYG
OrthoDBⁱ	EOG091G0IZP
PhylomeDBⁱ	Q8NEA6
TreeFamⁱ	TF350216

Enzyme and pathway databases

SIGNORⁱ	Q8NEA6

SIGNORⁱ

Q8NEA6

Miscellaneous databases

ChiTaRSⁱ	GLIS3 human
GenomeRNAiⁱ	169792
Protein Ontology More...PROⁱ	PR:Q8NEA6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000107249 Expressed in 156 organ(s), highest expression level in buccal mucosa cell
CleanExⁱ	HS_GLIS3
ExpressionAtlasⁱ	Q8NEA6 baseline and differential
Genevisibleⁱ	Q8NEA6 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR030405 GLIS3 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR19818:SF123 PTHR19818:SF123, 1 hit
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GLIS3_HUMAN
Accessionⁱ	Q8NEA6Primary (citable) accession number: Q8NEA6 Secondary accession number(s): B1AL19, Q1PHK5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
	Last sequence update:	February 8, 2011
	Last modified:	November 7, 2018
	This is version 139 of the entry and version 5 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

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UniProtKB - Q8NEA6 (GLIS3_HUMAN)

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Zinc finger protein GLIS3

GLIS3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ