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Protein

Blood vessel epicardial substance

Gene

BVES

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells (PubMed:16188940). Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca2+-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density (PubMed:26642364). Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury.By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cAMP binding Source: GO_Central
  • structural molecule activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion
LigandcAMP, cAMP-binding, Nucleotide-binding

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8NE79

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Blood vessel epicardial substanceImported
Short name:
hBVES
Alternative name(s):
Popeye domain-containing protein 1
Short name:
Popeye protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BVESImported
Synonyms:POP1Imported, POPDC1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000112276.13

Human Gene Nomenclature Database

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HGNCi
HGNC:1152 BVES

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604577 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NE79

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 48ExtracellularSequence analysisAdd BLAST48
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70CytoplasmicSequence analysis1
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Topological domaini92ExtracellularSequence analysis1
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Topological domaini114 – 360CytoplasmicSequence analysisAdd BLAST247

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Limb-girdle muscular dystrophy 2X (LGMD2X)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of autosomal recessive limb-girdle muscular dystrophy, a degenerative myopathy characterized by slowly progressive wasting and weakness of the proximal muscles of arms and legs around the pelvic or shoulder girdles, elevated creatine kinase levels and dystrophic features on muscle biopsy. LGMD2X patients also develop cardiac arrhythmias resulting in syncopal episodes as young adults or later in life.
See also OMIM:616812
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075625201S → F in LGMD2X; reduces membrane localization of BVES and POPDC2; decreases by 50% affinity for cAMP; disrupts enhancement of KCKN2 surface expression; increases KCKN2 outward currents; no effect on total protein levels. 1 PublicationCorresponds to variant dbSNP:rs869025337EnsemblClinVar.1

Keywords - Diseasei

Limb-girdle muscular dystrophy

Organism-specific databases

DisGeNET

More...
DisGeNETi
11149

MalaCards human disease database

More...
MalaCardsi
BVES
MIMi616812 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000112276

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
476084 Autosomal recessive limb-girdle muscular dystrophy type 2X

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25469

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BVES

Domain mapping of disease mutations (DMDM)

More...
DMDMi
38257661

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000467911 – 360Blood vessel epicardial substanceAdd BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei295PhosphoserineBy similarity1
Modified residuei318PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NE79

PeptideAtlas

More...
PeptideAtlasi
Q8NE79

PRoteomics IDEntifications database

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PRIDEi
Q8NE79

ProteomicsDB human proteome resource

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ProteomicsDBi
73133

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NE79

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NE79

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in epithelial cells (at protein level). Expressed in fetal and adult heart and skeletal muscle.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000112276 Expressed in 159 organ(s), highest expression level in heart

CleanEx database of gene expression profiles

More...
CleanExi
HS_BVES
HS_POP1

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8NE79 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA014788
HPA018176

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Homodimerization requires the C-terminus cytoplasmic region. Interacts (via the C-terminus cytoplasmic tail) with TJP1. Interacts (via the C-terminus cytoplasmic tail) with ARHGEF25/GEFT (via the DH domain). Interacts (via the C-terminus cytoplasmic tail) with VAMP3 (By similarity). Interacts with KCNK2; the interaction enhances KCNK2 surface expression and is inhibited by cAMP (By similarity) (PubMed:26642364). Interacts with CAV3 (By similarity).By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116321, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NE79, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000313172

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8NE79

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NE79

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni93 – 115Required for interaction with CAV3By similarityAdd BLAST23
Regioni136 – 186Required for interaction with KCNK21 PublicationAdd BLAST51

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the popeye family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGHK Eukaryota
ENOG410ZTIT LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000002563

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG053638

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8NE79

KEGG Orthology (KO)

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KOi
K21108

Identification of Orthologs from Complete Genome Data

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OMAi
TIGCTLY

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0B7Q

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NE79

TreeFam database of animal gene trees

More...
TreeFami
TF326644

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.120.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR018490 cNMP-bd-like
IPR006916 Popeye_prot
IPR014710 RmlC-like_jellyroll

The PANTHER Classification System

More...
PANTHERi
PTHR12101 PTHR12101, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04831 Popeye, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51206 SSF51206, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8NE79-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNYTESSPLR ESTAIGFTPE LESIIPVPSN KTTCENWREI HHLVFHVANI
60 70 80 90 100
CFAVGLVIPT TLHLHMIFLR GMLTLGCTLY IVWATLYRCA LDIMIWNSVF
110 120 130 140 150
LGVNILHLSY LLYKKRPVKI EKELSGMYRR LFEPLRVPPD LFRRLTGQFC
160 170 180 190 200
MIQTLKKGQT YAAEDKTSVD DRLSILLKGK MKVSYRGHFL HNIYPCAFID
210 220 230 240 250
SPEFRSTQMH KGEKFQVTII ADDNCRFLCW SRERLTYFLE SEPFLYEIFR
260 270 280 290 300
YLIGKDITNK LYSLNDPTLN DKKAKKLEHQ LSLCTQISML EMRNSIASSS
310 320 330 340 350
DSDDGLHQFL RGTSSMSSLH VSSPHQRASA KMKPIEEGAE DDDDVFEPAS
360
PNTLKVHQLP
Length:360
Mass (Da):41,451
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i15B21A995FEEA351
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti27V → P in AAD51780 (PubMed:10441744).Curated1
Sequence conflicti110Y → I in AAG23405 (PubMed:10882522).Curated1
Sequence conflicti123E → D in AAG23405 (PubMed:10882522).Curated1
Sequence conflicti128Y → V in AAG23405 (PubMed:10882522).Curated1
Sequence conflicti132F → V in AAG23405 (PubMed:10882522).Curated1
Sequence conflicti342D → G in AAH40502 (PubMed:15489334).Curated1
Sequence conflicti358Q → R in BAF82668 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053600127M → I. Corresponds to variant dbSNP:rs9486039Ensembl.1
Natural variantiVAR_017155129R → W. Corresponds to variant dbSNP:rs2275289Ensembl.1
Natural variantiVAR_075625201S → F in LGMD2X; reduces membrane localization of BVES and POPDC2; decreases by 50% affinity for cAMP; disrupts enhancement of KCKN2 surface expression; increases KCKN2 outward currents; no effect on total protein levels. 1 PublicationCorresponds to variant dbSNP:rs869025337EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF204172 mRNA Translation: AAG23405.1
AK289979 mRNA Translation: BAF82668.1
AL356775 Genomic DNA No translation available.
Z95329 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48430.1
CH471051 Genomic DNA Translation: EAW48431.1
CH471051 Genomic DNA Translation: EAW48432.1
BC034425 mRNA Translation: AAH34425.1
BC040502 mRNA Translation: AAH40502.2
AF124512 mRNA Translation: AAD51780.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5051.1

NCBI Reference Sequences

More...
RefSeqi
NP_001186492.1, NM_001199563.1
NP_009004.2, NM_007073.4
NP_671488.1, NM_147147.3
XP_011533700.1, XM_011535398.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.221660

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000314641; ENSP00000313172; ENSG00000112276
ENST00000336775; ENSP00000337259; ENSG00000112276
ENST00000446408; ENSP00000397310; ENSG00000112276

Database of genes from NCBI RefSeq genomes

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GeneIDi
11149

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11149

UCSC genome browser

More...
UCSCi
uc003pqw.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204172 mRNA Translation: AAG23405.1
AK289979 mRNA Translation: BAF82668.1
AL356775 Genomic DNA No translation available.
Z95329 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48430.1
CH471051 Genomic DNA Translation: EAW48431.1
CH471051 Genomic DNA Translation: EAW48432.1
BC034425 mRNA Translation: AAH34425.1
BC040502 mRNA Translation: AAH40502.2
AF124512 mRNA Translation: AAD51780.1
CCDSiCCDS5051.1
RefSeqiNP_001186492.1, NM_001199563.1
NP_009004.2, NM_007073.4
NP_671488.1, NM_147147.3
XP_011533700.1, XM_011535398.2
UniGeneiHs.221660

3D structure databases

ProteinModelPortaliQ8NE79
SMRiQ8NE79
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116321, 4 interactors
IntActiQ8NE79, 2 interactors
STRINGi9606.ENSP00000313172

PTM databases

iPTMnetiQ8NE79
PhosphoSitePlusiQ8NE79

Polymorphism and mutation databases

BioMutaiBVES
DMDMi38257661

Proteomic databases

PaxDbiQ8NE79
PeptideAtlasiQ8NE79
PRIDEiQ8NE79
ProteomicsDBi73133

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
11149
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314641; ENSP00000313172; ENSG00000112276
ENST00000336775; ENSP00000337259; ENSG00000112276
ENST00000446408; ENSP00000397310; ENSG00000112276
GeneIDi11149
KEGGihsa:11149
UCSCiuc003pqw.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11149
DisGeNETi11149
EuPathDBiHostDB:ENSG00000112276.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BVES
HGNCiHGNC:1152 BVES
HPAiHPA014788
HPA018176
MalaCardsiBVES
MIMi604577 gene
616812 phenotype
neXtProtiNX_Q8NE79
OpenTargetsiENSG00000112276
Orphaneti476084 Autosomal recessive limb-girdle muscular dystrophy type 2X
PharmGKBiPA25469

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGHK Eukaryota
ENOG410ZTIT LUCA
GeneTreeiENSGT00390000002563
HOVERGENiHBG053638
InParanoidiQ8NE79
KOiK21108
OMAiTIGCTLY
OrthoDBiEOG091G0B7Q
PhylomeDBiQ8NE79
TreeFamiTF326644

Enzyme and pathway databases

SIGNORiQ8NE79

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
BVES human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Blood_vessel_epicardial_substance

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
11149

Protein Ontology

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PROi
PR:Q8NE79

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000112276 Expressed in 159 organ(s), highest expression level in heart
CleanExiHS_BVES
HS_POP1
GenevisibleiQ8NE79 HS

Family and domain databases

Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR006916 Popeye_prot
IPR014710 RmlC-like_jellyroll
PANTHERiPTHR12101 PTHR12101, 1 hit
PfamiView protein in Pfam
PF04831 Popeye, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOPD1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NE79
Secondary accession number(s): A8K1R4
, E1P5D8, Q5T550, Q5T551, Q8IWC6, Q9HBV0, Q9UNG6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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